Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

References

• Margolis RL. Tetraploidy and tumor development. Cancer Cell 2005; 8:353 - 354; PMID: 16286243; http://dx.doi.org/10.1016/j.ccr.2005.10.017
   PubMed Web of Science ®Google Scholar
• Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437:1043 - 1047; PMID: 16222300; http://dx.doi.org/10.1038/nature04217
   PubMed Web of Science ®Google Scholar
• Gortchakov AA, Eggert H, Gan M, Mattow J, Zhimulev IF, Saumweber H. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Chromosoma 2005; 114:54 - 66; PMID: 15821938; http://dx.doi.org/10.1007/s00412-005-0339-3
   PubMed Web of Science ®Google Scholar
• Cimini D, Wan X, Hirel CB, Salmon ED. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr Biol 2006; 16:1711 - 1718; PMID: 16950108; http://dx.doi.org/10.1016/j.cub.2006.07.022
   PubMed Web of Science ®Google Scholar
• Hoar K, Chakravarty A, Rabino C, Wysong D, Bowman D, Roy N, et al. MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol Cell Biol 2007; 27:4513 - 4525; PMID: 17438137; http://dx.doi.org/10.1128/MCB.02364-06
   PubMed Web of Science ®Google Scholar
• Giet R, Petretti C, Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link?. Trends Cell Biol 2005; 15:241 - 250; PMID: 15866028; http://dx.doi.org/10.1016/j.tcb.2005.03.004
   PubMed Web of Science ®Google Scholar
• Sumara I, Quadroni M, Frei C, Olma MH, Sumara G, Ricci R, et al. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell 2007; 12:887 - 900; PMID: 17543862; http://dx.doi.org/10.1016/j.devcel.2007.03.019
   PubMed Web of Science ®Google Scholar
• Sumara I, Peter MA. A Cul3-based E3 ligase regulates mitosis and is required to maintain the spindle assembly checkpoint in human cells. Cell Cycle 2007; 6:3004 - 3010; PMID: 18075312; http://dx.doi.org/10.4161/cc.6.24.5068
   PubMed Web of Science ®Google Scholar
• Carmena M, Earnshaw WC. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 2003; 4:842 - 854; PMID: 14625535; http://dx.doi.org/10.1038/nrm1245
   PubMed Web of Science ®Google Scholar
• Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J Cell Sci 1999; 112:3591 - 3601; PMID: 10523496
   PubMed Web of Science ®Google Scholar
• Jiang Y, Zhang Y, Lees E, Seghezzi W. Aurora A over-expression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer. Oncogene 2003; 22:8293 - 8301; PMID: 14614453; http://dx.doi.org/10.1038/sj.onc.1206873
   PubMed Web of Science ®Google Scholar
• Tyler RK, Shpiro N, Marquez R, Eyers PA. VX-680 inhibits Aurora A and Aurora B kinase activity in human cells. Cell Cycle 2007; 6:2846 - 2854; PMID: 18032922; http://dx.doi.org/10.4161/cc.6.22.4940
   PubMed Web of Science ®Google Scholar
• Rao B, van Leeuwen IM, Higgins M, Campbel J, Thompson AM, Lane DP, et al. Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy. Oncotarget 2010; 1:639 - 650; PMID: 21317459
   PubMed Web of Science ®Google Scholar
• Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV. Aurora A, meiosis and mitosis. Biol Cell 2004; 96:215 - 229; PMID: 15182704; http://dx.doi.org/10.1016/j.biolcel.2003.09.008
   PubMed Web of Science ®Google Scholar
• Nguyen HG, Chinnappan D, Urano T, Ravid K. Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol Cell Biol 2005; 25:4977 - 4992; PMID: 15923616; http://dx.doi.org/10.1128/MCB.25.12.4977-92.2005
   PubMed Web of Science ®Google Scholar
• Maerki S, Olma MH, Staubli T, Steigemann P, Gerlich DW, Quadroni M, et al. The Cul3-KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol 2009; 187:791 - 800; PMID: 19995937; http://dx.doi.org/10.1083/jcb.200906117
   PubMed Web of Science ®Google Scholar
• Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, et al. Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res 2009; 69:1125 - 1134; PMID: 19176389; http://dx.doi.org/10.1158/0008-5472.CAN-08-2134
   PubMed Web of Science ®Google Scholar
• Maerki S, Beck J, Sumara I, Peter M. Finding the midzone: the role of ubiquitination for CPC localization during anaphase. Cell Cycle 2010; 9:2921 - 2922; PMID: 20714224; http://dx.doi.org/10.4161/cc.9.15.12740
   PubMed Web of Science ®Google Scholar
• Visconti R, Palazzo L, Grieco D. Requirement for proteolysis in spindle assembly checkpoint silencing. Cell Cycle 2010; 9:564 - 569; PMID: 20081372; http://dx.doi.org/10.4161/cc.9.3.10581
   PubMed Web of Science ®Google Scholar
• Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, et al. Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 2008; 452:365 - 369; PMID: 18354482; http://dx.doi.org/10.1038/nature06641
   PubMed Web of Science ®Google Scholar
• Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G. Plk1-and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol 2008; 181:65 - 78; PMID: 18378770; http://dx.doi.org/10.1083/jcb.200712027
   PubMed Web of Science ®Google Scholar
• Gusti A, Baumberger N, Nowack M, Pusch S, Eisler H, Potuschak T, et al. The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development. PLoS One 2009; 4:4780; PMID: 19277118; http://dx.doi.org/10.1371/journal.pone.0004780
   PubMed Web of Science ®Google Scholar
• D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP, et al. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 2010; 466:138 - 142; PMID: 20596027; http://dx.doi.org/10.1038/nature09140
   PubMed Web of Science ®Google Scholar
• Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, et al. The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol 2011; 13:1004 - 1009; PMID: 21725316; http://dx.doi.org/10.1038/ncb2282
   PubMed Web of Science ®Google Scholar
• Littlepage LE, Ruderman JV. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev 2002; 16:2274 - 2285; PMID: 12208850; http://dx.doi.org/10.1101/gad.1007302
   PubMed Web of Science ®Google Scholar
• Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, et al. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 2002; 416:703 - 709; PMID: 11961546; http://dx.doi.org/10.1038/416703a
   PubMed Web of Science ®Google Scholar
• Cardozo T, Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 2004; 5:739 - 751; PMID: 15340381; http://dx.doi.org/10.1038/nrm1471
   PubMed Web of Science ®Google Scholar
• Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M. Identification of a family of human F-box proteins. Curr Biol 1999; 9:1177 - 1179; PMID: 10531035; http://dx.doi.org/10.1016/S0960-9822(00)80020-2
   PubMed Web of Science ®Google Scholar
• Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. FEBS Lett 1999; 459:75 - 79; PMID: 10508920; http://dx.doi.org/10.1016/S0014-5793(99)01211-9
   PubMed Web of Science ®Google Scholar
• Skaar JR, Pagan JK, Pagano M. SnapShot: F-box proteins I. Cell 2009; 137:1160 - 1161; PMID: 19524517; http://dx.doi.org/10.1016/j.cell.2009.05.039
   PubMed Web of Science ®Google Scholar
• Chen BB, Glasser JR, Coon TA, Mallampalli RK. FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest. Cell Cycle 2011; 10:3487 - 3494; PMID: 22024926; http://dx.doi.org/10.4161/cc.10.20.17742
   PubMed Web of Science ®Google Scholar
• Tao Y, Zhang P, Girdler F, Frascogna V, Castedo M, Bourhis J, et al. Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene 2008; 27:3244 - 3255; PMID: 18084327; http://dx.doi.org/10.1038/sj.onc.1210990
   PubMed Web of Science ®Google Scholar
• Long ZJ, Xu J, Yan M, Zhang JG, Guan Z, Xu DZ, et al. ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture. Cell Cycle 2008; 7:1473 - 1479; PMID: 18418083; http://dx.doi.org/10.4161/cc.7.10.5949
   PubMed Web of Science ®Google Scholar
• Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, et al. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem 2008; 283:31785 - 31790; PMID: 18801727; http://dx.doi.org/10.1074/jbc.M805880200
   PubMed Web of Science ®Google Scholar
• Ho CC, Hau PM, Marxer M, Poon RY. The requirement of p53 for maintaining chromosomal stability during tetraploidization. Oncotarget 2010; 1:583 - 595; PMID: 21317454
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis. Cell Cycle 2009; 8:2385 - 2398; PMID: 19556893; http://dx.doi.org/10.4161/cc.8.15.9082
   PubMed Web of Science ®Google Scholar
• Ray NB, Durairaj L, Chen BB, McVerry BJ, Ryan AJ, Donahoe M, et al. Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia. Nat Med 2010; 16:1120 - 1127; PMID: 20852622; http://dx.doi.org/10.1038/nm.2213
   PubMed Web of Science ®Google Scholar
• Chen BB, Mallampalli RK. Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase. J Biol Chem 2007; 282:33494 - 33506; PMID: 17804406; http://dx.doi.org/10.1074/jbc.M706472200
   PubMed Web of Science ®Google Scholar
• Agassandian M, Chen BB, Schuster CC, Houtman JC, Mallampalli RK. 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. FASEB J 2010; 24:1271 - 1283; PMID: 20007511; http://dx.doi.org/10.1096/fj.09-136044
   PubMed Web of Science ®Google Scholar
• Chen BB, Mallampalli RK. Masking of a nuclear signal motif by monoubiquitination leads to mislocalization and degradation of the regulatory enzyme cytidylyltransferase. Mol Cell Biol 2009; 29:3062 - 3075; PMID: 19332566; http://dx.doi.org/10.1128/MCB.01824-08
   PubMed Web of Science ®Google Scholar