797
Views
39
CrossRef citations to date
0
Altmetric
Report

Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration

, , , &
Pages 695-705 | Received 24 Oct 2011, Accepted 19 Dec 2011, Published online: 15 Feb 2012

References

  • Huang ES, Basu A, O'Grady M, Capretta JC. Projecting the future diabetes population size and related costs for the US. Diabetes Care 2009; 32:2225 - 2229; PMID: 19940225; http://dx.doi.org/10.2337/dc090459
  • Butler PC, Meier JJ, Butler AE, Bhushan A. The replication of β cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab 2007; 3:758 - 768; PMID: 17955017; http://dx.doi.org/10.1038/ncpendmet0647
  • Meier JJ. Beta cell mass in diabetes: a realistic therapeutic target?. Diabetologia 2008; 51:703 - 713; PMID: 18317728; http://dx.doi.org/10.1007/s00125-008-0936-9
  • Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?. Diabetologia 2005; 48:2221 - 2228; PMID: 16205882; http://dx.doi.org/10.1007/s00125-005-1949-2
  • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52:102 - 110; PMID: 12502499; http://dx.doi.org/10.2337/diabetes.52.1.102
  • Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol 2005; 23:857 - 861; PMID: 16003374; http://dx.doi.org/10.1038/nbt1115
  • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004; 429:41 - 46; PMID: 15129273; http://dx.doi.org/10.1038/nature02520
  • Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455:627 - 632; PMID: 18754011; http://dx.doi.org/10.1038/nature07314
  • Levine F, Itkin-Ansari P. β-cell Regeneration: neogenesis, replication or both?. J Mol Med (Berl) 2008; 86:247 - 258; PMID: 17922102; http://dx.doi.org/10.1007/s00109-007-0259-1
  • Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, et al. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev 2006; 27:356 - 370; PMID: 16638909; http://dx.doi.org/10.1210/er.2006-0004
  • Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, et al. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 2005; 25:3752 - 3762; PMID: 15831479; http://dx.doi.org/10.1128/MCB.25.9.3752-62.2005
  • Georgia S, Bhushan A. p27 Regulates the transition of β-cells from quiescence to proliferation. Diabetes 2006; 55:2950 - 2956; PMID: 17065330; http://dx.doi.org/10.2337/db06-0249
  • Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes 2005; 54:2557 - 2567; PMID: 16123343; http://dx.doi.org/10.2337/diabetes.54.9.2557
  • Vasavada RC, Gonzalez-Pertusa JA, Fujinaka Y, Fiaschi-Taesch N, Cozar-Castellano I, Garcia-Ocaña A. Growth factors and beta cell replication. Int J Biochem Cell Biol 2006; 38:931 - 950; PMID: 16168703; http://dx.doi.org/10.1016/j.biocel.2005.08.003
  • Kushner JA. Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle 2006; 5:234 - 237; PMID: 16410729; http://dx.doi.org/10.4161/cc.5.3.2399
  • He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, Long SY, et al. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol 2009; 23:1865 - 1875; PMID: 19628581; http://dx.doi.org/10.1210/me.2009-0057
  • Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes 2004; 53:149 - 159; PMID: 14693709; http://dx.doi.org/10.2337/diabetes.53.1.149
  • Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, Velazquez-Garcia S, et al. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes 2009; 58:882 - 893; PMID: 19136653; http://dx.doi.org/10.2337/db08-0631
  • Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004; 114:963 - 968; PMID: 15467835
  • Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest 2007; 117:2869 - 2876; PMID: 17823659; http://dx.doi.org/10.1172/JCI32198
  • Chen S, Ding JH, Bekeredjian R, Yang BZ, Shohet RV, Johnston SA, et al. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci USA 2006; 103:8469 - 8474; PMID: 16709667; http://dx.doi.org/10.1073/pnas.0602921103
  • Chen S, Ding J, Yu C, Yang B, Wood DR, Grayburn PA. Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1. Gene Ther 2007; 14:1102 - 1110; PMID: 17460716; http://dx.doi.org/10.1038/sj.gt.3302963
  • Chai RJ, Chen S, Ding J, Grayburn PA. Efficient, glucose responsive and islet-specific transgene expression by a modified rat insulin promoter. Gene Ther 2009; 16:1202 - 1209; PMID: 19727136; http://dx.doi.org/10.1038/gt.2009.114
  • Chen S, Shimoda M, Wang MY, Ding J, Noguchi H, Matsumoto S, et al. Regeneration of pancreatic islets in vivo by ultrasound-targeted gene therapy. Gene Ther 2010; 17:1411 - 1420; PMID: 20508600; http://dx.doi.org/10.1038/gt.2010.85
  • Ku HT. Minireview: pancreatic progenitor cells—recent studies. Endocrinology 2008; 149:4312 - 4316; PMID: 18535096; http://dx.doi.org/10.1210/en.20080546
  • Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 2000; 127:3533 - 3542; PMID: 10903178
  • Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, Selk K, et al. Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 2010; 59:1926 - 1936; PMID: 20668294; http://dx.doi.org/10.2337/db09-1776
  • De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, et al. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metab 2010; 11:543 - 553; PMID: 20519125; http://dx.doi.org/10.1016/j.cmet.2010.04.007
  • Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004; 306:2261 - 2264; PMID: 15564314; http://dx.doi.org/10.1126/science.1101968
  • Davani B, Ariely S, Ikonomou L, Oron Y, Gershengorn MC. Human islet-derived precursor cells can cycle between epithelial clusters and mesenchymal phenotypes. J Cell Mol Med 2009; 13:2570 - 2581; PMID: 19175683; http://dx.doi.org/10.1111/j.1582-4934.2008.00570.x
  • Smukler SR, Arntfield ME, Razavi R, Bikopoulos G, Karpowicz P, Seaberg R, et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 2011; 8:281 - 293; PMID: 21362568; http://dx.doi.org/10.1016/j.stem.2011.01.015
  • Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol 2004; 22:1115 - 1124; PMID: 15322557; http://dx.doi.org/10.1038/nbt1004
  • Tavana O, Zhu C. Too many breaks (brakes): pancreatic β-cell senescence leads to diabetes. Cell Cycle 2011; 10:2471 - 2484; PMID: 21750406; http://dx.doi.org/10.4161/cc.10.15.16741
  • Gunasekaran U, Gannon M. Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) 2011; 3:565 - 575; PMID: 21765202
  • Kuhlow D, Florian S, von Figura G, Weimer S, Schulz N, Petzke KJ, et al. Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) 2010; 2:650 - 658; PMID: 20876939
  • Joglekar MV, Hardikar AA. Epithelial-to-mesenchymal transition in pancreatic islet beta cells. Cell Cycle 2010; 9:4077 - 4079; PMID: 20948307; http://dx.doi.org/10.4161/cc.9.20.13590
  • Baker GL, Landis MW, Hinds PW. Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle 2005; 4:330 - 338; PMID: 15684604; http://dx.doi.org/10.4161/cc.4.2.1485
  • van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993; 262:2050 - 2054; PMID: 8266103; http://dx.doi.org/10.1126/science.8266103
  • Choi S, Oh S, Lee M, Kim SW. Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. Mol Ther 2005; 12:885 - 891; PMID: 16039908; http://dx.doi.org/10.1016/j.ymthe.2005.03.039
  • Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, et al. Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest 2007; 117:246 - 257; PMID: 17200721; http://dx.doi.org/10.1172/JCI17645

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.