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Bindarit

An anti-inflammatory small molecule that modulates the NFkB pathway

Pages 159-169 | Received 21 Oct 2011, Accepted 27 Oct 2011, Published online: 01 Jan 2012

References

  • Baeuerle PA, Henkel T. Function and activation of NFkappaB in the immune system. Annu Rev Immunol 1994; 12:141 - 179; PMID: 8011280; http://dx.doi.org/10.1146/annurev.iy.12.040194.001041
  • Sun XF, Zhang H. NFκB and NFκBI polymorphisms in relation to susceptibility of tumor and other diseases. Histol Histopathol 2007; 22:1387 - 1398; PMID: 17701919
  • Mantovani A. Molecular pathways linking inflammation and cancer. Curr Mol Med 2010; 10:369 - 373; PMID: 20455855; http://dx.doi.org/10.2174/156652410791316968
  • Chefetz I, Holmberg JC, Alvero AB, Visintin I, Mor G. Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFκB pathway. Cell Cycle 2011; 10:2206 - 2214; PMID: 21623171; http://dx.doi.org/10.4161/cc.10.13.16348
  • Hayden MS, Ghosh S. Signaling to NFkappaB. Genes Dev 2004; 18:2195 - 2224; PMID: 15371334; http://dx.doi.org/10.1101/gad.1228704
  • Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NFkappaB. Annu Rev Cell Biol 1994; 10:405 - 455; PMID: 7888182; http://dx.doi.org/10.1146/annurev.cb.10.110194.002201
  • Pahl HL. Activators and target genes of Rel/NFkappaB transcription factors. Oncogene 1999; 18:6853 - 6866; PMID: 10602461; http://dx.doi.org/10.1038/sj.onc.1203239
  • Ghosh S, Karin M. Missing pieces in the NFκB puzzle. Cell 2002; 109:81 - 96; PMID: 11983155; http://dx.doi.org/10.1016/S0092-8674(02)00703-1
  • Bonizzi G, Karin M. The two NFκB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004; 25:280 - 288; PMID: 15145317; http://dx.doi.org/10.1016/j.it.2004.03.008
  • Derudder E, Dejardin E, Pritchard LL, Green DR, Korner M, Baud V. RelB/p50 dimers are differentially regulated by tumor necrosis factora and lymphotoxinß receptor activation. J Biol Chem 2003; 278:23278 - 23284; PMID: 12709443; http://dx.doi.org/10.1074/jbc.M300106200
  • Claudio E, Brown K, Park S, Wang H, Siebenlist U. BAFF-induced NEMO-independent processing of NFκB2 in maturing B cells. Nat Immunol 2002; 3:958 - 965; PMID: 12352969; http://dx.doi.org/10.1038/ni842
  • Dejardin E. The alternative NFκB pathway from biochemistry to biology: pitfalls and promises for future drug development. Biochem Pharmacol 2006; 72:1161 - 1179; PMID: 16970925; http://dx.doi.org/10.1016/j.bcp.2006.08.007
  • Mihalcik SA, Tschumper RC, Jelinek DF. Transcriptional and post-transcriptional mechanisms of BAFF-receptor dysregulation in human B lineage malignancies. Cell Cycle 2010; 9:4884 - 4892; PMID: 21099364; http://dx.doi.org/10.4161/cc.9.24.14156
  • Guglielmotti A, Silvestrini B, Saso L, Zwain I, Cheng CY. Chronic inflammatory response in the rat can be blocked by bindarit. Biochem Mol Biol Int 1993; 29:747 - 756; PMID: 7683947
  • Guglielmotti A, D'Onofrio E, Coletta I, Aquilini L, Milanese C, Pinza M. Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNFalpha production. Inflamm Res 2002; 51:252 - 258; PMID: 12056513; http://dx.doi.org/10.1007/PL00000301
  • Ialenti A, Grassia G, Gordon P, Maddaluno M, Di Lauro MV, Baker AH, et al. Inhibition of In-Stent Stenosis by Oral Administration of Bindarit in Porcine Coronary Arteries. Arterioscler Thromb Vasc Biol 2011; 31:2448 - 2454; PMID: 21852559; http://dx.doi.org/10.1161/ATVBAHA.111.230078
  • Zoja C, Corna D, Benedetti G, Morigi M, Donadelli R, Guglielmotti A, et al. Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int 1998; 53:726 - 734; PMID: 9507220; http://dx.doi.org/10.1046/j.1523-1755.1998.00804.x
  • Ramnath RD, Ng SW, Guglielmotti A, Bhatia M. Role of MCP-1 in endotoxemia and sepsis. Int Immunopharmacol 2008; 8:810 - 818; PMID: 18442784; http://dx.doi.org/10.1016/j.intimp.2008.01.033
  • Conductier G, Blondeau N, Guyon A, Nahon JL, Rovíre C. The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol 2010; 224:93 - 100; PMID: 20681057; http://dx.doi.org/10.1016/j.jneuroim.2010.05.010
  • Lloyd CM, Dorf ME, Proydfoot A, Salant DJ, Gutierrez-Ramos JC. Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis. J Leukoc Biol 1997; 62:676; PMID: 9365123
  • Luster AD, Rothenberg ME. Role of the monocyte chemoattractant protein and eotaxin subfamily of chemokines in allergic inflammation. J Leukoc Biol 1997; 62:620; PMID: 9365117
  • Baggiolini M, Dahinden CA. CC chemokines in allergic inflammation. Immunol Today 1994; 15:127; PMID: 8172645; http://dx.doi.org/10.1016/0167-5699(94)90156-2
  • Jia T, Serbina NV, Brandl K, Zhong MX, Leiner IM, Charo IF, et al. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J Immunol 2008; 180:6846 - 6853; PMID: 18453605
  • Van Damme J, Proost P, Lenaerts JP, Opdenakker G. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J Exp Med 1992; 176:59 - 65; PMID: 1613466; http://dx.doi.org/10.1084/jem.176.1.59
  • Ping D, Boekhoudt GH, Rogers EM, Boss JM. Nuclear factor-kappaB p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene. J Immunol 1999; 162:727 - 734; PMID: 9916692
  • Ping D, Jones PL, Boss JM. TNF regulates the in vivo occupancy of both distal and proximal regulatory regions of the MCP-1/JE gene. Immunity 1996; 4:455 - 469; PMID: 8630731; http://dx.doi.org/10.1016/S1074-7613(00)80412-4
  • Boekhoudt GH, Guo, Beresford GW, Boss JM. Communication between NFkappaB and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene. J Immunol 2003; 170:4139 - 4147; PMID: 12682245
  • Ping D, Boekhoudt G, Zhang F, Morris A, Philipsen S, Warren ST, et al. Sp1 binding is critical for promoter assembly and activation of the MCP-1 gene by tumor necrosis factor. J Biol Chem 2000; 275:1708 - 1714; PMID: 10636866; http://dx.doi.org/10.1074/jbc.275.3.1708
  • Akira S, Takeda K, Kaisho T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2:675 - 680; PMID: 11477402; http://dx.doi.org/10.1038/90609
  • Takeuchi O, Hemmi H, Akira S. Interferon response induced by Toll-like receptor signaling. J Endotoxin Res 2004; 10:252 - 256; PMID: 15373970
  • Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20:197 - 216; PMID: 11861602; http://dx.doi.org/10.1146/annurev.immunol.20.083001.084359
  • O'Neill LA. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol 2006; 18:3 - 9; PMID: 16343886; http://dx.doi.org/10.1016/j.coi.2005.11.012
  • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 2008; 42:145 - 151; PMID: 18304834; http://dx.doi.org/10.1016/j.cyto.2008.01.006
  • Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300:1524 - 1525; PMID: 12791976; http://dx.doi.org/10.1126/science.1085536
  • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2:675 - 680; PMID: 11477402; http://dx.doi.org/10.1038/90609
  • Schmitz ML, Bacher S, Kracht M. Ikappa B-independent control of NFkappaB activity by modulatory phosphorylations. Trends Biochem Sci 2001; 26:186 - 190; PMID: 11246025; http://dx.doi.org/10.1016/S0968-0004(00)01753-9
  • Chen LF, Williams SA, Mu Y, Nakano H, Duerr JM, BuckBinder L, et al. NFkappaB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol 2005; 25:7966 - 7975; PMID: 16135789; http://dx.doi.org/10.1128/MCB.25.18.7966-7975.2005
  • Teferedegne B, Green MR, Guo Z, Boss JM. Mechanism of action of a distal NFkappaB-dependent enhancer. Mol Cell Biol 2006; 26:5759 - 5770; PMID: 16847329; http://dx.doi.org/10.1128/MCB.00271-06
  • Ueda A, Okuda K, Ohno S, Shirai A, Igarashi T, Matsunaga K, et al. NFkappaB and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J Immunol 1994; 153:2052 - 2063; PMID: 8051410
  • Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation of interleukin 12 p40 expression through an NFkappaB half-site. Mol Cell Biol 1995; 15:5258 - 5267; PMID: 7565674
  • Sironi M, Guglielmotti A, Polentarutti N, Fioretti F, Milanese C, Romano M, et al. A small synthetic molecule capable of preferentially inhibiting the production of the CC chemokine monocyte chemotactic protein-1. Eur Cytokine Netw 1999; 10:437 - 442; PMID: 10477401
  • Mirolo M, Fabbri M, Sironi M, Vecchi A, Guglielmotti A, Mangano G, et al. Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins. Eur Cytokine Netw 2008; 19:119 - 122; PMID: 18775807
  • Akira S, Uematsu O, Takeuchi. Pathogen recognition and innate immunity. Cell 2006; 124:783 - 801; PMID: 16497588; http://dx.doi.org/10.1016/j.cell.2006.02.015
  • Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22:891 - 928; PMID: 15032599; http://dx.doi.org/10.1146/annurev.immunol.22.012703.104543
  • DeVries ME, Kelvin AA, Xu L, Ran L, Robinson J, Kelvin DJ. Defining the origins and evolution of the chemokine/chemokine receptor system. J Immunol 2006; 176:401 - 415; PMID: 16365434
  • Zlotnik A, Yoshie O, Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol 2006; 7:243; PMID: 17201934; http://dx.doi.org/10.1186/gb-2006-7-12-243
  • Lee SM, Suen Y, Qian J, Knoppel E, Cairo MS. The regulation and biological activity of interleukin 12. Leuk Lymphoma 1998; 29:427 - 438; PMID: 9643557; http://dx.doi.org/10.3109/10428199809050903
  • Del Vecchio M, Bajetta E, Canova S, Lotze MT, Wesa A, Parmiani G, et al. Interleukin-12: biological properties and clinical application. Clin Cancer Res 2007; 13:4677 - 4685; PMID: 17699845; http://dx.doi.org/10.1158/1078-0432.CCR-07-0776
  • Kim S, Chung EY, Ma X. Immunological consequences of macrophage-mediated clearance of apoptotic cells. Cell Cycle 2005; 4:231 - 234; PMID: 15655362; http://dx.doi.org/10.4161/cc.4.2.1428
  • Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci USA 1985; 82:5328 - 5331; PMID: 2410919; http://dx.doi.org/10.1073/pnas.82.16.5328
  • Sommers CD, Thompson JM, Guzova JA, Bonar SL, Rader RK, Mathialagan S, et al. Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. J Pharmacol Exp Ther 2009; 330:377 - 388; PMID: 19478133; http://dx.doi.org/10.1124/jpet.108.147538
  • Nowak DE, Tian B, Brasier AR. Two-step cross-linking method for identification of NFkappaB gene network by chromatin immunoprecipitation. Biotechniques 2005; 39:715 - 725; PMID: 16315372; http://dx.doi.org/10.2144/000112014
  • Saccani S, Pantano S, Natoli G. Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med 2001; 193:1351 - 1359; PMID: 11413190; http://dx.doi.org/10.1084/jem.193.12.1351
  • Grimaldi B, Nakahata Y, Sahar S, Kaluzova M, Gauthier D, Pham K, et al. Chromatin remodeling and circadian control: master regulator CLOCK is an enzyme. Cold Spring Harb Symp Quant Biol 2007; 72:105 - 112; PMID: 18419267; http://dx.doi.org/10.1101/sqb.2007.72.049
  • Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo JJ, Sassone-Corsi P. Circadian clock control by SUMOylation of BMAL1. Science 2005; 309:1390 - 1394; PMID: 16109848; http://dx.doi.org/10.1126/science.1110689
  • Nóvak EM, Dantas KC, Charbel CE, Bydlowski SP. Association of hepatic nuclear factor-4 in the apolipoprotein B promoter: a preliminary report. Braz J Med Biol Res 1998; 31:1405 - 1408; PMID: 9921275
  • Hosoe S, Ogura T, Hayashi S, Komuta K, Ikeda T, Shirasaka T, et al. Induction of tumoricidal macrophages from bone marrow cells of normal mice or mice bearing a colony-stimulating-factor-producing tumor. Cancer Immunol Immunother 1989; 28:116 - 122; PMID: 2645051; http://dx.doi.org/10.1007/BF00199111
  • Kim JB, Wright HM, Wright M, Spiegelman BM. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 1998; 95:4333 - 4337; PMID: 9539737; http://dx.doi.org/10.1073/pnas.95.8.4333
  • Srivastava GK, de Larrea GZ. UVB-induced murine bone marrow derived macrophages and apoptosis. Immunol Invest 2008; 37:293 - 313; PMID: 18569072; http://dx.doi.org/10.1080/08820130802083689
  • Waheed A, Shadduck RK. Purification and properties of L cell-derived colony-stimulating factor. J Lab Clin Med 1979; 94:180 - 193; PMID: 313966
  • Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappaB. Proc Natl Acad Sci USA 1989; 86:2336 - 2340; PMID: 2494664; http://dx.doi.org/10.1073/pnas.86.7.2336
  • Brou C, Chaudhary S, Davidson I, Lutz Y, Wu J, Egly JM, et al. Distinct TFIID complexes mediate the effect of different transcriptional activators. EMBO J 1993; 12:489 - 499; PMID: 8440239
  • Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, et al. PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab 2010; 12:509 - 520; PMID: 21035761; http://dx.doi.org/10.1016/j.cmet.2010.10.005
  • Piehler AP, Grimholt RM, Ovstebø R, Berg JP. Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes. BMC Immunol 2010; 11:21; PMID: 20441576; http://dx.doi.org/10.1186/1471-2172-11-21

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