Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2

References

• Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69 - 90; http://dx.doi.org/10.3322/caac.20107; PMID: 21296855
   PubMed Web of Science ®Google Scholar
• Peralta-Zaragoza O, Deas J, Gómez-Cerón C, García-Suastegui WA, Fierros-Zárate GdelS, Jacobo-Herrera NJ. HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia. Obstet Gynecol Int 2013; 2013:912780; http://dx.doi.org/10.1155/2013/912780; PMID: 23690785
   PubMedGoogle Scholar
• Luhn P, Wentzensen N. HPV-based Tests for Cervical Cancer Screening and Management of Cervical Disease. Curr Obstet Gynecol Rep 2013; 2:76 - 85; http://dx.doi.org/10.1007/s13669-013-0040-0; PMID: 23705102
   PubMedGoogle Scholar
• Mathew A, George PS. Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix--worldwide. Asian Pac J Cancer Prev 2009; 10:645 - 50; PMID: 19827887
   PubMed Web of Science ®Google Scholar
• Iida K, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Yeasmin S, Otsuki Y, Kobayashi H, Nakayama S, et al. EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target. Br J Cancer 2011; 105:420 - 7; http://dx.doi.org/10.1038/bjc.2011.222; PMID: 21730982
   PubMed Web of Science ®Google Scholar
• Kawana K, Adachi K, Kojima S, Kozuma S, Fujii T. Therapeutic Human Papillomavirus (HPV) Vaccines: A Novel Approach. Open Virol J 2012; 6:264 - 9; http://dx.doi.org/10.2174/1874357901206010264; PMID: 23341862
   PubMedGoogle Scholar
• Denny L. Cervical cancer: prevention and treatment. Discov Med 2012; 14:125 - 31; PMID: 22935209
   PubMed Web of Science ®Google Scholar
• Lee S. Artemisinin, promising lead natural product for various drug developments. Mini Rev Med Chem 2007; 7:411 - 22; http://dx.doi.org/10.2174/138955707780363837; PMID: 17430226
   PubMed Web of Science ®Google Scholar
• Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR. The anti-malarial artesunate is also active against cancer. Int J Oncol 2001; 18:767 - 73; PMID: 11251172
   PubMed Web of Science ®Google Scholar
• Hien TT, White NJ. Qinghaosu. Lancet 1993; 341:603 - 8; http://dx.doi.org/10.1016/0140-6736(93)90362-K; PMID: 8094838
   PubMed Web of Science ®Google Scholar
• Chen HH, Zhou HJ, Fang X. Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res 2003; 48:231 - 6; http://dx.doi.org/10.1016/S1043-6618(03)00107-5; PMID: 12860439
   PubMed Web of Science ®Google Scholar
• Disbrow GL, Baege AC, Kierpiec KA, Yuan H, Centeno JA, Thibodeaux CA, Hartmann D, Schlegel R. Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. Cancer Res 2005; 65:10854 - 61; http://dx.doi.org/10.1158/0008-5472.CAN-05-1216; PMID: 16322232
   PubMed Web of Science ®Google Scholar
• Chen H, Sun B, Pan S, Jiang H, Sun X. Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Anticancer Drugs 2009; 20:131 - 40; http://dx.doi.org/10.1097/CAD.0b013e3283212ade; PMID: 19209030
   PubMed Web of Science ®Google Scholar
• Wu GS, Lu JJ, Guo JJ, Huang MQ, Gan L, Chen XP, Wang YT. Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharmacol Rep 2013; 65:453 - 9; PMID: 23744430
   PubMed Web of Science ®Google Scholar
• Du XX, Li YJ, Wu CL, Zhou JH, Han Y, Sui H, Wei XL, Liu L, Huang P, Yuan HH, et al. Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin. Biomed Pharmacother 2013; 67:417 - 24; http://dx.doi.org/10.1016/j.biopha.2013.01.013; PMID: 23582790
   PubMed Web of Science ®Google Scholar
• Luo J, Chen X, Chen G, Zhou X, Lu X, Ling Y, Zhang S, Zhu W, Cao J. Dihydroartemisinin induces radiosensitivity in cervical cancer cells by modulating cell cycle progression. Saudi Med J 2013; 34:254 - 60; PMID: 23475089
   PubMed Web of Science ®Google Scholar
• Wang SJ, Gao Y, Chen H, Kong R, Jiang HC, Pan SH, Xue DB, Bai XW, Sun B. Dihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo. Cancer Lett 2010; 293:99 - 108; http://dx.doi.org/10.1016/j.canlet.2010.01.001; PMID: 20137856
   PubMed Web of Science ®Google Scholar
• Hagan S, Al-Mulla F, Mallon E, Oien K, Ferrier R, Gusterson B, García JJ, Kolch W. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res 2005; 11:7392 - 7; http://dx.doi.org/10.1158/1078-0432.CCR-05-0283; PMID: 16243812
   PubMed Web of Science ®Google Scholar
• Fu Z, Smith PC, Zhang L, Rubin MA, Dunn RL, Yao Z, Keller ET. Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 2003; 95:878 - 89; http://dx.doi.org/10.1093/jnci/95.12.878; PMID: 12813171
   PubMed Web of Science ®Google Scholar
• Li HZ, Wang Y, Gao Y, Shao J, Zhao XL, Deng WM, Liu YX, Yang J, Yao Z. Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer. Mol Cancer Res 2008; 6:917 - 28; http://dx.doi.org/10.1158/1541-7786.MCR-08-0093; PMID: 18567796
   PubMed Web of Science ®Google Scholar
• Al-Awadhi R, Husain S, Chehadeh W, Al-Jassar W, Kapila K, Al-Mulla F. Immunocytochemical detection of raf kinase inhibitor protein and human papillomavirus profiling of normal and abnormal cervical ThinPrep samples. Acta Cytol 2013; 57:259 - 65; http://dx.doi.org/10.1159/000350249; PMID: 23636063
   PubMed Web of Science ®Google Scholar
• Al-Mulla F, Bitar MS, Taqi Z, Yeung KC. RKIP: much more than Raf kinase inhibitory protein. J Cell Physiol 2013; 228:1688 - 702; http://dx.doi.org/10.1002/jcp.24335; PMID: 23359513
   PubMed Web of Science ®Google Scholar
• Hu CJ, Zhou L, Zhang J, Huang C, Zhang GM. Immunohistochemical detection of Raf kinase inhibitor protein in normal cervical tissue and cervical cancer tissue. J Int Med Res 2011; 39:229 - 37; http://dx.doi.org/10.1177/147323001103900125; PMID: 21672326
   PubMed Web of Science ®Google Scholar
• Martinho O, Pinto F, Granja S, Miranda-Gonçalves V, Moreira MA, Ribeiro LF, di Loreto C, Rosner MR, Longatto-Filho A, Reis RM. RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. PLoS One 2013; 8:e59104; http://dx.doi.org/10.1371/journal.pone.0059104; PMID: 23527098
   PubMedGoogle Scholar
• Peralta-Zaragoza O, Bermúdez-Morales VH, Pérez-Plasencia C, Salazar-León J, Gómez-Cerón C, Madrid-Marina V. Targeted treatments for cervical cancer: a review. Onco Targets Ther 2012; 5:315 - 28; http://dx.doi.org/10.2147/OTT.S25123; PMID: 23144564
   PubMed Web of Science ®Google Scholar
• Efferth T, Benakis A, Romero MR, Tomicic M, Rauh R, Steinbach D, Häfer R, Stamminger T, Oesch F, Kaina B, et al. Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. Free Radic Biol Med 2004; 37:998 - 1009; http://dx.doi.org/10.1016/j.freeradbiomed.2004.06.023; PMID: 15336316
   PubMed Web of Science ®Google Scholar
• Lu JJ, Meng LH, Cai YJ, Chen Q, Tong LJ, Lin LP, Ding J. Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species. Cancer Biol Ther 2008; 7:1017 - 23; http://dx.doi.org/10.4161/cbt.7.7.6035; PMID: 18414062
   PubMed Web of Science ®Google Scholar
• Ferreira JF, Luthria DL, Sasaki T, Heyerick A. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules 2010; 15:3135 - 70; http://dx.doi.org/10.3390/molecules15053135; PMID: 20657468
   PubMed Web of Science ®Google Scholar
• Zhang XM, Gu H, Yan L, Zhang GY. RKIP inhibits the malignant phenotypes of gastric cancer cells. Neoplasma 2012; Forthcoming http://dx.doi.org/10.4149/neo_2013_026; PMID: 23176280
   PubMed Web of Science ®Google Scholar
• al-Mulla F, Bitar MS, Taqi Z, Rath O, Kolch W. RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility. Mol Biosyst 2011; 7:928 - 41; http://dx.doi.org/10.1039/c0mb00208a; PMID: 21180766
   PubMed Web of Science ®Google Scholar
• Baritaki S, Chapman A, Yeung K, Spandidos DA, Palladino M, Bonavida B. Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene 2009; 28:3573 - 85; http://dx.doi.org/10.1038/onc.2009.214; PMID: 19633685
   PubMed Web of Science ®Google Scholar
• Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol 2001; 21:7207 - 17; http://dx.doi.org/10.1128/MCB.21.21.7207-7217.2001; PMID: 11585904
   PubMed Web of Science ®Google Scholar
• Wu K, Bonavida B. The activated NF-kappaB-Snail-RKIP circuitry in cancer regulates both the metastatic cascade and resistance to apoptosis by cytotoxic drugs. Crit Rev Immunol 2009; 29:241 - 54; http://dx.doi.org/10.1615/CritRevImmunol.v29.i3.40; PMID: 19538137
   PubMed Web of Science ®Google Scholar
• Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006; 9:351 - 65; http://dx.doi.org/10.1016/j.ccr.2006.03.027; PMID: 16697956
   PubMed Web of Science ®Google Scholar
• Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA. Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. Mol Cancer Res 2005; 3:21 - 31; PMID: 15671246
   PubMed Web of Science ®Google Scholar
• Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435:677 - 81; http://dx.doi.org/10.1038/nature03579; PMID: 15902208
   PubMed Web of Science ®Google Scholar
• VanBrocklin MW, Verhaegen M, Soengas MS, Holmen SL. Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma. Cancer Res 2009; 69:1985 - 94; http://dx.doi.org/10.1158/0008-5472.CAN-08-3934; PMID: 19244105
   PubMed Web of Science ®Google Scholar
• Schwarz CS, Evert BO, Seyfried J, Schaupp M, Kunz WS, Vielhaber S, Klockgether T, Wüllner U. Overexpression of bcl-2 results in reduction of cytochrome c content and inhibition of complex I activity. Biochem Biophys Res Commun 2001; 280:1021 - 7; http://dx.doi.org/10.1006/bbrc.2001.4242; PMID: 11162629
   PubMed Web of Science ®Google Scholar
• Al-Mulla F, Bitar MS, Al-Maghrebi M, Behbehani AI, Al-Ali W, Rath O, Doyle B, Tan KY, Pitt A, Kolch W. Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β. Cancer Res 2011; 71:1334 - 43; http://dx.doi.org/10.1158/0008-5472.CAN-10-3102; PMID: 21303975
   PubMed Web of Science ®Google Scholar