APC/C-Cdh1

References

• Li M, Zhang P. The function of APC/CCdh1 in cell cycle and beyond. Cell Div 2009; 4:2
   PubMed Web of Science ®Google Scholar
• Peters JM. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 2006; 7:2 - 4
   Web of Science ®Google Scholar
• Visintin R, Prinz S, Amon A. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis. Science 1997; 278:460 - 463
   PubMed Web of Science ®Google Scholar
• Fang G, Yu H, Kirschner MW. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell 1998; 2:163 - 171
   PubMed Web of Science ®Google Scholar
• Lorca T, Castro A, Martinez AM, Vigneron S, Morin N, Sigrist S, et al. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts. EMBO J 1998; 17:3565 - 3575
   PubMed Web of Science ®Google Scholar
• Wasch R, Robbins JA, Cross FR. The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. Oncogene 2010; 29:1 - 10
   PubMed Web of Science ®Google Scholar
• Zhang L, Park CH, Wu J, Kim H, Liu W, Fujita T, et al. Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. EMBO J 2010; 29:1726 - 1737
   PubMed Web of Science ®Google Scholar
• Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, et al. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell 2009; 20:3305 - 3316
   PubMed Web of Science ®Google Scholar
• Ke PY, Kuo YY, Hu CM, Chang ZF. Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability. Genes Dev 2005; 19:1920 - 1933
   PubMed Web of Science ®Google Scholar
• Chabes AL, Pfleger CM, Kirschner MW, Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci USA 2003; 100:3925 - 3929
   PubMed Web of Science ®Google Scholar
• Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 2008; 134:256 - 267
   PubMed Web of Science ®Google Scholar
• Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, Pellman D. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 1997; 275:1311 - 1314
   PubMed Web of Science ®Google Scholar
• Taylor S, Peters JM. Polo and Aurora kinases: Lessons derived from chemical biology. Curr Opin Cell Biol 2008; 20:77 - 84
   PubMed Web of Science ®Google Scholar
• Li W, Wu G, Wan Y. The dual effects of Cdh1/APC in myogenesis. FASEB J 2007; 21:3606 - 3617
   PubMed Web of Science ®Google Scholar
• Garcia-Higuera I, Manchado E, Dubus P, Canamero M, Mendez J, Moreno S, et al. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 2008; 10:802 - 811
   PubMed Web of Science ®Google Scholar
• Engelbert D, Schnerch D, Baumgarten A, Wasch R. The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. Oncogene 2008; 27:907 - 917
   PubMed Web of Science ®Google Scholar
• Rudner AD, Murray AW. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J Cell Biol 2000; 149:1377 - 1390
   PubMed Web of Science ®Google Scholar
• Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007; 8:379 - 393
   PubMed Web of Science ®Google Scholar
• Pesin JA, Orr-Weaver TL. Regulation of APC/C activators in mitosis and meiosis. Annu Rev Cell Dev Biol 2008; 24:475 - 499
   PubMed Web of Science ®Google Scholar
• Crasta K, Lim HH, Giddings TH Jr, Winey M, Surana U. Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle. Nat Cell Biol 2008; 10:665 - 675
   PubMed Web of Science ®Google Scholar
• Zachariae W, Schwab M, Nasmyth K, Seufert W. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 1998; 282:1721 - 1724
   PubMed Web of Science ®Google Scholar
• Pfleger CM, Kirschner MW. The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev 2000; 14:655 - 665
   PubMed Web of Science ®Google Scholar
• Zhao WM, Fang G. Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis. J Biol Chem 2005; 280:33516 - 33524
   PubMed Web of Science ®Google Scholar
• Stewart S, Fang G. Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol 2005; 25:10516 - 10527
   PubMed Web of Science ®Google Scholar
• Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr. Degradation of the SCF component Skp2 in cell cycle phase G1 by the anaphase-promoting complex. Nature 2004; 428:194 - 198
   PubMed Web of Science ®Google Scholar
• Li M, Shin YH, Hou L, Huang X, Wei Z, Klann E, et al. The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol 2008; 10:1083 - 1089
   PubMed Web of Science ®Google Scholar
• Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell 2003; 113:101 - 113
   PubMed Web of Science ®Google Scholar
• Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 1999; 9:661 - 664
   PubMed Web of Science ®Google Scholar
• Albanese C, Johnson J, Watanabe G, Eklund N, Vu D, Arnold A, et al. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 1995; 270:23589 - 23597
   PubMed Web of Science ®Google Scholar
• Diffley JF. Regulation of early events in chromosome replication. Curr Biol 2004; 14:778 - 786
   PubMed Web of Science ®Google Scholar
• McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 1998; 93:1043 - 1053
   PubMed Web of Science ®Google Scholar
• Petersen BO, Wagener C, Marinoni F, Kramer ER, Melixetian M, Lazzerini Denchi E, et al. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev 2000; 14:2330 - 2343
   PubMed Web of Science ®Google Scholar
• Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J. Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Mol Cell Biol 2000; 20:7613 - 7623
   PubMed Web of Science ®Google Scholar
• Hsu JY, Reimann JD, Sorensen CS, Lukas J, Jackson PK. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol 2002; 4:358 - 366
   PubMed Web of Science ®Google Scholar
• Grosskortenhaus R, Sprenger F. Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev Cell 2002; 2:29 - 40
   PubMed Web of Science ®Google Scholar
• Lukas C, Sorensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters JM, et al. Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 1999; 401:815 - 818
   PubMed Web of Science ®Google Scholar
• Benmaamar R, Pagano M. Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle 2005; 4:1230 - 1232
   PubMed Web of Science ®Google Scholar
• Rape M, Kirschner MW. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 2004; 432:588 - 595
   PubMed Web of Science ®Google Scholar
• Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell 2006; 124:89 - 103
   PubMed Web of Science ®Google Scholar
• Huang X, Tran T, Zhang L, Hatcher R, Zhang P. DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci USA 2005; 102:1065 - 1070
   PubMed Web of Science ®Google Scholar
• Liu W, Li W, Fujita T, Yang Q, Wan Y. Proteolysis of CDH1 enhances susceptibility to UV radiation-induced apoptosis. Carcinogenesis 2008; 29:263 - 272
   PubMed Web of Science ®Google Scholar
• Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, et al. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell 2006; 23:331 - 341
   PubMed Web of Science ®Google Scholar
• Chini CC, Chen J. Claspin a regulator of Chk1 in DNA replication stress pathway. DNA Repair 2004; 3:1033 - 1037
   PubMed Web of Science ®Google Scholar
• Vaziri C, Saxena S, Jeon Y, Lee C, Murata K, Machida Y, et al. A p53-dependent checkpoint pathway prevents rereplication. Mol Cell 2003; 11:997 - 1008
   PubMed Web of Science ®Google Scholar
• Ekholm-Reed S, Mendez J, Tedesco D, Zetterberg A, Stillman B, Reed SI. Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol 2004; 165:789 - 800
   PubMed Web of Science ®Google Scholar
• Wiebusch L, Hagemeier C. p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress. Oncogene 2010; 29:3477 - 3489
   PubMed Web of Science ®Google Scholar
• Jeganathan KB, Malureanu L, van Deursen JM. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature 2005; 438:1036 - 1039
   PubMed Web of Science ®Google Scholar
• Karamysheva Z, Diaz-Martinez LA, Crow SE, Li B, Yu H. Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. J Biol Chem 2009; 284:1772 - 1780
   PubMed Web of Science ®Google Scholar
• Jeganathan KB, Baker DJ, van Deursen JM. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle 2006; 5:366 - 370
   PubMed Web of Science ®Google Scholar
• Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 2006; 38:1043 - 1048
   PubMed Web of Science ®Google Scholar
• Davoli T, Denchi EL, de Lange T. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 2010; 141:81 - 93
   PubMed Web of Science ®Google Scholar
• Wan Y, Liu X, Kirschner MW. The anaphase-promoting complex mediates TGFbeta signaling by targeting SnoN for destruction. Mol Cell 2001; 8:1027 - 1039
   PubMed Web of Science ®Google Scholar
• Stroschein SL, Bonni S, Wrana JL, Luo K. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev 2001; 15:2822 - 2836
   PubMed Web of Science ®Google Scholar
• Liu W, Wu G, Li W, Lobur D, Wan Y. Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition. Mol Cell Biol 2007; 27:2967 - 2979
   PubMed Web of Science ®Google Scholar
• Schaeffer V, Althauser C, Shcherbata HR, Deng WM, Ruohola-Baker H. Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. Curr Biol 2004; 14:630 - 636
   PubMed Web of Science ®Google Scholar
• Gutierrez GJ, Tsuji T, Chen M, Jiang W, Ronai ZA. Interplay between Cdh1 and JNK activity during the cell cycle. Nat Cell Biol 2010; 12:686 - 695
   PubMed Web of Science ®Google Scholar
• Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88:593 - 602
   PubMed Web of Science ®Google Scholar
• Wang CX, Fisk BC, Wadehra M, Su H, Braun J. Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth. Blood 2000; 96:259 - 263
   PubMed Web of Science ®Google Scholar
• Maestre C, Delgado-Esteban M, Gomez-Sanchez JC, Bolanos JP, Almeida A. Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. EMBO J 2008; 27:2736 - 2745
   PubMed Web of Science ®Google Scholar
• Bolanos JP, Almeida A, Moncada S. Glycolysis: A bioenergetic or a survival pathway?. Trends Biochem Sci 2010; 35:145 - 149
   PubMed Web of Science ®Google Scholar
• Wirth KG, Ricci R, Gimenez-Abian JF, Taghybeeglu S, Kudo NR, Jochum W, et al. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev 2004; 18:88 - 98
   PubMed Web of Science ®Google Scholar
• Stegmuller J, Huynh MA, Yuan Z, Konishi Y, Bonni A. TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis. J Neurosci 2008; 28:1961 - 1969
   PubMed Web of Science ®Google Scholar
• Wu G, Glickstein S, Liu W, Fujita T, Li W, Yang Q, et al. The anaphase-promoting complex coordinates initiation of lens differentiation. Mol Biol Cell 2007; 18:1018 - 1029
   PubMed Web of Science ®Google Scholar
• Cuende J, Moreno S, Bolanos JP, Almeida A. Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. Oncogene 2008; 27:3339 - 3344
   PubMed Web of Science ®Google Scholar
• Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 2005; 5:603 - 614
   PubMed Web of Science ®Google Scholar
• Lasorella A, Stegmuller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, et al. Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature 2006; 442:471 - 474
   PubMed Web of Science ®Google Scholar
• Fujita T, Liu W, Doihara H, Wan Y. An in vivo study of Cdh1/APC in breast cancer formation. Int J Cancer 2009; 125:826 - 836
   PubMed Web of Science ®Google Scholar
• Fujita T, Liu W, Doihara H, Date H, Wan Y. Dissection of the APCCdh1-Skp2 cascade in breast cancer. Clin Cancer Res 2008; 14:1966 - 1975
   PubMed Web of Science ®Google Scholar
• Fujita T, Liu W, Doihara H, Wan Y. Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis. Am J Pathol 2008; 173:217 - 228
   PubMed Web of Science ®Google Scholar
• Lwin T, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, et al. Cell adhesion induces p27Kip1-associated cell cycle arrest through downregulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Blood 2007; 110:1631 - 1638
   PubMed Web of Science ®Google Scholar
• Jaquenoud M, van Drogen F, Peter M. Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1). EMBO J 2002; 21:6515 - 6526
   PubMed Web of Science ®Google Scholar
• Hall MC, Warren EN, Borchers CH. Multi-kinase phosphorylation of the APC/C activator Cdh1 revealed by mass spectrometry. Cell Cycle 2004; 3:1278 - 1284
   PubMed Web of Science ®Google Scholar
• Gao D, Inuzuka H, Tseng A, Wei W. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Div 2009; 4:11
   PubMed Web of Science ®Google Scholar
• Kitajima S, Kudo Y, Ogawa I, Tatsuka M, Kawai H, Pagano M, et al. Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PLoS One 2007; 2:e944
   PubMed Web of Science ®Google Scholar
• Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC. Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. Cell Cycle 2006; 5:2676 - 2687
   PubMed Web of Science ®Google Scholar