Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity

References

• Kwon OB, Longart M, Vullhorst D, Hoffman DA, Buonanno A. Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses. J Neurosci 2005; 25:9378 - 9383
   PubMed Web of Science ®Google Scholar
• Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, et al. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 2000; 26:443 - 455
   PubMed Web of Science ®Google Scholar
• Bjarnadottir M, Misner DL, Haverfield-Gross S, Bruun S, Helgason VG, Stefansson H, et al. Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/− knock-outs compared with wild-type mice. J Neurosci 2007; 27:4519 - 4529
   PubMed Web of Science ®Google Scholar
• Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71:877 - 892
   PubMed Web of Science ®Google Scholar
• Seeman P, Schwarz J, Chen JF, Szechtman H, Perreault M, McKnight GS, et al. Psychosis pathways converge via D2(High) dopamine receptors. Synapse 2006; 60:319 - 346
   PubMed Web of Science ®Google Scholar
• Horacek J, Bubenikova-Valesova V, Kopecek M, Palenicek T, Dockery C, Mohr P, et al. Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs 2006; 20:389 - 409
   PubMed Web of Science ®Google Scholar
• Kwon OB, Paredes D, Gonzalez CM, Neddens J, Hernandez L, Vullhorst D, et al. Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors. Proc Natl Acad Sci USA 2008; 105:15587 - 15592
   PubMed Web of Science ®Google Scholar
• Gasbarri A, Sulli A, Packard MG. The dopaminergic mesencephalic projections to the hippocampal formation in the rat. Prog Neuropsychopharmacol Biol Psychiatry 1997; 21:1 - 22
   PubMed Web of Science ®Google Scholar
• Li S, Cullen WK, Anwyl R, Rowan MJ. Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty. Nat Neurosci 2003; 6:526 - 531
   PubMed Web of Science ®Google Scholar
• Huang YY, Kandel ER. D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proc Natl Acad Sci USA 1995; 92:2446 - 2450
   PubMed Web of Science ®Google Scholar
• Granado N, Ortiz O, Suarez LM, Martin ED, Cena V, Solis JM, et al. D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus. Cereb Cortex 2008; 18:1 - 12
   PubMed Web of Science ®Google Scholar
• Lemon N, Manahan-Vaughan D. Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. J Neurosci 2006; 26:7723 - 7729
   PubMed Web of Science ®Google Scholar
• Williams S, Mmbaga N, Chirwa S. Dopaminergic D1 receptor agonist SKF 38393 induces GAP-43 expression and long-term potentiation in hippocampus in vivo. Neurosci Lett 2006; 402:46 - 50
   PubMed Web of Science ®Google Scholar
• Frey U, Schroeder H, Matthies H. Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices. Brain Res 1990; 522:69 - 75
   PubMed Web of Science ®Google Scholar
• Frey U, Hartmann S, Matthies H. Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats. Biomed Biochim Acta 1989; 48:473 - 476
   PubMedGoogle Scholar
• Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 1996; 381:245 - 248
   PubMed Web of Science ®Google Scholar
• Noain D, Avale ME, Wedemeyer C, Calvo D, Peper M, Rubinstein M. Identification of brain neurons expressing the dopamine D4 receptor gene using BAC transgenic mice. Eur J Neurosci 2006; 24:2429 - 2438
   PubMed Web of Science ®Google Scholar
• Khan ZU, Gutierrez A, Martin R, Penafiel A, Rivera A, De La Calle A. Differential regional and cellular distribution of dopamine D2-like receptors: an immunocytochemical study of subtype-specific antibodies in rat and human brain. J Comp Neurol 1998; 402:353 - 371
   PubMed Web of Science ®Google Scholar
• Gasbarri A, Verney C, Innocenzi R, Campana E, Pacitti C. Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study. Brain Res 1994; 668:71 - 79
   PubMed Web of Science ®Google Scholar
• Jansson A, Goldstein M, Tinner B, Zoli M, Meador-Woodruff JH, Lew JY, et al. On the distribution patterns of D1, D2, tyrosine hydroxylase and dopamine transporter immunoreactivities in the ventral striatum of the rat. Neuroscience 1999; 89:473 - 489
   PubMed Web of Science ®Google Scholar
• Woo RS, Li XM, Tao Y, Carpenter-Hyland E, Huang YZ, Weber J, et al. Neuregulin-1 Enhances Depolarization-Induced GABA Release. Neuron 2007; 54:599 - 610
   PubMed Web of Science ®Google Scholar
• Benes FM, Berretta S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 2001; 25:1 - 27
   PubMed Web of Science ®Google Scholar
• Blum BP, Mann JJ. The GABAergic system in schizophrenia. Int J Neuropsychopharmacol 2002; 5:159 - 179
   PubMed Web of Science ®Google Scholar
• Coyle JT. The GABA-glutamate connection in schizophrenia: which is the proximate cause?. Biochem Pharmacol 2004; 68:1507 - 1514
   PubMed Web of Science ®Google Scholar
• Lewis DA, Hashimoto T, Volk DW. Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 2005; 6:312 - 324
   PubMed Web of Science ®Google Scholar
• Fisahn A, Neddens J, Yan L, Buonanno A. Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia. Cereb Cortex 2008; http://dx.doi.org/10.1093/cercor/bhn107
   PubMed Web of Science ®Google Scholar
• Fox IJ, Kornblum HI. Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. J Neurosci Res 2005; 79:584 - 597
   PubMed Web of Science ®Google Scholar
• Yau HJ, Wang HF, Lai C, Liu FC. Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences. Cereb Cortex 2003; 13:252 - 264
   PubMed Web of Science ®Google Scholar
• Corfas G, Rosen KM, Aratake H, Krauss R, Fischbach GD. Differential expression of ARIA isoforms in the rat brain. Neuron 1995; 14:103 - 115
   PubMed Web of Science ®Google Scholar
• Eilam R, Pinkas-Kramarski R, Ratzkin BJ, Segal M, Yarden Y. Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain. Proc Natl Acad Sci USA 1998; 95:1888 - 1893
   PubMed Web of Science ®Google Scholar
• Pinkas-Kramarski R, Eilam R, Spiegler O, Lavi S, Liu N, Chang D, et al. Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes. Proc Natl Acad Sci USA 1994; 91:9387 - 9391
   PubMed Web of Science ®Google Scholar
• Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci 2008; 31:234 - 242
   PubMed Web of Science ®Google Scholar
• Anton ES, Ghashghaei HT, Weber JL, McCann C, Fischer TM, Cheung ID, et al. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 2004; 7:1319 - 1328
   PubMed Web of Science ®Google Scholar
• Flames N, Long JE, Garratt AN, Fischer TM, Gassmann M, Birchmeier C, et al. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron 2004; 44:251 - 261
   PubMed Web of Science ®Google Scholar
• Ghashghaei HT, Weber J, Pevny L, Schmid R, Schwab MH, Lloyd KC, et al. The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci USA 2006; 103:1930 - 1935
   PubMed Web of Science ®Google Scholar
• Krivosheya D, Tapia L, Levinson JN, Huang K, Kang Y, Hines R, et al. ErbB4-Neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. J Biol Chem 2008; 283:32944 - 32956
   PubMed Web of Science ®Google Scholar
• Li B, Woo RS, Mei L, Malinow R. The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity. Neuron 2007; 54:583 - 597
   PubMed Web of Science ®Google Scholar
• Corfas G, Roy K, Buxbaum JD. Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia. Nat Neurosci 2004; 7:575 - 580
   PubMed Web of Science ®Google Scholar
• Roy K, Murtie JC, El-Khodor BF, Edgar N, Sardi SP, Hooks BM, et al. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci USA 2007; 104:8131 - 8136
   PubMed Web of Science ®Google Scholar
• Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Muller T, Wende H, et al. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 2008; 59:581 - 595
   PubMed Web of Science ®Google Scholar
• Hall J, Whalley HC, Job DE, Baig BJ, McIntosh AM, Evans KL, et al. A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci 2006; 9:1477 - 1478
   PubMed Web of Science ®Google Scholar
• Keri S, Kiss I, Kelemen O. Effects of a neuregulin 1 variant on conversion to schizophrenia and schizophreniform disorder in people at high risk for psychosis. Mol Psychiatry 2009; 14:118 - 119
   PubMed Web of Science ®Google Scholar
• Crowley JJ, Keefe RS, Perkins DO, Stroup TS, Lieberman JA, Sullivan PF. The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition. Am J Med Genet B Neuropsychiatr Genet 2008; 147B:1298 - 1300
   PubMed Web of Science ®Google Scholar
• Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, et al. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease. Proc Natl Acad Sci USA 2006; 103:6747 - 6752
   PubMed Web of Science ®Google Scholar
• Silberberg G, Darvasi A, Pinkas-Kramarski R, Navon R. The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet B Neuropsychiatr Genet 2006; 141:142 - 148
   Web of Science ®Google Scholar
• Hahn CG, Wang HY, Cho DS, Talbot K, Gur RE, Berrettini WH, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia. Nat Med 2006; 12:824 - 828
   PubMed Web of Science ®Google Scholar
• Chang Q, Fischbach GD. An acute effect of neuregulin 1 β to suppress α7-containing nicotinic acetylcholine receptors in hippocampal interneurons. J Neurosci 2006; 26:11295 - 11303
   PubMed Web of Science ®Google Scholar
• Hancock ML, Canetta SE, Role LW, Talmage DA. Presynaptic type III neuregulin1-ErbB signaling targets α7 nicotinic acetylcholine receptors to axons. J Cell Biol 2008; 181:511 - 521
   PubMed Web of Science ®Google Scholar
• Zhong C, Du C, Hancock M, Mertz M, Talmage DA, Role LW. Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of α7 nicotinic acetylcholine receptors. J Neurosci 2008; 28:9111 - 9116
   PubMed Web of Science ®Google Scholar
• Martin LF, Freedman R. Schizophrenia and the α7 Nicotinic Acetylcholine Receptor. Int Rev Neurobiol 2007; 78:225 - 246
   PubMed Web of Science ®Google Scholar
• Severance EG, Yolken RH. Novel α7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia. Genes Brain Behav 2008; 7:37 - 45
   PubMed Web of Science ®Google Scholar
• Longart M, Liu Y, Karavanova I, Buonanno A. Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons. J Comp Neurol 2004; 472:156 - 172
   PubMed Web of Science ®Google Scholar
• Britto JM, Lukehurst S, Weller R, Fraser C, Qiu Y, Hertzog P, et al. Generation and characterization of neuregulin-2-deficient mice. Mol Cell Biol 2004; 24:8221 - 8226
   PubMed Web of Science ®Google Scholar