All-trans-retinoic acid antagonizes the hedgehog pathway by inducing patched

References

• Verhoeven RHA, Gondos A, Janssen-Heijnen MLG, Saum KU, Brewster DH, Holleczek B, Crocetti E, Rosso S, Hakulinen T, Aareleid T, et al, EUNICE Survival Working Group. Testicular cancer in Europe and the USA: survival still rising among older patients. Ann Oncol 2013; 24:508 - 13; http://dx.doi.org/10.1093/annonc/mds460; PMID: 23110807
   PubMed Web of Science ®Google Scholar
• Spinella MJ, Kerley JS, White KA, Curtin JC. Retinoid target gene activation during induced tumor cell differentiation: human embryonal carcinoma as a model. J Nutr 2003; 133:273S - 6S; PMID: 12514308
   PubMedGoogle Scholar
• Andrews PW. Teratocarcinomas and human embryology: pluripotent human EC cell lines. Review article. APMIS 1998; 106:158 - 67, discussion 167-8; http://dx.doi.org/10.1111/j.1699-0463.1998.tb01331.x; PMID: 9524574
   PubMed Web of Science ®Google Scholar
• Andrews PW. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 1984; 103:285 - 93; http://dx.doi.org/10.1016/0012-1606(84)90316-6; PMID: 6144603
   PubMed Web of Science ®Google Scholar
• Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 2003; 22:7305 - 15; http://dx.doi.org/10.1038/sj.onc.1206936; PMID: 14576840
   PubMed Web of Science ®Google Scholar
• Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell 2008; 134:921 - 31; http://dx.doi.org/10.1016/j.cell.2008.09.002; PMID: 18805086
   PubMed Web of Science ®Google Scholar
• Bastien J, Rochette-Egly C. Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene 2004; 328:1 - 16; http://dx.doi.org/10.1016/j.gene.2003.12.005; PMID: 15019979
   PubMed Web of Science ®Google Scholar
• Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15:3059 - 87; http://dx.doi.org/10.1101/gad.938601; PMID: 11731473
   PubMed Web of Science ®Google Scholar
• Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993; 75:1417 - 30; http://dx.doi.org/10.1016/0092-8674(93)90627-3; PMID: 7916661
   PubMed Web of Science ®Google Scholar
• Katoh Y, Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 2009; 9:873 - 86; http://dx.doi.org/10.2174/156652409789105570; PMID: 19860666
   PubMed Web of Science ®Google Scholar
• Ribes V, Wang Z, Dollé P, Niederreither K. Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development 2006; 133:351 - 61; http://dx.doi.org/10.1242/dev.02204; PMID: 16368932
   PubMed Web of Science ®Google Scholar
• Niederreither K, Dollé P. Retinoic acid in development: towards an integrated view. Nat Rev Genet 2008; 9:541 - 53; http://dx.doi.org/10.1038/nrg2340; PMID: 18542081
   PubMed Web of Science ®Google Scholar
• Langlois A, Duval D. Differentiation of the human NT2 cells into neurons and glia. Methods Cell Sci 1997; 19:213 - 9; http://dx.doi.org/10.1023/A:1009731707443
   Google Scholar
• Moasser MM, Khoo K-S, Maerz WJ, Zelenetz A, Dmitrovsky E. Derivation and characterization of retinoid-resistant human embryonal carcinoma cells. Differentiation 1996; 60:251 - 7; http://dx.doi.org/10.1046/j.1432-0436.1996.6040251.x; PMID: 8765055
   PubMed Web of Science ®Google Scholar
• Kogerman P, Krause D, Rahnama F, Kogerman L, Undén AB, Zaphiropoulos PG, Toftgård R. Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein. Oncogene 2002; 21:6007 - 16; http://dx.doi.org/10.1038/sj.onc.1205865; PMID: 12203113
   PubMed Web of Science ®Google Scholar
• Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002; 16:2743 - 8; http://dx.doi.org/10.1101/gad.1025302; PMID: 12414725
   PubMed Web of Science ®Google Scholar
• Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, et al. GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett 2009; 19:5576 - 81; http://dx.doi.org/10.1016/j.bmcl.2009.08.049; PMID: 19716296
   PubMed Web of Science ®Google Scholar
• Yamada T, Urano-Tashiro Y, Tanaka S, Akiyama H, Tashiro F. Involvement of crosstalk between Oct4 and Meis1a in neural cell fate decision. PLoS One 2013; 8:e56997; http://dx.doi.org/10.1371/journal.pone.0056997; PMID: 23451132
   PubMedGoogle Scholar
• Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER, Sadek HA. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 2013; 497:249 - 53; http://dx.doi.org/10.1038/nature12054; PMID: 23594737
   PubMed Web of Science ®Google Scholar
• Mercader N, Tanaka EM, Torres M. Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins. Development 2005; 132:4131 - 42; http://dx.doi.org/10.1242/dev.01976; PMID: 16107473
   PubMed Web of Science ®Google Scholar
• Oulad-Abdelghani M, Chazaud C, Bouillet P, Sapin V, Chambon P, Dollé P. Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Dev Dyn 1997; 210:173 - 83; http://dx.doi.org/10.1002/(SICI)1097-0177(199710)210:2<173::AID-AJA9>3.0.CO;2-D; PMID: 9337137
   PubMed Web of Science ®Google Scholar
• Kroft TL, Patterson J, Won Yoon J, Doglio L, Walterhouse DO, Iannaccone PM, Goldberg E. GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene. Biol Reprod 2001; 65:1663 - 71; http://dx.doi.org/10.1095/biolreprod65.6.1663; PMID: 11717126
   PubMed Web of Science ®Google Scholar
• Vestergaard J, Lind-Thomsen A, Pedersen MW, Jarmer HØ, Bak M, Hasholt L, Tommerup N, Tümer Z, Larsen LA. GLI1 is involved in cell cycle regulation and proliferation of NT2 embryonal carcinoma stem cells. DNA Cell Biol 2008; 27:251 - 6; http://dx.doi.org/10.1089/dna.2007.0625; PMID: 18241033
   PubMed Web of Science ®Google Scholar
• Yao HH-C, Whoriskey W, Capel B. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev 2002; 16:1433 - 40; http://dx.doi.org/10.1101/gad.981202; PMID: 12050120
   PubMed Web of Science ®Google Scholar
• Barsoum I, Yao HHC. Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells. Biol Reprod 2011; 84:894 - 9; http://dx.doi.org/10.1095/biolreprod.110.088997; PMID: 21209421
   PubMed Web of Science ®Google Scholar
• Bitgood MJ, Shen L, McMahon AP. Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol 1996; 6:298 - 304; http://dx.doi.org/10.1016/S0960-9822(02)00480-3; PMID: 8805249
   PubMed Web of Science ®Google Scholar
• Clark AM, Garland KK, Russell LD. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Biol Reprod 2000; 63:1825 - 38; http://dx.doi.org/10.1095/biolreprod63.6.1825; PMID: 11090455
   PubMed Web of Science ®Google Scholar
• Szczepny A, Hime GR, Loveland KL. Expression of hedgehog signalling components in adult mouse testis. Dev Dyn 2006; 235:3063 - 70; http://dx.doi.org/10.1002/dvdy.20931; PMID: 16958114
   PubMed Web of Science ®Google Scholar
• Morales CR, Fox A, El-Alfy M, Ni X, Argraves WS. Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 2009; 72:809 - 15; http://dx.doi.org/10.1002/jemt.20733; PMID: 19484749
   PubMed Web of Science ®Google Scholar
• Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009; 361:1173 - 8; http://dx.doi.org/10.1056/NEJMoa0902903; PMID: 19726761
   PubMed Web of Science ®Google Scholar
• Caro I, Low JA. The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment. Clin Cancer Res 2010; 16:3335 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-09-2570; PMID: 20439455
   PubMed Web of Science ®Google Scholar
• Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009; 361:1164 - 72; http://dx.doi.org/10.1056/NEJMoa0905360; PMID: 19726763
   PubMed Web of Science ®Google Scholar
• Low JA, de Sauvage FJ. Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol 2010; 28:5321 - 6; http://dx.doi.org/10.1200/JCO.2010.27.9943; PMID: 21041712
   PubMed Web of Science ®Google Scholar
• Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003; 3:903 - 11; http://dx.doi.org/10.1038/nrc1229; PMID: 14737121
   PubMed Web of Science ®Google Scholar
• White KA, Yore MM, Deng D, Spinella MJ. Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid. J Biol Chem 2005; 280:7829 - 35; http://dx.doi.org/10.1074/jbc.M412707200; PMID: 15632153
   PubMed Web of Science ®Google Scholar
• Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, et al. Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models. Cancer Prev Res (Phila) 2011; 4:818 - 28; http://dx.doi.org/10.1158/1940-6207.CAPR-10-0376; PMID: 21636548
   PubMed Web of Science ®Google Scholar
• Dragnev KH, Petty WJ, Shah S, Biddle A, Desai NB, Memoli V, Rigas JR, Dmitrovsky E. Bexarotene and erlotinib for aerodigestive tract cancer. J Clin Oncol 2005; 23:8757 - 64; http://dx.doi.org/10.1200/JCO.2005.01.9521; PMID: 16314636
   PubMed Web of Science ®Google Scholar
• Snow GE, Kasper AC, Busch AM, Schwarz E, Ewings KE, Bee T, Spinella MJ, Dmitrovsky E, Freemantle SJ. Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. BMC Cancer 2009; 9:383; http://dx.doi.org/10.1186/1471-2407-9-383; PMID: 19874621
   PubMed Web of Science ®Google Scholar
• Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen ISY, Hahn WC, Sharp PA, et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 2003; 9:493 - 501; http://dx.doi.org/10.1261/rna.2192803; PMID: 12649500
   PubMed Web of Science ®Google Scholar
• Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, et al. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol 2012; 41:1751 - 61; PMID: 22923130
   PubMed Web of Science ®Google Scholar
• Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ. Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. J Biol Chem 2011; 286:19381 - 91; http://dx.doi.org/10.1074/jbc.M111.218040; PMID: 21489989
   PubMed Web of Science ®Google Scholar
• Petty WJ, Dragnev KH, Memoli VA, Ma Y, Desai NB, Biddle A, Davis TH, Nugent WC, Memoli N, Hamilton M, et al. Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers. Clin Cancer Res 2004; 10:7547 - 54; http://dx.doi.org/10.1158/1078-0432.CCR-04-1169; PMID: 15569985
   PubMed Web of Science ®Google Scholar
• Ma Y, Fiering S, Black C, Liu X, Yuan Z, Memoli VA, Robbins DJ, Bentley HA, Tsongalis GJ, Demidenko E, et al. Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc Natl Acad Sci U S A 2007; 104:4089 - 94; http://dx.doi.org/10.1073/pnas.0606537104; PMID: 17360482
   PubMed Web of Science ®Google Scholar
• Náray-Fejes-Tóth A, Fejes-Tóth G. Novel mouse strain with Cre recombinase in 11β-hydroxysteroid dehydrogenase-2-expressing cells. Am J Physiol Renal Physiol 2007; 292:F486 - 94; http://dx.doi.org/10.1152/ajprenal.00188.2006; PMID: 16896181
   PubMedGoogle Scholar