2,373
Views
87
CrossRef citations to date
0
Altmetric
Extra Views

PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A

, &
Pages 4305-4309 | Published online: 03 Oct 2012

References

  • Walker LS, Abbas AK. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2002; 2:11 - 9; http://dx.doi.org/10.1038/nri701; PMID: 11908514
  • Li L, Boussiotis VA. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. J Mol Med (Berl) 2006; 84:887 - 99; http://dx.doi.org/10.1007/s00109-006-0098-5; PMID: 16972086
  • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010; 236:219 - 42; http://dx.doi.org/10.1111/j.1600-065X.2010.00923.x; PMID: 20636820
  • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992; 11:3887 - 95; PMID: 1396582
  • Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26:677 - 704; http://dx.doi.org/10.1146/annurev.immunol.26.021607.090331; PMID: 18173375
  • Brown JA, Dorfman DM, Ma FR, Sullivan EL, Munoz O, Wood CR, et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 2003; 170:1257 - 66; PMID: 12538684
  • Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001; 2:261 - 8; http://dx.doi.org/10.1038/85330; PMID: 11224527
  • Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, et al. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med 2001; 193:839 - 46; http://dx.doi.org/10.1084/jem.193.7.839; PMID: 11283156
  • Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5:1365 - 9; http://dx.doi.org/10.1038/70932; PMID: 10581077
  • Terawaki S, Chikuma S, Shibayama S, Hayashi T, Yoshida T, Okazaki T, et al. IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. J Immunol 2011; 186:2772 - 9; http://dx.doi.org/10.4049/jimmunol.1003208; PMID: 21263073
  • Keir ME, Freeman GJ, Sharpe AH. PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol 2007; 179:5064 - 70; PMID: 17911591
  • Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M. Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nat Immunol 2005; 6:280 - 6; http://dx.doi.org/10.1038/ni1165; PMID: 15685176
  • Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, et al. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol 2009; 182:2102 - 12; http://dx.doi.org/10.4049/jimmunol.0802769; PMID: 19201863
  • Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 2006; 203:883 - 95; http://dx.doi.org/10.1084/jem.20051776; PMID: 16606670
  • Blank C, Gajewski TF, Mackensen A. Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. Cancer Immunol Immunother 2005; 54:307 - 14; http://dx.doi.org/10.1007/s00262-004-0593-x; PMID: 15599732
  • Currie AJ, Prosser A, McDonnell A, Cleaver AL, Robinson BW, Freeman GJ, et al. Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation. J Immunol 2009; 183:7898 - 908; http://dx.doi.org/10.4049/jimmunol.0901060; PMID: 20007574
  • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009; 206:1327 - 37; http://dx.doi.org/10.1084/jem.20082173; PMID: 19451266
  • Zhang L, Gajewski TF, Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood 2009; 114:1545 - 52; http://dx.doi.org/10.1182/blood-2009-03-206672; PMID: 19417208
  • Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, Bessette B, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006; 12:1198 - 202; http://dx.doi.org/10.1038/nm1482; PMID: 16917489
  • Watanabe T, Bertoletti A, Tanoto TA. PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection. J Viral Hepat 2010; 17:453 - 8; PMID: 20487259
  • Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 2006; 203:2281 - 92; http://dx.doi.org/10.1084/jem.20061496; PMID: 16954372
  • Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443:350 - 4; http://dx.doi.org/10.1038/nature05115; PMID: 16921384
  • Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18:2699 - 711; http://dx.doi.org/10.1101/gad.1256504; PMID: 15545627
  • Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 1996; 382:325 - 31; http://dx.doi.org/10.1038/382325a0; PMID: 8684460
  • Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, et al. The p21(Cip1) and p27(Kip1) CDK ‘inhibitors’ are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999; 18:1571 - 83; http://dx.doi.org/10.1093/emboj/18.6.1571; PMID: 10075928
  • Boutros R, Dozier C, Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol 2006; 18:185 - 91; http://dx.doi.org/10.1016/j.ceb.2006.02.003; PMID: 16488126
  • Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal 2012; 5:ra46; http://dx.doi.org/10.1126/scisignal.2002796; PMID: 22740686
  • Larrea MD, Wander SA, Slingerland JM. p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle 2009; 8:3455 - 61; http://dx.doi.org/10.4161/cc.8.21.9789; PMID: 19829074
  • Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999; 98:859 - 69; http://dx.doi.org/10.1016/S0092-8674(00)81519-6; PMID: 10499802
  • Harbour JW, Dean DC. Chromatin remodeling and Rb activity. Curr Opin Cell Biol 2000; 12:685 - 9; http://dx.doi.org/10.1016/S0955-0674(00)00152-6; PMID: 11063932
  • Hua XH, Newport J. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J Cell Biol 1998; 140:271 - 81; http://dx.doi.org/10.1083/jcb.140.2.271; PMID: 9442103
  • Harbour JW, Dean DC. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 2000; 14:2393 - 409; http://dx.doi.org/10.1101/gad.813200; PMID: 11018009
  • Wells AD. Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance. Semin Immunol 2007; 19:173 - 9; http://dx.doi.org/10.1016/j.smim.2007.02.009; PMID: 17383195
  • Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004; 430:226 - 31; http://dx.doi.org/10.1038/nature02650; PMID: 15241418
  • Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206:3015 - 29; http://dx.doi.org/10.1084/jem.20090847; PMID: 20008522
  • Massagué J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000; 1:169 - 78; http://dx.doi.org/10.1038/35043051; PMID: 11252892
  • Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, et al. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol 1999; 19:6379 - 95; PMID: 10454584
  • Iavarone A, Massagué J. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature 1997; 387:417 - 22; http://dx.doi.org/10.1038/387417a0; PMID: 9163429
  • Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta GF. Dual mode of degradation of Cdc25 A phosphatase. EMBO J 2002; 21:4875 - 84; http://dx.doi.org/10.1093/emboj/cdf491; PMID: 12234927
  • Donzelli M, Draetta GF. Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep 2003; 4:671 - 7; http://dx.doi.org/10.1038/sj.embor.embor887; PMID: 12835754
  • Donzelli M, Busino L, Chiesa M, Ganoth D, Hershko A, Draetta GF. Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle 2004; 3:469 - 71; http://dx.doi.org/10.4161/cc.3.4.770; PMID: 14752276
  • Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, et al. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 2003; 426:87 - 91; http://dx.doi.org/10.1038/nature02082; PMID: 14603323
  • Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, et al. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 2003; 17:3062 - 74; http://dx.doi.org/10.1101/gad.1157503; PMID: 14681206
  • Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001; 410:842 - 7; http://dx.doi.org/10.1038/35071124; PMID: 11298456
  • Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, et al. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 2003; 3:247 - 58; http://dx.doi.org/10.1016/S1535-6108(03)00048-5; PMID: 12676583
  • Hassepass I, Voit R, Hoffmann I. Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. J Biol Chem 2003; 278:29824 - 9; http://dx.doi.org/10.1074/jbc.M302704200; PMID: 12759351
  • Kittipatarin C, Li WQ, Bulavin DV, Durum SK, Khaled AR. Cell cycling through Cdc25A: transducer of cytokine proliferative signals. Cell Cycle 2006; 5:907 - 12; http://dx.doi.org/10.4161/cc.5.9.2693; PMID: 16628013
  • Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, et al. Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol 2005; 25:3338 - 47; http://dx.doi.org/10.1128/MCB.25.8.3338-3347.2005; PMID: 15798217
  • Khaled AR, Bulavin DV, Kittipatarin C, Li WQ, Alvarez M, Kim K, et al. Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol 2005; 169:755 - 63; http://dx.doi.org/10.1083/jcb.200409099; PMID: 15928203
  • Macián F, García-Cózar F, Im SH, Horton HF, Byrne MC, Rao A. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 2002; 109:719 - 31; http://dx.doi.org/10.1016/S0092-8674(02)00767-5; PMID: 12086671

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.