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Cell Cycle Volume 12, 2013 - Issue 15
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Editorials: Cell Cycle Features

The adenovirus E4orf4 protein induces a unique mode of cell death while inhibiting classical apoptosis

Antonina Pechkovsky Department of Molecular Microbiology; The Rappaport Faculty of Medicine and Research Institute; Technion – Israel Institute of Technology; Haifa, Israel; Department of Genetics; The Rappaport Faculty of Medicine and Research Institute; Technion – Israel Institute of Technology; Haifa, Israel
,
Adi Salzberg Department of Genetics; The Rappaport Faculty of Medicine and Research Institute; Technion – Israel Institute of Technology; Haifa, Israel
&
Tamar Kleinberger Department of Molecular Microbiology; The Rappaport Faculty of Medicine and Research Institute; Technion – Israel Institute of Technology; Haifa, IsraelCorrespondence[email protected]
Pages 2343-2344 | Received 24 May 2013, Accepted 04 Jun 2013, Published online: 11 Jul 2013

References

  • Shtrichman R, Sharf R, Barr H, Dobner T, Kleinberger T. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A. Proc Natl Acad Sci U S A 1999; 96:10080 - 5; http://dx.doi.org/10.1073/pnas.96.18.10080; PMID: 10468565
  • Lavoie JN, Champagne C, Gingras M-C, Robert A. Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases. J Cell Biol 2000; 150:1037 - 56; http://dx.doi.org/10.1083/jcb.150.5.1037; PMID: 10973994
  • Livne A, Shtrichman R, Kleinberger T. Caspase activation by adenovirus E4orf4 protein is cell line specific and is mediated by the death receptor pathway. J Virol 2001; 75:789 - 98; http://dx.doi.org/10.1128/JVI.75.2.789-798.2001; PMID: 11134292
  • Brestovitsky A, Sharf R, Mittelman K, Kleinberger T. The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes. Nucleic Acids Res 2011; 39:6414 - 27; http://dx.doi.org/10.1093/nar/gkr231; PMID: 21546548
  • Kornitzer D, Sharf R, Kleinberger T. Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome. J Cell Biol 2001; 154:331 - 44; http://dx.doi.org/10.1083/jcb.200104104; PMID: 11470822
  • Maoz T, Koren R, Ben-Ari I, Kleinberger T. YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity. J Biol Chem 2005; 280:41270 - 7; http://dx.doi.org/10.1074/jbc.M507281200; PMID: 16227198
  • Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T. E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways. Proc Natl Acad Sci U S A 2013; 110:E1724 - 33; http://dx.doi.org/10.1073/pnas.1220282110; PMID: 23613593
  • Horowitz B, Sharf R, Avital-Shacham M, Pechkovsky A, Kleinberger T. Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit. J Biol Chem 2013; 288:13718 - 27; http://dx.doi.org/10.1074/jbc.M112.343756; PMID: 23530045

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