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Short Communication

The role of Connexin 46 promoter in lens and other hypoxic tissues

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Pages 114-117 | Published online: 01 Mar 2012

References

  • Ahmad S, Martin PEM, Evans WH. Assembly of gap junction channels: mechanism, effects of calmodulin antagonists and identification of connexin oligomerization determinants. Eur J Biochem 2001; 268:4544 - 52; http://dx.doi.org/10.1046/j.1432-1327.2001.02380.x; PMID: 11502216
  • Harris AL, Locke D. Connexins: A Guide. New York, NY: Springer, 2009.
  • Griffith TM. Which connexins connect?. Circ Res 2007; 101:1219 - 21; http://dx.doi.org/10.1161/CIRCRESAHA.107.165670; PMID: 18063817
  • Mathias RT, White TW, Gong X. Lens gap junctions in growth, differentiation, and homeostasis. Physiol Rev 2010; 90:179 - 206; http://dx.doi.org/10.1152/physrev.00034.2009; PMID: 20086076
  • Winterhager E. Gap Junctions in Development and Disease. Berlin: Springer, 2005.
  • Xia CH, Liu H, Cheung D, Cheng C, Wang E, Du X, et al. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development 2006; 133:2033 - 40; http://dx.doi.org/10.1242/dev.02361; PMID: 16611690
  • Dunia I, Cibert C, Gong X, Xia CH, Recouvreur M, Levy E, et al. Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice. Eur J Cell Biol 2006; 85:729 - 52; http://dx.doi.org/10.1016/j.ejcb.2006.03.006; PMID: 16740340
  • Ebihara L, Tong JJ, Vertel B, White TW, Chen TL. Properties of connexin 46 hemichannels in dissociated lens fiber cells. Invest Ophthalmol Vis Sci 2011; 52:882 - 9; http://dx.doi.org/10.1167/iovs.10-6200; PMID: 20861491
  • Eckert R. pH gating of lens fibre connexins. Pflugers Arch 2002; 443:843 - 51; http://dx.doi.org/10.1007/s00424-001-0760-2; PMID: 11889584
  • Fleschner CR. Connexin 46 and connexin 50 in selenite cataract. Ophthalmic Res 2006; 38:24 - 8; http://dx.doi.org/10.1159/000088527; PMID: 16192745
  • Gong X, Baldo GJ, Kumar NM, Gilula NB, Mathias RT. Gap junctional coupling in lenses lacking alpha3 connexin. Proc Natl Acad Sci U S A 1998; 95:15303 - 8; http://dx.doi.org/10.1073/pnas.95.26.15303; PMID: 9860964
  • Mackay D, Ionides A, Kibar Z, Rouleau G, Berry V, Moore A, et al. Connexin46 mutations in autosomal dominant congenital cataract. Am J Hum Genet 1999; 64:1357 - 64; http://dx.doi.org/10.1086/302383; PMID: 10205266
  • Pal JD, Liu X, Mackay D, Shiels A, Berthoud VM, Beyer EC, et al. Connexin46 mutations linked to congenital cataract show loss of gap junction channel function. Am J Physiol Cell Physiol 2000; 279:C596 - 602; PMID: 10942709
  • Gong X, Li E, Klier G, Huang Q, Wu Y, Lei H, et al. Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell 1997; 91:833 - 43; http://dx.doi.org/10.1016/S0092-8674(00)80471-7; PMID: 9413992
  • White TW. Unique and redundant connexin contributions to lens development. Science 2002; 295:319 - 20; http://dx.doi.org/10.1126/science.1067582; PMID: 11786642
  • Xia CH, Cheng C, Huang Q, Cheung D, Li L, Dunia I, et al. Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. Exp Eye Res 2006; 83:688 - 96; http://dx.doi.org/10.1016/j.exer.2006.03.013; PMID: 16696970
  • Xia CH, Cheung D, DeRosa AM, Chang B, Lo WK, White TW, et al. Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation. J Cell Sci 2006; 119:2138 - 44; http://dx.doi.org/10.1242/jcs.02940; PMID: 16687738
  • Banerjee D, Gakhar G, Madgwick D, Hurt A, Takemoto D, Nguyen TA. A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia. Int J Cancer 2010; 127:839 - 48; PMID: 20013805
  • Burr DB, Molina SA, Banerjee D, Low DM, Takemoto DJ. Treatment with connexin 46 siRNA suppresses the growth of human Y79 retinoblastoma cell xenografts in vivo. Exp Eye Res 2011; 92:251 - 9; http://dx.doi.org/10.1016/j.exer.2011.02.003; PMID: 21320488
  • Vinken M, Vanhaecke T, Papeleu P, Snykers S, Henkens T, Rogiers V. Connexins and their channels in cell growth and cell death. Cell Signal 2006; 18:592 - 600; http://dx.doi.org/10.1016/j.cellsig.2005.08.012; PMID: 16183253
  • Yamasaki H, Krutovskikh V, Mesnil M, Tanaka T, Zaidan-Dagli ML, Omori Y. Role of connexin (gap junction) genes in cell growth control and carcinogenesis. C R Acad Sci III 1999; 322:151 - 9; http://dx.doi.org/10.1016/S0764-4469(99)80038-9; PMID: 10196667
  • Rodríguez-Sinovas A, Cabestrero A, López D, Torre I, Morente M, Abellán A, et al. The modulatory effects of connexin 43 on cell death/survival beyond cell coupling. Prog Biophys Mol Biol 2007; 94:219 - 32; http://dx.doi.org/10.1016/j.pbiomolbio.2007.03.003; PMID: 17462722
  • Mesnil M. Connexins and cancer. Biol Cell 2002; 94:493 - 500; http://dx.doi.org/10.1016/S0248-4900(02)00025-4; PMID: 12566222
  • Das S, Wang H, Molina SA, Martinez-Wittinghan FJ, Jena S, Bossmann LK, et al. PKCγ, role in lens differentiation and gap junction coupling. Curr Eye Res 2011; 36:620 - 31; PMID: 21599470
  • Akoyev V, Das S, Jena S, Grauer L, Takemoto DJ. Hypoxia-regulated activity of PKCepsilon in the lens. Invest Ophthalmol Vis Sci 2009; 50:1271 - 82; http://dx.doi.org/10.1167/iovs.08-2599; PMID: 18997087
  • Saleh SM, Takemoto LJ, Zoukhri D, Takemoto DJ. PKC-gamma phosphorylation of connexin 46 in the lens cortex. Mol Vis 2001; 7:240 - 6; PMID: 11702063
  • Banerjee D, Das S, Molina SA, Madgwick D, Katz MR, Jena S, et al. Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43. J Biol Chem 2011; 286:24519 - 33; http://dx.doi.org/10.1074/jbc.M110.217208; PMID: 21606502
  • Koval M, Harley JE, Hick E, Steinberg TH. Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells. J Cell Biol 1997; 137:847 - 57; http://dx.doi.org/10.1083/jcb.137.4.847; PMID: 9151687
  • Sanches DS, Pires CG, Fukumasu H, Cogliati B, Matsuzaki P, Chaible LM, et al. Expression of connexins in normal and neoplastic canine bone tissue. Vet Pathol 2009; 46:846 - 59; http://dx.doi.org/10.1354/vp.08-VP-0263-S-FL; PMID: 19429987
  • Nakatsugawa M, Hirohashi Y, Torigoe T, Asanuma H, Takahashi A, Inoda S, et al. Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. Cancer Sci 2009; 100:1485 - 93; http://dx.doi.org/10.1111/j.1349-7006.2009.01187.x; PMID: 19459848
  • Deng M, Chen P, Xie S, Zhao J, Gong L, Liu J, et al. The small heat shock protein αA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis. Biochimica et Biophysica Acta 2010; 1802:621-31
  • Shimoda LA, Semenza GL. HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. Am J Respir Crit Care Med 2011; 183:152 - 6; http://dx.doi.org/10.1164/rccm.201009-1393PP; PMID: 21242594
  • Patterson AJ, Zhang L. Hypoxia and fetal heart development. Curr Mol Med 2010; 10:653 - 66; http://dx.doi.org/10.2174/156652410792630643; PMID: 20712587
  • Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson RS, et al. Role of HIF-1alpha in skeletal development. Ann N Y Acad Sci 2010; 1192:322 - 6; http://dx.doi.org/10.1111/j.1749-6632.2009.05238.x; PMID: 20392254
  • Lendahl U, Lee KL, Yang H, Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet 2009; 10:821 - 32; http://dx.doi.org/10.1038/nrg2665; PMID: 19884889
  • Shui YB, Arbeit JM, Johnson RS, Beebe DC. HIF-1: an age-dependent regulator of lens cell proliferation. Invest Ophthalmol Vis Sci 2008; 49:4961 - 70; http://dx.doi.org/10.1167/iovs.08-2118; PMID: 18586877
  • Edsjö A, Holmquist L, Påhlman S. Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation. Semin Cancer Biol 2007; 17:248 - 56; http://dx.doi.org/10.1016/j.semcancer.2006.04.005; PMID: 16828305
  • Provot S, Schipani E. Fetal growth plate: a developmental model of cellular adaptation to hypoxia. Ann N Y Acad Sci 2007; 1117:26 - 39; http://dx.doi.org/10.1196/annals.1402.076; PMID: 18056035
  • Xie XJ, Wang JA, Cao J, Zhang X. Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin 2006; 27:1153 - 8; http://dx.doi.org/10.1111/j.1745-7254.2006.00436.x; PMID: 16923335