Tumor-suppressive effects of CDK8 in endometrial cancer cells

References

• Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, et al. Cyclin-dependent kinases: a family portrait. Nat Cell Biol 2009; 11:1275 - 6; http://dx.doi.org/10.1038/ncb1109-1275; PMID: 19884882
   PubMed Web of Science ®Google Scholar
• Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009; 9:153 - 66; http://dx.doi.org/10.1038/nrc2602; PMID: 19238148
   PubMed Web of Science ®Google Scholar
• Morgan DO. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol 1997; 13:261 - 91; http://dx.doi.org/10.1146/annurev.cellbio.13.1.261; PMID: 9442875
   PubMed Web of Science ®Google Scholar
• Malumbres M, Barbacid M. Mammalian cyclin-dependent kinases. Trends Biochem Sci 2005; 30:630 - 41; http://dx.doi.org/10.1016/j.tibs.2005.09.005; PMID: 16236519
   PubMed Web of Science ®Google Scholar
• Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18:2699 - 711; http://dx.doi.org/10.1101/gad.1256504; PMID: 15545627
   PubMed Web of Science ®Google Scholar
• Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 2008; 455:547 - 51; http://dx.doi.org/10.1038/nature07179; PMID: 18794900
   PubMed Web of Science ®Google Scholar
• Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, et al. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature 2010; 468:1105 - 9; http://dx.doi.org/10.1038/nature09590; PMID: 21179167
   PubMed Web of Science ®Google Scholar
• Osherovich L.. CDK8 is enough in colorectal cancer. Science-Business eXchange 2008; 1:5 - 7; http://dx.doi.org/10.1038/scibx.2008.815
   Google Scholar
• Taatjes DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci 2010; 35:315 - 22; http://dx.doi.org/10.1016/j.tibs.2010.02.004; PMID: 20299225
   PubMed Web of Science ®Google Scholar
• Kornberg RD. Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 2005; 30:235 - 9; http://dx.doi.org/10.1016/j.tibs.2005.03.011; PMID: 15896740
   PubMed Web of Science ®Google Scholar
• Conaway RC, Conaway JW. Function and regulation of the Mediator complex. Curr Opin Genet Dev 2011; 21:225 - 30; http://dx.doi.org/10.1016/j.gde.2011.01.013; PMID: 21330129
   PubMed Web of Science ®Google Scholar
• Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW. The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci 2005; 30:250 - 5; http://dx.doi.org/10.1016/j.tibs.2005.03.002; PMID: 15896743
   PubMed Web of Science ®Google Scholar
• Malik S, Roeder RG. Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci 2005; 30:256 - 63; http://dx.doi.org/10.1016/j.tibs.2005.03.009; PMID: 15896744
   PubMed Web of Science ®Google Scholar
• Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 2004; 14:553 - 7; http://dx.doi.org/10.1016/j.molcel.2004.05.011; PMID: 15175151
   PubMed Web of Science ®Google Scholar
• Bourbon HM. Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res 2008; 36:3993 - 4008; http://dx.doi.org/10.1093/nar/gkn349; PMID: 18515835
   PubMed Web of Science ®Google Scholar
• Galbraith MD, Donner AJ, Espinosa JM. CDK8: a positive regulator of transcription. Transcription 2010; 1:4 - 12; http://dx.doi.org/10.4161/trns.1.1.12373; PMID: 21327159
   PubMedGoogle Scholar
• Xu W, Ji JY. Dysregulation of CDK8 and Cyclin C in tumorigenesis. J Genet Genomics 2011; 38:439 - 52; http://dx.doi.org/10.1016/j.jgg.2011.09.002; PMID: 22035865
   PubMed Web of Science ®Google Scholar
• Tsafrir D, Bacolod M, Selvanayagam Z, Tsafrir I, Shia J, Zeng Z, et al. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res 2006; 66:2129 - 37; http://dx.doi.org/10.1158/0008-5472.CAN-05-2569; PMID: 16489013
   PubMed Web of Science ®Google Scholar
• Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, et al. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res 2007; 67:10736 - 43; http://dx.doi.org/10.1158/0008-5472.CAN-07-2742; PMID: 18006816
   PubMed Web of Science ®Google Scholar
• Sheffer M, Bacolod MD, Zuk O, Giardina SF, Pincas H, Barany F, et al. Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci USA 2009; 106:7131 - 6; http://dx.doi.org/10.1073/pnas.0902232106; PMID: 19359472
   PubMed Web of Science ®Google Scholar
• Seo JO, Han SI, Lim SC. Role of CDK8 and beta-catenin in colorectal adenocarcinoma. Oncol Rep 2010; 24:285 - 91; PMID: 20514474
   PubMed Web of Science ®Google Scholar
• Kim MY, Han SI, Lim SC. Roles of cyclin-dependent kinase 8 and β-catenin in the oncogenesis and progression of gastric adenocarcinoma. Int J Oncol 2011; 38:1375 - 83; PMID: 21344156
   PubMed Web of Science ®Google Scholar
• Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, et al. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. Int J Cancer 2010; 126:2863 - 73; PMID: 19790197
   PubMed Web of Science ®Google Scholar
• Ji JY, Dyson NJ. Interplay between Cyclin-dependent Kinases and E2F-dependent Transcription. In: Enders G, ed. Cell Cycle Deregulation in Cancer: Springer Science 2010:23-41.
   Google Scholar
• Brewster CD, Birkenheuer CH, Vogt MB, Quackenbush SL, Rovnak J. The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8. Virology 2011; 409:299 - 307; http://dx.doi.org/10.1016/j.virol.2010.10.022; PMID: 21067790
   PubMed Web of Science ®Google Scholar
• Rovnak J, Brewster CD, Quackenbush SL. Retroviral cyclin enhances cyclin-dependent kinase-8 activity. J Virol 2012; 86:5742 - 51; http://dx.doi.org/10.1128/JVI.07006-11; PMID: 22379099
   PubMed Web of Science ®Google Scholar
• Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010; 463:899 - 905; http://dx.doi.org/10.1038/nature08822; PMID: 20164920
   PubMed Web of Science ®Google Scholar
• Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, et al. Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. Mutat Res 2010; 696:130 - 8; http://dx.doi.org/10.1016/j.mrgentox.2010.01.001; PMID: 20083228
   PubMed Web of Science ®Google Scholar
• Mitra AP, Almal AA, George B, Fry DW, Lenehan PF, Pagliarulo V, et al. The use of genetic programming in the analysis of quantitative gene expression profiles for identification of nodal status in bladder cancer. BMC Cancer 2006; 6:159; http://dx.doi.org/10.1186/1471-2407-6-159; PMID: 16780590
   PubMed Web of Science ®Google Scholar
• Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007; 446:153 - 8; http://dx.doi.org/10.1038/nature05610; PMID: 17344846
   PubMed Web of Science ®Google Scholar
• Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest 2012; 122:2417 - 27; http://dx.doi.org/10.1172/JCI61462; PMID: 22684109
   PubMed Web of Science ®Google Scholar
• Trentham-Dietz A, Newcomb PA, Egan KM, Titus-Ernstoff L, Baron JA, Storer BE, et al. Weight change and risk of postmenopausal breast cancer (United States). Cancer Causes Control 2000; 11:533 - 42; http://dx.doi.org/10.1023/A:1008961931534; PMID: 10880035
   PubMed Web of Science ®Google Scholar
• Goodman MT, Hankin JH, Wilkens LR, Lyu LC, McDuffie K, Liu LQ, et al. Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 1997; 57:5077 - 85; PMID: 9371506
   PubMed Web of Science ®Google Scholar
• Renehan AG, Frystyk J, Flyvbjerg A. Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol Metab 2006; 17:328 - 36; http://dx.doi.org/10.1016/j.tem.2006.08.006; PMID: 16956771
   PubMed Web of Science ®Google Scholar
• Webb PM. Commentary: weight gain, weight loss, and endometrial cancer. Int J Epidemiol 2006; 35:166 - 8; http://dx.doi.org/10.1093/ije/dyi301; PMID: 16394116
   PubMed Web of Science ®Google Scholar
• Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 2008; 455:552 - 6; http://dx.doi.org/10.1038/nature07310; PMID: 18794899
   PubMed Web of Science ®Google Scholar
• Zhao J, Ramos R, Demma M. CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation. Oncogene 2012; http://dx.doi.org/10.1038/onc.2012.364; PMID: 22945643
   PubMed Web of Science ®Google Scholar
• Adler AS, McCleland ML, Truong T, Lau S, Modrusan Z, Soukup TM, et al. CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. Cancer Res 2012; 72:2129 - 39; http://dx.doi.org/10.1158/0008-5472.CAN-11-3886; PMID: 22345154
   PubMed Web of Science ®Google Scholar
• Tansey WP. Transcriptional activation: risky business. Genes Dev 2001; 15:1045 - 50; http://dx.doi.org/10.1101/gad.896501; PMID: 11331599
   PubMed Web of Science ®Google Scholar
• Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109:1125 - 31; PMID: 11994399
   PubMed Web of Science ®Google Scholar
• Espenshade PJ, Hughes AL. Regulation of sterol synthesis in eukaryotes. Annu Rev Genet 2007; 41:401 - 27; http://dx.doi.org/10.1146/annurev.genet.41.110306.130315; PMID: 17666007
   PubMed Web of Science ®Google Scholar
• Goldstein JL, Rawson RB, Brown MS. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys 2002; 397:139 - 48; http://dx.doi.org/10.1006/abbi.2001.2615; PMID: 11795864
   PubMed Web of Science ®Google Scholar
• Raghow R, Yellaturu C, Deng X, Park EA, Elam MB. SREBPs: the crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol Metab 2008; 19:65 - 73; http://dx.doi.org/10.1016/j.tem.2007.10.009; PMID: 18291668
   PubMed Web of Science ®Google Scholar
• Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007; 7:763 - 77; http://dx.doi.org/10.1038/nrc2222; PMID: 17882277
   PubMed Web of Science ®Google Scholar
• Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 2008; 27:1447 - 57; PMID: 18418385
   PubMed Web of Science ®Google Scholar
• Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol 2009; 29:650 - 61; http://dx.doi.org/10.1128/MCB.00993-08; PMID: 19047373
   PubMed Web of Science ®Google Scholar
• Knuesel MT, Meyer KD, Bernecky C, Taatjes DJ. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev 2009; 23:439 - 51; http://dx.doi.org/10.1101/gad.1767009; PMID: 19240132
   PubMed Web of Science ®Google Scholar
• Donner AJ, Szostek S, Hoover JM, Espinosa JM. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol Cell 2007; 27:121 - 33; http://dx.doi.org/10.1016/j.molcel.2007.05.026; PMID: 17612495
   PubMed Web of Science ®Google Scholar
• Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 2009; 139:757 - 69; http://dx.doi.org/10.1016/j.cell.2009.09.035; PMID: 19914168
   PubMed Web of Science ®Google Scholar
• Fryer CJ, White JB, Jones KA. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 2004; 16:509 - 20; http://dx.doi.org/10.1016/j.molcel.2004.10.014; PMID: 15546612
   PubMed Web of Science ®Google Scholar
• Wang Y, van der Zee M, Fodde R, Blok LJ. Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer. Oncotarget 2010; 1:674 - 84; PMID: 21317462
   PubMed Web of Science ®Google Scholar
• Wang C, Fu M, D’Amico M, Albanese C, Zhou JN, Brownlee M, et al. Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. Mol Cell Biol 2001; 21:3057 - 70; http://dx.doi.org/10.1128/MCB.21.9.3057-3070.2001; PMID: 11287611
   PubMed Web of Science ®Google Scholar
• Zhou J, Liu Y, Zhang W, Popov VM, Wang M, Pattabiraman N, et al. Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J Biol Chem 2010; 285:40342 - 50; http://dx.doi.org/10.1074/jbc.M110.156141; PMID: 20956529
   PubMed Web of Science ®Google Scholar