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Research Paper

Generation and characterization of an analog-sensitive PERK allele

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Pages 1106-1111 | Received 13 May 2014, Accepted 17 May 2014, Published online: 20 May 2014

References

  • Luo B, Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 2013; 32:805 - 18; http://dx.doi.org/10.1038/onc.2012.130; PMID: 22508478
  • Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2000; 2:326 - 32; http://dx.doi.org/10.1038/35014014; PMID: 10854322
  • Shen J, Chen X, Hendershot L, Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 2002; 3:99 - 111; http://dx.doi.org/10.1016/S1534-5807(02)00203-4; PMID: 12110171
  • Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol 1998; 18:7499 - 509; PMID: 9819435
  • Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999; 397:271 - 4; http://dx.doi.org/10.1038/16729; PMID: 9930704
  • Brewer JW, Hendershot LM, Sherr CJ, Diehl JA. Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci U S A 1999; 96:8505 - 10; http://dx.doi.org/10.1073/pnas.96.15.8505; PMID: 10411905
  • Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003; 11:619 - 33; http://dx.doi.org/10.1016/S1097-2765(03)00105-9; PMID: 12667446
  • Hetz C, Chevet E, Harding HP. Targeting the unfolded protein response in disease. Nat Rev Drug Discov 2013; 12:703 - 19; http://dx.doi.org/10.1038/nrd3976; PMID: 23989796
  • Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011; 13:184 - 90; http://dx.doi.org/10.1038/ncb0311-184; PMID: 21364565
  • Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe?. Nat Rev Cancer 2004; 4:966 - 77; http://dx.doi.org/10.1038/nrc1505; PMID: 15573118
  • Feng Y, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, et al. Epithelial-to-mesenchymal transition activates PERK-eIF2a and sensitizes cells to endoplasmic reticulum stress. Cancer Discov 2014; http://dx.doi.org/10.1158/2159-8290.CD-13-0945; PMID: 24705811
  • Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 2005; 24:3470 - 81; http://dx.doi.org/10.1038/sj.emboj.7600777; PMID: 16148948
  • Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene 2010; 29:3881 - 95; http://dx.doi.org/10.1038/onc.2010.153; PMID: 20453876
  • Nagelkerke A, Bussink J, Mujcic H, Wouters BG, Lehmann S, Sweep FC, Span PN. Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response. Breast Cancer Res 2013; 15:R2; http://dx.doi.org/10.1186/bcr3373; PMID: 23294542
  • Mujcic H, Nagelkerke A, Rouschop KM, Chung S, Chaudary N, Span PN, Clarke B, Milosevic M, Sykes J, Hill RP, et al. Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3. Clin Cancer Res 2013; 19:6126 - 37; http://dx.doi.org/10.1158/1078-0432.CCR-13-0526; PMID: 24045183
  • Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol 2011; 31:3616 - 29; http://dx.doi.org/10.1128/MCB.05164-11; PMID: 21709020
  • Blais JD, Addison CL, Edge R, Falls T, Zhao H, Wary K, Koumenis C, Harding HP, Ron D, Holcik M, et al. Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol 2006; 26:9517 - 32; http://dx.doi.org/10.1128/MCB.01145-06; PMID: 17030613
  • Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen 2014; Forthcoming http://dx.doi.org/10.1177/1087057114525853; PMID: 24598103
  • Axten JM, Medina JR, Feng Y, Shu A, Romeril SP, Grant SW, Li WH, Heerding DA, Minthorn E, Mencken T, et al. Discovery of 7-methyl-5-(1-[3-(trifluoromethyl)phenyl]acetyl-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem 2012; 55:7193 - 207; http://dx.doi.org/10.1021/jm300713s; PMID: 22827572
  • Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat KM. Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol 1998; 8:257 - 66; http://dx.doi.org/10.1016/S0960-9822(98)70198-8; PMID: 9501066
  • Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000; 407:395 - 401; http://dx.doi.org/10.1038/35030148; PMID: 11014197
  • Shokat K, Velleca M. Novel chemical genetic approaches to the discovery of signal transduction inhibitors. Drug Discov Today 2002; 7:872 - 9; http://dx.doi.org/10.1016/S1359-6446(02)02391-7; PMID: 12546954
  • Buzko O, Shokat KM. A kinase sequence database: sequence alignments and family assignment. Bioinformatics 2002; 18:1274 - 5; http://dx.doi.org/10.1093/bioinformatics/18.9.1274; PMID: 12217924
  • Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol 2010; 11:1085 - 92; http://dx.doi.org/10.1038/ni.1955; PMID: 21037577
  • Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat KM, Hahn S. Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol 2009; 29:4852 - 63; http://dx.doi.org/10.1128/MCB.00609-09; PMID: 19581288
  • Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem 2008; 283:15419 - 30; http://dx.doi.org/10.1074/jbc.M709000200; PMID: 18378687
  • Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5:897 - 904; http://dx.doi.org/10.1016/S1097-2765(00)80330-5; PMID: 10882126
  • Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, et al. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell 2011; 44:878 - 92; http://dx.doi.org/10.1016/j.molcel.2011.11.005; PMID: 22137581
  • Allen JJ, Lazerwith SE, Shokat KM. Bio-orthogonal affinity purification of direct kinase substrates. J Am Chem Soc 2005; 127:5288 - 9; http://dx.doi.org/10.1021/ja050727t; PMID: 15826144
  • Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, et al. A semisynthetic epitope for kinase substrates. Nat Methods 2007; 4:511 - 6; http://dx.doi.org/10.1038/nmeth1048; PMID: 17486086
  • Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A 2008; 105:1442 - 7; http://dx.doi.org/10.1073/pnas.0708966105; PMID: 18234856
  • Fedorov O, Müller S, Knapp S. The (un)targeted cancer kinome. Nat Chem Biol 2010; 6:166 - 9; http://dx.doi.org/10.1038/nchembio.297; PMID: 20154661
  • Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol 2013; 8:1931 - 8; http://dx.doi.org/10.1021/cb400376p; PMID: 23841803
  • Garske AL, Peters U, Cortesi AT, Perez JL, Shokat KM. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A 2011; 108:15046 - 52; http://dx.doi.org/10.1073/pnas.1111239108; PMID: 21852571
  • Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003; 23:7198 - 209; http://dx.doi.org/10.1128/MCB.23.20.7198-7209.2003; PMID: 14517290
  • Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol 2012; 32:5129 - 39; http://dx.doi.org/10.1128/MCB.01009-12; PMID: 23071091
  • Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA. PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol Cell Biol 2012; 32:2268 - 78; http://dx.doi.org/10.1128/MCB.00063-12; PMID: 22493067
  • Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol 2010; 2:15 - 36; PMID: 23836541

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