Mice lacking G0S2 are lean and cold-tolerant

References

• Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR. A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. DNA Cell Biol 1990; 9:579 - 87; http://dx.doi.org/10.1089/dna.1990.9.579; PMID: 1702972
   PubMed Web of Science ®Google Scholar
• Yang X, Lu X, Lombès M, Rha GB, Chi Y-I, Guerin TM, Smart EJ, Liu J. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 2010; 11:194 - 205; http://dx.doi.org/10.1016/j.cmet.2010.02.003; PMID: 20197052
   PubMed Web of Science ®Google Scholar
• Schweiger M, Paar M, Eder C, Brandis J, Moser E, Gorkiewicz G, Grond S, Radner FPW, Cerk I, Cornaciu I, et al. G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J Lipid Res 2012; 53:2307 - 17; http://dx.doi.org/10.1194/jlr.M027409; PMID: 22891293
   PubMed Web of Science ®Google Scholar
• Zandbergen F, Mandard S, Escher P, Tan NS, Patsouris D, Jatkoe T, Rojas-Caro S, Madore S, Wahli W, Tafuri S, et al. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 2005; 392:313 - 24; http://dx.doi.org/10.1042/BJ20050636; PMID: 16086669
   PubMed Web of Science ®Google Scholar
• Yamada T, Park CS, Burns A, Nakada D, Lacorazza HD. The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. PLoS One 2012; 7:e38280; http://dx.doi.org/10.1371/journal.pone.0038280; PMID: 22693613
   PubMed Web of Science ®Google Scholar
• Kitareewan S, Blumen S, Sekula D, Bissonnette RP, Lamph WW, Cui Q, Gallagher R, Dmitrovsky E. G0S2 is an all-trans-retinoic acid target gene. Int J Oncol 2008; 33:397 - 404; PMID: 18636162
   PubMed Web of Science ®Google Scholar
• Welch C, Santra MK, El-Assaad W, Zhu X, Huber WE, Keys RA, Teodoro JG, Green MR. Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. Cancer Res 2009; 69:6782 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-09-0128; PMID: 19706769
   PubMed Web of Science ®Google Scholar
• Kusakabe M, Watanabe K, Emoto N, Aki N, Kage H, Nagase T, Nakajima J, Yatomi Y, Ohishi N, Takai D. Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. Biochem Biophys Res Commun 2009; 390:1283 - 7; http://dx.doi.org/10.1016/j.bbrc.2009.10.137; PMID: 19878646
   PubMed Web of Science ®Google Scholar
• Kusakabe M, Kutomi T, Watanabe K, Emoto N, Aki N, Kage H, Hamano E, Kitagawa H, Nagase T, Sano A, et al. Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int J Cancer 2010; 126:1895 - 902; PMID: 19816938
   PubMed Web of Science ®Google Scholar
• Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun D-I, Xiao Y, Hoque MO, Westra WH, Califano JA, Sidransky D. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res 2004; 64:5982 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-04-0993; PMID: 15342377
   PubMed Web of Science ®Google Scholar
• Walther TC, Farese RV Jr.. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 2012; 81:687 - 714; http://dx.doi.org/10.1146/annurev-biochem-061009-102430; PMID: 22524315
   PubMed Web of Science ®Google Scholar
• Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006; 312:734 - 7; http://dx.doi.org/10.1126/science.1123965; PMID: 16675698
   PubMed Web of Science ®Google Scholar
• German JB. Dietary lipids from an evolutionary perspective: sources, structures and functions. Matern Child Nutr 2011; 7:Suppl 2 2 - 16; http://dx.doi.org/10.1111/j.1740-8709.2011.00300.x; PMID: 21366863
   PubMed Web of Science ®Google Scholar
• Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin B, Haman F, Turcotte EE, Richard D, Carpentier AC. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 2012; 122:545 - 52; http://dx.doi.org/10.1172/JCI60433; PMID: 22269323
   PubMed Web of Science ®Google Scholar
• Haman F. Shivering in the cold: from mechanisms of fuel selection to survival. J Appl Physiol (1985) 2006; 100:1702 - 8; http://dx.doi.org/10.1152/japplphysiol.01088.2005; PMID: 16614367
   PubMed Web of Science ®Google Scholar
• Kobayashi S, Ito A, Okuzaki D, Onda H, Yabuta N, Nagamori I, Suzuki K, Hashimoto H, Nojima H. Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients. DNA Res 2008; 15:253 - 65; http://dx.doi.org/10.1093/dnares/dsn014; PMID: 18562305
   PubMed Web of Science ®Google Scholar
• Nakamura N, Shimaoka Y, Tougan T, Onda H, Okuzaki D, Zhao H, Fujimori A, Yabuta N, Nagamori I, Tanigawa A, et al. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. DNA Res 2006; 13:169 - 83; http://dx.doi.org/10.1093/dnares/dsl006; PMID: 17082220
   PubMed Web of Science ®Google Scholar
• Koczan D, Guthke R, Thiesen H-J, Ibrahim SM, Kundt G, Krentz H, Gross G, Kunz M. Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory molecules. Eur J Dermatol 2005; 15:251 - 7; PMID: 16048752
   PubMed Web of Science ®Google Scholar
• Russell TD, Schaack J, Orlicky DJ, Palmer C, Chang BH-J, Chan L, McManaman JL. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands. J Cell Sci 2011; 124:3247 - 53; http://dx.doi.org/10.1242/jcs.082974; PMID: 21878492
   PubMed Web of Science ®Google Scholar
• Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, et al. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes 2009; 58:855 - 66; http://dx.doi.org/10.2337/db08-1644; PMID: 19136649
   PubMed Web of Science ®Google Scholar
• Zhang L-H, Zhang L-J, Wang Q, Wang B, Yang G-S. Expression of TGH and its role in porcine primary adipocyte lipolysis. Mol Cell Biochem 2008; 315:159 - 67; http://dx.doi.org/10.1007/s11010-008-9800-y; PMID: 18543084
   PubMed Web of Science ®Google Scholar
• Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans 2003; 31:1120 - 4; http://dx.doi.org/10.1042/BST0311120; PMID: 14641008
   PubMed Web of Science ®Google Scholar
• Okazaki H, Igarashi M, Nishi M, Tajima M, Sekiya M, Okazaki S, Yahagi N, Ohashi K, Tsukamoto K, Amemiya-Kudo M, et al. Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis. Diabetes 2006; 55:2091 - 7; http://dx.doi.org/10.2337/db05-0585; PMID: 16804080
   PubMed Web of Science ®Google Scholar
• Granneman JG, Burnazi M, Zhu Z, Schwamb LA. White adipose tissue contributes to UCP1-independent thermogenesis. Am J Physiol Endocrinol Metab 2003; 285:E1230 - 6; PMID: 12954594
   PubMed Web of Science ®Google Scholar
• Jensen DR, Knaub LA, Konhilas JP, Leinwand LA, MacLean PS, Eckel RH. Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?. J Lipid Res 2008; 49:870 - 9; http://dx.doi.org/10.1194/jlr.M700519-JLR200; PMID: 18175800
   PubMed Web of Science ®Google Scholar
• Shabalina IG, Hoeks J, Kramarova TV, Schrauwen P, Cannon B, Nedergaard J. Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects. Biochim Biophys Acta 2010; 1797:968 - 80; http://dx.doi.org/10.1016/j.bbabio.2010.02.033; PMID: 20227385
   PubMed Web of Science ®Google Scholar
• Yamada T, Park CS, Shen Y, Rabin KR, Lacorazza HD. G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol. Leuk Res 2014; 38:210 - 7; http://dx.doi.org/10.1016/j.leukres.2013.10.006; PMID: 24183236
   PubMed Web of Science ®Google Scholar
• Mongelard F, Bouvet P. Nucleolin: a multiFACeTed protein. Trends Cell Biol 2007; 17:80 - 6; http://dx.doi.org/10.1016/j.tcb.2006.11.010; PMID: 17157503
   PubMed Web of Science ®Google Scholar
• Ma T, Fuld AD, Rigas JR, Hagey AE, Gordon GB, Dmitrovsky E, Dragnev KH. A phase I trial and in vitro studies combining ABT-751 with carboplatin in previously treated non-small cell lung cancer patients. Chemotherapy 2012; 58:321 - 9; http://dx.doi.org/10.1159/000343165; PMID: 23147218
   PubMed Web of Science ®Google Scholar
• Náray-Fejes-Tóth A, Fejes-Tóth G. Novel mouse strain with Cre recombinase in 11beta-hydroxysteroid dehydrogenase-2-expressing cells. Am J Physiol Renal Physiol 2007; 292:F486 - 94; http://dx.doi.org/10.1152/ajprenal.00188.2006; PMID: 16896181
   PubMedGoogle Scholar
• Megens AA, Voeten J, Rombouts J, Meert TF, Niemegeers CJ. Behavioral activity of rats measured by a new method based on the piezo-electric principle. Psychopharmacology (Berl) 1987; 93:382 - 8; http://dx.doi.org/10.1007/BF00187261; PMID: 3124168
   PubMed Web of Science ®Google Scholar
• Ma T, Dong JP, Sekula DJ, Fei DL, Lamph WW, Henderson M, Lu Y, Blumen S, Freemantle SJ, Dmitrovsky E. Repression of exogenous gene expression by the retinoic acid target gene G0S2. Int J Oncol 2013; 42:1743 - 53; PMID: 23546556
   PubMed Web of Science ®Google Scholar
• Zhang X, Xie X, Heckmann BL, Saarinen AM, Czyzyk TA, Liu J. Targeted disruption of g0/g1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes 2014; 63:934 - 46; http://dx.doi.org/10.2337/db13-1422; PMID: 24194501
   PubMed Web of Science ®Google Scholar