Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae

References

• Magasanik B, Kaiser CA. Nitrogen regulation in Saccharomyces cerevisiae. Gene 2002; 290:1 - 18
   PubMed Web of Science ®Google Scholar
• Beck T, Hall MN. The TOR signalling pathway controls nuclear localization of nutrientregulated transcription factors. Nature 1999; 402:689 - 692
   PubMed Web of Science ®Google Scholar
• Cardenas ME, Cutler NS, Lorenz MC, Di Como CJ, Heitman J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 1999; 13:3271 - 3279
   PubMed Web of Science ®Google Scholar
• Hardwick JS, Kuruvilla FG, Tong JK, Shamji AF, Schreiber SL. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci USA 1999; 96:14866 - 14870
   PubMed Web of Science ®Google Scholar
• Bertram PG, Choi JH, Carvalho J, Ai W, Zeng C, Chan TF, Zheng XF. Tripartite regulation of Gln3p by TOR, Ure2p and phosphatases. J Biol Chem 2000; 275:35727 - 35733
   PubMed Web of Science ®Google Scholar
• Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10:457 - 468
   PubMed Web of Science ®Google Scholar
• Yan G, Shen X, Jiang Y. Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1. EMBO J 2006; 25:3546 - 3555
   PubMed Web of Science ®Google Scholar
• Di Como CJ, Jiang Y. The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling. Cell Cycle 2006; 5:2729 - 2732
   PubMed Web of Science ®Google Scholar
• Cox KH, Kulkarni A, Tate JJ, Cooper TG. Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by rapamycin inhibition of Tor1/2 in Saccharomyces cerevisiae. J Biol Chem 2004; 279:10270 - 10278
   PubMed Web of Science ®Google Scholar
• Tate JJ, Feller A, Dubois E, Cooper TG. Saccharomyces cerevisiae Sit4 phosphatase is active irrespective of the nitrogen source provided, and Gln3 phosphorylation levels become nitrogen source-responsive in a sit4-deleted strain. J Biol Chem 2006; 281:37980 - 37992
   PubMed Web of Science ®Google Scholar
• Srivastava A, Woolford CA, Jones EW. Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae. Genetics 2000; 156:105 - 122
   PubMed Web of Science ®Google Scholar
• Peterson MR, Emr SD. The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic 2001; 2:476 - 486
   PubMed Web of Science ®Google Scholar
• Kitamoto K, Yoshizawa K, Ohsumi Y, Anraku Y. Mutants of Saccharomyces cerevisiae with defective vacuolar function. J Bacteriol 1988; 170:2687 - 2691
   PubMed Web of Science ®Google Scholar
• Raymond CK, Howald-Stevenson I, Vater CA, Stevens TH. Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 1992; 3:1389 - 1402
   PubMed Web of Science ®Google Scholar
• Zurita-Martinez SA, Puria R, Pan X, Boeke JD, Cardenas ME. Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics 2007; 176:2139 - 2150
   PubMedGoogle Scholar
• Puria R, Zurita-Martinez SA, Cardenas ME. Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2008; 105:7194 - 7199
   PubMed Web of Science ®Google Scholar
• Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, Wanke V, Anrather D, Ammerer G, Riezman H, et al. Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 2007; 26:663 - 674
   PubMed Web of Science ®Google Scholar
• Rohde JR, Bastidas R, Puria R, Cardenas ME. Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 2008; 11:153 - 160
   PubMed Web of Science ®Google Scholar
• Mitchell AP. A VAST staging area for regulatory proteins. Proc Natl Acad Sci USA 2008; 105:7111 - 7112
   PubMed Web of Science ®Google Scholar