Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12

References

• Passos JF, Simillion C, Hallinan J, Wipat A, von Zglinicki T. Cellular senescence: Unravelling complexity. Age (Dordr) 2009; 31:353 - 363
   PubMed Web of Science ®Google Scholar
• Caino MC, Meshki J, Kazanietz MG. Hallmarks for senescence in carcinogenesis: Novel signaling players. Apoptosis 2009; 14:392 - 408
   PubMed Web of Science ®Google Scholar
• Ben Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005; 37:961 - 976
   PubMed Web of Science ®Google Scholar
• Gelman IH. The role of the SSeCKS/Gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development. Front Biosci 2002; 7:1782 - 1797
   Web of Science ®Google Scholar
• Lin X, Nelson PJ, Frankfort B, Tombler E, Johnson R, Gelman IH. Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol 1995; 15:2754 - 2762
   PubMed Web of Science ®Google Scholar
• Lin X, Tombler E, Nelson PJ, Ross M, Gelman IH. A novel src- and ras-suppressed protein kinase C substrate associated with cytoskeletal architecture. J Biol Chem 1996; 271:28
   Google Scholar
• Chapline C, Mousseau B, Ramsay K, Duddy S, Li Y, Kiley SC, et al. Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts—Decreased expression in transformed cells. J Biol Chem 1996; 271:6417 - 6422
   PubMed Web of Science ®Google Scholar
• Chapline C, Cottom J, Tobin H, Hulmes J, Crabb J, Jaken S. A major, transformation-sensitive PKC-binding protein is also a PKC substrate involved in cytoskeletal remodeling. J Biol Chem 1998; 273:19482 - 19489
   PubMed Web of Science ®Google Scholar
• Nauert J, Klauck T, Langeberg LK, Scott JD. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffolding protein. Current Biology 1997; 7:52 - 62
   PubMed Web of Science ®Google Scholar
• Tchernitsa OI, Zuber J, Sers C, Brinckmann R, Britsch SK, Adams V, et al. Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators. Oncogene 1999; 18:5448 - 5454
   PubMed Web of Science ®Google Scholar
• Lin X, Gelman IH. Calmodulin and cyclin D anchoring sites on the Src-Suppressed C Kinase Substrate, SSeCKS. Biochem Biophys Res Commun 2002; 290:1368 - 1375
   PubMed Web of Science ®Google Scholar
• Su B, Bu Y, Engelberg D, Gelman IH. SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a PKC-RAF/MEK/ERK pathway. J Biol Chem 2010; 285:4578 - 4586
   PubMed Web of Science ®Google Scholar
• Piontek J, Brandt R. Differential and regulated binding of PKA and PKC isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization of kinases during neuronal development. J Biol Chem 2003; 278:38970 - 38979
   PubMed Web of Science ®Google Scholar
• Tao J, Wang HY, Malbon CC. Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor. EMBO J 2003; 22:6419 - 6429
   PubMed Web of Science ®Google Scholar
• Akakura S, Huang C, Nelson PJ, Foster B, Gelman IH. Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia. Cancer Res 2008; 68:5096 - 5103
   PubMed Web of Science ®Google Scholar
• Lin X, Nelson P, Gelman IH. Regulation of G→S Progression by the SSeCKS tumor suppressor: Control of cyclin D expression and cellular compartmentalization. Mol Cell Biol 2000; 20:7259 - 7272
   PubMed Web of Science ®Google Scholar
• Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005; 436:725 - 730
   PubMed Web of Science ®Google Scholar
• Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92:9363 - 9367
   PubMed Web of Science ®Google Scholar
• Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004; 36:744 - 749
   PubMed Web of Science ®Google Scholar
• Nelson PJ, Moissoglu K, Vargas JJ, Klotman PE, Gelman IH. Involvement of the protein kinase C substrate, SSeCKS, in the actin-based stellate morphology of mesangial cells. J Cell Sci 1999; 112:361 - 370
   PubMed Web of Science ®Google Scholar
• Campisi J, d'Adda dF. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8:729 - 740
   PubMed Web of Science ®Google Scholar
• Hinds PW, Weinberg RA. Tumor Suppressor Genes. Curr Opin Genet Dev 1994; 4:135 - 141
   PubMed Web of Science ®Google Scholar
• Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW. Implications of cellular senescence in tissue damage response, tumor suppression and stem cell biology. Cold Spring Harb Symp Quant Biol 2008; 73:513 - 522
   PubMedGoogle Scholar
• Funk JO, Waga S, Harry JB, Espling E, Stillman B, Galloway DA. Inhibition of CDK activity and PCNAdependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev 1997; 11:2090 - 2100
   PubMed Web of Science ®Google Scholar
• Grove BD, Bruchey AK. Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells. J Vasc Res 2001; 38:163 - 175
   PubMed Web of Science ®Google Scholar
• Ohtani N, Yamakoshi K, Takahashi A, Hara E. The p16Ink4a-RB pathway: Molecular link between cellular senescence and tumor suppression. J Med Invest 2004; 51:146 - 153
   PubMedGoogle Scholar
• Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, et al. Opposing effects of Ets and Id proteins on p16Ink4a expression during cellular senescence. Nature 2001; 409:1067 - 1070
   PubMed Web of Science ®Google Scholar
• Ushio K, Hashimoto T, Kitamura N, Tanaka T. Id1 is downregulated by hepatocyte growth factor via ERK-dependent and ERK-independent signaling pathways, leading to increased expression of p16Ink4a in hepatoma cells. Mol Cancer Res 2009; 7:1179 - 1188
   PubMed Web of Science ®Google Scholar
• Bothos J, Tuttle RL, Ottey M, Luca FC, Halazonetis TD. Human LATS1 is a mitotic exit network kinase. Cancer Res 2005; 65:6568 - 6575
   PubMed Web of Science ®Google Scholar
• Yang X, Yu K, Hao Y, Li DM, Stewart R, Insogna KL, et al. LATS1 tumor suppressor affects cytokinesis by inhibiting LIMK1. Nat Cell Biol 2004; 6:609 - 617
   PubMed Web of Science ®Google Scholar
• Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, et al. Mitogenic signalling and the p16Ink4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 2006; 8:1291 - 1297
   PubMed Web of Science ®Google Scholar
• Fridman AL, Tainsky MA. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene 2008; 27:5975 - 5987
   PubMed Web of Science ®Google Scholar
• Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, et al. Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem 2008; 283:27957 - 27972
   PubMed Web of Science ®Google Scholar
• Larochelle DA, Vithalani KK, De Lozanne A. A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. J Cell Biol 1996; 133:1321 - 1329
   PubMed Web of Science ®Google Scholar
• Saito S, Tatsumoto T, Lorenzi MV, Chedid M, Kapoor V, Sakata H, et al. Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. J Cell Biochem 2003; 90:819 - 836
   PubMed Web of Science ®Google Scholar
• Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ. The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol 2008; 10:891 - 901
   PubMed Web of Science ®Google Scholar
• Gelman IH, Lee K, Tombler E, Gordon R, Lin X. Control of cytoskeletal architecture by the src-suppressed C kinase substrate, SSeCKS. Cell Motil Cytoskeleton 1998; 41:1 - 17
   PubMed Web of Science ®Google Scholar
• Gelman IH, Gao L. The SSeCKS/Gravin/AKAP12 metastasis suppressor inhibits podosome formation via rhoA- and Cdc42-dependent pathways. Molecular Cancer Research 2006; 4:151 - 158
   PubMed Web of Science ®Google Scholar
• Xia W, Gelman IH. Mitogen- and FAK-regulated tyrosine phosphorylation of the SSeCKS scaffolding protein modulates its actin-binding properties. Exp Cell Res 2002; 277:139 - 151
   PubMed Web of Science ®Google Scholar
• Choi MC, Lee YU, Kim SH, Park JH, Kim HA, Oh DY, et al. A-kinase anchoring protein 12 regulates the completion of cytokinesis. Biochem Biophys Res Commun 2008; 373:85 - 89
   PubMed Web of Science ®Google Scholar
• Takahashi A, Ohtani N, Hara E. Irreversibility of cellular senescence: Dual roles of p16Ink4a/Rb-pathway in cell cycle control. Cell Div 2007; 2:10
   PubMed Web of Science ®Google Scholar
• Swift S, Lorens J, Achacoso P, Nolan GP. Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems. Curr Protoc Immunol 2001; 10:17; PMID: 18432682
   PubMedGoogle Scholar
• Morgenstern JP, Land H. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper- free packaging cell line. Nucl Acids Res 1990; 18:3587 - 3596
   PubMed Web of Science ®Google Scholar
• Su B, Zheng Q, Vaughan MM, Bu Y, Gelman IH. SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with VEGF inhibition. Cancer Res 2006; 66:5599 - 5607
   PubMed Web of Science ®Google Scholar
• Moissoglu K, Sachdev S, Gelman IH. Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by phosphatidylinositol 3-kinase. Biochem Biophys Res Commun 2005; 330:673 - 684
   PubMed Web of Science ®Google Scholar
• Bihani T, Chicas A, Lo CP, Lin AW. Dissecting the senescence-like program in tumor cells activated by Ras signaling. J Biol Chem 2007; 282:2666 - 2675
   PubMed Web of Science ®Google Scholar
• Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 2002; 22:2111 - 2123
   PubMed Web of Science ®Google Scholar
• Iwabu A, Smith K, Allen FD, Lauffenburger DA, Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C deltadependent pathway. J Biol Chem 2004; 279:14551 - 14560
   PubMed Web of Science ®Google Scholar
• Hazeki K, Inoue K, Nigorikawa K, Hazeki O. Negative regulation of class IA phosphoinositide 3-kinase by protein kinase Cdelta Limits Fcgamma receptor-mediated phagocytosis in macrophages. J Biochem 2009; 145:87 - 94
   PubMed Web of Science ®Google Scholar
• Gelman IH, Tombler E, Vargas J Jr. A role for SSeCKS, a major protein kinase C substrate with tumor suppressor activity, in cytoskeletal architecture, formation of migratory processes and cell migration during embryogenesis. Histochem J 2000; 32:13 - 26
   PubMedGoogle Scholar
• Matsui S, Yoshida H, Weinfeld H, Sandberg AA. Induction of prophase in interphase nuclei by fusion with metaphase cells. J Cell Biol 1972; 54:120 - 132
   PubMed Web of Science ®Google Scholar
• Karpf AR, Matsui S. Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 2005; 65:8635 - 8639
   PubMed Web of Science ®Google Scholar
• Rodriguez EM, Dunham EE, Martin GS. Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells. J Cell Physiol 2009; 221:171 - 182
   PubMed Web of Science ®Google Scholar