1,021
Views
21
CrossRef citations to date
0
Altmetric
Research Paper

Genetic amplification of PPME1 in gastric and lung cancer and its potential as a novel therapeutic target

, , , , , , , , , , & show all
Pages 128-134 | Received 10 Oct 2013, Accepted 10 Nov 2013, Published online: 19 Nov 2013

References

  • Trends Progress Report C. – 2011/2012 Update, National Cancer Institute, NIH, DHHS, Bethesda, MD, August 2012. Available from: http://progressreport.cancer.gov
  • National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified <05/30/2013>. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/healthprofessional. Accessed 06/18/2013.
  • Shaw EG, Brindle JS, Creagan ET, Foote RL, Trastek VF, Buskirk SJ. Locally recurrent non-small-cell lung cancer after complete surgical resection. Mayo Clin Proc 1992; 67:1129 - 33; http://dx.doi.org/10.1016/S0025-6196(12)61141-0; PMID: 1335100
  • Kelsey CR, Marks LB, Hollis D, Hubbs JL, Ready NE, D’Amico TA, Boyd JA. Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients. Cancer 2009; 115:5218 - 27; http://dx.doi.org/10.1002/cncr.24625; PMID: 19672942
  • Thomas P, Rubinstein L, Lung Cancer Study Group. Cancer recurrence after resection: T1 N0 non-small cell lung cancer. Ann Thorac Surg 1990; 49:242 - 6, discussion 246-7; http://dx.doi.org/10.1016/0003-4975(90)90145-V; PMID: 2154958
  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69 - 90; http://dx.doi.org/10.3322/caac.20107; PMID: 21296855
  • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, et al, ToGA Trial Investigators. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376:687 - 97; http://dx.doi.org/10.1016/S0140-6736(10)61121-X; PMID: 20728210
  • Gorringe KL, Boussioutas A, Bowtell DD, Melbourne Gastric Cancer Group, Peter Mac Micro Array Facility. Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Genes Chromosomes Cancer 2005; 42:247 - 59; http://dx.doi.org/10.1002/gcc.20136; PMID: 15611932
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646 - 74; http://dx.doi.org/10.1016/j.cell.2011.02.013; PMID: 21376230
  • Stuart D, Sellers WR. Linking somatic genetic alterations in cancer to therapeutics. Curr Opin Cell Biol 2009; 21:304 - 10; http://dx.doi.org/10.1016/j.ceb.2009.02.001; PMID: 19328671
  • Gazdar AF, Shigematsu H, Herz J, Minna JD. Mutations and addiction to EGFR: the Achilles ‘heal’ of lung cancers?. Trends Mol Med 2004; 10:481 - 6; http://dx.doi.org/10.1016/j.molmed.2004.08.008; PMID: 15464447
  • Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007; 448:561 - 6; http://dx.doi.org/10.1038/nature05945; PMID: 17625570
  • Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007; 446:153 - 8; http://dx.doi.org/10.1038/nature05610; PMID: 17344846
  • Buffart TE, Louw M, van Grieken NC, Tijssen M, Carvalho B, Ylstra B, Grabsch H, Mulder CJ, van de Velde CJ, van der Merwe SW, et al. Gastric cancers of Western European and African patients show different patterns of genomic instability. BMC Med Genomics 2011; 4:7; http://dx.doi.org/10.1186/1755-8794-4-7; PMID: 21226972
  • Janjigian YY, Tang LH, Coit DG, Kelsen DP, Francone TD, Weiser MR, Jhanwar SC, Shah MA. MET expression and amplification in patients with localized gastric cancer. Cancer Epidemiol Biomarkers Prev 2011; 20:1021 - 7; http://dx.doi.org/10.1158/1055-9965.EPI-10-1080; PMID: 21393565
  • Longin S, Zwaenepoel K, Louis JV, Dilworth S, Goris J, Janssens V. Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit. J Biol Chem 2007; 282:26971 - 80; http://dx.doi.org/10.1074/jbc.M704059200; PMID: 17635907
  • Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J Biol Chem 1999; 274:14382 - 91; http://dx.doi.org/10.1074/jbc.274.20.14382; PMID: 10318862
  • Yu XX, Du X, Moreno CS, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, Pallas DC. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell 2001; 12:185 - 99; http://dx.doi.org/10.1091/mbc.12.1.185; PMID: 11160832
  • Turowski P, Myles T, Hemmings BA, Fernandez A, Lamb NJ. Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55. Mol Biol Cell 1999; 10:1997 - 2015; http://dx.doi.org/10.1091/mbc.10.6.1997; PMID: 10359611
  • Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta 2009; 1795:1 - 15; PMID: 18588945
  • Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, et al. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. Cancer Res 2009; 69:2870 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-08-2760; PMID: 19293187
  • Kalev P, Sablina AA. Protein phosphatase 2A as a potential target for anticancer therapy. Anticancer Agents Med Chem 2011; 11:38 - 46; http://dx.doi.org/10.2174/187152011794941172; PMID: 21288198
  • Arroyo JD, Hahn WC. Involvement of PP2A in viral and cellular transformation. Oncogene 2005; 24:7746 - 55; http://dx.doi.org/10.1038/sj.onc.1209038; PMID: 16299534
  • Zhou J, Pham HT, Walter G. The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit. J Biol Chem 2003; 278:8617 - 22; http://dx.doi.org/10.1074/jbc.M211181200; PMID: 12506124
  • Li X, Virshup DM. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem 2002; 269:546 - 52; http://dx.doi.org/10.1046/j.0014-2956.2001.02680.x; PMID: 11856313
  • Bononi A, Agnoletto C, De Marchi E, Marchi S, Patergnani S, Bonora M, Giorgi C, Missiroli S, Poletti F, Rimessi A, et al. Protein kinases and phosphatases in the control of cell fate. Enzyme Res 2011; 2011:329098; http://dx.doi.org/10.4061/2011/329098; PMID: 21904669
  • McCaddon A, Hudson PR. Methylation and phosphorylation: a tangled relationship?. Clin Chem 2007; 53:999 - 1000; http://dx.doi.org/10.1373/clinchem.2007.086579; PMID: 17517583
  • Chen J, Martin BL, Brautigan DL. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 1992; 257:1261 - 4; http://dx.doi.org/10.1126/science.1325671; PMID: 1325671
  • Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC. Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity. Cancer Res 2005; 65:8183 - 92; http://dx.doi.org/10.1158/0008-5472.CAN-05-1103; PMID: 16166293
  • Jackson JB, Pallas DC. Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner. Neoplasia 2012; 14:585 - 99; PMID: 22904676
  • Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, Cravatt BF. Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS One 2008; 3:e2486; http://dx.doi.org/10.1371/journal.pone.0002486; PMID: 18596935
  • Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell 2008; 133:154 - 63; http://dx.doi.org/10.1016/j.cell.2008.02.041; PMID: 18394995
  • Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proc Natl Acad Sci U S A 2011; 108:6811 - 6; http://dx.doi.org/10.1073/pnas.1015248108; PMID: 21398589
  • Hechtman JF, Polydorides AD. HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. Arch Pathol Lab Med 2012; 136:691 - 7; http://dx.doi.org/10.5858/arpa.2011-0168-RS; PMID: 22646280
  • Gunturu KS, Woo Y, Beaubier N, Remotti HE, Saif MW. Gastric cancer and trastuzumab: first biologic therapy in gastric cancer. Ther Adv Med Oncol 2013; 5:143 - 51; http://dx.doi.org/10.1177/1758834012469429; PMID: 23450234
  • Dropulić B. Lentiviral vectors: their molecular design, safety, and use in laboratory and preclinical research. Hum Gene Ther 2011; 22:649 - 57; http://dx.doi.org/10.1089/hum.2011.058; PMID: 21486177

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.