Tissue-specific expression of p73 C-terminal isoforms in mice

References

• Levine AJ, Tomasini R, McKeon FD, Mak TW, Melino G. The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol 2011; 12:259 - 65; http://dx.doi.org/10.1038/nrm3086; PMID: 21427767
   PubMed Web of Science ®Google Scholar
• Talos F, Abraham A, Vaseva AV, Holembowski L, Tsirka SE, Scheel A, et al. p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis. Cell Death Differ 2010; 17:1816 - 29; http://dx.doi.org/10.1038/cdd.2010.131; PMID: 21076477
   PubMed Web of Science ®Google Scholar
• Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 2000; 404:99 - 103; http://dx.doi.org/10.1038/35003607; PMID: 10716451
   PubMed Web of Science ®Google Scholar
• Kommagani R, Whitlatch A, Leonard MK, Kadakia MP. p73 is essential for vitamin D-mediated osteoblastic differentiation. Cell Death Differ 2010; 17:398 - 407; http://dx.doi.org/10.1038/cdd.2009.135; PMID: 19779497
   PubMed Web of Science ®Google Scholar
• Das SSK, Somasundaram K. Therapeutic potential of an adenovirus expressing p73 β, a p53 homologue, against human papilloma virus positive cervical cancer in vitro and in vivo. Cancer Biol Ther 2006; 5:210 - 7; http://dx.doi.org/10.4161/cbt.5.2.2402; PMID: 16481734
   PubMed Web of Science ®Google Scholar
• Müller M, Schleithoff ES, Stremmel W, Melino G, Krammer PH, Schilling T. One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat 2006; 9:288 - 306; http://dx.doi.org/10.1016/j.drup.2007.01.001; PMID: 17287142
   PubMed Web of Science ®Google Scholar
• Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen BF, et al. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ 2011; 18:1130 - 9; http://dx.doi.org/10.1038/cdd.2010.179; PMID: 21233848
   PubMed Web of Science ®Google Scholar
• John K, Alla V, Meier C, Pützer BM. GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell Death Differ 2011; 18:874 - 86; http://dx.doi.org/10.1038/cdd.2010.153; PMID: 21127500
   PubMed Web of Science ®Google Scholar
• Jiang M, Chiu SY, Hsu W. SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death Differ 2011; 18:1005 - 15; http://dx.doi.org/10.1038/cdd.2010.168; PMID: 21183956
   PubMed Web of Science ®Google Scholar
• Slatter TL, Ganesan P, Holzhauer C, Mehta R, Rubio C, Williams G, et al. p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ 2010; 17:540 - 50; http://dx.doi.org/10.1038/cdd.2009.136; PMID: 19779492
   PubMed Web of Science ®Google Scholar
• Knoll S, Fürst K, Thomas S, Villanueva Baselga S, Stoll A, Schaefer S, et al. Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC. Cell Cycle 2011; 10:3554 - 65; http://dx.doi.org/10.4161/cc.10.20.17856; PMID: 22030623
   PubMed Web of Science ®Google Scholar
• Klanrit P, Flinterman MB, Odell EW, Melino G, Killick R, Norris JS, et al. Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin. Cell Cycle 2008; 7:205 - 15; http://dx.doi.org/10.4161/cc.7.2.5361; PMID: 18256531
   PubMed Web of Science ®Google Scholar
• Ramadan S, Terrinoni A, Catani MV, Sayan AE, Knight RA, Mueller M, et al. p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun 2005; 331:713 - 7; http://dx.doi.org/10.1016/j.bbrc.2005.03.156; PMID: 15865927
   PubMed Web of Science ®Google Scholar
• Toh WH, Nam SY, Sabapathy K. An essential role for p73 in regulating mitotic cell death. Cell Death Differ 2010; 17:787 - 800; http://dx.doi.org/10.1038/cdd.2009.181; PMID: 20010785
   PubMed Web of Science ®Google Scholar
• Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, et al. TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev 2012; 26:2009 - 14; http://dx.doi.org/10.1101/gad.197640.112; PMID: 22987635
   PubMed Web of Science ®Google Scholar
• Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan SP. TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death Differ 2012; 19:274 - 83; http://dx.doi.org/10.1038/cdd.2011.93; PMID: 21738216
   PubMed Web of Science ®Google Scholar
• Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY) 2010; 2:748; PMID: 21068468
   PubMedGoogle Scholar
• Galluzzi L, Kepp O, Kroemer G. TP53 and MTOR crosstalk to regulate cellular senescence. Aging (Albany NY) 2010; 2:535 - 7; PMID: 20876940
   PubMedGoogle Scholar
• Horikawa I, Fujita K, Harris CC. p53 governs telomere regulation feedback too, via TRF2. Aging (Albany NY) 2011; 3:26 - 32; PMID: 21266744
   PubMedGoogle Scholar
• Dulic V. Be quiet and you’ll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?. Aging (Albany NY) 2011; 3:3 - 4; PMID: 21248373
   PubMedGoogle Scholar
• Hulbert AJ. Longevity, lipids and C. elegans. Aging (Albany NY) 2011; 3:81 - 2; PMID: 21386134
   PubMedGoogle Scholar
• Darzynkiewicz Z. Another “Janus paradox” of p53: induction of cell senescence versus quiescence. Aging (Albany NY) 2010; 2:329 - 30; PMID: 20603525
   PubMedGoogle Scholar
• Poyurovsky MV, Prives C. P53 and aging: A fresh look at an old paradigm. Aging (Albany NY) 2010; 2:380 - 2; PMID: 20657036
   PubMedGoogle Scholar
• Oswald C, Stiewe T. In good times and bad: p73 in cancer. Cell Cycle 2008; 7:1726 - 31; http://dx.doi.org/10.4161/cc.7.12.6148; PMID: 18583938
   PubMed Web of Science ®Google Scholar
• Collavin L, Lunardi A, Del Sal G. p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death Differ 2010; 17:901 - 11; http://dx.doi.org/10.1038/cdd.2010.35; PMID: 20379196
   PubMed Web of Science ®Google Scholar
• Toh WH, Nam SY, Sabapathy K. An essential role for p73 in regulating mitotic cell death. Cell Death Differ 2010; 17:787 - 800; http://dx.doi.org/10.1038/cdd.2009.181; PMID: 20010785
   PubMed Web of Science ®Google Scholar
• Schuster A, Schilling T, De Laurenzi V, Koch AF, Seitz S, Staib F, et al. ΔNp73β is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell Cycle 2010; 9:2629 - 39; http://dx.doi.org/10.4161/cc.9.13.12110; PMID: 20581467
   PubMed Web of Science ®Google Scholar
• Ravni A, Tissir F, Goffinet AM. DeltaNp73 transcription factors modulate cell survival and tumor development. Cell Cycle 2010; 9:1523 - 7; http://dx.doi.org/10.4161/cc.9.8.11291; PMID: 20372082
   PubMed Web of Science ®Google Scholar
• Spinnler C, Hedström E, Li H, de Lange J, Nikulenkov F, Teunisse AF, et al. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell Death Differ 2011; 18:1736 - 45; http://dx.doi.org/10.1038/cdd.2011.45; PMID: 21546907
   PubMed Web of Science ®Google Scholar
• Trinh DL, Elwi AN, Kim SW. Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis. Oncotarget 2010; 1:396 - 404; PMID: 21311096
   PubMed Web of Science ®Google Scholar
• Li H, Lakshmikanth T, Garofalo C, Enge M, Spinnler C, Anichini A, et al. Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2. Cell Cycle 2011; 10:3346 - 58; http://dx.doi.org/10.4161/cc.10.19.17630; PMID: 21941086
   PubMed Web of Science ®Google Scholar
• Bao W, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, et al. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell Cycle 2011; 10:301 - 7; http://dx.doi.org/10.4161/cc.10.2.14538; PMID: 21239882
   PubMed Web of Science ®Google Scholar
• Gao W, Shen Z, Shang L, Wang X. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. Cell Death Differ 2011; 18:1598 - 607; http://dx.doi.org/10.1038/cdd.2011.33; PMID: 21475306
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY) 2010; 2:924 - 35; PMID: 21212465
   PubMedGoogle Scholar
• Ho CC, Hau PM, Marxer M, Poon RY. The requirement of p53 for maintaining chromosomal stability during tetraploidization. Oncotarget 2010; 1:583 - 95; PMID: 21317454
   PubMed Web of Science ®Google Scholar
• Koster R, Timmer-Bosscha H, Bischoff R, Gietema JA, de Jong S. Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell Death Dis 2011; 2:e148; http://dx.doi.org/10.1038/cddis.2011.33; PMID: 21509038
   PubMed Web of Science ®Google Scholar
• Hölzel M, Burger K, Mühl B, Orban M, Kellner M, Eick D. The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword. Oncotarget 2010; 1:43 - 7; PMID: 21293052
   PubMed Web of Science ®Google Scholar
• Aoubala M, Murray-Zmijewski F, Khoury MP, Fernandes K, Perrier S, Bernard H, et al. p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage. Cell Death Differ 2011; 18:248 - 58; http://dx.doi.org/10.1038/cdd.2010.91; PMID: 20689555
   PubMed Web of Science ®Google Scholar
• Madan E, Gogna R, Bhatt M, Pati U, Kuppusamy P, Mahdi AA. Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor. Oncotarget 2011; 2:948 - 57; PMID: 22248668
   PubMed Web of Science ®Google Scholar
• Muppani N, Nyman U, Joseph B. TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death. Oncotarget 2011; 2:1145 - 54; PMID: 22201672
   PubMed Web of Science ®Google Scholar
• Napoli M, Girardini JE, Piazza S, Del Sal G. Wiring the oncogenic circuitry: Pin1 unleashes mutant p53. Oncotarget 2011; 2:654 - 6; PMID: 21926448
   PubMed Web of Science ®Google Scholar
• Steelman LS, Martelli AM, Nicoletti F, McCubrey JA. Exploiting p53 status to enhance effectiveness of chemotherapy by lowering associated toxicity. Oncotarget 2011; 2:109 - 12; PMID: 21487160
   PubMed Web of Science ®Google Scholar
• Sorscher SM, Hill AE, Belizaire R, Sorscher EJ. Spontaneous inactivating p53 mutations and the “selfish cell”. Aging (Albany NY) 2011; 3:181; PMID: 21389353
   PubMedGoogle Scholar
• Lane DP, Madhumalar A, Lee AP, Tay BH, Verma C, Brenner S, et al. Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle 2011; 10:4272 - 9; http://dx.doi.org/10.4161/cc.10.24.18567; PMID: 22107961
   PubMed Web of Science ®Google Scholar
• Zawacka-Pankau J, Kostecka A, Sznarkowska A, Hedström E, Kawiak A. p73 tumor suppressor protein: a close relative of p53 not only in structure but also in anti-cancer approach?. Cell Cycle 2010; 9:720 - 8; http://dx.doi.org/10.4161/cc.9.4.10668; PMID: 20160513
   PubMed Web of Science ®Google Scholar
• Tissir F, Goffinet AM. p73 and p63: Estranged relatives?. Cell Cycle 2011; 10:1351; http://dx.doi.org/10.4161/cc.10.9.15383; PMID: 21460637
   PubMed Web of Science ®Google Scholar
• Sayan AE, D’Angelo B, Sayan BS, Tucci P, Cimini A, Cerù MP, et al. p73 and p63 regulate the expression of fibroblast growth factor receptor 3. Biochem Biophys Res Commun 2010; 394:824 - 8; http://dx.doi.org/10.1016/j.bbrc.2010.03.084; PMID: 20298673
   PubMed Web of Science ®Google Scholar
• Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008; 22:2677 - 91; http://dx.doi.org/10.1101/gad.1695308; PMID: 18805989
   PubMed Web of Science ®Google Scholar
• Grob TJ, Novak U, Maisse C, Barcaroli D, Lüthi AU, Pirnia F, et al. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ 2001; 8:1213 - 23; http://dx.doi.org/10.1038/sj.cdd.4400962; PMID: 11753569
   PubMed Web of Science ®Google Scholar
• Slade N, Zaika AI, Erster S, Moll UM. DeltaNp73 stabilises TAp73 proteins but compromises their function due to inhibitory hetero-oligomer formation. Cell Death Differ 2004; 11:357 - 60; http://dx.doi.org/10.1038/sj.cdd.4401335; PMID: 14685155
   PubMed Web of Science ®Google Scholar
• Vernersson-Lindahl E, Mills AA. DeltaNp73beta puts the brakes on DNA repair. Genes Dev 2010; 24:517 - 20; http://dx.doi.org/10.1101/gad.1914210; PMID: 20231313
   PubMed Web of Science ®Google Scholar
• Niikura Y, Ogi H, Kikuchi K, Kitagawa K. BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD). Cell Death Differ 2010; 17:1011 - 24; http://dx.doi.org/10.1038/cdd.2009.207; PMID: 20057499
   PubMed Web of Science ®Google Scholar
• Bantel H, Simon HU. DeltaNp73beta is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death receptors and mitochondria. Cell Cycle 2010; 9:2710 - 1; http://dx.doi.org/10.4161/cc.9.14.12592; PMID: 20676032
   PubMed Web of Science ®Google Scholar
• Hüttinger-Kirchhof N, Cam H, Griesmann H, Hofmann L, Beitzinger M, Stiewe T. The p53 family inhibitor DeltaNp73 interferes with multiple developmental programs. Cell Death Differ 2006; 13:174 - 7; http://dx.doi.org/10.1038/sj.cdd.4401809; PMID: 16341031
   PubMed Web of Science ®Google Scholar
• Tissir F, Ravni A, Achouri Y, Riethmacher D, Meyer G, Goffinet AM. DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci USA 2009; 106:16871 - 6; http://dx.doi.org/10.1073/pnas.0903191106; PMID: 19805388
   PubMed Web of Science ®Google Scholar
• Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev 2010; 24:549 - 60; http://dx.doi.org/10.1101/gad.1873910; PMID: 20194434
   PubMed Web of Science ®Google Scholar
• Kon N, Zhong J, Kobayashi Y, Li M, Szabolcs M, Ludwig T, et al. Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ 2011; 18:1366 - 75; http://dx.doi.org/10.1038/cdd.2011.12; PMID: 21350561
   PubMed Web of Science ®Google Scholar
• Holembowski L, Schulz R, Talos F, Scheel A, Wolff S, Dobbelstein M, et al. While p73 is essential, p63 is completely dispensable for the development of the central nervous system. Cell Cycle 2011; 10:680 - 9; http://dx.doi.org/10.4161/cc.10.4.14859; PMID: 21293190
   PubMed Web of Science ®Google Scholar
• Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, et al. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci USA 2011; 108:21099 - 104; http://dx.doi.org/10.1073/pnas.1112063108; PMID: 22160706
   PubMed Web of Science ®Google Scholar
• Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P, et al. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci USA 2011; 108:21093 - 8; http://dx.doi.org/10.1073/pnas.1112061109; PMID: 22160687
   PubMed Web of Science ®Google Scholar
• Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997; 90:809 - 19; http://dx.doi.org/10.1016/S0092-8674(00)80540-1; PMID: 9288759
   PubMed Web of Science ®Google Scholar
• Chi SW, Ayed A, Arrowsmith CH. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. EMBO J 1999; 18:4438 - 45; http://dx.doi.org/10.1093/emboj/18.16.4438; PMID: 10449409
   PubMed Web of Science ®Google Scholar
• Thanos CD, Bowie JU. p53 Family members p63 and p73 are SAM domain-containing proteins. Protein Sci 1999; 8:1708 - 10; http://dx.doi.org/10.1110/ps.8.8.1708; PMID: 10452616
   PubMed Web of Science ®Google Scholar
• Arrowsmith CH. Structure and function in the p53 family. Cell Death Differ 1999; 6:1169 - 73; http://dx.doi.org/10.1038/sj.cdd.4400619; PMID: 10637432
   PubMed Web of Science ®Google Scholar
• De Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, et al. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J Exp Med 1998; 188:1763 - 8; http://dx.doi.org/10.1084/jem.188.9.1763; PMID: 9802988
   PubMed Web of Science ®Google Scholar
• De Laurenzi VD, Catani MV, Terrinoni A, Corazzari M, Melino G, Costanzo A, et al. Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta. Cell Death Differ 1999; 6:389 - 90; http://dx.doi.org/10.1038/sj.cdd.4400521; PMID: 10381648
   PubMed Web of Science ®Google Scholar
• Coutandin D, Löhr F, Niesen FH, Ikeya T, Weber TA, Schäfer B, et al. Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death Differ 2009; 16:1582 - 9; http://dx.doi.org/10.1038/cdd.2009.139; PMID: 19763140
   PubMed Web of Science ®Google Scholar
• Rosenbluth JM, Johnson K, Tang L, Triplett T, Pietenpol JA. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle 2009; 8:3702 - 6; http://dx.doi.org/10.4161/cc.8.22.10036; PMID: 19855172
   PubMed Web of Science ®Google Scholar
• Sayan AE, Paradisi A, Vojtesek B, Knight RA, Melino G, Candi E. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun 2005; 330:186 - 93; http://dx.doi.org/10.1016/j.bbrc.2005.02.145; PMID: 15781249
   PubMed Web of Science ®Google Scholar
• Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG Jr., Levrero M, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999; 399:806 - 9; http://dx.doi.org/10.1038/21690; PMID: 10391249
   PubMed Web of Science ®Google Scholar
• De Laurenzi V, Raschellá G, Barcaroli D, Annicchiarico-Petruzzelli M, Ranalli M, Catani MV, et al. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem 2000; 275:15226 - 31; http://dx.doi.org/10.1074/jbc.275.20.15226; PMID: 10809758
   PubMed Web of Science ®Google Scholar
• Conforti F, Sayan AE, Sreekumar R, Sayan BS. Regulation of p73 activity by post-translational modifications. Cell Death Dis 2012; 3:e285; http://dx.doi.org/10.1038/cddis.2012.27; PMID: 22419114
   PubMed Web of Science ®Google Scholar
• Gonzalez-Cano L, Herreros-Villanueva M, Fernandez-Alonso R, Ayuso-Sacido A, Meyer G, Garcia-Verdugo JM, et al. p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53. Cell Death Dis 2010; 1:e109; http://dx.doi.org/10.1038/cddis.2010.87; PMID: 21368881
   PubMed Web of Science ®Google Scholar
• Saifudeen Z, Diavolitsis V, Stefkova J, Dipp S, Fan H, El-Dahr SS. Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. J Biol Chem 2005; 280:23094 - 102; http://dx.doi.org/10.1074/jbc.M414575200; PMID: 15805112
   PubMed Web of Science ®Google Scholar
• V. Dötsch FB. D. Coutandin, E. Candi and G. Melino. p63 and p73, the Ancestors of p53. Cold Spring Harb Perspect Biol 2010; 00:a004887
   Web of Science ®Google Scholar
• Wang X, Zeng L, Wang J, Chau JF, Lai KP, Jia D, et al. A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ 2011; 18:5 - 15; http://dx.doi.org/10.1038/cdd.2010.106; PMID: 20798688
   PubMed Web of Science ®Google Scholar
• Toh WH, Siddique MM, Boominathan L, Lin KW, Sabapathy K. c-Jun regulates the stability and activity of the p53 homologue, p73. J Biol Chem 2004; 279:44713 - 22; http://dx.doi.org/10.1074/jbc.M407672200; PMID: 15302867
   PubMed Web of Science ®Google Scholar
• Seviour EG, Lin SY. The DNA damage response: Balancing the scale between cancer and ageing. Aging (Albany NY) 2010; 2:900 - 7; PMID: 21191148
   PubMedGoogle Scholar
• Prendergast AM, Cruet-Hennequart S, Shaw G, Barry FP, Carty MP. Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation. Cell Cycle 2011; 10:3768 - 77; http://dx.doi.org/10.4161/cc.10.21.17972; PMID: 22037398
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, et al. Molecular mechanisms of cisplatin resistance. Oncogene 2012; 31:1869 - 83; http://dx.doi.org/10.1038/onc.2011.384; PMID: 21892204
   PubMed Web of Science ®Google Scholar
• De Zio D, Bordi M, Tino E, Lanzuolo C, Ferraro E, Mora E, et al. The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage. Cell Death Differ 2011; 18:516 - 27; http://dx.doi.org/10.1038/cdd.2010.125; PMID: 20966962
   PubMed Web of Science ®Google Scholar
• Zalckvar E, Yosef N, Reef S, Ber Y, Rubinstein AD, Mor I, et al. A systems level strategy for analyzing the cell death network: implication in exploring the apoptosis/autophagy connection. Cell Death Differ 2010; 17:1244 - 53; http://dx.doi.org/10.1038/cdd.2010.7; PMID: 20150916
   PubMed Web of Science ®Google Scholar
• Bialik S, Zalckvar E, Ber Y, Rubinstein AD, Kimchi A. Systems biology analysis of programmed cell death. Trends Biochem Sci 2010; 35:556 - 64; http://dx.doi.org/10.1016/j.tibs.2010.04.008; PMID: 20537543
   PubMed Web of Science ®Google Scholar
• Meley D, Spiller DG, White MR, McDowell H, Pizer B, Sée V. p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma. Cell Death Dis 2010; 1:e41; http://dx.doi.org/10.1038/cddis.2010.16; PMID: 21364648
   PubMedGoogle Scholar
• Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H, et al. MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ 2011; 18:1702 - 10; http://dx.doi.org/10.1038/cdd.2011.28; PMID: 21455217
   PubMed Web of Science ®Google Scholar
• Boehler C, Dantzer F. PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and mitotic progression. Cell Cycle 2011; 10:1023 - 4; http://dx.doi.org/10.4161/cc.10.7.15169; PMID: 21358266
   PubMed Web of Science ®Google Scholar
• Straten P, Andersen MH. The anti-apoptotic members of the Bcl-2 family are attractive tumor-associated antigens. Oncotarget 2010; 1:239 - 45; PMID: 21304176
   PubMed Web of Science ®Google Scholar
• van Vuurden DG, Hulleman E, Meijer OL, Wedekind LE, Kool M, Witt H, et al. PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. Oncotarget 2011; 2:984 - 96; PMID: 22184287
   PubMed Web of Science ®Google Scholar
• Cantó C, Auwerx J. Interference between PARPs and SIRT1: a novel approach to healthy ageing?. Aging (Albany NY) 2011; 3:543 - 7; PMID: 21566260
   PubMedGoogle Scholar
• Schultz J, Ponting CP, Hofmann K, Bork P. SAM as a protein interaction domain involved in developmental regulation. Protein Sci 1997; 6:249 - 53; http://dx.doi.org/10.1002/pro.5560060128; PMID: 9007998
   PubMed Web of Science ®Google Scholar
• Liu G, Chen X. The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73. J Biol Chem 2005; 280:20111 - 9; http://dx.doi.org/10.1074/jbc.M413889200; PMID: 15769743
   PubMed Web of Science ®Google Scholar
• Ozaki T, Naka M, Takada N, Tada M, Sakiyama S, Nakagawara A. Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells. Cancer Res 1999; 59:5902 - 7; PMID: 10606232
   PubMed Web of Science ®Google Scholar
• Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, et al. DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell 2011; 144:566 - 76; http://dx.doi.org/10.1016/j.cell.2011.01.013; PMID: 21335238
   PubMed Web of Science ®Google Scholar
• Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 2011; 18:1487 - 99; http://dx.doi.org/10.1038/cdd.2011.81; PMID: 21760596
   PubMed Web of Science ®Google Scholar
• Yalcin-Ozuysal O, Fiche M, Guitierrez M, Wagner KU, Raffoul W, Brisken C. Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ 2010; 17:1600 - 12; http://dx.doi.org/10.1038/cdd.2010.37; PMID: 20379195
   PubMed Web of Science ®Google Scholar
• Huang Y, Ratovitski EA. Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY) 2010; 2:959 - 68; PMID: 21191146
   PubMedGoogle Scholar
• Straub WE, Weber TA, Schäfer B, Candi E, Durst F, Ou HD, et al. The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis 2010; 1:e5; http://dx.doi.org/10.1038/cddis.2009.1; PMID: 21364624
   PubMedGoogle Scholar
• Neilsen PM, Noll JE, Suetani RJ, Schulz RB, Al-Ejeh F, Evdokiou A, et al. Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome. Oncotarget 2011; 2:1203 - 17; PMID: 22203497
   PubMed Web of Science ®Google Scholar
• Lena AM, Cipollone R, Amelio I, Catani MV, Ramadan S, Browne G, et al. Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression. Biochem Biophys Res Commun 2010; 401:568 - 73; http://dx.doi.org/10.1016/j.bbrc.2010.09.102; PMID: 20888799
   PubMed Web of Science ®Google Scholar
• Ghioni P, Bolognese F, Duijf PH, Van Bokhoven H, Mantovani R, Guerrini L. Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. Mol Cell Biol 2002; 22:8659 - 68; http://dx.doi.org/10.1128/MCB.22.24.8659-8668.2002; PMID: 12446784
   PubMed Web of Science ®Google Scholar
• Shalom-Feuerstein R, Lena AM, Zhou H, De La Forest Divonne S, Van Bokhoven H, Candi E, et al. ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ 2011; 18:887 - 96; http://dx.doi.org/10.1038/cdd.2010.159; PMID: 21127502
   PubMed Web of Science ®Google Scholar
• Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, et al. The p63 target HBP1 is required for skin differentiation and stratification. Cell Death Differ 2010; 17:1896 - 907; http://dx.doi.org/10.1038/cdd.2010.59; PMID: 20523354
   PubMed Web of Science ®Google Scholar
• Talos F, Wolff S, Beyer U, Dobbelstein M, Moll UM. Brdm2 - an aberrant hypomorphic p63 allele. Cell Death Differ 2010; 17:184 - 6; http://dx.doi.org/10.1038/cdd.2009.158; PMID: 20161489
   PubMed Web of Science ®Google Scholar
• Leonard MK, Kommagani R, Payal V, Mayo LD, Shamma HN, Kadakia MP. ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ 2011; 18:1924 - 33; http://dx.doi.org/10.1038/cdd.2011.73; PMID: 21637289
   PubMed Web of Science ®Google Scholar
• van Bokhoven H, Hamel BC, Bamshad M, Sangiorgi E, Gurrieri F, Duijf PH, et al. p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. Am J Hum Genet 2001; 69:481 - 92; http://dx.doi.org/10.1086/323123; PMID: 11462173
   PubMed Web of Science ®Google Scholar
• Forster N, Ellisen LW. Notch signaling mediates p63-induced quiescence: a new facet of p63/Notch crosstalk. Cell Cycle 2011; 10:3632 - 3; http://dx.doi.org/10.4161/cc.10.21.18182; PMID: 22041817
   PubMed Web of Science ®Google Scholar
• Kim DA, Lee BL, Suh EK. Ionizing radiation-induced TAp63α phosphorylation at C-terminal S/TQ motifs requires the N-terminal transactivation (TA) domain. Cell Cycle 2011; 10:840 - 9; http://dx.doi.org/10.4161/cc.10.5.15008; PMID: 21325887
   PubMed Web of Science ®Google Scholar
• Lee J, Hwang YJ, Boo JH, Han D, Kwon OK, Todorova K, et al. Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington’s disease. Cell Death Differ 2011; 18:1726 - 35; http://dx.doi.org/10.1038/cdd.2011.38; PMID: 21546905
   PubMed Web of Science ®Google Scholar
• Penas C, Font-Nieves M, Forés J, Petegnief V, Planas A, Navarro X, et al. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Cell Death Differ 2011; 18:1617 - 27; http://dx.doi.org/10.1038/cdd.2011.24; PMID: 21436843
   PubMed Web of Science ®Google Scholar
• Rass U, Ahel I, West SC. Defective DNA repair and neurodegenerative disease. Cell 2007; 130:991 - 1004; http://dx.doi.org/10.1016/j.cell.2007.08.043; PMID: 17889645
   PubMed Web of Science ®Google Scholar
• Nisoli I, Chauvin JP, Napoletano F, Calamita P, Zanin V, Fanto M, et al. Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. Cell Death Differ 2010; 17:1577 - 87; http://dx.doi.org/10.1038/cdd.2010.31; PMID: 20339376
   PubMed Web of Science ®Google Scholar
• Ciavardelli D, Silvestri E, Del Viscovo A, Bomba M, De Gregorio D, Moreno M, et al. Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer’s disease. Cell Death Dis 2010; 1:e90; http://dx.doi.org/10.1038/cddis.2010.68; PMID: 21368863
   PubMedGoogle Scholar
• Stanga S, Lanni C, Govoni S, Uberti D, D’Orazi G, Racchi M. Unfolded p53 in the pathogenesis of Alzheimer’s disease: is HIPK2 the link?. Aging (Albany NY) 2010; 2:545 - 54; PMID: 20876941
   PubMedGoogle Scholar
• Olsson M, Zhivotovsky B. Caspases and cancer. Cell Death Differ 2011; 18:1441 - 9; http://dx.doi.org/10.1038/cdd.2011.30; PMID: 21455218
   PubMed Web of Science ®Google Scholar
• Kelly PN, Strasser A. The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ 2011; 18:1414 - 24; http://dx.doi.org/10.1038/cdd.2011.17; PMID: 21415859
   PubMed Web of Science ®Google Scholar
• Ahmed A, Yang J, Maya-Mendoza A, Jackson DA, Ashcroft M. Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. Cell Death Dis 2011; 2:e160; http://dx.doi.org/10.1038/cddis.2011.42; PMID: 21593792
   PubMed Web of Science ®Google Scholar
• Smit MA, Peeper DS. Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths. Aging (Albany NY) 2010; 2:735 - 41; PMID: 20975209
   PubMedGoogle Scholar
• Lu WJ, Lee NP, Kaul SC, Lan F, Poon RT, Wadhwa R, et al. Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. Cell Death Differ 2011; 18:1046 - 56; http://dx.doi.org/10.1038/cdd.2010.177; PMID: 21233847
   PubMed Web of Science ®Google Scholar
• Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G. SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence. Aging (Albany NY) 2010; 2:445 - 52; PMID: 20622265
   PubMedGoogle Scholar
• Agostini M, Tucci P, Melino G. Cell death pathology: perspective for human diseases. Biochem Biophys Res Commun 2011; 414:451 - 5; http://dx.doi.org/10.1016/j.bbrc.2011.09.081; PMID: 21964290
   PubMed Web of Science ®Google Scholar
• Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, Niklison-Chirou MV, et al. p73 in Cancer. Genes Cancer 2011; 2:491 - 502; http://dx.doi.org/10.1177/1947601911408890; PMID: 21779517
   PubMedGoogle Scholar
• Rufini S, Lena AM, Cadot B, Mele S, Amelio I, Terrinoni A, et al. The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochem Pharmacol 2011; 82:1262 - 8; http://dx.doi.org/10.1016/j.bcp.2011.07.087; PMID: 21820419
   PubMed Web of Science ®Google Scholar
• Barrera FN, Poveda JA, González-Ros JM, Neira JL. Binding of the C-terminal sterile alpha motif (SAM) domain of human p73 to lipid membranes. J Biol Chem 2003; 278:46878 - 85; http://dx.doi.org/10.1074/jbc.M307846200; PMID: 12954612
   PubMed Web of Science ®Google Scholar
• Drakas R, Prisco M, Baserga R. A modified tandem affinity purification tag technique for the purification of protein complexes in mammalian cells. Proteomics 2005; 5:132 - 7; http://dx.doi.org/10.1002/pmic.200400919; PMID: 15602769
   PubMed Web of Science ®Google Scholar
• Knuesel M, Wan Y, Xiao Z, Holinger E, Lowe N, Wang W, et al. Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics 2003; 2:1225 - 33; http://dx.doi.org/10.1074/mcp.T300007-MCP200; PMID: 12963786
   PubMed Web of Science ®Google Scholar
• Eyckerman S, Lemmens I, Lievens S, Van der Heyden J, Verhee A, Vandekerckhove J, et al. Design and use of a mammalian protein-protein interaction trap (MAPPIT). Sci STKE 2002; 2002:pl18; http://dx.doi.org/10.1126/stke.2002.162.pl18; PMID: 12476003
   PubMedGoogle Scholar
• Tavernier J, Eyckerman S, Lemmens I, Van der Heyden J, Vandekerckhove J, Van Ostade X. MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells. Clin Exp Allergy 2002; 32:1397 - 404; http://dx.doi.org/10.1046/j.1365-2745.2002.01520.x; PMID: 12372116
   PubMed Web of Science ®Google Scholar
• Grespi F, Ottina E, Yannoutsos N, Geley S, Villunger A. Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis. PLoS One 2011; 6:e18051; http://dx.doi.org/10.1371/journal.pone.0018051; PMID: 21445314
   PubMedGoogle Scholar
• Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. J Cell Biol 2012; 199:347 - 63; http://dx.doi.org/10.1083/jcb.201203134; PMID: 23071155
   PubMed Web of Science ®Google Scholar