Female infertility in PDE3A^-/- mice

References

• Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annu Rev Biochem 2007; 76:481 - 511
   PubMed Web of Science ®Google Scholar
• Thompson PE, Manganiello V, Degerman E. Re-discovering PDE3 inhibitors—new opportunities for a long neglected target. Curr Top Med Chem 2007; 7:421 - 436
   PubMed Web of Science ®Google Scholar
• Sun QY, Miao YL, Schatten H. Towards a new understanding on the regulation of mammalian oocyte meiosis resumption. Cell Cycle 2009; 8:2741 - 2747
   PubMed Web of Science ®Google Scholar
• Conti M. Signaling networks in somatic cells and oocytes activated during ovulation. Ann Endocrinol (Paris) 2010; 71:189 - 190
   PubMed Web of Science ®Google Scholar
• Dekel N. Cellular, biochemical and molecular mechanisms regulating oocyte maturation. Mol Cell Endocrinol 2005; 234:19 - 25
   PubMed Web of Science ®Google Scholar
• Han SJ, Conti M. New pathways from PKA to the Cdc2/cyclin B complex in oocytes: Wee1B as a potential PKA substrate. Cell Cycle 2006; 5:227 - 231
   PubMed Web of Science ®Google Scholar
• Duckworth BC, Weaver JS, Ruderman JV. G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. Proc Natl Acad Sci USA 2002; 99:16794 - 16799
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang Z, Xu XY, Li XS, Yu M, Yu AM, et al. Protein kinase A modulates Cdc25B activity during meiotic resumption of mouse oocytes. Dev Dyn 2008; 237:3777 - 3786
   PubMed Web of Science ®Google Scholar
• Pirino G, Wescott MP, Donovan PJ. Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle 2009; 8:665 - 670
   PubMed Web of Science ®Google Scholar
• Han SJ, Chen R, Paronetto MP, Conti M. Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol 2005; 15:1670 - 1676
   PubMed Web of Science ®Google Scholar
• Norris RP, Ratzan WJ, Freudzon M, Mehlmann LM, Krall J, Movsesian MA, et al. Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development 2009; 136:1869 - 1878
   PubMed Web of Science ®Google Scholar
• Vaccari S, Weeks JL 2nd, Hsieh M, Menniti FS, Conti M. Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes. Biol Reprod 2009; 81:595 - 604
   PubMed Web of Science ®Google Scholar
• Shitsukawa K, Andersen CB, Richard FJ, Horner AK, Wiersma A, van Duin M, et al. Cloning and characterization of the cyclic guanosine monophosphate-inhibited phosphodiesterase PDE3A expressed in mouse oocyte. Biol Reprod 2001; 65:188 - 196
   PubMed Web of Science ®Google Scholar
• Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, et al. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J Clin Invest 2004; 114:196 - 205
   PubMed Web of Science ®Google Scholar
• Richard FJ, Tsafriri A, Conti M. Role of phosphodiesterase type 3A in rat oocyte maturation. Biol Reprod 2001; 65:1444 - 1451
   PubMed Web of Science ®Google Scholar
• Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell Cycle 1991; 64:1111 - 1122
   Google Scholar
• Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 1992; 257:1955 - 1957
   PubMed Web of Science ®Google Scholar
• Mueller PR, Coleman TR, Kumagai A, Dunphy WG. Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 1995; 270:86 - 90
   PubMed Web of Science ®Google Scholar
• Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. J Cell Sci 1999; 112:3361 - 3371
   PubMed Web of Science ®Google Scholar
• Fesquet D, Labbé JC, Derancourt J, Capony JP, Galas S, Girard F, et al. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J 1993; 12:3111 - 3121
   PubMed Web of Science ®Google Scholar
• Solomon MJ, Harper JW, Shuttleworth J. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J 1993; 12:3133 - 3142
   PubMed Web of Science ®Google Scholar
• Karlsson-Rosenthal C, Millar JB. Cdc25: Mechanisms of checkpoint inhibition and recovery. Trends Cell Biol 2006; 16:285 - 292
   PubMed Web of Science ®Google Scholar
• Boutros R, Dozier C, Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol 2006; 18:185 - 191
   PubMed Web of Science ®Google Scholar
• Lincoln AJ, Wickramasinghe D, Stein P, Schultz RM, Palko ME, De Miguel MP, et al. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet 2002; 30:446 - 449
   PubMed Web of Science ®Google Scholar
• Solc P, Saskova A, Baran V, Kubelka M, Schultz RM, Motlik J. CDC25A phosphatase controls meiosis I progression in mouse oocytes. Dev Biol 2008; 317:260 - 269
   PubMed Web of Science ®Google Scholar
• Oh JS, Han SJ, Conti M. Wee1B, Myt1 and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol 2010; 188:199 - 207
   PubMed Web of Science ®Google Scholar
• Archambault V, Glover DM. Polo-like kinases: Conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol 2009; 10:265 - 275
   PubMed Web of Science ®Google Scholar
• Barr FA, Silljé HH, Nigg EA. Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 2004; 5:429 - 440
   PubMed Web of Science ®Google Scholar
• Kishimoto T. Cell cycle control during meiotic maturation. Curr Opin Cell Biol 2003; 15:654 - 663
   PubMed Web of Science ®Google Scholar
• Lobjois V, Jullien D, Bouché JP, Ducommun B. The polo-like kinase 1 regulates CDC25B-dependent mitosis entry. Biochim Biophys Acta 2009; 1793:462 - 468
   PubMed Web of Science ®Google Scholar
• Roshak AK, Capper EA, Imburgia C, Fornwald J, Scott G, Marshall LA. The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal 2000; 12:405 - 411
   PubMed Web of Science ®Google Scholar
• Qian YW, Erikson E, Taieb FE, Maller JL. The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes. Mol Biol Cell 2001; 12:1791 - 1799
   PubMed Web of Science ®Google Scholar
• Kumagai A, Dunphy WG. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science 1996; 273:1377 - 1380
   PubMed Web of Science ®Google Scholar
• Lindqvist A, Rodríguez-Bravo V, Medema RH. The decision to enter mitosis: Feedback and redundancy in the mitotic entry network. J Cell Biol 2009; 185:193 - 202
   PubMed Web of Science ®Google Scholar
• Abrieu A, Brassac T, Galas S, Fisher D, Labbé JC, Dorée M. The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. J Cell Sci 1998:1751 - 1757
   Google Scholar
• Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J Biol Chem 2003; 278:25277 - 25280
   PubMed Web of Science ®Google Scholar
• Inoue D, Sagata N. The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs. EMBO J 2005; 24:1057 - 1067
   PubMed Web of Science ®Google Scholar
• Toyoshima-Morimoto F, Taniguchi E, Nishida E. Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep 2002; 3:341 - 348
   PubMed Web of Science ®Google Scholar
• Toyoshima-Morimoto F, Taniguchi E, Shinya N, Iwamatsu A, Nishida E. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Nature 2001; 410:215 - 220
   PubMed Web of Science ®Google Scholar
• Wiersma A, Hirsch B, Tsafriri A, Hanssen RG, Van de Kant M, Kloosterboer HJ, et al. Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents. J Clin Invest 1998; 102:532 - 537
   PubMed Web of Science ®Google Scholar
• Gurley LR, D'Anna JA, Barham SS, Deaven LL, Tobey RA. Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells. Eur J Biochem 1978; 84:1 - 15
   PubMedGoogle Scholar
• Wei Y, Mizzen CA, Cook RG, Gorovsky MA, Allis CD. Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena. Proc Natl Acad Sci USA 1998; 95:7480 - 7484
   PubMed Web of Science ®Google Scholar
• Van Hooser A, Goodrich DW, Allis CD, Brinkley BR, Mancini MA. Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation. J Cell Sci 1998; 111:3497 - 3506
   PubMed Web of Science ®Google Scholar
• DeManno DA, Cottom JE, Kline MP, Peters CA, Maizels ET, Hunzicker-Dunn M. Follicle-stimulating hormone promotes histone H3 phosphorylation on serine-10. Mol Endocrinol 1999; 13:91 - 105
   PubMed Web of Science ®Google Scholar
• Huo LJ, Yu LZ, Liang CG, Fan HY, Chen DY, Sun QY. Cell cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse. Zygote 2005; 13:45 - 53
   PubMed Web of Science ®Google Scholar
• Li J, Meyer AN, Donoghue DJ. Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation. Proc Natl Acad Sci USA 1997; 94:502 - 507
   PubMed Web of Science ®Google Scholar
• Gershon E, Galiani D, Dekel N. Cytoplasmic polyadenylation controls cdc25B mRNA translation in rat oocytes resuming meiosis. Reproduction 2006; 132:21 - 31
   PubMed Web of Science ®Google Scholar
• Gabrielli BG, De Souza CP, Tonks ID, Clark JM, Hayward NK, Ellem KA. Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. J Cell Sci 1996; 109:1081 - 1093
   PubMed Web of Science ®Google Scholar
• Krömer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, et al. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol 2004; 6:884 - 891
   PubMed Web of Science ®Google Scholar
• Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA and CHK1. Genes Dev 2008; 22:587 - 600
   PubMed Web of Science ®Google Scholar
• Rivers DM, Moreno S, Abraham M, Ahringer J. PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25. J Cell Biol 2008; 180:877 - 885
   PubMed Web of Science ®Google Scholar
• Pahlavan G, Polanski Z, Kalab P, Golsteyn R, Nigg EA, Maro B. Characterization of polo-like kinase 1 during meiotic maturation of the mouse oocyte. Dev Biol 2000; 220:392 - 400
   PubMed Web of Science ®Google Scholar
• Takizawa CG, Morgan DO. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol 2000; 12:658 - 665
   PubMed Web of Science ®Google Scholar
• Smits VA, Medema RH. Checking out the G(2)/M transition. Biochim Biophys Acta 2001; 1519:1 - 12
   PubMed Web of Science ®Google Scholar
• Wang J, Cao WL, Liu XJ. Protein kinase A(PKA)-restrictive and PKA-permissive phases of oocyte maturation. Cell Cycle 2006; 5:213 - 217
   PubMed Web of Science ®Google Scholar
• Jackman M, Lindon C, Nigg EA, Pines J. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 2003; 5:143 - 148
   PubMed Web of Science ®Google Scholar
• Bailly E, Pines J, Hunter T, Bornens M. Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J Cell Sci 1992; 101:529 - 545
   PubMed Web of Science ®Google Scholar
• Tsvetkov L, Xu X, Li J, Stern DF. Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem 2003; 278:8468 - 8475
   PubMed Web of Science ®Google Scholar
• Matyakhina L, Lenherr SM, Stratakis CA. Protein kinase A and chromosomal stability. Ann NY Acad Sci 2002; 968:148 - 157
   PubMed Web of Science ®Google Scholar
• Carlson CR, Witczak O, Vossebein L, Labbé JC, Skålhegg BS, Keryer G, et al. CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis. J Cell Sci 2001; 3243 - 3254
   PubMed Web of Science ®Google Scholar
• Kovo M, Schillace RV, Galiani D, Josefsberg LB, Carr DW, Dekel N. Expression and modification of PKA and AKAPs during meiosis in rat oocytes. Mol Cell Endocrinol 2002; 192:105 - 113
   PubMed Web of Science ®Google Scholar
• Brown RL, Ord T, Moss SB, Williams CJ. A-kinase anchor proteins as potential regulators of protein kinase A function in oocytes. Biol Reprod 2002; 67:981 - 987
   PubMed Web of Science ®Google Scholar
• Kelm O, Wind M, Lehmann WD, Nigg EA. Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1. J Biol Chem 2002; 277:25247 - 25256
   PubMed Web of Science ®Google Scholar
• Okano-Uchida T, Okumura E, Iwashita M, Yoshida H, Tachibana K, Kishimoto T. Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles. EMBO J 2003; 22:5633 - 5642
   PubMed Web of Science ®Google Scholar
• Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, et al. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol 2008; 10:1076 - 1082
   PubMed Web of Science ®Google Scholar
• Xiong B, Sun SC, Lin SL, Li M, Xu BZ, OuYang YC, et al. Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis. Cell Cycle 2008; 15:1804 - 1809
   Web of Science ®Google Scholar
• Golsteyn RM, Mundt KE, Fry AM, Nigg EA. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. J Cell Biol 1995; 129:1617 - 1628
   PubMed Web of Science ®Google Scholar
• Tong C, Fan HY, Lian L, Li SW, Chen DY, Schatten H, et al. Polo-like kinase-1 is a pivotal regulator of microtubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis. Biol Reprod 2002; 67:546 - 554
   PubMed Web of Science ®Google Scholar
• Lane HA, Nigg EA. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J Cell Biol 1996; 135:1701 - 1713
   PubMed Web of Science ®Google Scholar
• Klipper-Aurbach Y, Wasserman M, Braunspiegel-Weintrob N, Borstein D, Peleg S, Assa S, et al. Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus. Med Hypotheses 1995; 45:486 - 490
   PubMed Web of Science ®Google Scholar
• Bonnet J, Coopman P, Morris MC. Characterization of centrosomal localization and dynamics of Cdc25C phosphatase in mitosis. Cell Cycle 2008; 7:1991 - 1998
   PubMed Web of Science ®Google Scholar
• Krämer A, Lukas J, Bartek J. Checking out the centrosome. Cell Cycle 2004; 3:1390 - 1393
   PubMed Web of Science ®Google Scholar
• Bailly E, Doree M, Nurse P, Bormens M. p34cdc2 is located in both nucleus and cytoplasm; patr is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO J 1989; 8:3985 - 3995
   PubMed Web of Science ®Google Scholar
• Ookata K, Hisanaga S, Okano T, Tachibana K, Kishimoto T. Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. EMBO J 1992; 11:1763 - 1772
   PubMed Web of Science ®Google Scholar
• Andreassen PR, Margolis RL. Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells. J Cell Biol 1994; 127:789 - 802
   PubMed Web of Science ®Google Scholar
• Morisaki T, Hirota T, Iida S, Marumoto T, Hara T, Nishiyama Y, et al. WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. FEBS Lett 2002; 529:319 - 324
   PubMed Web of Science ®Google Scholar
• Wu Q, Guo Y, Yamada A, Perry JA, Wang MZ, Araki M, et al. A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr Biol 2007; 17:213 - 224
   PubMed Web of Science ®Google Scholar
• Chung E, Chen RH. Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint. Nat Cell Biol 2003; 5:748 - 753
   PubMed Web of Science ®Google Scholar
• Wong OK, Fang G. Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope. J Cell Biol 2007; 179:611 - 617
   PubMed Web of Science ®Google Scholar
• Athar M, Kim AL, Ahmad N, Mukhtar H, Gautier J, Bickers DR. Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53. Biochem Biophys Res Commun 2000; 277:107 - 111
   PubMed Web of Science ®Google Scholar
• Narayanan PK, Rudnick JM, Walthers EA, Crissman HA. Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine. Exp Cell Res 1997; 233:118 - 127
   PubMed Web of Science ®Google Scholar
• Nascimento R, Parkhouse RM. Murine gammaherpesvirus 68 ORF20 induces cell cycle arrest in G2 by inhibiting the Cdc2-cyclin B complex. J Gen Virol 2007; 88:1446 - 1453
   PubMed Web of Science ®Google Scholar