Human rpL3 induces G₁/S arrest or apoptosis by modulating p21^waf1/cip1 levels in a p53-independent manner

References

• Jung YS, Qian Y, Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22:1003 - 12; http://dx.doi.org/10.1016/j.cellsig.2010.01.013; PMID: 20100570
   PubMed Web of Science ®Google Scholar
• Chang LJ, Eastman A. Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle 2012; 11:1818 - 26; http://dx.doi.org/10.4161/cc.20208; PMID: 22510560
   PubMed Web of Science ®Google Scholar
• Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009; 9:400 - 14; http://dx.doi.org/10.1038/nrc2657; PMID: 19440234
   PubMed Web of Science ®Google Scholar
• Tsao YP, Huang SJ, Chang JL, Hsieh JT, Pong RC, Chen SL. Adenovirus-mediated p21((WAF1/SDII/CIP1)) gene transfer induces apoptosis of human cervical cancer cell lines. J Virol 1999; 73:4983 - 90; PMID: 10233960
   PubMed Web of Science ®Google Scholar
• Yang HL, Pan JX, Sun L, Yeung SC. p21 Waf-1 (Cip-1) enhances apoptosis induced by manumycin and paclitaxel in anaplastic thyroid cancer cells. J Clin Endocrinol Metab 2003; 88:763 - 72; http://dx.doi.org/10.1210/jc.2002-020992; PMID: 12574211
   PubMed Web of Science ®Google Scholar
• Kraljevic Pavelic S, Cacev T, Kralj M. A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther 2008; 15:576 - 90; http://dx.doi.org/10.1038/cgt.2008.28; PMID: 18483502
   PubMed Web of Science ®Google Scholar
• Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, et al. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 1995; 9:935 - 44; http://dx.doi.org/10.1101/gad.9.8.935; PMID: 7774811
   PubMed Web of Science ®Google Scholar
• Koutsodontis G, Moustakas A, Kardassis D. The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter. Biochemistry 2002; 41:12771 - 84; http://dx.doi.org/10.1021/bi026141q; PMID: 12379120
   PubMed Web of Science ®Google Scholar
• Wu J, Lingrel JB. KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1. Oncogene 2004; 23:8088 - 96; http://dx.doi.org/10.1038/sj.onc.1207996; PMID: 15361832
   PubMed Web of Science ®Google Scholar
• Gartel AL, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, et al. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci USA 2001; 98:4510 - 5; http://dx.doi.org/10.1073/pnas.081074898; PMID: 11274368
   PubMed Web of Science ®Google Scholar
• Koutsodontis G, Kardassis D. Inhibition of p53-mediated transcriptional responses by mithramycin A. Oncogene 2004; 23:9190 - 200; PMID: 15489892
   PubMed Web of Science ®Google Scholar
• Chew YC, Adhikary G, Wilson GM, Xu W, Eckert RL. Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. J Biol Chem 2012; 287:16168 - 78; http://dx.doi.org/10.1074/jbc.M111.305292; PMID: 22427654
   PubMed Web of Science ®Google Scholar
• Kondoh N, Shuda M, Tanaka K, Wakatsuki T, Hada A, Yamamoto M. Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma. Anticancer Res 2001; 21:4A 2429 - 33; PMID: 11724303
   PubMed Web of Science ®Google Scholar
• Mduff FK, Hook CE, Tooze RM, Huntly BJ, Pandolfi PP, Turner SD. Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis. Lab Invest 2011; 91:1298 - 303; http://dx.doi.org/10.1038/labinvest.2011.96; PMID: 21709672
   PubMed Web of Science ®Google Scholar
• Amsterdam A, Sadler KC, Lai K, Farrington S, Bronson RT, Lees JA, et al. Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol 2004; 2:E139; http://dx.doi.org/10.1371/journal.pbio.0020139; PMID: 15138505
   PubMed Web of Science ®Google Scholar
• Castro ME, Leal JF, Lleonart ME, Ramon Y Cajal S, Carnero A. Loss-of-function genetic screening identifies a cluster of ribosomal proteins regulating p53 function. Carcinogenesis 2008; 29:1343 - 50; http://dx.doi.org/10.1093/carcin/bgm302; PMID: 18515283
   PubMed Web of Science ®Google Scholar
• Deisenroth C, Zhang Y. Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway. Oncogene 2010; 29:4253 - 60; http://dx.doi.org/10.1038/onc.2010.189; PMID: 20498634
   PubMed Web of Science ®Google Scholar
• Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M. Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell 2008; 32:180 - 9; http://dx.doi.org/10.1016/j.molcel.2008.08.031; PMID: 18951086
   PubMed Web of Science ®Google Scholar
• Morgado-Palacin L, Llanos S, Serrano M. Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells. Cell Cycle 2012; 11:503 - 10; http://dx.doi.org/10.4161/cc.11.3.19002; PMID: 22262176
   PubMed Web of Science ®Google Scholar
• Colombo E, Marine JC, Danovi D, Falini B, Pelicci PG. Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol 2002; 4:529 - 33; http://dx.doi.org/10.1038/ncb814; PMID: 12080348
   PubMed Web of Science ®Google Scholar
• Lo D, Lu H. Nucleostemin: Another nucleolar “Twister” of the p53-MDM2 loop. Cell Cycle 2010; 9:3227 - 32; http://dx.doi.org/10.4161/cc.9.16.12605; PMID: 20703089
   PubMed Web of Science ®Google Scholar
• Wanzel M, Russ AC, Kleine-Kohlbrecher D, Colombo E, Pelicci PG, Eilers M. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat Cell Biol 2008; 10:1051 - 61; http://dx.doi.org/10.1038/ncb1764; PMID: 19160485
   PubMed Web of Science ®Google Scholar
• Cuccurese M, Russo G, Russo A, Pietropaolo C. Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression. Nucleic Acids Res 2005; 33:5965 - 77; http://dx.doi.org/10.1093/nar/gki905; PMID: 16254077
   PubMed Web of Science ®Google Scholar
• Russo A, Catillo M, Esposito D, Briata P, Pietropaolo C, Russo G. Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP. Nucleic Acids Res 2011; 39:7576 - 85; http://dx.doi.org/10.1093/nar/gkr461; PMID: 21705779
   PubMed Web of Science ®Google Scholar
• Russo A, Siciliano G, Catillo M, Giangrande C, Amoresano A, Pucci P, et al. hnRNP H1 and intronic G runs in the splicing control of the human rpL3 gene. Biochim Biophys Acta 2010; 1799:419 - 28; http://dx.doi.org/10.1016/j.bbagrm.2010.01.008; PMID: 20100605
   PubMed Web of Science ®Google Scholar
• Russo G, Cuccurese M, Monti G, Russo A, Amoresano A, Pucci P, et al. Ribosomal protein L7a binds RNA through two distinct RNA-binding domains. Biochem J 2005; 385:289 - 99; http://dx.doi.org/10.1042/BJ20040371; PMID: 15361074
   PubMed Web of Science ®Google Scholar
• Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, et al. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 2003; 22:351 - 60; http://dx.doi.org/10.1038/sj.onc.1206145; PMID: 12545156
   PubMed Web of Science ®Google Scholar
• Cen B, Deguchi A, Weinstein IB. Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. Cancer Res 2008; 68:5355 - 62; http://dx.doi.org/10.1158/0008-5472.CAN-07-6869; PMID: 18593937
   PubMed Web of Science ®Google Scholar
• Huang L, Sowa Y, Sakai T, Pardee AB. Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites. Oncogene 2000; 19:5712 - 9; http://dx.doi.org/10.1038/sj.onc.1203963; PMID: 11126357
   PubMed Web of Science ®Google Scholar
• Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35:495 - 516; http://dx.doi.org/10.1080/01926230701320337; PMID: 17562483
   PubMed Web of Science ®Google Scholar
• Oliver FJ, de la Rubia G, Rolli V, Ruiz-Ruiz MC, de Murcia G, Murcia JM. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J Biol Chem 1998; 273:33533 - 9; http://dx.doi.org/10.1074/jbc.273.50.33533; PMID: 9837934
   PubMed Web of Science ®Google Scholar
• Caldarola S, De Stefano MC, Amaldi F, Loreni F. Synthesis and function of ribosomal proteins--fading models and new perspectives. FEBS J 2009; 276:3199 - 210; http://dx.doi.org/10.1111/j.1742-4658.2009.07036.x; PMID: 19438715
   PubMed Web of Science ®Google Scholar
• Fromont-Racine M, Senger B, Saveanu C, Fasiolo F. Ribosome assembly in eukaryotes. Gene 2003; 313:17 - 42; http://dx.doi.org/10.1016/S0378-1119(03)00629-2; PMID: 12957375
   PubMed Web of Science ®Google Scholar
• Kressler D, Hurt E, Bassler J. Driving ribosome assembly. Biochim Biophys Acta 2010; 1803:673 - 83; http://dx.doi.org/10.1016/j.bbamcr.2009.10.009; PMID: 19879902
   PubMed Web of Science ®Google Scholar
• Lempiäinen H, Shore D. Growth control and ribosome biogenesis. Curr Opin Cell Biol 2009; 21:855 - 63; http://dx.doi.org/10.1016/j.ceb.2009.09.002; PMID: 19796927
   PubMed Web of Science ®Google Scholar
• Miliani de Marval PL, Zhang Y. The RP-Mdm2-p53 pathway and tumorigenesis. Oncotarget 2011; 2:234 - 8; PMID: 21406728
   PubMed Web of Science ®Google Scholar
• Hölzel M, Burger K, Mühl B, Orban M, Kellner M, Eick D. The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword. Oncotarget 2010; 1:43 - 7; PMID: 21293052
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lu H. Signaling to p53: ribosomal proteins find their way. Cancer Cell 2009; 16:369 - 77; http://dx.doi.org/10.1016/j.ccr.2009.09.024; PMID: 19878869
   PubMed Web of Science ®Google Scholar
• Donati G, Montanaro L, Derenzini M. Ribosome biogenesis and control of cell proliferation: p53 is not alone. Cancer Res 2012; 72:1602 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-11-3992; PMID: 22282659
   PubMed Web of Science ®Google Scholar
• Sherr CJ. Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 2006; 6:663 - 73; http://dx.doi.org/10.1038/nrc1954; PMID: 16915296
   PubMed Web of Science ®Google Scholar
• Koutsodontis G, Tentes I, Papakosta P, Moustakas A, Kardassis D. Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. J Biol Chem 2001; 276:29116 - 25; http://dx.doi.org/10.1074/jbc.M104130200; PMID: 11384995
   PubMed Web of Science ®Google Scholar
• Gartel AL. The conflicting roles of the cdk inhibitor p21(CIP1/WAF1) in apoptosis. Leuk Res 2005; 29:1237 - 8; http://dx.doi.org/10.1016/j.leukres.2005.04.023; PMID: 15946739
   PubMed Web of Science ®Google Scholar
• Chopin V, Toillon RA, Jouy N, Le Bourhis X. P21(WAF1/CIP1) is dispensable for G1 arrest, but indispensable for apoptosis induced by sodium butyrate in MCF-7 breast cancer cells. Oncogene 2004; 23:21 - 9; http://dx.doi.org/10.1038/sj.onc.1207020; PMID: 14712207
   PubMed Web of Science ®Google Scholar
• Hsu SL, Chen MC, Chou YH, Hwang GY, Yin SC. Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. Exp Cell Res 1999; 248:87 - 96; http://dx.doi.org/10.1006/excr.1999.4397; PMID: 10094816
   PubMed Web of Science ®Google Scholar
• Wu Q, Kirschmeier P, Hockenberry T, Yang TY, Brassard DL, Wang L, et al. Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells. J Biol Chem 2002; 277:36329 - 37; http://dx.doi.org/10.1074/jbc.M204962200; PMID: 12138103
   PubMed Web of Science ®Google Scholar
• Pacifico F, Crescenzi E, Mellone S, Iannetti A, Porrino N, Liguoro D, et al. Nuclear factor-kappaB contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. J Clin Endocrinol Metab 2010; 95:1421 - 30; http://dx.doi.org/10.1210/jc.2009-1128; PMID: 20061417
   PubMed Web of Science ®Google Scholar
• Iannetti A, Pacifico F, Acquaviva R, Lavorgna A, Crescenzi E, Vascotto C, et al. The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells. Proc Natl Acad Sci USA 2008; 105:14058 - 63; http://dx.doi.org/10.1073/pnas.0710846105; PMID: 18768801
   PubMed Web of Science ®Google Scholar