FG repeats facilitate integral protein trafficking to the inner nuclear membrane

References

• Prunuske AJ, Ullman KS. The nuclear envelope: form and reformation. Curr Opin Cell Biol 2006; 18:108 - 116
   PubMed Web of Science ®Google Scholar
• Suntharalingam M, Wente SR. Peering through the pore: nuclear pore complex structure, assembly and function. Dev Cell 2003; 4:775 - 789
   PubMed Web of Science ®Google Scholar
• Alber F, Dokudovskaya S, Veenhoff LM, Zhang W, Kipper J, Devos D, et al. The molecular architecture of the nuclear pore complex. Nature 2007; 450:695 - 701
   PubMed Web of Science ®Google Scholar
• Wente SR, Rout MP, Blobel G. A new family of yeast nuclear pore complex proteins. J Cell Biol 1992; 119:705 - 723
   PubMedGoogle Scholar
• Denning DP, Patel SS, Uversky V, Fink AL, Rexach M. Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded. Proc Natl Acad Sci USA 2003; 100:2450 - 2455
   PubMed Web of Science ®Google Scholar
• Lim RY, Huang NP, Köser J, Deng J, Lau KH, Schwarz-Herion K, et al. Flexible phenylalanineglycine nucleoporins as entropic barriers to nucleocytoplasmic transport. Proc Natl Acad Sci USA 2006; 103:9512 - 9517
   PubMed Web of Science ®Google Scholar
• Rexach M, Blobel G. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors and nucleoporins. Cell 1995; 83:683 - 692
   PubMed Web of Science ®Google Scholar
• Strawn LA, Shen T, Shulga N, Goldfarb DS, Wente SR. Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 2004; 6:197 - 206
   PubMed Web of Science ®Google Scholar
• Reichelt R, Holzenburg A, Buhle EL Jr, Jarnik M, Engel A, Aebi U. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components. J Cell Biol 1990; 110:883 - 894
   PubMed Web of Science ®Google Scholar
• Soullam B, Worman HJ. The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal. J Cell Biol 1993; 120:1093 - 1100
   PubMed Web of Science ®Google Scholar
• Soullam B, Worman HJ. Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane. J Cell Biol 1995; 130:15 - 27
   PubMedGoogle Scholar
• Saksena S, Shao Y, Braunagel SC, Summers MD, Johnson AE. Cotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membrane. Proc Natl Acad Sci USA 2004; 101:12537 - 12542
   PubMed Web of Science ®Google Scholar
• Ohba T, Schirmer EC, Nishimoto T, Gerace L. Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore. J Cell Biol 2004; 167:1051 - 1062
   Google Scholar
• Theerthagiri G, Eisenhardt N, Schwarz H, Antonin W. The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex. J Cell Biol 2010; 189:1129 - 1142
   PubMed Web of Science ®Google Scholar
• Mitchell JM, Mansfeld J, Capitanio J, Kutay U, Wozniak RW. Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane. J Cell Biol 2010; 191:505 - 521
   PubMed Web of Science ®Google Scholar
• King MC, Lusk CP, Blobel G. Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 2006; 442:1003 - 1007
   PubMedGoogle Scholar
• Zuleger N, Kelly DA, Richardson AC, Kerr AR, Goldberg MW, Goryachev AB, et al. System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics. J Cell Biol 2011; 193:109 - 123
   Google Scholar
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol Biol Cell 2005; 16:2382 - 2394
   PubMed Web of Science ®Google Scholar
• Korfali N, Wilkie GS, Swanson SK, Srsen V, Batrakou DG, Fairley EA, et al. The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture. Mol Cell Proteomics 2010; 9:2571 - 2585
   PubMed Web of Science ®Google Scholar
• Wilkie GS, Korfali N, Swanson SK, Malik P, Srsen V, Batrakou DG, et al. Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations. Mol Cell Proteomics 2011; 10:110.003129
   Web of Science ®Google Scholar
• Tseng SS, Weaver PL, Liu Y, Hitomi M, Tartakoff AM, Chang TH. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J 1998; 17:2651 - 2662
   PubMed Web of Science ®Google Scholar
• Batrakou DG, Kerr AR, Schirmer EC. Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions. J Proteomics 2008; 72:56 - 70
   PubMed Web of Science ®Google Scholar
• Krogh A, Larsson B, von Heijne G, Sonnhammer EL. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 2001; 305:567 - 580
   PubMed Web of Science ®Google Scholar