990
Views
19
CrossRef citations to date
0
Altmetric
Report

Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway

Pages 4110-4118 | Received 12 Jun 2011, Accepted 27 Sep 2011, Published online: 01 Dec 2011

References

  • Vaccari T, Bilder D. At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression. Mol Oncol 2009; 3:354 - 365; PMID: 19560990; http://dx.doi.org/10.1016/j.molonc.2009.05.005
  • Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004; 18:1909 - 1925; PMID: 15314019; http://dx.doi.org/10.1101/gad.1211604
  • Martinez AM, Cavalli G. Uncovering a tumor-suppressor function for Drosophila polycomb group genes. Cell Cycle 2010; 9:215 - 216; PMID: 20046098; http://dx.doi.org/10.4161/cc.9.2.10518
  • Moberg KH, Schelble S, Burdick SK, Hariharan IK. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell 2005; 9:699 - 710; PMID: 16256744; http://dx.doi.org/10.1016/j.devcel.2005.09.018
  • Thompson BJ, Mathieu J, Sung HH, Loeser E, Rorth P, Cohen SM. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell 2005; 9:711 - 720; PMID: 16256745; http://dx.doi.org/10.1016/j.devcel.2005.09.020
  • Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics 2007; 177:1667 - 1677; PMID: 17947427; http://dx.doi.org/10.1534/genetics.107.078360
  • Vaccari T, Bilder D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell 2005; 9:687 - 698; PMID: 16256743; http://dx.doi.org/10.1016/j.devcel.2005.09.019
  • Raiborg C, Rusten TE, Stenmark H. Protein sorting into multivesicular endosomes. Curr Opin Cell Biol 2003; 15:446 - 455; PMID: 12892785; http://dx.doi.org/10.1016/S0955-0674(03)00080-2
  • Lu H, Bilder D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol 2005; 7:1232 - 1239; PMID: 16258546; http://dx.doi.org/10.1038/ncb1324
  • Vaccari T, Rusten TE, Menut L, Nezis IP, Brech A, Stenmark H, et al. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci 2009; 122:2413 - 2423; PMID: 19571114; http://dx.doi.org/10.1242/jcs.046391
  • Gilbert MM, Robinson BS, Moberg KH. Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors. PLoS ONE 2009; 4:7039; PMID: 19855819; http://dx.doi.org/10.1371/journal.pone.0007039
  • Gilbert MM, Beam CK, Robinson BS, Moberg KH. Genetic interactions between the Drosophila tumor suppressor gene ept and the stat92E transcription factor. PLoS ONE 2009; 4:7083; PMID: 19787055; http://dx.doi.org/10.1371/journal.pone.0007083
  • Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010; 19:491 - 505; PMID: 20951342; http://dx.doi.org/10.1016/j.devcel.2010.09.011
  • Grusche FA, Richardson HE, Harvey KF. Upstream regulation of the hippo size control pathway. Curr Biol 2010; 20:574 - 582; PMID: 20619814; http://dx.doi.org/10.1016/j.cub.2010.05.023
  • Bennett FC, Harvey KF. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/ippo signaling pathway. Curr Biol 2006; 16:2101 - 2110; PMID: 17045801; http://dx.doi.org/10.1016/j.cub.2006.09.045
  • Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol 2006; 16:2081 - 2089; PMID: 16996266; http://dx.doi.org/10.1016/j.cub.2006.09.004
  • Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 2006; 16:2090 - 3100; PMID: 16996265; http://dx.doi.org/10.1016/j.cub.2006.09.005
  • Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine KD. Delineation of a Fat tumor suppressor pathway. Nat Genet 2006; 38:1142 - 1150; PMID: 16980976; http://dx.doi.org/10.1038/ng1887
  • Robinson BS, Huang J, Hong Y, Moberg KH. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol 2010; 20:582 - 590; PMID: 20362445; http://dx.doi.org/10.1016/j.cub.2010.03.019
  • Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE. Lgl, aPKC and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 2010; 20:573 - 581; PMID: 20362447; http://dx.doi.org/10.1016/j.cub.2010.01.055
  • Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci USA 2010; 107:10532 - 10537; PMID: 20498073; http://dx.doi.org/10.1073/pnas.1004279107
  • Chen CL, Gajewski KM, Hamaratoglu F, Bossuyt W, Sansores-Garcia L, Tao C, et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci USA 2010; 107:15810 - 15815; PMID: 20798049; http://dx.doi.org/10.1073/pnas.1004060107
  • Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGFβ-SMAD pathway. Dev Cell 2010; 19:831 - 844; PMID: 21145499; http://dx.doi.org/10.1016/j.devcel.2010.11.012
  • Rogulja D, Rauskolb C, Irvine KD. Morphogen control of wing growth through the Fat signaling pathway. Dev Cell 2008; 15:309 - 321; PMID: 18694569; http://dx.doi.org/10.1016/j.devcel.2008.06.003
  • Rappoport JZ. Focusing on clathrin-mediated endocytosis. Biochem J 2008; 412:415 - 423; PMID: 18498251; http://dx.doi.org/10.1042/BJ20080474
  • Vidal M. The dark side of fly TNF: an ancient developmental proof reading mechanism turned into tumor promoter. Cell Cycle 2010; 9:3851 - 3856; PMID: 20935490; http://dx.doi.org/10.4161/cc.9.19.13280
  • Sun G, Irvine KD. Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol 2011; 350:139 - 151; PMID: 21145886; http://dx.doi.org/10.1016/j.ydbio.2010.11.036
  • Staley BK, Irvine KD. Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation. Curr Biol 2010; 20:1580 - 1587; PMID: 20727758; http://dx.doi.org/10.1016/j.cub.2010.07.041
  • Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 2010; 137:4135 - 4145; PMID: 21098564; http://dx.doi.org/10.1242/dev.060483
  • Grusche FA, Degoutin JL, Richardson HE, Harvey KF. The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev Biol 2011; 350:255 - 266; PMID: 21111727; http://dx.doi.org/10.1016/j.ydbio.2010.11.020
  • White K, Grether ME, Abrams JM, Young L, Farrell K, Steller H. Genetic control of programmed cell death in Drosophila. Science 1994; 264:677 - 683; PMID: 8171319; http://dx.doi.org/10.1126/science.8171319
  • Gilbert MM, Tipping M, Veraksa A, Moberg KH. A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell 2011; 20:700 - 712; PMID: 21571226; http://dx.doi.org/10.1016/j.devcel.2011.04.012
  • Tapon N, Harvey KF, Bell DW, Wahrer DCR, Schiripo TA, Haber DA, et al. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002; 110:467 - 478; PMID: 12202036; http://dx.doi.org/10.1016/S0092-8674(02)00824-3
  • Harvey K, Tapon N. The Salvador-Warts-Hippo pathway—an emerging tumour-suppressor network. Nat Rev Cancer 2007; 7:182 - 191; PMID: 17318211; http://dx.doi.org/10.1038/nrc2070
  • Herz HM, Chen Z, Scherr H, Lackey M, Bolduc C, Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development 2006; 133:1871 - 1880; PMID: 16611691; http://dx.doi.org/10.1242/dev.02356
  • Tomlinson V, Gudmundsdottir K, Luong P, Leung KY, Knebel A, Basu S. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Cell Death Dis 2010; 1:29; PMID: 21364637; http://dx.doi.org/10.1038/cddis.2010.7
  • Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Genet Dev 2002; 12:14 - 21; PMID: PMID:11790549; http://dx.doi.org/10.1016/S0959-437X(01)00258-1
  • Perkins KK, Dailey GM, Tjian R. Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1. EMBO J 1988; 7:4265 - 4273; PMID: 3149584
  • Martín-Blanco E, Gampel A, Ring J, Virdee K, Kirov N, Tolkovsky AM, et al. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev 1998; 12:557 - 570; PMID: 9472024; http://dx.doi.org/10.1101/gad.12.4.557
  • Uhlirova M, Bohmann D. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 2006; 25:5294 - 5304; PMID: 17082773; http://dx.doi.org/10.1038/sj.emboj.7601401
  • Zhu M, Xin T, Weng S, Gao Y, Zhang Y, Li Q, et al. Activation of JNK signaling links lgl mutations to disruption of the cell polarity and epithelial organization in Drosophila imaginal discs. Cell Res 2010; 20:242 - 245; PMID: 20066009; http://dx.doi.org/10.1038/cr.2010.2
  • Giebel B, Wodarz A. Tumor suppressors: control of signaling by endocytosis. Curr Biol 2006; 16:91 - 92; PMID: 16461271; http://dx.doi.org/10.1016/j.cub.2006.01.022
  • Sigismund S, Argenzio E, Tosoni D, Cavallaro E, Polo S, Di Fiore PP. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell 2008; 15:209 - 219; PMID: 18694561; http://dx.doi.org/10.1016/j.devcel.2008.06.012
  • Wu M, Pastor-Pareja JC, Xu T. Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature 2010; 463:545 - 548; PMID: 20072127; http://dx.doi.org/10.1038/nature08702
  • Igaki T, Pagliarini RA, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 2006; 16:1139 - 1146; PMID: 16753569; http://dx.doi.org/10.1016/j.cub.2006.04.042
  • Brumby AM, Richardson HE. Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 2003; 22:5769 - 5779; PMID: 14592975; http://dx.doi.org/10.1093/emboj/cdg548
  • Grzeschik NA, Parsons LM, Richardson HE. Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!. Cell Cycle 2010; 9:3202 - 3212; PMID: 20724829; http://dx.doi.org/10.4161/cc.9.16.12633
  • Warner SJ, Yashiro H, Longmore GD. The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia. Curr Biol 2010; 20:677 - 686; PMID: 20381350; http://dx.doi.org/10.1016/j.cub.2010.03.025
  • Henrique D, Schweisguth F. Cell polarity: the ups and downs of the Par6/aPKC complex. Curr Opin Genet Dev 2003; 13:341 - 350; PMID: 12888006; http://dx.doi.org/10.1016/S0959-437X(03)00077-7
  • Balklava Z, Pant S, Fares H, Grant BD. Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat Cell Biol 2007; 9:1066 - 1073; PMID: 17704769; http://dx.doi.org/10.1038/ncb1627
  • Kanda H, Igaki T, Kanuka H, Yagi T, Miura M. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem 2002; 277:28372 - 28375; PMID: 12084706; http://dx.doi.org/10.1074/jbc.C200324200
  • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGFbeta receptor signalling and turnover. Nat Cell Biol 2003; 5:410 - 421; PMID: 12717440; http://dx.doi.org/10.1038/ncb975
  • Rodahl LM, Haglund K, Sem-Jacobsen C, Wendler F, Vincent JP, Lindmo K, et al. Disruption of Vps4 and JNK function in Drosophila causes tumour growth. PLoS ONE 2009; 4:4354; PMID: PMID:19194501; http://dx.doi.org/10.1371/journal.pone.0004354
  • Carstens MJ, Krempler A, Triplett AA, Van Lohuizen M, Wagner KU. Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J Biol Chem 2004; 279:35984 - 35994; PMID: 15210712; http://dx.doi.org/10.1074/jbc.M400408200
  • Krempler A, Henry MD, Triplett AA, Wagner KU. Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death. J Biol Chem 2002; 277:43216 - 43223; PMID: 12205095; http://dx.doi.org/10.1074/jbc.M207662200
  • Ruland J, Sirard C, Elia A, MacPherson D, Wakeham A, Li L, et al. p53 accumulation, defective cell proliferation and early embryonic lethality in mice lacking tsg101. Proc Natl Acad Sci USA 2001; 98:1859 - 1864; PMID: 11172041; http://dx.doi.org/10.1073/pnas.98.4.1859
  • Herz HM, Bergmann A. Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101. Biochem Soc Trans 2009; 37:204 - 207; PMID: 19143632; http://dx.doi.org/10.1042/BST0370204
  • Boedigheimer M, Bryant P, Laughon A. Expanded, a negative regulator of cell proliferation in Drosophila, shows homology to the NF2 tumor suppressor. Mech Dev 1993; 44:83 - 84; PMID: 8155582; http://dx.doi.org/10.1016/0925-4773(93)90058-6
  • Boedigheimer M, Laughon A. Expanded: a gene involved in the control of cell proliferation in imaginal discs. Development 1993; 118:1291 - 1301; PMID: 8269855
  • Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol 2004; 14:965 - 974; PMID: 15182669; http://dx.doi.org/10.1016/j.cub.2004.04.040
  • Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE. Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene 2008; 27:6888 - 6907; PMID: 19029932; http://dx.doi.org/10.1038/onc.2008.341
  • Javier RT,. Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene 2008; 27:7031 - 7046; PMID: 19029943; http://dx.doi.org/10.1038/onc.2008.352
  • Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet 2006; 40:335 - 361; PMID: 16872256; http://dx.doi.org/10.1146/annurev.genet.39.073003.100738

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.