Targeting the unfolded protein response, XBP1, and the NLRP3 inflammasome in fibrosis and cancer

References

• Chakrabarti A, Chen AW, Varner JD. A review of the mammalian unfolded protein response. Biotechnol Bioeng 2011; 108:2777 - 93; http://dx.doi.org/10.1002/bit.23282; PMID: 21809331
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Kepp O, Galluzzi L, Kroemer G. Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol 2012; 13:343 - 51; http://dx.doi.org/10.1038/ni.2224; PMID: 22430787
   PubMed Web of Science ®Google Scholar
• Lamkanfi M. Emerging inflammasome effector mechanisms. Nat Rev Immunol 2011; 11:213 - 20; http://dx.doi.org/10.1038/nri2936; PMID: 21350580
   PubMed Web of Science ®Google Scholar
• Chu J, Thomas LM, Watkins SC, Franchi L, Núñez G, Salter RD. Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner. J Leukoc Biol 2009; 86:1227 - 38; http://dx.doi.org/10.1189/jlb.0309164; PMID: 19675207
   PubMed Web of Science ®Google Scholar
• Dostert C, Guarda G, Romero JF, Menu P, Gross O, Tardivel A, Suva M-L, Stehle J-C, Kopf M, Stamenkovic I, et al. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 2009; 4:e6510; http://dx.doi.org/10.1371/journal.pone.0006510; PMID: 19652710
   PubMed Web of Science ®Google Scholar
• Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006; 126:1135 - 45; http://dx.doi.org/10.1016/j.cell.2006.07.033; PMID: 16990137
   PubMed Web of Science ®Google Scholar
• Thomas PG, Dash P, Aldridge JR Jr., Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 2009; 30:566 - 75; http://dx.doi.org/10.1016/j.immuni.2009.02.006; PMID: 19362023
   PubMed Web of Science ®Google Scholar
• Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A 2008; 105:9035 - 40; http://dx.doi.org/10.1073/pnas.0803933105; PMID: 18577586
   PubMed Web of Science ®Google Scholar
• Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008; 320:674 - 7; http://dx.doi.org/10.1126/science.1156995; PMID: 18403674
   PubMed Web of Science ®Google Scholar
• Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 9:847 - 56; http://dx.doi.org/10.1038/ni.1631; PMID: 18604214
   PubMed Web of Science ®Google Scholar
• Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VFJ, Ryffel B, et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 2009; 179:903 - 13; http://dx.doi.org/10.1164/rccm.200808-1274OC; PMID: 19218193
   PubMed Web of Science ®Google Scholar
• Mariathasan S, Weiss DS, Newton K, McBride J, O’Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006; 440:228 - 32; http://dx.doi.org/10.1038/nature04515; PMID: 16407890
   PubMed Web of Science ®Google Scholar
• Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer’s pathology. J Cell Mol Med 2008; 12:6A 2255 - 62; http://dx.doi.org/10.1111/j.1582-4934.2008.00496.x; PMID: 18793350
   PubMedGoogle Scholar
• Yamasaki K, Muto J, Taylor KR, Cogen AL, Audish D, Bertin J, Grant EP, Coyle AJ, Misaghi A, Hoffman HM, et al. NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem 2009; 284:12762 - 71; http://dx.doi.org/10.1074/jbc.M806084200; PMID: 19258328
   PubMed Web of Science ®Google Scholar
• Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C, Ting JP. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med 2010; 207:1045 - 56; http://dx.doi.org/10.1084/jem.20100050; PMID: 20385749
   PubMed Web of Science ®Google Scholar
• Artlett CM, Sassi-Gaha S, Rieger JL, Boesteanu AC, Feghali-Bostwick CA, Katsikis PD. The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis. Arthritis Rheum 2011; 63:3563 - 74; http://dx.doi.org/10.1002/art.30568; PMID: 21792841
   PubMed Web of Science ®Google Scholar
• Thacker JD, Brown MA, Rest RF, Purohit M, Sassi-Gaha S, Artlett CM. 1-Peptidyl-2-arachidonoyl-3-stearoyl-sn-glyceride: an immunologically active lipopeptide from goat serum (Capra hircus) is an endogenous damage-associated molecular pattern. J Nat Prod 2009; 72:1993 - 9; http://dx.doi.org/10.1021/np900360m; PMID: 19835390
   PubMed Web of Science ®Google Scholar
• Thacker JD, Balin BJ, Appelt DM, Sassi-Gaha S, Purohit M, Rest RF, Artlett CM. NLRP3 inflammasome is a target for development of broad-spectrum anti-infective drugs. Antimicrob Agents Chemother 2012; 56:1921 - 30; http://dx.doi.org/10.1128/AAC.06372-11; PMID: 22290938
   PubMed Web of Science ®Google Scholar
• Majumder M, Huang C, Snider MD, Komar AA, Tanaka J, Kaufman RJ, Krokowski D, Hatzoglou M. A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation. Mol Cell Biol 2012; 32:992 - 1003; http://dx.doi.org/10.1128/MCB.06665-11; PMID: 22215619
   PubMed Web of Science ®Google Scholar
• Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008; 454:455 - 62; http://dx.doi.org/10.1038/nature07203; PMID: 18650916
   PubMed Web of Science ®Google Scholar
• Luckett EM. THX314: Intravenous toxicity study in female C57Bl/6 mice. MPI Research, Inc. Mattawan, MI 49071 February 25, 2010.
   Google Scholar
• Paetzel M, Karla A, Strynadka NCJ, Dalbey RE. Signal peptidases. Chem Rev 2002; 102:4549 - 80; http://dx.doi.org/10.1021/cr010166y; PMID: 12475201
   PubMed Web of Science ®Google Scholar
• Bryan NB, Dorfleutner A, Rojanasakul Y, Stehlik C. Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain. J Immunol 2009; 182:3173 - 82; http://dx.doi.org/10.4049/jimmunol.0802367; PMID: 19234215
   PubMed Web of Science ®Google Scholar
• Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469:221 - 5; http://dx.doi.org/10.1038/nature09663; PMID: 21124315
   PubMed Web of Science ®Google Scholar
• Koong AC, Chauhan V, Romero-Ramirez L. Targeting XBP-1 as a novel anti-cancer strategy. Cancer Biol Ther 2006; 5:756 - 9; http://dx.doi.org/10.4161/cbt.5.7.2973; PMID: 16861911
   PubMed Web of Science ®Google Scholar
• Mimura N, Fulciniti M, Gorgun G, Tai Y-T, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood 2012; 119:5772 - 81; http://dx.doi.org/10.1182/blood-2011-07-366633; PMID: 22538852
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang X, Liang Y, Yu H, Chen X, Zheng T, Zheng B, Wang L, Zhao L, Shi C, et al. Targeting X box-binding protein-1 (XBP1) enhances sensitivity of glioma cells to oxidative stress. Neuropathol Appl Neurobiol 2011; 37:395 - 405; http://dx.doi.org/10.1111/j.1365-2990.2010.01155.x; PMID: 21138464
   PubMed Web of Science ®Google Scholar
• Andres SA, Wittliff JL. Relationships of ESR1 and XBP1 expression in human breast carcinoma and stromal cells isolated by laser capture microdissection compared to intact breast cancer tissue. Endocrine 2011; 40:212 - 21; http://dx.doi.org/10.1007/s12020-011-9522-x; PMID: 21858728
   PubMed Web of Science ®Google Scholar
• Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 2004; 64:5943 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-04-1606; PMID: 15342372
   PubMed Web of Science ®Google Scholar
• Iwakoshi NN, Pypaert M, Glimcher LH. The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med 2007; 204:2267 - 75; http://dx.doi.org/10.1084/jem.20070525; PMID: 17875675
   PubMed Web of Science ®Google Scholar
• Lenna S, Farina AG, Martyanov V, Christmann RB, Wood TA, Farber HW, Scorza R, Whitfield ML, Lafyatis R, Trojanowska M. Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension. Arthritis Rheum 2013; 65:1357 - 66; http://dx.doi.org/10.1002/art.37891; PMID: 23400395
   PubMed Web of Science ®Google Scholar
• Derk CT, Artlett CM, Jimenez SA. Morbidity and mortality of patients diagnosed with systemic sclerosis after the age of 75: a nested case-control study. Clin Rheumatol 2006; 25:831 - 4; http://dx.doi.org/10.1007/s10067-005-0177-y; PMID: 16435160
   PubMed Web of Science ®Google Scholar
• Derk CT, Rasheed M, Artlett CM, Jimenez SA. A cohort study of cancer incidence in systemic sclerosis. J Rheumatol 2006; 33:1113 - 6; PMID: 16622904
   PubMed Web of Science ®Google Scholar