Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

References

• Revollo JR, Cidlowski JA. Mechanisms generating diversity in glucocorticoid receptor signaling. Ann N Y Acad Sci 2009; 1179:167 - 78; http://dx.doi.org/10.1111/j.1749-6632.2009.04986.x; PMID: 19906239
   PubMed Web of Science ®Google Scholar
• Ramamoorthy S, Cidlowski JA. Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance. Endocr Dev 2013; 24:41 - 56; http://dx.doi.org/10.1159/000342502; PMID: 23392094
   PubMedGoogle Scholar
• Sandri M. Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda) 2008; 23:160 - 70; http://dx.doi.org/10.1152/physiol.00041.2007; PMID: 18556469
   PubMed Web of Science ®Google Scholar
• Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117:399 - 412; http://dx.doi.org/10.1016/S0092-8674(04)00400-3; PMID: 15109499
   PubMed Web of Science ®Google Scholar
• Mammucari C, Schiaffino S, Sandri M. Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy 2008; 4:524 - 6; PMID: 18367868
   PubMed Web of Science ®Google Scholar
• Lynch GS, Schertzer JD, Ryall JG. Therapeutic approaches for muscle wasting disorders. Pharmacol Ther 2007; 113:461 - 87; http://dx.doi.org/10.1016/j.pharmthera.2006.11.004; PMID: 17258813
   PubMed Web of Science ®Google Scholar
• Wang X, Blagden C, Fan J, Nowak SJ, Taniuchi I, Littman DR, Burden SJ. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev 2005; 19:1715 - 22; http://dx.doi.org/10.1101/gad.1318305; PMID: 16024660
   PubMed Web of Science ®Google Scholar
• Dobrowolny G, Aucello M, Rizzuto E, Beccafico S, Mammucari C, Boncompagni S, Belia S, Wannenes F, Nicoletti C, Del Prete Z, et al. Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab 2008; 8:425 - 36; http://dx.doi.org/10.1016/j.cmet.2008.09.002; PMID: 19046573
   PubMed Web of Science ®Google Scholar
• Deval C, Mordier S, Obled C, Bechet D, Combaret L, Attaix D, Ferrara M. Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting. Biochem J 2001; 360:143 - 50; http://dx.doi.org/10.1042/0264-6021:3600143; PMID: 11696001
   PubMed Web of Science ®Google Scholar
• Lokireddy S, Wijesoma IW, Teng S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R. The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli. Cell Metab 2012; 16:613 - 24; http://dx.doi.org/10.1016/j.cmet.2012.10.005; PMID: 23140641
   PubMed Web of Science ®Google Scholar
• Yamamoto D, Maki T, Herningtyas EH, Ikeshita N, Shibahara H, Sugiyama Y, Nakanishi S, Iida K, Iguchi G, Takahashi Y, et al. Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats. Muscle Nerve 2010; 41:819 - 27; http://dx.doi.org/10.1002/mus.21621; PMID: 20169591
   PubMed Web of Science ®Google Scholar
• Lee SR, Kim HK, Song IS, Youm J, Dizon LA, Jeong SH, Ko TH, Heo HJ, Ko KS, Rhee BD, et al. Glucocorticoids and their receptors: insights into specific roles in mitochondria. Prog Biophys Mol Biol 2013; 112:44 - 54; http://dx.doi.org/10.1016/j.pbiomolbio.2013.04.001; PMID: 23603102
   PubMed Web of Science ®Google Scholar
• Verdejo HE, del Campo A, Troncoso R, Gutierrez T, Toro B, Quiroga C, Pedrozo Z, Munoz JP, Garcia L, Castro PF, et al. Mitochondria, myocardial remodeling, and cardiovascular disease. Curr Hypertens Rep 2012; 14:532 - 9; http://dx.doi.org/10.1007/s11906-012-0305-4; PMID: 22972531
   PubMed Web of Science ®Google Scholar
• Romanello V, Guadagnin E, Gomes L, Roder I, Sandri C, Petersen Y, Milan G, Masiero E, Del Piccolo P, Foretz M, et al. Mitochondrial fission and remodelling contributes to muscle atrophy. EMBO J 2010; 29:1774 - 85; http://dx.doi.org/10.1038/emboj.2010.60; PMID: 20400940
   PubMed Web of Science ®Google Scholar
• Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 2010; 141:280 - 9; http://dx.doi.org/10.1016/j.cell.2010.02.026; PMID: 20403324
   PubMed Web of Science ®Google Scholar
• Hernández-Alvarez MI, Paz JC, Sebastián D, Muñoz JP, Liesa M, Segalés J, Palacín M, Zorzano A. Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1. Antioxid Redox Signal 2013; 19:366 - 78; http://dx.doi.org/10.1089/ars.2011.4269; PMID: 22703557
   PubMed Web of Science ®Google Scholar
• Xia X, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald LF, Biswas SK, Lo WK, Jiang JX. Glucocorticoid-induced autophagy in osteocytes. J Bone Miner Res 2010; 25:2479 - 88; http://dx.doi.org/10.1002/jbmr.160; PMID: 20564240
   PubMed Web of Science ®Google Scholar
• Grandér D, Kharaziha P, Laane E, Pokrovskaja K, Panaretakis T. Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies. Autophagy 2009; 5:1198 - 200; http://dx.doi.org/10.4161/auto.5.8.10122; PMID: 19855186
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445 - 544; http://dx.doi.org/10.4161/auto.19496; PMID: 22966490
   PubMed Web of Science ®Google Scholar
• Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Cardiovascular autophagy: concepts, controversies, and perspectives. Autophagy 2013; 9:1455 - 66; http://dx.doi.org/10.4161/auto.25969; PMID: 23959233
   PubMed Web of Science ®Google Scholar
• Kadmiel M, Cidlowski JA. Glucocorticoid receptor signaling in health and disease. Trends Pharmacol Sci 2013; 34:518 - 30; http://dx.doi.org/10.1016/j.tips.2013.07.003; PMID: 23953592
   PubMed Web of Science ®Google Scholar
• Kewalramani G, Puthanveetil P, Wang F, Kim MS, Deppe S, Abrahani A, Luciani DS, Johnson JD, Rodrigues B. AMP-activated protein kinase confers protection against TNF-alpha-induced cardiac cell death. Cardiovasc Res 2009; 84:42 - 53; http://dx.doi.org/10.1093/cvr/cvp166; PMID: 19477967
   PubMed Web of Science ®Google Scholar
• del Campo A, Parra V, Vásquez-Trincado C, Gutiérrez T, Morales PE, López-Crisosto C, Bravo-Sagua R, Navarro-Marquez MF, Verdejo HE, Contreras-Ferrat A, et al. Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake. Am J Physiol Endocrinol Metab 2014; 306:E1 - 13; PMID: 24085037
   PubMedGoogle Scholar
• Chan DC. Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 2012; 46:265 - 87; http://dx.doi.org/10.1146/annurev-genet-110410-132529; PMID: 22934639
   PubMed Web of Science ®Google Scholar
• Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP. Glucocorticoid-induced skeletal muscle atrophy. Int J Biochem Cell Biol 2013; 45:2163 - 72; http://dx.doi.org/10.1016/j.biocel.2013.05.036; PMID: 23806868
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069 - 75; http://dx.doi.org/10.1038/nature06639; PMID: 18305538
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G. Autophagy in aging, disease and death: the true identity of a cell death impostor. Cell Death Differ 2009; 16:1 - 2; http://dx.doi.org/10.1038/cdd.2008.139; PMID: 19079285
   PubMed Web of Science ®Google Scholar
• Raben N, Wong A, Ralston E, Myerowitz R. Autophagy and mitochondria in Pompe disease: nothing is so new as what has long been forgotten. Am J Med Genet C Semin Med Genet 2012; 160C:13 - 21; http://dx.doi.org/10.1002/ajmg.c.31317; PMID: 22253254
   PubMed Web of Science ®Google Scholar
• Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, Mora M, Riggs JE, Oh SJ, Koga Y, et al. Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature 2000; 406:906 - 10; http://dx.doi.org/10.1038/35022604; PMID: 10972294
   PubMed Web of Science ®Google Scholar
• Suzuki T, Nakagawa M, Yoshikawa A, Sasagawa N, Yoshimori T, Ohsumi Y, Nishino I, Ishiura S, Nonaka I. The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem 2002; 131:647 - 51; http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003147; PMID: 11983070
   PubMed Web of Science ®Google Scholar
• Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, Metzger D, Reggiani C, Schiaffino S, Sandri M. Autophagy is required to maintain muscle mass. Cell Metab 2009; 10:507 - 15; http://dx.doi.org/10.1016/j.cmet.2009.10.008; PMID: 19945408
   PubMed Web of Science ®Google Scholar
• Buttgereit F, Krauss S, Brand MD. Methylprednisolone inhibits uptake of Ca2+ and Na+ ions into concanavalin A-stimulated thymocytes. Biochem J 1997; 326:329 - 32; PMID: 9291100
   PubMed Web of Science ®Google Scholar
• Croxtall JD, Choudhury Q, Flower RJ. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol 2000; 130:289 - 98; http://dx.doi.org/10.1038/sj.bjp.0703272; PMID: 10807665
   PubMed Web of Science ®Google Scholar
• Buttgereit F, Scheffold A. Rapid glucocorticoid effects on immune cells. Steroids 2002; 67:529 - 34; http://dx.doi.org/10.1016/S0039-128X(01)00171-4; PMID: 11960631
   PubMed Web of Science ®Google Scholar
• Buttgereit F, Wehling M, Burmester GR. A new hypothesis of modular glucocorticoid actions: steroid treatment of rheumatic diseases revisited. Arthritis Rheum 1998; 41:761 - 7; http://dx.doi.org/10.1002/1529-0131(199805)41:5<761::AID-ART2>3.0.CO;2-M; PMID: 9588727
   PubMed Web of Science ®Google Scholar
• Ayroldi E, Cannarile L, Migliorati G, Nocentini G, Delfino DV, Riccardi C. Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways. FASEB J 2012; 26:4805 - 20; http://dx.doi.org/10.1096/fj.12-216382; PMID: 22954589
   PubMed Web of Science ®Google Scholar
• Lee SR, Kim HK, Youm JB, Dizon LA, Song IS, Jeong SH, Seo DY, Ko KS, Rhee BD, Kim N, et al. Non-genomic effect of glucocorticoids on cardiovascular system. Pflugers Arch 2012; 464:549 - 59; http://dx.doi.org/10.1007/s00424-012-1155-2; PMID: 23001133
   PubMed Web of Science ®Google Scholar
• Bellavance MA, Rivest S. The neuroendocrine control of the innate immune system in health and brain diseases. Immunol Rev 2012; 248:36 - 55; http://dx.doi.org/10.1111/j.1600-065X.2012.01129.x; PMID: 22725953
   PubMed Web of Science ®Google Scholar
• Pérez MH, Cormack J, Mallinson D, Mutungi G. A membrane glucocorticoid receptor mediates the rapid/non-genomic actions of glucocorticoids in mammalian skeletal muscle fibres. J Physiol 2013; 591:5171 - 85; http://dx.doi.org/10.1113/jphysiol.2013.256586; PMID: 23878367
   PubMed Web of Science ®Google Scholar
• Nishimura M, Mikura M, Hirasaka K, Okumura Y, Nikawa T, Kawano Y, Nakayama M, Ikeda M. Effects of dimethyl sulphoxide and dexamethasone on mRNA expression of myogenesis- and muscle proteolytic system-related genes in mouse myoblastic C2C12 cells. J Biochem 2008; 144:717 - 24; http://dx.doi.org/10.1093/jb/mvn126; PMID: 18835828
   PubMed Web of Science ®Google Scholar
• Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol Endocrinol Metab 2008; 295:E785 - 97; http://dx.doi.org/10.1152/ajpendo.00646.2007; PMID: 18612045
   PubMed Web of Science ®Google Scholar
• Kuo T, Lew MJ, Mayba O, Harris CA, Speed TP, Wang JC. Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling. Proc Natl Acad Sci U S A 2012; 109:11160 - 5; http://dx.doi.org/10.1073/pnas.1111334109; PMID: 22733784
   PubMed Web of Science ®Google Scholar
• Yu CY, Mayba O, Lee JV, Tran J, Harris C, Speed TP, Wang JC. Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PLoS One 2010; 5:e15188; http://dx.doi.org/10.1371/journal.pone.0015188; PMID: 21187916
   PubMed Web of Science ®Google Scholar
• Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 2007; 6:472 - 83; http://dx.doi.org/10.1016/j.cmet.2007.11.004; PMID: 18054316
   PubMed Web of Science ®Google Scholar
• Dodson S, Baracos VE, Jatoi A, Evans WJ, Cella D, Dalton JT, Steiner MS. Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies. Annu Rev Med 2011; 62:265 - 79; http://dx.doi.org/10.1146/annurev-med-061509-131248; PMID: 20731602
   PubMed Web of Science ®Google Scholar
• Emery AE. The muscular dystrophies. Lancet 2002; 359:687 - 95; http://dx.doi.org/10.1016/S0140-6736(02)07815-7; PMID: 11879882
   PubMed Web of Science ®Google Scholar
• Evans WJ. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr 2010; 91:1123S - 7S; http://dx.doi.org/10.3945/ajcn.2010.28608A; PMID: 20164314
   PubMed Web of Science ®Google Scholar
• Lecker SH. Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?. Curr Opin Clin Nutr Metab Care 2003; 6:271 - 5; http://dx.doi.org/10.1097/01.mco.0000068963.34812.e5; PMID: 12690258
   PubMed Web of Science ®Google Scholar
• Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 2010; 142:270 - 83; http://dx.doi.org/10.1016/j.cell.2010.06.007; PMID: 20655468
   PubMed Web of Science ®Google Scholar
• Rambold AS, Lippincott-Schwartz J. Mechanisms of mitochondria and autophagy crosstalk. Cell Cycle 2011; 10:4032 - 8; http://dx.doi.org/10.4161/cc.10.23.18384; PMID: 22101267
   PubMed Web of Science ®Google Scholar
• Pi H, Xu S, Zhang L, Guo P, Li Y, Xie J, Tian L, He M, Lu Y, Li M, et al. Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium. Autophagy 2013; 9:1780 - 800; http://dx.doi.org/10.4161/auto.25665; PMID: 24121705
   PubMed Web of Science ®Google Scholar
• Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40:280 - 93; http://dx.doi.org/10.1016/j.molcel.2010.09.023; PMID: 20965422
   PubMed Web of Science ®Google Scholar
• East DA, Campanella M. Ca2+ in quality control: an unresolved riddle critical to autophagy and mitophagy. Autophagy 2013; 9:1710 - 9; http://dx.doi.org/10.4161/auto.25367; PMID: 24121708
   PubMed Web of Science ®Google Scholar
• Tiao G, Fagan J, Roegner V, Lieberman M, Wang JJ, Fischer JE, Hasselgren PO. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest 1996; 97:339 - 48; http://dx.doi.org/10.1172/JCI118421; PMID: 8567953
   PubMed Web of Science ®Google Scholar
• Fang CH, James HJ, Ogle C, Fischer JE, Hasselgren PO. Influence of burn injury on protein metabolism in different types of skeletal muscle and the role of glucocorticoids. J Am Coll Surg 1995; 180:33 - 42; PMID: 8000653
   PubMed Web of Science ®Google Scholar
• Hu Z, Wang H, Lee IH, Du J, Mitch WE. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest 2009; 119:3059 - 69; PMID: 19759515
   PubMed Web of Science ®Google Scholar
• Fitts RH, Romatowski JG, Peters JR, Paddon-Jones D, Wolfe RR, Ferrando AA. The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation. Am J Physiol Cell Physiol 2007; 293:C313 - 20; http://dx.doi.org/10.1152/ajpcell.00573.2006; PMID: 17409123
   PubMed Web of Science ®Google Scholar
• Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 2006; 17:1807 - 19; http://dx.doi.org/10.1681/ASN.2006010083; PMID: 16738015
   PubMed Web of Science ®Google Scholar
• Castillero E, Alamdari N, Lecker SH, Hasselgren PO. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism 2013; 62:1495 - 502; http://dx.doi.org/10.1016/j.metabol.2013.05.018; PMID: 23866982
   PubMed Web of Science ®Google Scholar
• Givvimani S, Munjal C, Tyagi N, Sen U, Metreveli N, Tyagi SC. Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure. PLoS One 2012; 7:e32388; http://dx.doi.org/10.1371/journal.pone.0032388; PMID: 22479323
   PubMedGoogle Scholar
• Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, Hausenloy DJ. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation 2010; 121:2012 - 22; http://dx.doi.org/10.1161/CIRCULATIONAHA.109.906610; PMID: 20421521
   PubMed Web of Science ®Google Scholar
• Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, Shen Y, Wang RR, Wang X, Hu WW, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy 2013; 9:1321 - 33; http://dx.doi.org/10.4161/auto.25132; PMID: 23800795
   PubMed Web of Science ®Google Scholar
• Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C, et al. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res 2008; 77:387 - 97; http://dx.doi.org/10.1093/cvr/cvm029; PMID: 18006463
   PubMed Web of Science ®Google Scholar
• Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, Del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, et al. Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res 2012; 93:320 - 9; http://dx.doi.org/10.1093/cvr/cvr321; PMID: 22135164
   PubMed Web of Science ®Google Scholar
• Munoz JP, Chiong M, García L, Troncoso R, Toro B, Pedrozo Z, Diaz-Elizondo J, Salas D, Parra V, Núñez MT, et al. Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide. Free Radic Biol Med 2010; 48:526 - 34; http://dx.doi.org/10.1016/j.freeradbiomed.2009.11.017; PMID: 19969068
   PubMed Web of Science ®Google Scholar
• Marambio P, Toro B, Sanhueza C, Troncoso R, Parra V, Verdejo H, García L, Quiroga C, Munafo D, Díaz-Elizondo J, et al. Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes. Biochim Biophys Acta 2010; 1802:509 - 18; http://dx.doi.org/10.1016/j.bbadis.2010.02.002; PMID: 20176105
   PubMed Web of Science ®Google Scholar
• Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, et al. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci 2011; 124:2143 - 52; http://dx.doi.org/10.1242/jcs.080762; PMID: 21628424
   PubMed Web of Science ®Google Scholar