Transgenerational cell fate profiling

References

• Lee HO, Davidson JM, Duronio RJ. Endoreplication: polyploidy with purpose. Genes Dev 2009; 23:2461 - 77; http://dx.doi.org/10.1101/gad.1829209; PMID: 19884253
   PubMed Web of Science ®Google Scholar
• Davoli T, de Lange T. The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol 2011; 27:585 - 610; http://dx.doi.org/10.1146/annurev-cellbio-092910-154234; PMID: 21801013
   PubMed Web of Science ®Google Scholar
• Vitale I, Galluzzi L, Senovilla L, Criollo A, Jemaà M, Castedo M, et al. Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ 2011; 18:1403 - 13; http://dx.doi.org/10.1038/cdd.2010.145; PMID: 21072053
   PubMed Web of Science ®Google Scholar
• Storchova Z, Kuffer C. The consequences of tetraploidy and aneuploidy. J Cell Sci 2008; 121:3859 - 66; http://dx.doi.org/10.1242/jcs.039537; PMID: 19020304
   PubMed Web of Science ®Google Scholar
• Duelli DM, Padilla-Nash HM, Berman D, Murphy KM, Ried T, Lazebnik Y. A virus causes cancer by inducing massive chromosomal instability through cell fusion. Curr Biol 2007; 17:431 - 7; http://dx.doi.org/10.1016/j.cub.2007.01.049; PMID: 17320392
   PubMed Web of Science ®Google Scholar
• Ogle BM, Cascalho M, Platt JL. Biological implications of cell fusion. Nat Rev Mol Cell Biol 2005; 6:567 - 75; http://dx.doi.org/10.1038/nrm1678; PMID: 15957005
   PubMed Web of Science ®Google Scholar
• Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 2010; 141:81 - 93; http://dx.doi.org/10.1016/j.cell.2010.01.031; PMID: 20371347
   PubMed Web of Science ®Google Scholar
• Brito DA, Rieder CL. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol 2006; 16:1194 - 200; http://dx.doi.org/10.1016/j.cub.2006.04.043; PMID: 16782009
   PubMed Web of Science ®Google Scholar
• Lacroix B, Maddox AS. Cytokinesis, ploidy and aneuploidy. J Pathol 2012; 226:338 - 51; http://dx.doi.org/10.1002/path.3013; PMID: 21984283
   PubMed Web of Science ®Google Scholar
• Gisselsson D, Håkanson U, Stoller P, Marti D, Jin Y, Rosengren AH, et al. When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses. PLoS One 2008; 3:e1871; http://dx.doi.org/10.1371/journal.pone.0001871; PMID: 18392149
   PubMed Web of Science ®Google Scholar
• Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009; 460:278 - 82; http://dx.doi.org/10.1038/nature08136; PMID: 19506557
   PubMed Web of Science ®Google Scholar
• Vitale I, Senovilla L, Jemaà M, Michaud M, Galluzzi L, Kepp O, et al. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. EMBO J 2010; 29:1272 - 84; http://dx.doi.org/10.1038/emboj.2010.11; PMID: 20186124
   PubMed Web of Science ®Google Scholar
• Levine DS, Rabinovitch PS, Haggitt RC, Blount PL, Dean PJ, Rubin CE, et al. Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer. Gastroenterology 1991; 101:1198 - 210; PMID: 1936790
   PubMed Web of Science ®Google Scholar
• Olaharski AJ, Sotelo R, Solorza-Luna G, Gonsebatt ME, Guzman P, Mohar A, et al. Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 2006; 27:337 - 43; http://dx.doi.org/10.1093/carcin/bgi218; PMID: 16123119
   PubMed Web of Science ®Google Scholar
• Maley CC, Galipeau PC, Li X, Sanchez CA, Paulson TG, Blount PL, et al. The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma. Cancer Res 2004; 64:7629 - 33; http://dx.doi.org/10.1158/0008-5472.CAN-04-1738; PMID: 15492292
   PubMed Web of Science ®Google Scholar
• Geigl JB, Obenauf AC, Schwarzbraun T, Speicher MR. Defining ‘chromosomal instability’. Trends Genet 2008; 24:64 - 9; http://dx.doi.org/10.1016/j.tig.2007.11.006; PMID: 18192061
   PubMed Web of Science ®Google Scholar
• Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 2009; 10:478 - 87; http://dx.doi.org/10.1038/nrm2718; PMID: 19546858
   PubMed Web of Science ®Google Scholar
• Knutsen T, Padilla-Nash HM, Wangsa D, Barenboim-Stapleton L, Camps J, McNeil N, et al. Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. Genes Chromosomes Cancer 2010; 49:204 - 23; PMID: 19927377
   PubMed Web of Science ®Google Scholar
• Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437:1043 - 7; http://dx.doi.org/10.1038/nature04217; PMID: 16222300
   PubMed Web of Science ®Google Scholar
• Castillo A, Morse HC 3rd, Godfrey VL, Naeem R, Justice MJ. Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res 2007; 67:10138 - 47; http://dx.doi.org/10.1158/0008-5472.CAN-07-0326; PMID: 17974955
   PubMed Web of Science ®Google Scholar
• Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, et al. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 2007; 11:9 - 23; http://dx.doi.org/10.1016/j.ccr.2006.10.019; PMID: 17189715
   PubMed Web of Science ®Google Scholar
• Meraldi P, Honda R, Nigg EA. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J 2002; 21:483 - 92; http://dx.doi.org/10.1093/emboj/21.4.483; PMID: 11847097
   PubMed Web of Science ®Google Scholar
• Wang X, Zhou YX, Qiao W, Tominaga Y, Ouchi M, Ouchi T, et al. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. Oncogene 2006; 25:7148 - 58; http://dx.doi.org/10.1038/sj.onc.1209707; PMID: 16715125
   PubMed Web of Science ®Google Scholar
• Li Q, Dang CV. c-Myc overexpression uncouples DNA replication from mitosis. Mol Cell Biol 1999; 19:5339 - 51; PMID: 10409725
   PubMed Web of Science ®Google Scholar
• Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, et al. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 2007; 176:183 - 95; http://dx.doi.org/10.1083/jcb.200610099; PMID: 17227893
   PubMed Web of Science ®Google Scholar
• Daniels MJ, Wang Y, Lee M, Venkitaraman AR. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 2004; 306:876 - 9; http://dx.doi.org/10.1126/science.1102574; PMID: 15375219
   PubMed Web of Science ®Google Scholar
• Aylon Y, Oren M. p53: guardian of ploidy. Mol Oncol 2011; 5:315 - 23; http://dx.doi.org/10.1016/j.molonc.2011.07.007; PMID: 21852209
   PubMed Web of Science ®Google Scholar
• Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011; 12:385 - 92; http://dx.doi.org/10.1038/nrm3115; PMID: 21527953
   PubMed Web of Science ®Google Scholar
• Sperka T, Wang J, Rudolph KL. DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol 2012; 13:579 - 90; http://dx.doi.org/10.1038/nrm3420; PMID: 22914294
   PubMed Web of Science ®Google Scholar
• Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007; 8:379 - 93; http://dx.doi.org/10.1038/nrm2163; PMID: 17426725
   PubMed Web of Science ®Google Scholar
• Margolis RL, Lohez OD, Andreassen PR. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem 2003; 88:673 - 83; http://dx.doi.org/10.1002/jcb.10411; PMID: 12577301
   PubMed Web of Science ®Google Scholar
• Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P, et al. Apoptosis regulation in tetraploid cancer cells. EMBO J 2006; 25:2584 - 95; http://dx.doi.org/10.1038/sj.emboj.7601127; PMID: 16675948
   PubMed Web of Science ®Google Scholar
• Thompson SL, Compton DA. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol 2010; 188:369 - 81; http://dx.doi.org/10.1083/jcb.200905057; PMID: 20123995
   PubMed Web of Science ®Google Scholar
• Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, et al. An immunosurveillance mechanism controls cancer cell ploidy. Science 2012; 337:1678 - 84; http://dx.doi.org/10.1126/science.1224922; PMID: 23019653
   PubMed Web of Science ®Google Scholar
• Vitale I, Galluzzi L, Vivet S, Nanty L, Dessen P, Senovilla L, et al. Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PLoS One 2007; 2:e1337; http://dx.doi.org/10.1371/journal.pone.0001337; PMID: 18159231
   PubMed Web of Science ®Google Scholar
• Rello-Varona S, Vitale I, Kepp O, Senovilla L, Jemaá M, Métivier D, et al. Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5. Cell Cycle 2009; 8:1030 - 5; http://dx.doi.org/10.4161/cc.8.7.7950; PMID: 19270519
   PubMed Web of Science ®Google Scholar
• Jemaà M, Vitale I, Kepp O, Berardinelli F, Galluzzi L, Senovilla L, et al. Selective killing of p53-deficient cancer cells by SP600125. EMBO Mol Med 2012; 4:500 - 14; http://dx.doi.org/10.1002/emmm.201200228; PMID: 22438244
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19:107 - 20; http://dx.doi.org/10.1038/cdd.2011.96; PMID: 21760595
   PubMed Web of Science ®Google Scholar
• Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, et al, Nomenclature Committee on Cell Death 2009. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16:3 - 11; http://dx.doi.org/10.1038/cdd.2008.150; PMID: 18846107
   PubMed Web of Science ®Google Scholar
• Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010; 11:700 - 14; http://dx.doi.org/10.1038/nrm2970; PMID: 20823910
   PubMed Web of Science ®Google Scholar
• Kepp O, Galluzzi L, Lipinski M, Yuan J, Kroemer G. Cell death assays for drug discovery. Nat Rev Drug Discov 2011; 10:221 - 37; http://dx.doi.org/10.1038/nrd3373; PMID: 21358741
   PubMed Web of Science ®Google Scholar
• Zhang P, Castedo M, Tao Y, Violot D, Métivier D, Deutsch E, et al. Caspase independence of radio-induced cell death. Oncogene 2006; 25:7758 - 70; http://dx.doi.org/10.1038/sj.onc.1209744; PMID: 16862186
   PubMed Web of Science ®Google Scholar