Inecalcitol, an analog of 1,25D₃, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system

References

• Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007; 7:684 - 700; http://dx.doi.org/10.1038/nrc2196; PMID: 17721433
   PubMed Web of Science ®Google Scholar
• Brown AJ, Dusso A, Slatopolsky E. Vitamin D. Am J Physiol 1999; 277:F157 - 75; PMID: 10444570
   PubMed Web of Science ®Google Scholar
• Verlinden L, Verstuyf A, Quack M, Van Camp M, Van Etten E, De Clercq P, et al. Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements. J Bone Miner Res 2001; 16:625 - 38; http://dx.doi.org/10.1359/jbmr.2001.16.4.625; PMID: 11315990
   PubMed Web of Science ®Google Scholar
• Eelen G, Verlinden L, Rochel N, Claessens F, De Clercq P, Vandewalle M, et al. Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction. Mol Pharmacol 2005; 67:1566 - 73; http://dx.doi.org/10.1124/mol.104.008730; PMID: 15728261
   PubMed Web of Science ®Google Scholar
• Verlinden L, Verstuyf A, Van Camp M, Marcelis S, Sabbe K, Zhao XY, et al. Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo. Cancer Res 2000; 60:2673 - 9; PMID: 10825140
   PubMed Web of Science ®Google Scholar
• Okamoto R, Delansorne R, Wakimoto N, Doan NB, Akagi T, Shen M, et al. Inecalcitol, an analog of 1α,25(OH)(2) D(3), induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer 2012; 130:2464 - 73; http://dx.doi.org/10.1002/ijc.26279; PMID: 21732345
   PubMed Web of Science ®Google Scholar
• Ma Y, Yu WD, Hershberger PA, Flynn G, Kong RX, Trump DL, et al. 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model. Mol Cancer Ther 2008; 7:3047 - 55; http://dx.doi.org/10.1158/1535-7163.MCT-08-0243; PMID: 18790784
   PubMed Web of Science ®Google Scholar
• Hidalgo AA, Deeb KK, Pike JW, Johnson CS, Trump DL. Dexamethasone enhances 1alpha,25-dihydroxyvitamin D3 effects by increasing vitamin D receptor transcription. J Biol Chem 2011; 286:36228 - 37; http://dx.doi.org/10.1074/jbc.M111.244061; PMID: 21868377
   PubMed Web of Science ®Google Scholar
• Hershberger PA, McGuire TF, Yu WD, Zuhowski EG, Schellens JH, Egorin MJ, et al. Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression. Mol Cancer Ther 2002; 1:821 - 9; PMID: 12492115
   PubMed Web of Science ®Google Scholar
• Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, et al. The emerging role of the PI3-K-Akt pathway in prostate cancer progression. Prostate Cancer Prostatic Dis 2005; 8:108 - 18; http://dx.doi.org/10.1038/sj.pcan.4500776; PMID: 15724144
   PubMed Web of Science ®Google Scholar
• Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005; 9:59 - 71; http://dx.doi.org/10.1111/j.1582-4934.2005.tb00337.x; PMID: 15784165
   PubMed Web of Science ®Google Scholar
• Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, et al. The role of vitamin D in cancer prevention. Am J Public Health 2006; 96:252 - 61; http://dx.doi.org/10.2105/AJPH.2004.045260; PMID: 16380576
   PubMed Web of Science ®Google Scholar
• Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006; 98:451 - 9; http://dx.doi.org/10.1093/jnci/djj101; PMID: 16595781
   PubMed Web of Science ®Google Scholar
• Hershberger PA, Modzelewski RA, Shurin ZR, Rueger RM, Trump DL, Johnson CS. 1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo. Cancer Res 1999; 59:2644 - 9; PMID: 10363987
   PubMed Web of Science ®Google Scholar
• Light BW, Yu WD, McElwain MC, Russell DM, Trump DL, Johnson CS. Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system. Cancer Res 1997; 57:3759 - 64; PMID: 9288784
   PubMed Web of Science ®Google Scholar
• Ma Y, Yu WD, Kong RX, Trump DL, Johnson CS. Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carcinoma cells. Cancer Res 2006; 66:8131 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-06-1333; PMID: 16912191
   PubMed Web of Science ®Google Scholar
• McGuire TF, Trump DL, Johnson CS. Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1. J Biol Chem 2001; 276:26365 - 73; http://dx.doi.org/10.1074/jbc.M010101200; PMID: 11331275
   PubMed Web of Science ®Google Scholar
• Narvaez CJ, Welsh J. Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J Biol Chem 2001; 276:9101 - 7; http://dx.doi.org/10.1074/jbc.M006876200; PMID: 11053435
   PubMed Web of Science ®Google Scholar
• Mathiasen IS, Sergeev IN, Bastholm L, Elling F, Norman AW, Jäättelä M. Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem 2002; 277:30738 - 45; http://dx.doi.org/10.1074/jbc.M201558200; PMID: 12072431
   PubMed Web of Science ®Google Scholar
• Díaz GD, Paraskeva C, Thomas MG, Binderup L, Hague A. Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. Cancer Res 2000; 60:2304 - 12; PMID: 10786699
   PubMed Web of Science ®Google Scholar
• Guzey M, Kitada S, Reed JC. Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther 2002; 1:667 - 77; PMID: 12479363
   PubMed Web of Science ®Google Scholar
• Jiang F, Bao J, Li P, Nicosia SV, Bai W. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. J Biol Chem 2004; 279:53213 - 21; http://dx.doi.org/10.1074/jbc.M410395200; PMID: 15485861
   PubMed Web of Science ®Google Scholar
• Pepper C, Thomas A, Hoy T, Milligan D, Bentley P, Fegan C. The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. Blood 2003; 101:2454 - 60; http://dx.doi.org/10.1182/blood-2002-07-1984; PMID: 12446453
   PubMed Web of Science ®Google Scholar
• Muindi JR, Modzelewski RA, Peng Y, Trump DL, Johnson CS. Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses. Oncology 2004; 66:62 - 6; http://dx.doi.org/10.1159/000076336; PMID: 15031600
   PubMed Web of Science ®Google Scholar
• Hidalgo AA, Trump DL, Johnson CS. Glucocorticoid regulation of the vitamin D receptor. J Steroid Biochem Mol Biol 2010; 121:372 - 5; http://dx.doi.org/10.1016/j.jsbmb.2010.03.081; PMID: 20398752
   PubMed Web of Science ®Google Scholar
• Yu WD, McElwain MC, Modzelewski RA, Russell DM, Smith DC, Trump DL, et al. Enhancement of 1,25-dihydroxyvitamin D3-mediated antitumor activity with dexamethasone. J Natl Cancer Inst 1998; 90:134 - 41; http://dx.doi.org/10.1093/jnci/90.2.134; PMID: 9450573
   PubMed Web of Science ®Google Scholar
• Luo W, Karpf AR, Deeb KK, Muindi JR, Morrison CD, Johnson CS, et al. Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. Cancer Res 2010; 70:5953 - 62; http://dx.doi.org/10.1158/0008-5472.CAN-10-0617; PMID: 20587525
   PubMed Web of Science ®Google Scholar
• Hershberger PA, Yu WD, Modzelewski RA, Rueger RM, Johnson CS, Trump DL. Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis. Clin Cancer Res 2001; 7:1043 - 51; PMID: 11309356
   PubMed Web of Science ®Google Scholar
• Muindi JR, Yu WD, Ma Y, Engler KL, Kong RX, Trump DL, et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology 2010; 151:4301 - 12; http://dx.doi.org/10.1210/en.2009-1156; PMID: 20591973
   PubMed Web of Science ®Google Scholar