Selective blockade of tumor angiogenesis

References

• Taraboletti G, Rusnati M, Ragona L, Colombo G. Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors. Oncotarget 2010; 1:662 - 73; PMID: 21317461
   PubMed Web of Science ®Google Scholar
• Kaur S, Roberts DD. CD47 applies the brakes to angiogenesis via vascular endothelial growth factor receptor-2. Cell Cycle 2011; 10:10 - 2; http://dx.doi.org/10.4161/cc.10.1.14324; PMID: 21191182
   PubMed Web of Science ®Google Scholar
• Shichiri M, Tanaka Y. Inhibition of cancer progression by rifampicin: involvement of antiangiogenic and anti-tumor effects. Cell Cycle 2010; 9:64 - 8; http://dx.doi.org/10.4161/cc.9.1.10354; PMID: 20016271
   PubMed Web of Science ®Google Scholar
• Acevedo VD, Ittmann M, Spencer DM. Paths of FGFR-driven tumorigenesis. Cell Cycle 2009; 8:580 - 8; http://dx.doi.org/10.4161/cc.8.4.7657; PMID: 19182515
   PubMed Web of Science ®Google Scholar
• Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358:2039 - 49; http://dx.doi.org/10.1056/NEJMra0706596; PMID: 18463380
   PubMed Web of Science ®Google Scholar
• Samant RS, Shevde LA. Recent advances in anti-angiogenic therapy of cancer. Oncotarget 2011; 2:122 - 34; PMID: 21399234
   PubMed Web of Science ®Google Scholar
• Ebos JM, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 2011; 8:210 - 21; http://dx.doi.org/10.1038/nrclinonc.2011.21; PMID: 21364524
   PubMed Web of Science ®Google Scholar
• Chen HX, Cleck JN. Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009; 6:465 - 77; http://dx.doi.org/10.1038/nrclinonc.2009.94; PMID: 19581909
   PubMed Web of Science ®Google Scholar
• Verheul HM, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 2007; 7:475 - 85; http://dx.doi.org/10.1038/nrc2152; PMID: 17522716
   PubMed Web of Science ®Google Scholar
• Eremina V, Cui S, Gerber H, Ferrara N, Haigh J, Nagy A, et al. Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol 2006; 17:724 - 35; http://dx.doi.org/10.1681/ASN.2005080810; PMID: 16436493
   PubMed Web of Science ®Google Scholar
• Sung HK, Michael IP, Nagy A. Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications. Curr Opin Hematol 2010; 17:206 - 12; PMID: 20216210
   PubMed Web of Science ®Google Scholar
• Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S, et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007; 130:691 - 703; http://dx.doi.org/10.1016/j.cell.2007.06.054; PMID: 17719546
   PubMed Web of Science ®Google Scholar
• Rouhi P, Lee SL, Cao Z, Hedlund EM, Jensen LD, Cao Y. Pathological angiogenesis facilitates tumor cell dissemination and metastasis. Cell Cycle 2010; 9:913 - 7; http://dx.doi.org/10.4161/cc.9.5.10853; PMID: 20160500
   PubMed Web of Science ®Google Scholar
• St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, et al. Genes expressed in human tumor endothelium. Science 2000; 289:1197 - 202; http://dx.doi.org/10.1126/science.289.5482.1197; PMID: 10947988
   PubMed Web of Science ®Google Scholar
• Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, et al. TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). Cancer Res 2004; 64:817 - 20; http://dx.doi.org/10.1158/0008-5472.CAN-03-2408; PMID: 14871805
   PubMed Web of Science ®Google Scholar
• Seaman S, Stevens J, Yang MY, Logsdon D, Graff-Cherry C, St Croix B. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 2007; 11:539 - 54; http://dx.doi.org/10.1016/j.ccr.2007.04.017; PMID: 17560335
   PubMed Web of Science ®Google Scholar
• Oh P, Li Y, Yu J, Durr E, Krasinska KM, Carver LA, et al. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 2004; 429:629 - 35; http://dx.doi.org/10.1038/nature02580; PMID: 15190345
   PubMed Web of Science ®Google Scholar
• Beaty RM, Edwards JB, Boon K, Siu IM, Conway JE, Riggins GJ. PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium. J Neurooncol 2007; 81:241 - 8; http://dx.doi.org/10.1007/s11060-006-9227-9; PMID: 17031559
   PubMed Web of Science ®Google Scholar
• Parker BS, Argani P, Cook BP, Liangfeng H, Chartrand SD, Zhang M, et al. Alterations in vascular gene expression in invasive breast carcinoma. Cancer Res 2004; 64:7857 - 66; http://dx.doi.org/10.1158/0008-5472.CAN-04-1976; PMID: 15520192
   PubMed Web of Science ®Google Scholar
• Carson-Walter E, St. Croix B. Molecular Targets of Tumor Vasculature. In: Aird WC, ed. Endothelial Cell Phenotypes in Health and Disease: Marcel Dekker, Inc., 2005.
   Google Scholar
• Madden SL, Cook BP, Nacht M, Weber WD, Callahan MR, Jiang Y, et al. Vascular gene expression in nonneoplastic and malignant brain. Am J Pathol 2004; 165:601 - 8; http://dx.doi.org/10.1016/S0002-9440(10)63324-X; PMID: 15277233
   PubMed Web of Science ®Google Scholar
• Roesli C, Neri D. Methods for the identification of vascular markers in health and disease: from the bench to the clinic. J Proteomics 2010; 73:2219 - 29; http://dx.doi.org/10.1016/j.jprot.2010.05.017; PMID: 20541635
   PubMed Web of Science ®Google Scholar
• Neri D, Bicknell R. Tumour vascular targeting. Nat Rev Cancer 2005; 5:436 - 46; http://dx.doi.org/10.1038/nrc1627; PMID: 15928674
   PubMed Web of Science ®Google Scholar
• Hajitou A, Pasqualini R, Arap W. Vascular targeting: recent advances and therapeutic perspectives. Trends Cardiovasc Med 2006; 16:80 - 8; http://dx.doi.org/10.1016/j.tcm.2006.01.003; PMID: 16546688
   PubMed Web of Science ®Google Scholar
• Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA. Identification of the cellular receptor for anthrax toxin. Nature 2001; 414:225 - 9; http://dx.doi.org/10.1038/n35101999; PMID: 11700562
   PubMed Web of Science ®Google Scholar
• Scobie HM, Rainey GJ, Bradley KA, Young JA. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A 2003; 100:5170 - 4; http://dx.doi.org/10.1073/pnas.0431098100; PMID: 12700348
   PubMed Web of Science ®Google Scholar
• Liu S, Crown D, Miller-Randolph S, Moayeri M, Wang H, Hu H, et al. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A 2009; 106:12424 - 9; http://dx.doi.org/10.1073/pnas.0905409106; PMID: 19617532
   PubMed Web of Science ®Google Scholar
• Liu S, Miller-Randolph S, Crown D, Moayeri M, Sastalla I, Okugawa S, et al. Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice. Cell Host Microbe 2010; 8:455 - 62; http://dx.doi.org/10.1016/j.chom.2010.10.004; PMID: 21075356
   PubMed Web of Science ®Google Scholar
• Chen KH, Liu S, Bankston LA, Liddington RC, Leppla SH. Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells. J Biol Chem 2007; 282:9834 - 45; http://dx.doi.org/10.1074/jbc.M611142200; PMID: 17251181
   PubMed Web of Science ®Google Scholar
• Hotchkiss KA, Basile CM, Spring SC, Bonuccelli G, Lisanti MP, Terman BI. TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen. Exp Cell Res 2005; 305:133 - 44; http://dx.doi.org/10.1016/j.yexcr.2004.12.025; PMID: 15777794
   PubMed Web of Science ®Google Scholar
• Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, et al. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J Cell Sci 2001; 114:2755 - 73; PMID: 11683410
   PubMed Web of Science ®Google Scholar
• Dowling O, Difeo A, Ramirez MC, Tukel T, Narla G, Bonafe L, et al. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet 2003; 73:957 - 66; http://dx.doi.org/10.1086/378781; PMID: 12973667
   PubMed Web of Science ®Google Scholar
• Hanks S, Adams S, Douglas J, Arbour L, Atherton DJ, Balci S, et al. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet 2003; 73:791 - 800; http://dx.doi.org/10.1086/378418; PMID: 14508707
   PubMed Web of Science ®Google Scholar
• Deuquet J, Lausch E, Superti-Furga A, van der Goot FG. The dark sides of capillary morphogenesis gene 2. EMBO J 2012; 31:3 - 13; http://dx.doi.org/10.1038/emboj.2011.442; PMID: 22215446
   PubMed Web of Science ®Google Scholar
• Tanaka K, Ebihara T, Kusubata M, Adachi E, Arai M, Kawaguchi N, et al. Abnormal collagen deposition in fibromas from patient with juvenile hyaline fibromatosis. J Dermatol Sci 2009; 55:197 - 200; http://dx.doi.org/10.1016/j.jdermsci.2009.06.005; PMID: 19592224
   PubMed Web of Science ®Google Scholar
• Murata K, Motoyama T, Suka M, Ohno M, Kuboki Y. High production of type VI collagen in multiple fibromatosis with multiple articular dysplasia. Biochem Biophys Res Commun 1987; 147:275 - 81; http://dx.doi.org/10.1016/S0006-291X(87)80117-1; PMID: 3632670
   PubMed Web of Science ®Google Scholar
• Glover MT, Lake BD, Atherton DJ. Infantile systemic hyalinosis: newly recognized disorder of collagen?. Pediatrics 1991; 87:228 - 34; PMID: 1702887
   PubMed Web of Science ®Google Scholar
• Katagiri K, Takasaki S, Fujiwara S, Kayashima K, Ono T, Shinkai H. Purification and structural analysis of extracellular matrix of a skin tumor from a patient with juvenile hyaline fibromatosis. J Dermatol Sci 1996; 13:37 - 48; http://dx.doi.org/10.1016/0923-1811(95)00492-0; PMID: 8902652
   PubMed Web of Science ®Google Scholar
• Iwata S, Horiuchi R, Maeda H, Ishikawa H. Systemic hyalinosis or juvenile hyaline fibromatosis. Ultrastructural and biochemical study of cultured skin fibroblasts. Arch Dermatol Res 1980; 267:115 - 21; http://dx.doi.org/10.1007/BF00569097; PMID: 6157366
   PubMed Web of Science ®Google Scholar
• Tzellos TG, Dionyssopoulos A, Klagas I, Karakiulakis G, Lazaridis L, Papakonstantinou E. Differential glycosaminoglycan expression and hyaluronan homeostasis in juvenile hyaline fibromatosis. J Am Acad Dermatol 2009; 61:629 - 38; http://dx.doi.org/10.1016/j.jaad.2009.03.042; PMID: 19559501
   PubMed Web of Science ®Google Scholar
• Stucki U, Spycher MA, Eich G, Rossi A, Sacher P, Steinmann B, et al. Infantile systemic hyalinosis in siblings: clinical report, biochemical and ultrastructural findings, and review of the literature. Am J Med Genet 2001; 100:122 - 9; http://dx.doi.org/10.1002/1096-8628(20010422)100:2<122::AID-AJMG1236>3.0.CO;2-0; PMID: 11298373
   PubMed Web of Science ®Google Scholar
• Cullen M, Seaman S, Chaudhary A, Yang MY, Hilton MB, Logsdon D, et al. Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res 2009; 69:6021 - 6; http://dx.doi.org/10.1158/0008-5472.CAN-09-1086; PMID: 19622764
   PubMed Web of Science ®Google Scholar
• Chaudhary A, Hilton MB, Seaman S, Haines DC, Stevenson S, Lemotte PK, et al. TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types. Cancer Cell 2012; 21:212 - 26; http://dx.doi.org/10.1016/j.ccr.2012.01.004; PMID: 22340594
   PubMed Web of Science ®Google Scholar
• Chaudhary A, St. Croix B. Unpublished Observations.
   Google Scholar
• Yang MY, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad MK, et al. The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton. Biochim Biophys Acta 2011; 1813:39 - 49; http://dx.doi.org/10.1016/j.bbamcr.2010.11.013; PMID: 21129411
   PubMed Web of Science ®Google Scholar
• Bonuccelli G, Sotgia F, Frank PG, Williams TM, de Almeida CJ, Tanowitz HB, et al. ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis’ three sites of entry: implications for the pathogenesis of anthrax infection. Am J Physiol Cell Physiol 2005; 288:C1402 - 10; http://dx.doi.org/10.1152/ajpcell.00582.2004; PMID: 15689409
   PubMedGoogle Scholar
• Eberhard A, Kahlert S, Goede V, Hemmerlein B, Plate KH, Augustin HG. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res 2000; 60:1388 - 93; PMID: 10728704
   PubMed Web of Science ®Google Scholar
• Dallas NA, Fan F, Gray MJ, Van Buren G 2nd, Lim SJ, Xia L, et al. Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells. Cancer Metastasis Rev 2007; 26:433 - 41; http://dx.doi.org/10.1007/s10555-007-9070-2; PMID: 17786539
   PubMed Web of Science ®Google Scholar
• Masood R, Cai J, Zheng T, Smith DL, Hinton DR, Gill PS. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood 2001; 98:1904 - 13; http://dx.doi.org/10.1182/blood.V98.6.1904; PMID: 11535528
   PubMed Web of Science ®Google Scholar
• Liu B, Earl HM, Baban D, Shoaibi M, Fabra A, Kerr DJ, et al. Melanoma cell lines express VEGF receptor KDR and respond to exogenously added VEGF. Biochem Biophys Res Commun 1995; 217:721 - 7; http://dx.doi.org/10.1006/bbrc.1995.2832; PMID: 8554590
   PubMed Web of Science ®Google Scholar
• Slongo ML, Molena B, Brunati AM, Frasson M, Gardiman M, Carli M, et al. Functional VEGF and VEGF receptors are expressed in human medulloblastomas. Neuro Oncol 2007; 9:384 - 92; http://dx.doi.org/10.1215/15228517-2007-032; PMID: 17704359
   PubMed Web of Science ®Google Scholar
• Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?. Semin Cancer Biol 2005; 15:254 - 66; http://dx.doi.org/10.1016/j.semcancer.2005.04.005; PMID: 15916903
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Bando H, Mori T, Takahashi K, Matsumoto H, Yasutome M, et al. Overexpression of soluble vascular endothelial growth factor receptor 1 in colorectal cancer: Association with progression and prognosis. Cancer Sci 2007; 98:405 - 10; http://dx.doi.org/10.1111/j.1349-7006.2007.00402.x; PMID: 17214745
   PubMed Web of Science ®Google Scholar
• Lamszus K, Ulbricht U, Matschke J, Brockmann MA, Fillbrandt R, Westphal M. Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin Cancer Res 2003; 9:1399 - 405; PMID: 12684411
   PubMed Web of Science ®Google Scholar
• Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem 1997; 272:23659 - 67; http://dx.doi.org/10.1074/jbc.272.38.23659; PMID: 9295307
   PubMed Web of Science ®Google Scholar
• Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40:280 - 93; http://dx.doi.org/10.1016/j.molcel.2010.09.023; PMID: 20965422
   PubMed Web of Science ®Google Scholar
• Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120:237 - 48; http://dx.doi.org/10.1016/j.cell.2004.11.046; PMID: 15680329
   PubMed Web of Science ®Google Scholar