1,031
Views
22
CrossRef citations to date
0
Altmetric
Report

PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2

, , , , , , & show all
Pages 3373-3382 | Received 25 Jul 2013, Accepted 19 Aug 2013, Published online: 03 Sep 2013

References

  • Lee MY, Zhang S, Lin SH, Chea J, Wang X, LeRoy C, Wong A, Zhang Z, Lee EY. Regulation of human DNA polymerase delta in the cellular responses to DNA damage. Environ Mol Mutagen 2012; 53:683 - 98; http://dx.doi.org/10.1002/em.21743; PMID: 23047826
  • Garg P, Burgers PM. DNA polymerases that propagate the eukaryotic DNA replication fork. Crit Rev Biochem Mol Biol 2005; 40:115 - 28; http://dx.doi.org/10.1080/10409230590935433; PMID: 15814431
  • Kunkel TA, Burgers PM. Dividing the workload at a eukaryotic replication fork. Trends Cell Biol 2008; 18:521 - 7; http://dx.doi.org/10.1016/j.tcb.2008.08.005; PMID: 18824354
  • Zhou Y, Meng X, Zhang S, Lee EY, Lee MY. Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac system. PLoS One 2012; 7:e39156; http://dx.doi.org/10.1371/journal.pone.0039156; PMID: 22723953
  • Prelich G, Tan CK, Kostura M, Mathews MB, So AG, Downey KM, Stillman B. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature 1987; 326:517 - 20; http://dx.doi.org/10.1038/326517a0; PMID: 2882424
  • Burgers PM. Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 2009; 284:4041 - 5; http://dx.doi.org/10.1074/jbc.R800062200; PMID: 18835809
  • Balakrishnan L, Bambara RA. Okazaki fragment metabolism. Cold Spring Harb Perspect Biol 2013; 5:a10173; http://dx.doi.org/10.1101/cshperspect.a010173; PMID: 23378587
  • Moldovan GL, Pfander B, Jentsch S. PCNA, the maestro of the replication fork. Cell 2007; 129:665 - 79; http://dx.doi.org/10.1016/j.cell.2007.05.003; PMID: 17512402
  • Mocquet V, Lainé JP, Riedl T, Yajin Z, Lee MY, Egly JM. Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step. EMBO J 2008; 27:155 - 67; http://dx.doi.org/10.1038/sj.emboj.7601948; PMID: 18079701
  • Chea J, Zhang S, Zhao H, Zhang Z, Lee EY, Darzynkiewicz Z, Lee MY. Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage. Cell Cycle 2012; 11:2885 - 95; http://dx.doi.org/10.4161/cc.21280; PMID: 22801543
  • Ogi T, Limsirichaikul S, Overmeer RM, Volker M, Takenaka K, Cloney R, Nakazawa Y, Niimi A, Miki Y, Jaspers NG, et al. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol Cell 2010; 37:714 - 27; http://dx.doi.org/10.1016/j.molcel.2010.02.009; PMID: 20227374
  • Overmeer RM, Gourdin AM, Giglia-Mari A, Kool H, Houtsmuller AB, Siegal G, Fousteri MI, Mullenders LH, Vermeulen W. Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment. Mol Cell Biol 2010; 30:4828 - 39; http://dx.doi.org/10.1128/MCB.00285-10; PMID: 20713449
  • Sebesta M, Burkovics P, Juhasz S, Zhang S, Szabo JE, Lee MY, Haracska L, Krejci L. Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair (Amst) 2013; 12:691 - 8; http://dx.doi.org/10.1016/j.dnarep.2013.05.001; PMID: 23731732
  • Zhang W, Qin Z, Zhang X, Xiao W. Roles of sequential ubiquitination of PCNA in DNA-damage tolerance. FEBS Lett 2011; 585:2786 - 94; http://dx.doi.org/10.1016/j.febslet.2011.04.044; PMID: 21536034
  • Sale JE, Lehmann AR, Woodgate R. Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol 2012; 13:141 - 52; http://dx.doi.org/10.1038/nrm3289; PMID: 22358330
  • Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. J Biol Chem 2003; 278:10041 - 7; http://dx.doi.org/10.1074/jbc.M208694200; PMID: 12522211
  • Xie B, Li H, Wang Q, Xie S, Rahmeh A, Dai W, Lee MY. Further characterization of human DNA polymerase delta interacting protein 38. J Biol Chem 2005; 280:22375 - 84; http://dx.doi.org/10.1074/jbc.M414597200; PMID: 15811854
  • Cheng X, Kanki T, Fukuoh A, Ohgaki K, Takeya R, Aoki Y, Hamasaki N, Kang D. PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid. J Biochem 2005; 138:673 - 8; http://dx.doi.org/10.1093/jb/mvi169; PMID: 16428295
  • Klaile E, Müller MM, Kannicht C, Otto W, Singer BB, Reutter W, Obrink B, Lucka L. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. J Biol Chem 2007; 282:26629 - 40; http://dx.doi.org/10.1074/jbc.M701807200; PMID: 17623671
  • Singer BB, Scheffrahn I, Obrink B. The tumor growth-inhibiting cell adhesion molecule CEACAM1 (C-CAM) is differently expressed in proliferating and quiescent epithelial cells and regulates cell proliferation. Cancer Res 2000; 60:1236 - 44; PMID: 10728682
  • Klaile E, Kukalev A, Obrink B, Müller MM. PDIP38 is a novel mitotic spindle-associated protein that affects spindle organization and chromosome segregation. Cell Cycle 2008; 7:3180 - 6; http://dx.doi.org/10.4161/cc.7.20.6813; PMID: 18843206
  • Tissier A, Janel-Bintz R, Coulon S, Klaile E, Kannouche P, Fuchs RP, Cordonnier AM. Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Poleta. DNA Repair (Amst) 2010; 9:922 - 8; http://dx.doi.org/10.1016/j.dnarep.2010.04.010; PMID: 20554254
  • Lyle AN, Deshpande NN, Taniyama Y, Seidel-Rogol B, Pounkova L, Du P, Papaharalambus C, Lassègue B, Griendling KK. Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res 2009; 105:249 - 59; http://dx.doi.org/10.1161/CIRCRESAHA.109.193722; PMID: 19574552
  • Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, et al. Polymerase Delta Interacting Protein 2 Sustains Vascular Structure and Function. [Epub ahead of print] Arterioscler Thromb Vasc Biol 2013; 33:2154 - 61; http://dx.doi.org/10.1161/ATVBAHA.113.301913; PMID: 23825363
  • Boucas J, Riabinska A, Jokic M, Herter-Sprie GS, Chen S, Höpker K, Reinhardt HC. Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response. Front Genet 2012; 3:159; http://dx.doi.org/10.3389/fgene.2012.00159; PMID: 22936947
  • Dutertre M, Sanchez G, Barbier J, Corcos L, Auboeuf D. The emerging role of pre-messenger RNA splicing in stress responses: sending alternative messages and silent messengers. RNA Biol 2011; 8:740 - 7; http://dx.doi.org/10.4161/rna.8.5.16016; PMID: 21712650
  • David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev 2010; 24:2343 - 64; http://dx.doi.org/10.1101/gad.1973010; PMID: 21041405
  • Venables JP. Unbalanced alternative splicing and its significance in cancer. Bioessays 2006; 28:378 - 86; http://dx.doi.org/10.1002/bies.20390; PMID: 16547952
  • Okoro DR, Rosso M, Bargonetti J. Splicing up mdm2 for cancer proteome diversity. Genes Cancer 2012; 3:311 - 9; http://dx.doi.org/10.1177/1947601912455323; PMID: 23150764
  • Bartel F, Harris LC, Würl P, Taubert H. MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides. Mol Cancer Res 2004; 2:29 - 35; PMID: 14757843
  • Matsumoto R, Tada M, Nozaki M, Zhang CL, Sawamura Y, Abe H. Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms. Cancer Res 1998; 58:609 - 13; PMID: 9485008
  • Sigalas I, Calvert AH, Anderson JJ, Neal DE, Lunec J. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat Med 1996; 2:912 - 7; http://dx.doi.org/10.1038/nm0896-912; PMID: 8705862
  • Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007; 28:739 - 45; http://dx.doi.org/10.1016/j.molcel.2007.11.015; PMID: 18082599
  • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300:1542 - 8; http://dx.doi.org/10.1126/science.1083430; PMID: 12791985
  • Dellaire G, Bazett-Jones DP. Beyond repair foci: subnuclear domains and the cellular response to DNA damage. Cell Cycle 2007; 6:1864 - 72; http://dx.doi.org/10.4161/cc.6.15.4560; PMID: 17660715
  • Emmott E, Hiscox JA. Nucleolar targeting: the hub of the matter. EMBO Rep 2009; 10:231 - 8; http://dx.doi.org/10.1038/embor.2009.14; PMID: 19229283
  • Mayer C, Grummt I. Cellular stress and nucleolar function. Cell Cycle 2005; 4:1036 - 8; http://dx.doi.org/10.4161/cc.4.8.1925; PMID: 16205120
  • Spector DL, Lamond AI. Nuclear speckles. Cold Spring Harb Perspect Biol 2011; 3; http://dx.doi.org/10.1101/cshperspect.a000646; PMID: 20926517
  • Lamond AI, Spector DL. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 2003; 4:605 - 12; http://dx.doi.org/10.1038/nrm1172; PMID: 12923522
  • Sakashita E, Endo H. SR and SR-related proteins redistribute to segregated fibrillar components of nucleoli in a response to DNA damage. Nucleus 2010; 1:367 - 80; http://dx.doi.org/10.4161/nucl.1.4.12683; PMID: 21327085
  • Lin S, Xiao R, Sun P, Xu X, Fu XD. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell 2005; 20:413 - 25; http://dx.doi.org/10.1016/j.molcel.2005.09.015; PMID: 16285923
  • Misteli T. Cell biology of transcription and pre-mRNA splicing: nuclear architecture meets nuclear function. J Cell Sci 2000; 113:1841 - 9; PMID: 10806095
  • Ljungman M. The DNA damage response--repair or despair?. Environ Mol Mutagen 2010; 51:879 - 89; http://dx.doi.org/10.1002/em.20597; PMID: 20818630
  • Ljungman M. The transcription stress response. Cell Cycle 2007; 6:2252 - 7; http://dx.doi.org/10.4161/cc.6.18.4751; PMID: 17700065
  • Ljungman M, Zhang F, Chen F, Rainbow AJ, McKay BC. Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene 1999; 18:583 - 92; http://dx.doi.org/10.1038/sj.onc.1202356; PMID: 9989808
  • Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A 1985; 82:5328 - 31; http://dx.doi.org/10.1073/pnas.82.16.5328; PMID: 2410919
  • Weinmann R, Raskas HJ, Roeder RG. Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection. Proc Natl Acad Sci U S A 1974; 71:3426 - 39; http://dx.doi.org/10.1073/pnas.71.9.3426; PMID: 4530313
  • Bartel F, Taubert H, Harris LC. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2002; 2:9 - 15; http://dx.doi.org/10.1016/S1535-6108(02)00091-0; PMID: 12150820
  • Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Res 2006; 66:9502 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-05-4271; PMID: 17018606
  • Jeyaraj S, O’Brien DM, Chandler DS. MDM2 and MDM4 splicing: an integral part of the cancer spliceome. Front Biosci (Landmark Ed) 2009; 14:2647 - 56; http://dx.doi.org/10.2741/3402; PMID: 19273224
  • Dias CS, Liu Y, Yau A, Westrick L, Evans SC. Regulation of hdm2 by stress-induced hdm2alt1 in tumor and nontumorigenic cell lines correlating with p53 stability. Cancer Res 2006; 66:9467 - 73; http://dx.doi.org/10.1158/0008-5472.CAN-05-3013; PMID: 17018602
  • Jones SN, Hancock AR, Vogel H, Donehower LA, Bradley A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A 1998; 95:15608 - 12; http://dx.doi.org/10.1073/pnas.95.26.15608; PMID: 9861017
  • Manley JL, Tacke R. SR proteins and splicing control. Genes Dev 1996; 10:1569 - 79; http://dx.doi.org/10.1101/gad.10.13.1569; PMID: 8682289
  • Shin C, Manley JL. The SR protein SRp38 represses splicing in M phase cells. Cell 2002; 111:407 - 17; http://dx.doi.org/10.1016/S0092-8674(02)01038-3; PMID: 12419250
  • Werwein E, Dzuganova M, Usadel C, Klempnauer KH. B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. Cell Death Dis 2013; 4:e511; http://dx.doi.org/10.1038/cddis.2013.36; PMID: 23449447
  • Werwein E, Schmedt T, Hoffmann H, Usadel C, Obermann N, Singer JD, Klempnauer KH. B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1). Cell Cycle 2012; 11:4047 - 58; http://dx.doi.org/10.4161/cc.22386; PMID: 23032261
  • Campalans A, Amouroux R, Bravard A, Epe B, Radicella JP. UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles. J Cell Sci 2007; 120:23 - 32; http://dx.doi.org/10.1242/jcs.03312; PMID: 17148573
  • Lassègue B, Griendling KK. NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol 2010; 30:653 - 61; http://dx.doi.org/10.1161/ATVBAHA.108.181610; PMID: 19910640
  • Lehmann AR. Replication of damaged DNA by translesion synthesis in human cells. FEBS Lett 2005; 579:873 - 6; http://dx.doi.org/10.1016/j.febslet.2004.11.029; PMID: 15680966
  • Sage E, Girard PM, Francesconi S. Unravelling UVA-induced mutagenesis. Photochem Photobiol Sci 2012; 11:74 - 80; http://dx.doi.org/10.1039/c1pp05219e; PMID: 21901217
  • Ikehata H, Ono T. The mechanisms of UV mutagenesis. J Radiat Res 2011; 52:115 - 25; http://dx.doi.org/10.1269/jrr.10175; PMID: 21436607

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.