1,515
Views
28
CrossRef citations to date
0
Altmetric
Clinical Study

Nimotuzumab in combination with radiotherapy in high grade glioma patients

A single institution experience

, , , , , , & show all
Pages 504-509 | Received 06 Dec 2013, Accepted 28 Jan 2014, Published online: 12 Feb 2014

References

  • Simpson JR, Horton J, Scott C, Curran WJ, Rubin P, Fischbach J, Isaacson S, Rotman M, Asbell SO, Nelson JS, et al. Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 1993; 26:239 - 44; http://dx.doi.org/10.1016/0360-3016(93)90203-8; PMID: 8387988
  • Pang BC, Wan WH, Lee CK, Khu KJ, Ng WH. The role of surgery in high-grade glioma--is surgical resection justified? A review of the current knowledge. Ann Acad Med Singapore 2007; 36:358 - 63; PMID: 17549284
  • Curran WJ Jr., Scott CB, Horton J, Nelson JS, Weinstein AS, Fischbach AJ, Chang CH, Rotman M, Asbell SO, Krisch RE, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 1993; 85:704 - 10; http://dx.doi.org/10.1093/jnci/85.9.704; PMID: 8478956
  • Juratli TA, Schackert G, Krex D. Current status of local therapy in malignant gliomas--a clinical review of three selected approaches. Pharmacol Ther 2013; 139:341 - 58; http://dx.doi.org/10.1016/j.pharmthera.2013.05.003; PMID: 23694764
  • Mrugala MM. Advances and challenges in the treatment of glioblastoma: a clinician’s perspective. Discov Med 2013; 15:221 - 30; PMID: 23636139
  • Curran WJ Jr., Scott CB, Horton J, Nelson JS, Weinstein AS, Nelson DF, Fischbach AJ, Chang CH, Rotman M, Asbell SO, et al. Does extent of surgery influence outcome for astrocytoma with atypical or anaplastic foci (AAF)? A report from three Radiation Therapy Oncology Group (RTOG) trials. J Neurooncol 1992; 12:219 - 27; http://dx.doi.org/10.1007/BF00172709; PMID: 1583555
  • Tsao-Wei DD, Hu J, Groshen SG, Chamberlain MC. Conditional survival of high-grade glioma in Los Angeles County during the year 1990-2000. J Neurooncol 2012; 110:145 - 52; http://dx.doi.org/10.1007/s11060-012-0949-6; PMID: 22875707
  • Real FX, Rettig WJ, Chesa PG, Melamed MR, Old LJ, Mendelsohn J. Expression of epidermal growth factor receptor in human cultured cells and tissues: relationship to cell lineage and stage of differentiation. Cancer Res 1986; 46:4726 - 31; PMID: 3015394
  • Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 2006; 33:369 - 85; http://dx.doi.org/10.1053/j.seminoncol.2006.04.003; PMID: 16890793
  • Yewale C, Baradia D, Vhora I, Patil S, Misra A. Epidermal growth factor receptor targeting in cancer: a review of trends and strategies. Biomaterials 2013; 34:8690 - 707; http://dx.doi.org/10.1016/j.biomaterials.2013.07.100; PMID: 23953842
  • Köhler J, Schuler M. Afatinib, erlotinib and gefitinib in the first-line therapy of EGFR mutation-positive lung adenocarcinoma: a review. Onkologie 2013; 36:510 - 8; http://dx.doi.org/10.1159/000354627; PMID: 24051929
  • Prenen H, Vecchione L, Van Cutsem E. Role of targeted agents in metastatic colorectal cancer. Target Oncol 2013; 8:83 - 96; http://dx.doi.org/10.1007/s11523-013-0281-x; PMID: 23645285
  • Dorsey K, Agulnik M. Promising new molecular targeted therapies in head and neck cancer. Drugs 2013; 73:315 - 25; http://dx.doi.org/10.1007/s40265-013-0025-3; PMID: 23440867
  • Fernández A, Pérez R, Macías A, Velandia A, Alvárez I, Ramos M, Velozo A. Generation and characterization of anti-EGFR antibodies. Interferon y Biotecnología 1989; 6:289 - 98
  • Fernández A, Spitzer E, Pérez R, Boehmer F, Eckert K, Zschiesche W, Grosse R. A new monoclonal antibody for detection of the EGF-R in Western Blot and paraffin embedded tissue sections. J Cell Biochem 1992; 49:157 - 65; http://dx.doi.org/10.1002/jcb.240490208; PMID: 1400622
  • Mateo C, Moreno E, Amour K, Lombardero J, Harris W, Pérez R. Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activity. Immunotechnology 1997; 3:71 - 81; http://dx.doi.org/10.1016/S1380-2933(97)00065-1; PMID: 9154469
  • Crombet-Ramos T, Rak J, Pérez R, Viloria-Petit A. Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibody. Int J Cancer 2002; 101:567 - 75; http://dx.doi.org/10.1002/ijc.10647; PMID: 12237899
  • Diaz Miqueli A, Rolff J, Lemm M, Fichtner I, Perez R, Montero E. Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies. Br J Cancer 2009; 100:950 - 8; http://dx.doi.org/10.1038/sj.bjc.6604943; PMID: 19293809
  • Perez R, Crombet T, de Leon J, Moreno E. A view on EGFR-targeted therapies from the oncogene-addiction perspective. Front Pharmacol 2013; 4:53; http://dx.doi.org/10.3389/fphar.2013.00053; PMID: 23637683
  • Perez R, Moreno E, Garrido G, Crombet T. EGFR-targeting as a biological therapy: understanding nimotuzumab’s clinical effects. Cancers (Basel) 2011; 3:2014 - 31; http://dx.doi.org/10.3390/cancers3022014; PMID: 24212794
  • Bode U, Massimino M, Bach F, Zimmermann M, Khuhlaeva E, Westphal M, Fleischhack G. Nimotuzumab treatment of malignant gliomas. Expert Opin Biol Ther 2012; 12:1649 - 59; http://dx.doi.org/10.1517/14712598.2012.733367; PMID: 23043252
  • Allan DG. Nimotuzumab: evidence of clinical benefit without rash. Oncologist 2005; 10:760 - 1; http://dx.doi.org/10.1634/theoncologist.10-9-760; PMID: 16249358
  • Rodríguez MO, Rivero TC, del Castillo Bahi R, Muchuli CR, Bilbao MA, Vinageras EN, Alert J, Galainena JJ, Rodríguez E, Gracias E, et al. Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck. Cancer Biol Ther 2010; 9:343 - 9; http://dx.doi.org/10.4161/cbt.9.5.10981; PMID: 20448462
  • Caruso C, Carcaterra M, Donato V. Role of radiotherapy for high grade gliomas management. J Neurosurg Sci 2013; 57:163 - 9; PMID: 23676864
  • Arjona D, Bello MJ, Alonso ME, Gonzalez-Gomez P, Lomas J, Aminoso C, Lopez-Marin I, Isla A, De Campos JM, Vaquero J, et al. Molecular analysis of the erbB gene family calmodulin-binding and calmodulin-like domains in astrocytic gliomas. Int J Oncol 2004; 25:1489 - 94; PMID: 15492843
  • Camara-Quintana JQ, Nitta RT, Li G. Pathology: commonly monitored glioblastoma markers: EFGR, EGFRvIII, PTEN, and MGMT. Neurosurg Clin N Am 2012; 23:237 - 46, viii; http://dx.doi.org/10.1016/j.nec.2012.01.011; PMID: 22440867
  • Tykocinski ES, Grant RA, Kapoor GS, Krejza J, Bohman LE, Gocke TA, Chawla S, Halpern CH, Lopinto J, Melhem ER, et al. Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma. Neuro Oncol 2012; 14:613 - 23; http://dx.doi.org/10.1093/neuonc/nos073; PMID: 22492960
  • Garrido G, Tikhomirov IA, Rabasa A, Yang E, Gracia E, Iznaga N, Fernández LE, Crombet T, Kerbel RS, Pérez R. Bivalent binding by intermediate affinity of nimotuzumab: a contribution to explain antibody clinical profile. Cancer Biol Ther 2011; 11:373 - 82; http://dx.doi.org/10.4161/cbt.11.4.14097; PMID: 21150278
  • Talavera A, Friemann R, Gómez-Puerta S, Martinez-Fleites C, Garrido G, Rabasa A, López-Requena A, Pupo A, Johansen RF, Sánchez O, et al. Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation. Cancer Res 2009; 69:5851 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-08-4518; PMID: 19584289
  • Solomón MT, Selva JC, Figueredo J, Vaquer J, Toledo C, Quintanal N, Salva S, Domíngez R, Alert J, Marinello JJ, et al. Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial. BMC Cancer 2013; 13:299; http://dx.doi.org/10.1186/1471-2407-13-299; PMID: 23782513
  • Van den Eynde M, Baurain JF, Mazzeo F, Machiels JP. Epidermal growth factor receptor targeted therapies for solid tumours. Acta Clin Belg 2011; 66:10 - 7; http://dx.doi.org/10.1179/ACB.66.1.2062508; PMID: 21485758
  • Loew S, Schmidt U, Unterberg A, Halatsch ME. The epidermal growth factor receptor as a therapeutic target in glioblastoma multiforme and other malignant neoplasms. Anticancer Agents Med Chem 2009; 9:703 - 15; http://dx.doi.org/10.2174/187152009788680019; PMID: 19601750
  • Maier S, Peltz G, Penrod JR, Sugarman KP. Retrospective evaluation of cetuximab-related adverse events from claims databases--methodological concerns. Ann Oncol 2010; 21:1731 - 2, author reply 1732-3; http://dx.doi.org/10.1093/annonc/mdq327; PMID: 20605932
  • Nie F, Shen J, Tong JL, Xu XT, Zhu MM, Ran ZH. Meta-analysis: the efficacy and safety of monoclonal antibody targeted to epidermal growth factor receptor in the treatment of patients with metastatic colorectal cancer. J Dig Dis 2009; 10:247 - 57; http://dx.doi.org/10.1111/j.1751-2980.2009.00393.x; PMID: 19906103
  • Petrelli F, Borgonovo K, Cabiddu M, Ghilardi M, Barni S. Risk of anti-EGFR monoclonal antibody-related hypomagnesemia: systematic review and pooled analysis of randomized studies. Expert Opin Drug Saf 2012; 11:Suppl 1 S9 - 19; http://dx.doi.org/10.1517/14740338.2011.606213; PMID: 21843103
  • Chaudhary P, Gajra A. Cardiovascular effects of EGFR (epidermal growth factor receptor) monoclonal antibodies. Cardiovasc Hematol Agents Med Chem 2010; 8:156 - 63; http://dx.doi.org/10.2174/187152510791698370; PMID: 20446909
  • Kiyohara Y, Yamazaki N, Kishi A. Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer. J Am Acad Dermatol 2013; 69:463 - 72; http://dx.doi.org/10.1016/j.jaad.2013.02.025; PMID: 23602600
  • Walleser S, Ray J, Bischoff H, Vergnenègre A, Rosery H, Chouaid C, Heigener D, de Castro Carpeño J, Tiseo M, Walzer S. Maintenance erlotinib in advanced nonsmall cell lung cancer: cost-effectiveness in EGFR wild-type across Europe. Clinicoecon Outcomes Res 2012; 4:269 - 75; PMID: 23028234
  • Gil-Gil MJ, Mesia C, Rey M, Bruna J. Bevacizumab for the treatment of glioblastoma. Clin Med Insights Oncol 2013; 7:123 - 35; http://dx.doi.org/10.4137/CMO.S8503; PMID: 23843722
  • Gilbert M, Dignam J, Won M, Blumenthal D, Vogelbaum M, Aldape K, Colman H, Chakravarti A, Jeraj R, Armstrong T, et al. RTOG 0825: Phase III double-blind placebo-controlled trial evaluating bevacizumab (Bev) in patients (Pts) with newly diagnosed glioblastoma (GBM). J Clin Oncol 2013; suppl abstr 1
  • Henriksson R, Bottomley A, Mason W, Saran F, Wick R, Nishikawa R, Cloughesy T, Carpentier A, Hoang-Xuan K, Kavan P, et al. Progression-free survival (PFS) and health-related quality of life (HRQoL) in AVAglio, a phase III study of bevacizumab (Bv), temozolomide (T), and radiotherapy (RT) in newly diagnosed glioblastoma (GBM). J Clin Oncol 2013; suppl abstr 2005

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.