824
Views
11
CrossRef citations to date
0
Altmetric
Report

The aggregation and inheritance of damaged proteins determines cell fate during mitosis

&
Pages 1201-1207 | Received 16 Dec 2013, Accepted 04 Feb 2014, Published online: 11 Feb 2014

References

  • López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153:1194 - 217; http://dx.doi.org/10.1016/j.cell.2013.05.039; PMID: 23746838
  • Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, et al. Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. Am J Pathol 2012; 180:963 - 72; http://dx.doi.org/10.1016/j.ajpath.2011.11.012; PMID: 22210478
  • Kruegel U, Robison B, Dange T, Kahlert G, Delaney JR, Kotireddy S, Tsuchiya M, Tsuchiyama S, Murakami CJ, Schleit J, et al. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS Genet 2011; 7:e1002253; http://dx.doi.org/10.1371/journal.pgen.1002253; PMID: 21931558
  • Cohen A, Ross L, Nachman I, Bar-Nun S. Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays. PLoS One 2012; 7:e44785; http://dx.doi.org/10.1371/journal.pone.0044785; PMID: 22970306
  • Hipp MS, Patel CN, Bersuker K, Riley BE, Kaiser SE, Shaler TA, Brandeis M, Kopito RR. Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease. J Cell Biol 2012; 196:573 - 87; http://dx.doi.org/10.1083/jcb.201110093; PMID: 22371559
  • Gutekunst CA, Li SH, Yi H, Mulroy JS, Kuemmerle S, Jones R, Rye D, Ferrante RJ, Hersch SM, Li XJ. Nuclear and neuropil aggregates in Huntington’s disease: relationship to neuropathology. J Neurosci 1999; 19:2522 - 34; PMID: 10087066
  • Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ. Huntington aggregates may not predict neuronal death in Huntington’s disease. Ann Neurol 1999; 46:842 - 9; http://dx.doi.org/10.1002/1531-8249(199912)46:6<842::AID-ANA6>3.0.CO;2-O; PMID: 10589536
  • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004; 431:805 - 10; http://dx.doi.org/10.1038/nature02998; PMID: 15483602
  • Todd TW, Lim J. Aggregation formation in the polyglutamine diseases: protection at a cost?. Mol Cells 2013; 36:185 - 94; http://dx.doi.org/10.1007/s10059-013-0167-x; PMID: 23794019
  • Bufalino MR, DeVeale B, van der Kooy D. The asymmetric segregation of damaged proteins is stem cell-type dependent. J Cell Biol 2013; 201:523 - 30; http://dx.doi.org/10.1083/jcb.201207052; PMID: 23649805
  • Rujano MA, Bosveld F, Salomons FA, Dijk F, van Waarde MAWH, van der Want JJL, de Vos RAI, Brunt ER, Sibon OCM, Kampinga HH. Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes. PLoS Biol 2006; 4:e417; http://dx.doi.org/10.1371/journal.pbio.0040417; PMID: 17147470
  • Lindner AB, Madden R, Demarez A, Stewart EJ, Taddei F. Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation. Proc Natl Acad Sci U S A 2008; 105:3076 - 81; http://dx.doi.org/10.1073/pnas.0708931105; PMID: 18287048
  • Aguilaniu H, Gustafsson L, Rigoulet M, Nyström T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 2003; 299:1751 - 3; http://dx.doi.org/10.1126/science.1080418; PMID: 12610228
  • Fuentealba LC, Eivers E, Geissert D, Taelman V, De Robertis EM. Asymmetric mitosis: Unequal segregation of proteins destined for degradation. Proc Natl Acad Sci U S A 2008; 105:7732 - 7; http://dx.doi.org/10.1073/pnas.0803027105; PMID: 18511557
  • Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, et al. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A 2003; 100:5950 - 5; http://dx.doi.org/10.1073/pnas.2628045100; PMID: 12730384
  • Ramdzan YM, Polling S, Chia CPZ, Ng IHW, Ormsby AR, Croft NP, Purcell AW, Bogoyevitch MA, Ng DCH, Gleeson PA, et al. Tracking protein aggregation and mislocalization in cells with flow cytometry. Nat Methods 2012; 9:467 - 70; http://dx.doi.org/10.1038/nmeth.1930; PMID: 22426490
  • Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, et al. Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci 2006; 9:824 - 31; http://dx.doi.org/10.1038/nn1702; PMID: 16699508
  • Arrasate M, Finkbeiner S. Protein aggregates in Huntington’s disease. Exp Neurol 2012; 238:1 - 11; http://dx.doi.org/10.1016/j.expneurol.2011.12.013; PMID: 22200539
  • Das KP, Freudenrich TM, Mundy WR. Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures. Neurotoxicol Teratol 2004; 26:397 - 406; http://dx.doi.org/10.1016/j.ntt.2004.02.006; PMID: 15113601
  • Song C-Z, Bai Z-L, Song C-C, Wang Q-W. Aggregate formation of hepatitis B virus X protein affects cell cycle and apoptosis. World J Gastroenterol 2003; 9:1521 - 4; PMID: 12854155
  • Benn J, Schneider RJ. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc Natl Acad Sci U S A 1995; 92:11215 - 9; http://dx.doi.org/10.1073/pnas.92.24.11215; PMID: 7479968
  • Gil JM, Rego AC. Mechanisms of neurodegeneration in Huntington’s disease. Eur J Neurosci 2008; 27:2803 - 20; http://dx.doi.org/10.1111/j.1460-9568.2008.06310.x; PMID: 18588526
  • Waelter S, Boeddrich A, Lurz R, Scherzinger E, Lueder G, Lehrach H, Wanker EE. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol Biol Cell 2001; 12:1393 - 407; http://dx.doi.org/10.1091/mbc.12.5.1393; PMID: 11359930
  • Fenteany G, Schreiber SL. Lactacystin, proteasome function, and cell fate. J Biol Chem 1998; 273:8545 - 8; http://dx.doi.org/10.1074/jbc.273.15.8545; PMID: 9535824
  • Ito Y, Fukushima H, Katagiri T, Seo Y, Hirata S, Zhang M, Hosokawa R, Jimi E. Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads. Biochem Biophys Res Commun 2011; 407:225 - 9; http://dx.doi.org/10.1016/j.bbrc.2011.03.003; PMID: 21377449
  • Calegari F, Huttner WB. An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. J Cell Sci 2003; 116:4947 - 55; http://dx.doi.org/10.1242/jcs.00825; PMID: 14625388
  • Reed SI. Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nat Rev Mol Cell Biol 2003; 4:855 - 64; http://dx.doi.org/10.1038/nrm1246; PMID: 14625536
  • Essers MA, Trumpp A, Trumpp A. Targeting leukemic stem cells by breaking their dormancy. Mol Oncol 2010; 4:443 - 50; http://dx.doi.org/10.1016/j.molonc.2010.06.001; PMID: 20599449
  • Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice. Acta Neuropathol 2011; 121:487 - 98; http://dx.doi.org/10.1007/s00401-010-0788-5; PMID: 21161248
  • Luzio JP, Pryor PR, Bright NA. Lysosomes: fusion and function. Nat Rev Mol Cell Biol 2007; 8:622 - 32; http://dx.doi.org/10.1038/nrm2217; PMID: 17637737
  • Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O’Kane CJ, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36:585 - 95; http://dx.doi.org/10.1038/ng1362; PMID: 15146184
  • Leontieva OV, Lenzo F, Demidenko ZN, Blagosklonny MV. Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle 2012; 11:4642 - 9; http://dx.doi.org/10.4161/cc.22937; PMID: 23187803

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.