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MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest 

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Pages 4893-4899 | Published online: 15 Dec 2010

References

  • Neitzel H, Neumann LM, Schindler D, Wirges A, Tonnies H, Trimborn M, et al. Premature chromosome condensation in humans associated with microcephaly and mental retardation: a novel autosomal recessive condition. Am J Hum Genet 2002; 70:1015 - 1022
  • Jackson AP, Eastwood H, Bell SM, Adu J, Toomes C, Carr IM, et al. Identification of microcephalin, a protein implicated in determining the size of the human brain. Am J Hum Genet 2002; 71:136 - 142
  • Trimborn M, Bell SM, Felix C, Rashid Y, Jafri H, Griffiths PD, et al. Mutations in microcephalin cause aberrant regulation of chromosome condensation. Am J Hum Genet 2004; 75:261 - 266
  • Trimborn M, Schindler D, Neitzel H, Hirano T. Misregulated chromosome condensation in MCPH1 primary microcephaly is mediated by condensin II. Cell Cycle 2006; 5:322 - 326
  • Thornton GK, Woods CG. Primary microcephaly: Do all roads lead to Rome?. Trends Genet 2009; 25:501 - 510
  • Xu X, Lee J, Stern DF. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem 2004; 279:34091 - 34094
  • Lin SY, Rai R, Li K, Xu ZX, Elledge SJ. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci USA 2005; 102:15105 - 15109
  • Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, et al. BRIT1 regulates early DNA damage response, chromosomal integrity and cancer. Cancer Cell 2006; 10:145 - 157
  • Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 2007; 282:35416 - 35423
  • Jeffers LJ, Coull BJ, Stack SJ, Morrison CG. Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. Oncogene 2008; 27:139 - 144
  • Wood JL, Li K, Liang Y, Chen J. Microcephalin/MCPH1 associates with the condensin ii complex to function in homologous recombination repair. J Biol Chem 2008;
  • Rai R, Phadnis A, Haralkar S, Badwe RA, Dai H, Li K, et al. Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle 2008; 7:2225 - 2233
  • Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, et al. BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet 2010; 6:1000826
  • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858 - 5868
  • Rieder CL, Cole RW. Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase. J Cell Biol 1998; 142:1013 - 1022
  • Peng G, Yim EK, Dai H, Jackson AP, Burgt I, Pan MR, et al. BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 2009; 11:865 - 872
  • Kerzendorfer C, O'Driscoll M. Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency. DNA Repair 2009; 8:1139 - 1152
  • Alderton GK, Galbiati L, Griffith E, Surinya KH, Neitzel H, Jackson AP, et al. Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol 2006; 8:725 - 733
  • Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001; 21:3445 - 3450
  • Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002; 22:1049 - 1059
  • Trimborn M, Ghani M, Walther DJ, Dopatka M, Dutrannoy V, Busche A, et al. Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function. PLoS One 2010; 5:9242
  • Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, et al. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci 2007; 120:3565 - 3577
  • Brown JA, Bourke E, Liptrot C, Dockery P, Morrison CG. MCPH1/BRIT1 limits ionizing radiationinduced centrosome amplification. Oncogene 2010; 29:5537 - 5544
  • Rakic P. A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution. Trends Neurosci 1995; 18:383 - 388