Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil

References

• Daniele B, Secondulfo M, De Vivo R, Pignata S, De Magistris L, Delrio P, Palaia R, Barletta E, Tambaro R, Carratù R. Effect of chemotherapy with 5-fluorouracil on intestinal permeability and absorption in patients with advanced colorectal cancer. J Clin Gastroenterol 2001; 32:228 - 30; http://dx.doi.org/10.1097/00004836-200103000-00010; PMID: 11246350
   PubMed Web of Science ®Google Scholar
• Duncan M, Grant G. Oral and intestinal mucositis - causes and possible treatments. Aliment Pharmacol Ther 2003; 18:853 - 74; http://dx.doi.org/10.1046/j.1365-2036.2003.01784.x; PMID: 14616150
   PubMed Web of Science ®Google Scholar
• Bowen JM, Gibson RJ, Cummins AG, Keefe DM. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer 2006; 14:713 - 31; http://dx.doi.org/10.1007/s00520-005-0004-7; PMID: 16453135
   PubMed Web of Science ®Google Scholar
• Anilkumar TV, Sarraf CE, Hunt T, Alison MR. The nature of cytotoxic drug-induced cell death in murine intestinal crypts. Br J Cancer 1992; 65:552 - 8; http://dx.doi.org/10.1038/bjc.1992.113; PMID: 1562464
   PubMed Web of Science ®Google Scholar
• Pritchard DM, Potten CS, Hickman JA. The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. Cancer Res 1998; 58:5453 - 65; PMID: 9850079
   PubMed Web of Science ®Google Scholar
• Keefe DM, Brealey J, Goland GJ, Cummins AG. Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans. Gut 2000; 47:632 - 7; http://dx.doi.org/10.1136/gut.47.5.632; PMID: 11034578
   PubMed Web of Science ®Google Scholar
• Inomata A, Horii I, Suzuki K. 5-Fluorouracil-induced intestinal toxicity: what determines the severity of damage to murine intestinal crypt epithelia?. Toxicol Lett 2002; 133:231 - 40; http://dx.doi.org/10.1016/S0378-4274(02)00204-7; PMID: 12119131
   PubMed Web of Science ®Google Scholar
• Kasper B, Petersen F. Molecular pathways of platelet factor 4/CXCL4 signaling. Eur J Cell Biol 2011; 90:521 - 6; http://dx.doi.org/10.1016/j.ejcb.2010.12.002; PMID: 21295372
   PubMed Web of Science ®Google Scholar
• Han ZC, Lu M, Li J, Defard M, Boval B, Schlegel N, Caen JP. Platelet factor 4 and other CXC chemokines support the survival of normal hematopoietic cells and reduce the chemosensitivity of cells to cytotoxic agents. Blood 1997; 89:2328 - 35; PMID: 9116276
   PubMed Web of Science ®Google Scholar
• Watson JB, Getzler SB, Mosher DF. Platelet factor 4 modulates the mitogenic activity of basic fibroblast growth factor. J Clin Invest 1994; 94:261 - 8; http://dx.doi.org/10.1172/JCI117316; PMID: 8040268
   PubMed Web of Science ®Google Scholar
• Han ZC, Bellucci S, Walz A, Baggiolini M, Caen JP. Negative regulation of human megakaryocytopoiesis by human platelet factor 4 (PF4) and connective tissue-activating peptide (CTAP-III). Int J Cell Cloning 1990; 8:253 - 9; http://dx.doi.org/10.1002/stem.5530080409; PMID: 2401804
   PubMedGoogle Scholar
• Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska MA, Fox-Talbot K, et al. Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe 2008; 4:179 - 87; http://dx.doi.org/10.1016/j.chom.2008.07.003; PMID: 18692777
   PubMedGoogle Scholar
• Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, Abou-Slaybi A, Naumov GN, Bender E, Almog N, Italiano JE Jr., et al. Platelet-associated PF-4 as a biomarker of early tumor growth. Blood 2008; 111:1201 - 7; http://dx.doi.org/10.1182/blood-2007-04-084798; PMID: 17914028
   PubMed Web of Science ®Google Scholar
• Lapchak PH, Ioannou A, Rani P, Lieberman LA, Yoshiya K, Kannan L, Dalle Lucca JJ, Kowalska MA, Tsokos GC. The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury. PLoS One 2012; 7:e39934; http://dx.doi.org/10.1371/journal.pone.0039934; PMID: 22792197
   PubMed Web of Science ®Google Scholar
• Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 2008; 135:194 - 204, e3; http://dx.doi.org/10.1053/j.gastro.2008.03.023; PMID: 18485912
   PubMed Web of Science ®Google Scholar
• Han X, Wu Z, Di J, Pan Y, Zhang H, Du Y, Cheng Z, Jin Z, Wang Z, Zheng Q, et al. CXCL9 attenuated chemotherapy-induced intestinal mucositis by inhibiting proliferation and reducing apoptosis. Biomed Pharmacother 2011; 65:547 - 54; http://dx.doi.org/10.1016/j.biopha.2011.03.008; PMID: 21775092
   PubMed Web of Science ®Google Scholar
• Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med 2003; 197:1537 - 49; http://dx.doi.org/10.1084/jem.20021897; PMID: 12782716
   PubMed Web of Science ®Google Scholar
• Green LA, Petrusca D, Rajashekhar G, Gianaris T, Schweitzer KS, Wang L, Justice MJ, Petrache I, Clauss M. Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis. Am J Respir Cell Mol Biol 2012; 47:807 - 14; http://dx.doi.org/10.1165/rcmb.2012-0132OC; PMID: 22936405
   PubMed Web of Science ®Google Scholar
• Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr.. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 1999; 18:6845 - 54; http://dx.doi.org/10.1093/emboj/18.23.6845; PMID: 10581258
   PubMed Web of Science ®Google Scholar
• Pritchard DM, Watson AJ, Potten CS, Jackman AL, Hickman JA. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci U S A 1997; 94:1795 - 9; http://dx.doi.org/10.1073/pnas.94.5.1795; PMID: 9050858
   PubMed Web of Science ®Google Scholar
• Wu ZQ, Han XD, Wang Y, Yuan KL, Jin ZM, Di JZ, Yan J, Pan Y, Zhang P, Huang XY, et al. Interleukin-1 receptor antagonist reduced apoptosis and attenuated intestinal mucositis in a 5-fluorouracil chemotherapy model in mice. Cancer Chemother Pharmacol 2011; 68:87 - 96; http://dx.doi.org/10.1007/s00280-010-1451-5; PMID: 20844880
   PubMed Web of Science ®Google Scholar
• Yasuda M, Kato S, Yamanaka N, Iimori M, Matsumoto K, Utsumi D, Kitahara Y, Amagase K, Horie S, Takeuchi K. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol 2013; 168:1388 - 400; http://dx.doi.org/10.1111/bph.12019; PMID: 23072534
   PubMed Web of Science ®Google Scholar
• Korniejewska A, McKnight AJ, Johnson Z, Watson ML, Ward SG. Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes. Immunology 2011; 132:503 - 15; http://dx.doi.org/10.1111/j.1365-2567.2010.03384.x; PMID: 21255008
   PubMed Web of Science ®Google Scholar
• Shahabuddin S, Ji R, Wang P, Brailoiu E, Dun N, Yang Y, Aksoy MO, Kelsen SG. CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol 2006; 291:C34 - 9; http://dx.doi.org/10.1152/ajpcell.00441.2005; PMID: 16467404
   PubMedGoogle Scholar
• Petrai I, Rombouts K, Lasagni L, Annunziato F, Cosmi L, Romanelli RG, Sagrinati C, Mazzinghi B, Pinzani M, Romagnani S, et al. Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. Int J Biochem Cell Biol 2008; 40:1764 - 74; http://dx.doi.org/10.1016/j.biocel.2008.01.008; PMID: 18291705
   PubMed Web of Science ®Google Scholar
• Sidahmed AM, León AJ, Bosinger SE, Banner D, Danesh A, Cameron MJ, Kelvin DJ. CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. Cytokine 2012; 59:433 - 41; http://dx.doi.org/10.1016/j.cyto.2012.05.002; PMID: 22652417
   PubMed Web of Science ®Google Scholar
• Singh L, Arora SK, Bakshi DK, Majumdar S, Wig JD. Potential role of CXCL10 in the induction of cell injury and mitochondrial dysfunction. Int J Exp Pathol 2010; 91:210 - 23; http://dx.doi.org/10.1111/j.1365-2613.2009.00697.x; PMID: 20041963
   PubMed Web of Science ®Google Scholar
• Sui Y, Potula R, Dhillon N, Pinson D, Li S, Nath A, Anderson C, Turchan J, Kolson D, Narayan O, et al. Neuronal apoptosis is mediated by CXCL10 overexpression in simian human immunodeficiency virus encephalitis. Am J Pathol 2004; 164:1557 - 66; http://dx.doi.org/10.1016/S0002-9440(10)63714-5; PMID: 15111302
   PubMed Web of Science ®Google Scholar
• Feldman ED, Weinreich DM, Carroll NM, Burness ML, Feldman AL, Turner E, Xu H, Alexander HR Jr.. Interferon gamma-inducible protein 10 selectively inhibits proliferation and induces apoptosis in endothelial cells. Ann Surg Oncol 2006; 13:125 - 33; http://dx.doi.org/10.1245/ASO.2006.03.038; PMID: 16378159
   PubMed Web of Science ®Google Scholar
• Liang P, Cheng SH, Cheng CK, Lau KM, Lin SY, Chow EY, Chan NP, Ip RK, Wong RS, Ng MH. Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma. Haematologica 2013; 98:288 - 95; http://dx.doi.org/10.3324/haematol.2012.065607; PMID: 22929979
   PubMed Web of Science ®Google Scholar
• Zhang HM, Yuan J, Cheung P, Chau D, Wong BW, McManus BM, Yang D. Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression. Mol Cell Biol 2005; 25:6247 - 58; http://dx.doi.org/10.1128/MCB.25.14.6247-6258.2005; PMID: 15988033
   PubMed Web of Science ®Google Scholar
• Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281:1305 - 8; http://dx.doi.org/10.1126/science.281.5381.1305; PMID: 9721089
   PubMed Web of Science ®Google Scholar
• Lacour S, Hammann A, Wotawa A, Corcos L, Solary E, Dimanche-Boitrel MT. Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis. Cancer Res 2001; 61:1645 - 51; PMID: 11245478
   PubMed Web of Science ®Google Scholar
• Nuñez G, Benedict MA, Hu Y, Inohara N. Caspases: the proteases of the apoptotic pathway. Oncogene 1998; 17:3237 - 45; http://dx.doi.org/10.1038/sj.onc.1202581; PMID: 9916986
   PubMed Web of Science ®Google Scholar
• Pietsch EC, Sykes SM, McMahon SB, Murphy ME. The p53 family and programmed cell death. Oncogene 2008; 27:6507 - 21; http://dx.doi.org/10.1038/onc.2008.315; PMID: 18955976
   PubMed Web of Science ®Google Scholar
• Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, Whitcomb KL, Yin S, Hill DC, Wiemann B, Starnes CO, et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 1998; 58:933 - 9; PMID: 9500453
   PubMed Web of Science ®Google Scholar
• Gibson RJ, Bowen JM, Inglis MR, Cummins AG, Keefe DM. Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer. J Gastroenterol Hepatol 2003; 18:1095 - 100; http://dx.doi.org/10.1046/j.1440-1746.2003.03136.x; PMID: 12911669
   PubMed Web of Science ®Google Scholar