1,551
Views
32
CrossRef citations to date
0
Altmetric
Report

Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2

, , , , , , , , & show all
Pages 2248-2261 | Received 11 Apr 2014, Accepted 17 May 2014, Published online: 29 May 2014

References

  • Walczak CE, Cai S, Khodjakov A. Mechanisms of chromosome behaviour during mitosis. Nat Rev Mol Cell Biol 2010; 11:91 - 102; PMID: 20068571
  • Barros TP, Kinoshita K, Hyman AA, Raff JW. Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J Cell Biol 2005; 170:1039 - 46; http://dx.doi.org/10.1083/jcb.200504097; PMID: 16186253
  • Giet R, McLean D, Descamps S, Lee MJ, Raff JW, Prigent C, Glover DM. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J Cell Biol 2002; 156:437 - 51; http://dx.doi.org/10.1083/jcb.200108135; PMID: 11827981
  • Terada Y, Uetake Y, Kuriyama R. Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. J Cell Biol 2003; 162:757 - 63; http://dx.doi.org/10.1083/jcb.200305048; PMID: 12939255
  • Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K, et al. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 2007; 27:352 - 67; http://dx.doi.org/10.1128/MCB.00878-06; PMID: 17060449
  • Maxwell CA, Keats JJ, Crainie M, Sun X, Yen T, Shibuya E, Hendzel M, Chan G, Pilarski LM. RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol Biol Cell 2003; 14:2262 - 76; http://dx.doi.org/10.1091/mbc.E02-07-0377; PMID: 12808028
  • Maxwell CA, Keats JJ, Belch AR, Pilarski LM, Reiman T. Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. Cancer Res 2005; 65:850 - 60; PMID: 15705883
  • Tolg C, Hamilton SR, Morningstar L, Zhang J, Zhang S, Esguerra KV, Telmer PG, Luyt LG, Harrison R, McCarthy JB, et al. RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity. J Biol Chem 2010; 285:26461 - 74; http://dx.doi.org/10.1074/jbc.M110.121491; PMID: 20558733
  • Dunsch AK, Hammond D, Lloyd J, Schermelleh L, Gruneberg U, Barr FA. Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. J Cell Biol 2012; 198:1039 - 54; http://dx.doi.org/10.1083/jcb.201202112; PMID: 22965910
  • Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol 2004; 14:1801 - 11; http://dx.doi.org/10.1016/j.cub.2004.10.002; PMID: 15498487
  • Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006; 127:539 - 52; http://dx.doi.org/10.1016/j.cell.2006.08.053; PMID: 17081976
  • Wittmann T, Boleti H, Antony C, Karsenti E, Vernos I. Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J Cell Biol 1998; 143:673 - 85; http://dx.doi.org/10.1083/jcb.143.3.673; PMID: 9813089
  • Bayliss R, Sardon T, Vernos I, Conti E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell 2003; 12:851 - 62; http://dx.doi.org/10.1016/S1097-2765(03)00392-7; PMID: 14580337
  • Dodson CA, Bayliss R. Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic. J Biol Chem 2012; 287:1150 - 7; http://dx.doi.org/10.1074/jbc.M111.312090; PMID: 22094468
  • Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet 2007; 39:1338 - 49; http://dx.doi.org/10.1038/ng.2007.2; PMID: 17922014
  • Katayama H, Sasai K, Kloc M, Brinkley BR, Sen S. Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle 2008; 7:2691 - 704; http://dx.doi.org/10.4161/cc.7.17.6460; PMID: 18773538
  • Booth DG, Hood FE, Prior IA, Royle SJA. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J 2011; 30:906 - 19; http://dx.doi.org/10.1038/emboj.2011.15; PMID: 21297582
  • Sankaran S, Crone DE, Palazzo RE, Parvin JD. Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res 2007; 67:11186 - 94; http://dx.doi.org/10.1158/0008-5472.CAN-07-2578; PMID: 18056443
  • Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD. Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol 2005; 25:8656 - 68; http://dx.doi.org/10.1128/MCB.25.19.8656-8668.2005; PMID: 16166645
  • Katayama H, Zhou H, Li Q, Tatsuka M, Sen S. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 2001; 276:46219 - 24; http://dx.doi.org/10.1074/jbc.M107540200; PMID: 11551964
  • Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003; 114:585 - 98; http://dx.doi.org/10.1016/S0092-8674(03)00642-1; PMID: 13678582
  • Hutterer A, Berdnik D, Wirtz-Peitz F, Zigman M, Schleiffer A, Knoblich JA. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell 2006; 11:147 - 57; http://dx.doi.org/10.1016/j.devcel.2006.06.002; PMID: 16890155
  • Eckerdt F, Pascreau G, Phistry M, Lewellyn AL, DePaoli-Roach AA, Maller JL. Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A. Cell Cycle 2009; 8:2413 - 9; http://dx.doi.org/10.4161/cc.8.15.9086; PMID: 19556869
  • Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell 2001; 104:83 - 93; http://dx.doi.org/10.1016/S0092-8674(01)00193-3; PMID: 11163242
  • Kalab P, Heald R. The RanGTP gradient - a GPS for the mitotic spindle. J Cell Sci 2008; 121:1577 - 86; http://dx.doi.org/10.1242/jcs.005959; PMID: 18469014
  • Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G. Control of Aurora-A stability through interaction with TPX2. J Cell Sci 2011; 124:113 - 22; http://dx.doi.org/10.1242/jcs.075457; PMID: 21147853
  • Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, Karsenti E, Vernos I. Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts. Mol Biol Cell 2004; 15:5318 - 28; http://dx.doi.org/10.1091/mbc.E04-05-0385; PMID: 15385625
  • Giesecke A, Stewart M. Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha. J Biol Chem 2010; 285:17628 - 35; http://dx.doi.org/10.1074/jbc.M110.102343; PMID: 20335181
  • Bird AW, Hyman AA. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol 2008; 182:289 - 300; http://dx.doi.org/10.1083/jcb.200802005; PMID: 18663142
  • Greenan G, Brangwynne CP, Jaensch S, Gharakhani J, Jülicher F, Hyman AA. Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos. Curr Biol 2010; 20:353 - 8; http://dx.doi.org/10.1016/j.cub.2009.12.050; PMID: 20137951
  • Liu D, Davydenko O, Lampson MA. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J Cell Biol 2012; 198:491 - 9; http://dx.doi.org/10.1083/jcb.201205090; PMID: 22908307
  • Bruinsma W, Macurek L, Freire R, Lindqvist A, Medema RH. Bora and Aurora-A continue to activate Plk1 in mitosis. J Cell Sci 2014; 127:801 - 11; http://dx.doi.org/10.1242/jcs.137216; PMID: 24338364
  • De Luca M, Lavia P, Guarguaglini G. A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle 2006; 5:296 - 303; http://dx.doi.org/10.4161/cc.5.3.2392; PMID: 16418575
  • Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 2008; 455:119 - 23; http://dx.doi.org/10.1038/nature07185; PMID: 18615013
  • Archambault V, Carmena M. Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?. Cell Cycle 2012; 11:1490 - 5; http://dx.doi.org/10.4161/cc.19724; PMID: 22433949
  • Neumann B, Walter T, Hériché JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Poser I, Held M, Liebel U, et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 2010; 464:721 - 7; http://dx.doi.org/10.1038/nature08869; PMID: 20360735
  • Sharp JA, Plant JJ, Ohsumi TK, Borowsky M, Blower MD. Functional analysis of the microtubule-interacting transcriptome. Mol Biol Cell 2011; 22:4312 - 23; http://dx.doi.org/10.1091/mbc.E11-07-0629; PMID: 21937723
  • Glover DM, Leibowitz MH, McLean DA, Parry H. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 1995; 81:95 - 105; http://dx.doi.org/10.1016/0092-8674(95)90374-7; PMID: 7720077
  • Song L, Rape M. Regulated degradation of spindle assembly factors by the anaphase-promoting complex. Mol Cell 2010; 38:369 - 82; http://dx.doi.org/10.1016/j.molcel.2010.02.038; PMID: 20471943
  • Stewart S, Fang G. Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol 2005; 25:10516 - 27; http://dx.doi.org/10.1128/MCB.25.23.10516-10527.2005; PMID: 16287863
  • Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, et al, HEBON, EMBRACE, SWE-BRCA, BCFR, GEMO Study Collaborators, kConFab. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol 2011; 9:e1001199; http://dx.doi.org/10.1371/journal.pbio.1001199; PMID: 22110403
  • Mohan P, Castellsague J, Jiang J, Allen K, Chen H, Nemirovsky O, Spyra M, Hu K, Kluwe L, Pujana MA, et al. Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition. Oncotarget 2013; 4:80 - 93; PMID: 23328114
  • Jiang J, Mohan P, Maxwell CA. The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells. PLoS One 2013; 8:e73548; http://dx.doi.org/10.1371/journal.pone.0073548; PMID: 24019927
  • Zeng K, Bastos RN, Barr FA, Gruneberg U. Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol 2010; 191:1315 - 32; http://dx.doi.org/10.1083/jcb.201008106; PMID: 21187329

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.