Nuclear importin α and its physiological importance

References

• Yasuda Y, Miyamoto Y, Yamashiro T, Asally M, Masui A, Wong C, et al. Nuclear retention of importin a coordinates cell fate through changes in gene expression. EMBO J 2012; 31:83 - 94; http://dx.doi.org/10.1038/emboj.2011.360; PMID: 21964068
   PubMed Web of Science ®Google Scholar
• LaCasse EC, Lefebvre YA. Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins. Nucleic Acids Res 1995; 23:1647 - 56; http://dx.doi.org/10.1093/nar/23.10.1647; PMID: 7540284
   PubMed Web of Science ®Google Scholar
• Cokol M, Nair R, Rost B. Finding nuclear localization signals. EMBO Rep 2000; 1:411 - 5; http://dx.doi.org/10.1093/embo-reports/kvd092; PMID: 11258480
   PubMed Web of Science ®Google Scholar
• Nair R, Carter P, Rost B. NLSdb: database of nuclear localization signals. Nucleic Acids Res 2003; 31:397 - 9; http://dx.doi.org/10.1093/nar/gkg001; PMID: 12520032
   PubMed Web of Science ®Google Scholar
• Ferrando-May E. Nucleocytoplasmic transport in apoptosis. Cell Death Differ 2005; 12:1263 - 76; http://dx.doi.org/10.1038/sj.cdd.4401626; PMID: 15861192
   PubMed Web of Science ®Google Scholar
• Fahrenkrog B. The nuclear pore complex, nuclear transport, and apoptosis. Can J Physiol Pharmacol 2006; 84:279 - 86; http://dx.doi.org/10.1139/y05-100; PMID: 16902575
   PubMed Web of Science ®Google Scholar
• Kodiha M, Stochaj U. Nuclear transport: a switch for the oxidative stress-signaling circuit? J Signal Transduct 2012; 2012:208650; PMID:22028962; DOI:10.1155/2012/208650.
   Google Scholar
• Grote P, Schaeuble K, Ferrando-May E. Commuting (to) suicide: an update on nucleocytoplasmic transport in apoptosis. Arch Biochem Biophys 2007; 462:156 - 61; http://dx.doi.org/10.1016/j.abb.2007.02.018; PMID: 17395148
   PubMed Web of Science ®Google Scholar
• Kelley JB, Paschal BM. Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP. Mol Biol Cell 2007; 18:4365 - 76; http://dx.doi.org/10.1091/mbc.E07-01-0089; PMID: 17761537
   PubMed Web of Science ®Google Scholar
• Yasuda Y, Miyamoto Y, Saiwaki T, Yoneda Y. Mechanism of the stress-induced collapse of the Ran distribution. Exp Cell Res 2006; 312:512 - 20; http://dx.doi.org/10.1016/j.yexcr.2005.11.017; PMID: 16368437
   PubMed Web of Science ®Google Scholar
• Schwoebel ED, Ho TH, Moore MS. The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. J Cell Biol 2002; 157:963 - 74; http://dx.doi.org/10.1083/jcb.200111077; PMID: 12058015
   PubMed Web of Science ®Google Scholar
• Golstein P, Kroemer G. Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 2007; 32:37 - 43; http://dx.doi.org/10.1016/j.tibs.2006.11.001; PMID: 17141506
   PubMed Web of Science ®Google Scholar
• Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185:1481 - 6; http://dx.doi.org/10.1084/jem.185.8.1481; PMID: 9126928
   PubMed Web of Science ®Google Scholar
• Yasuhara N, Eguchi Y, Tachibana T, Imamoto N, Yoneda Y, Tsujimoto Y. Essential role of active nuclear transport in apoptosis. Genes Cells 1997; 2:55 - 64; http://dx.doi.org/10.1046/j.1365-2443.1997.1010302.x; PMID: 9112440
   PubMed Web of Science ®Google Scholar
• Adam SA. The nuclear transport machinery in Caenorhabditis elegans: A central role in morphogenesis. Semin Cell Dev Biol 2009; 20:576 - 81; http://dx.doi.org/10.1016/j.semcdb.2009.03.013; PMID: 19577735
   PubMed Web of Science ®Google Scholar
• Giarrè M, Török I, Schmitt R, Gorjánácz M, Kiss I, Mechler BM. Patterns of importin-alpha expression during Drosophila spermatogenesis. J Struct Biol 2002; 140:279 - 90; http://dx.doi.org/10.1016/S1047-8477(02)00543-9; PMID: 12490175
   PubMed Web of Science ®Google Scholar
• Hogarth CA, Jans DA, Loveland KL. Subcellular distribution of importins correlates with germ cell maturation. Dev Dyn 2007; 236:2311 - 20; http://dx.doi.org/10.1002/dvdy.21238; PMID: 17654710
   PubMed Web of Science ®Google Scholar
• Whiley PA, Miyamoto Y, McLachlan RI, Jans DA, Loveland KL. Changing subcellular localization of nuclear transport factors during human spermatogenesis. Int J Androl 2011; 5:158 - 69; http://dx.doi.org/10.1111/j.1365-2605.2011.01202.x; PMID: 21812786
   PubMed Web of Science ®Google Scholar
• Young JC, Major AT, Miyamoto Y, Loveland KL, Jans DA. Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells. FASEB J 2011; 25:3958 - 65; http://dx.doi.org/10.1096/fj.10-176941; PMID: 21840941
   PubMed Web of Science ®Google Scholar
• Kelley JB, Talley AM, Spencer A, Gioeli D, Paschal BM. Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol 2010; 11:63; http://dx.doi.org/10.1186/1471-2121-11-63; PMID: 20701745
   PubMed Web of Science ®Google Scholar
• Hu J, Wang F, Yuan Y, Zhu X, Wang Y, Zhang Y, et al. Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse. J Biol Chem 2010; 285:33113 - 22; http://dx.doi.org/10.1074/jbc.M110.117044; PMID: 20699224
   PubMed Web of Science ®Google Scholar
• Tejomurtula J, Lee KB, Tripurani SK, Smith GW, Yao J. Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Biol Reprod 2009; 81:333 - 42; http://dx.doi.org/10.1095/biolreprod.109.077396; PMID: 19420384
   PubMed Web of Science ®Google Scholar
• Dahl E, Kristiansen G, Gottlob K, Klaman I, Ebner E, Hinzmann B, et al. Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Clin Cancer Res 2006; 12:3950 - 60; http://dx.doi.org/10.1158/1078-0432.CCR-05-2090; PMID: 16818692
   PubMed Web of Science ®Google Scholar
• Dankof A, Fritzsche FR, Dahl E, Pahl S, Wild P, Dietel M, et al. KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ. Virchows Arch 2007; 451:877 - 81; http://dx.doi.org/10.1007/s00428-007-0513-5; PMID: 17899179
   PubMed Web of Science ®Google Scholar
• Gluz O, Wild P, Meiler R, Diallo-Danebrock R, Ting E, Mohrmann S, et al. Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity. Int J Cancer 2008; 123:1433 - 8; http://dx.doi.org/10.1002/ijc.23628; PMID: 18561322
   PubMed Web of Science ®Google Scholar
• Noetzel E, Rose M, Bornemann J, Gajewski M, Knüchel R, Dahl E. Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro. Oncogene 2011; In press http://dx.doi.org/10.1038/onc.2011.403; PMID: 21909132
   PubMed Web of Science ®Google Scholar
• Wang CI, Wang CL, Wang CW, Chen CD, Wu CC, Liang Y, et al. Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. Int J Cancer 2011; 128:2364 - 72; http://dx.doi.org/10.1002/ijc.25568; PMID: 20658535
   PubMed Web of Science ®Google Scholar
• Sakai M, Sohda M, Miyazaki T, Suzuki S, Sano A, Tanaka N, et al. Significance of karyopherin-alpha 2 (KPNA2) expression in esophageal squamous cell carcinoma. Anticancer Res 2010; 30:851 - 6; PMID: 20393006
   PubMed Web of Science ®Google Scholar
• Jensen JB, Munksgaard PP, Sørensen CM, Fristrup N, Birkenkamp-Demtroder K, Ulhøi BP, et al. High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy. Eur Urol 2011; 59:841 - 8; http://dx.doi.org/10.1016/j.eururo.2011.01.048; PMID: 21330047
   PubMed Web of Science ®Google Scholar
• Mortezavi A, Hermanns T, Seifert HH, Baumgartner MK, Provenzano M, Sulser T, et al. KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy. Clin Cancer Res 2011; 17:1111 - 21; http://dx.doi.org/10.1158/1078-0432.CCR-10-0081; PMID: 21220479
   PubMed Web of Science ®Google Scholar
• Köhler M, Buchwalow IB, Alexander G, Christiansen M, Shagdarsuren E, Samoilova V, et al. Increased importin alpha protein expression in diabetic nephropathy. Kidney Int 2001; 60:2263 - 73; http://dx.doi.org/10.1046/j.1523-1755.2001.00069.x; PMID: 11737599
   PubMed Web of Science ®Google Scholar