Assessing developmental roles of MKK4 and MKK7 in vitro

References

• Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993; 268:14553 - 6; PMID: 8325833
   PubMed Web of Science ®Google Scholar
• Dérijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995; 267:682 - 5; http://dx.doi.org/10.1126/science.7839144; PMID: 7839144
   PubMed Web of Science ®Google Scholar
• Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001; 81:807 - 69; PMID: 11274345
   PubMed Web of Science ®Google Scholar
• Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19:2435 - 44; PMID: 10082509
   PubMed Web of Science ®Google Scholar
• Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103:239 - 52; http://dx.doi.org/10.1016/S0092-8674(00)00116-1; PMID: 11057897
   PubMed Web of Science ®Google Scholar
• Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, et al. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A 1998; 95:6881 - 6; http://dx.doi.org/10.1073/pnas.95.12.6881; PMID: 9618507
   PubMed Web of Science ®Google Scholar
• Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, et al. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 1999; 126:505 - 16; PMID: 9876179
   PubMed Web of Science ®Google Scholar
• Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ, et al. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci U S A 1997; 94:3004 - 9; http://dx.doi.org/10.1073/pnas.94.7.3004; PMID: 9096336
   PubMed Web of Science ®Google Scholar
• Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, et al. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol 2004; 6:215 - 26; http://dx.doi.org/10.1038/ncb1098; PMID: 15039780
   PubMed Web of Science ®Google Scholar
• Asaoka Y, Nishina H. Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J Biochem 2010; 148:393 - 401; PMID: 20801953
   PubMed Web of Science ®Google Scholar
• Wang X, Destrument A, Tournier C. Physiological roles of MKK4 and MKK7: insights from animal models. Biochim Biophys Acta 2007; 1773:1349 - 57; http://dx.doi.org/10.1016/j.bbamcr.2006.10.016; PMID: 17157936
   PubMed Web of Science ®Google Scholar
• Yao Z, Diener K, Wang XS, Zukowski M, Matsumoto G, Zhou G, et al. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J Biol Chem 1997; 272:32378 - 83; http://dx.doi.org/10.1074/jbc.272.51.32378; PMID: 9405446
   PubMed Web of Science ®Google Scholar
• Lee JK, Hwang WS, Lee YD, Han PL. Dynamic expression of SEK1 suggests multiple roles of the gene during embryogenesis and in adult brain of mice. Brain Res Mol Brain Res 1999; 66:133 - 40; http://dx.doi.org/10.1016/S0169-328X(99)00035-2; PMID: 10095085
   PubMedGoogle Scholar
• Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, et al. Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol 2007; 27:7935 - 46; http://dx.doi.org/10.1128/MCB.00226-07; PMID: 17875933
   PubMed Web of Science ®Google Scholar
• Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, et al. Mechanism of p38 MAP kinase activation in vivo. Genes Dev 2003; 17:1969 - 78; http://dx.doi.org/10.1101/gad.1107303; PMID: 12893778
   PubMed Web of Science ®Google Scholar
• Doza YN, Cuenda A, Thomas GM, Cohen P, Nebreda AR. Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. FEBS Lett 1995; 364:223 - 8; http://dx.doi.org/10.1016/0014-5793(95)00346-B; PMID: 7750576
   PubMed Web of Science ®Google Scholar
• Lawler S, Fleming Y, Goedert M, Cohen P. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr Biol 1998; 8:1387 - 90; http://dx.doi.org/10.1016/S0960-9822(98)00019-0; PMID: 9889102
   PubMed Web of Science ®Google Scholar
• Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 1995; 268:286 - 90; http://dx.doi.org/10.1126/science.7716521; PMID: 7716521
   PubMed Web of Science ®Google Scholar
• Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 2001; 15:1419 - 26; http://dx.doi.org/10.1101/gad.888501; PMID: 11390361
   PubMed Web of Science ®Google Scholar
• Wada T, Nakagawa K, Watanabe T, Nishitai G, Seo J, Kishimoto H, et al. Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation. J Biol Chem 2001; 276:30892 - 7; http://dx.doi.org/10.1074/jbc.M011780200; PMID: 11418587
   PubMed Web of Science ®Google Scholar
• Nishina H, Wada T, Katada T. Physiological roles of SAPK/JNK signaling pathway. J Biochem 2004; 136:123 - 6; http://dx.doi.org/10.1093/jb/mvh117; PMID: 15496581
   PubMed Web of Science ®Google Scholar
• Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 1996; 15:2760 - 70; PMID: 8654373
   PubMed Web of Science ®Google Scholar
• Martin JH, Mohit AA, Miller CA. Developmental expression in the mouse nervous system of the p493F12 SAP kinase. Brain Res Mol Brain Res 1996; 35:47 - 57; http://dx.doi.org/10.1016/0169-328X(95)00181-Q; PMID: 8717339
   PubMedGoogle Scholar
• Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ, et al. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci U S A 1997; 94:3004 - 9; http://dx.doi.org/10.1073/pnas.94.7.3004; PMID: 9096336
   PubMed Web of Science ®Google Scholar
• Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999; 22:667 - 76; http://dx.doi.org/10.1016/S0896-6273(00)80727-8; PMID: 10230788
   PubMed Web of Science ®Google Scholar
• Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 1999; 89:115 - 24; http://dx.doi.org/10.1016/S0925-4773(99)00213-0; PMID: 10559486
   PubMed Web of Science ®Google Scholar
• Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 2007; 1773:1358 - 75; http://dx.doi.org/10.1016/j.bbamcr.2007.03.010; PMID: 17481747
   PubMed Web of Science ®Google Scholar
• Hu MC, Wang YP, Mikhail A, Qiu WR, Tan TH. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. J Biol Chem 1999; 274:7095 - 102; http://dx.doi.org/10.1074/jbc.274.11.7095; PMID: 10066767
   PubMed Web of Science ®Google Scholar
• Hui L, Bakiri L, Stepniak E, Wagner EF. p38alpha: a suppressor of cell proliferation and tumorigenesis. Cell Cycle 2007; 6:2429 - 33; http://dx.doi.org/10.4161/cc.6.20.4774; PMID: 17957136
   PubMed Web of Science ®Google Scholar
• Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, et al. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 2000; 6:109 - 16; PMID: 10949032
   PubMed Web of Science ®Google Scholar
• Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA. Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med 2000; 191:859 - 70; http://dx.doi.org/10.1084/jem.191.5.859; PMID: 10704466
   PubMed Web of Science ®Google Scholar
• Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, et al. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A 2000; 97:10454 - 9; http://dx.doi.org/10.1073/pnas.180316397; PMID: 10973481
   PubMed Web of Science ®Google Scholar
• Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 2000; 102:221 - 31; http://dx.doi.org/10.1016/S0092-8674(00)00027-1; PMID: 10943842
   PubMed Web of Science ®Google Scholar
• Downs KM, Davies T. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development 1993; 118:1255 - 66; PMID: 8269852
   PubMed Web of Science ®Google Scholar
• Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282:1145 - 7; http://dx.doi.org/10.1126/science.282.5391.1145; PMID: 9804556
   PubMed Web of Science ®Google Scholar
• Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 2001; 17:435 - 62; http://dx.doi.org/10.1146/annurev.cellbio.17.1.435; PMID: 11687496
   PubMed Web of Science ®Google Scholar
• Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005; 19:1129 - 55; http://dx.doi.org/10.1101/gad.1303605; PMID: 15905405
   PubMed Web of Science ®Google Scholar
• Desbaillets I, Ziegler U, Groscurth P, Gassmann M. Embryoid bodies: an in vitro model of mouse embryogenesis. Exp Physiol 2000; 85:645 - 51; http://dx.doi.org/10.1017/S0958067000021047; PMID: 11187960
   PubMed Web of Science ®Google Scholar
• Höpfl G, Gassmann M, Desbaillets I. Differentiating embryonic stem cells into embryoid bodies. Methods Mol Biol 2004; 254:79 - 98; PMID: 15041757
   PubMedGoogle Scholar
• Keller GM. In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 1995; 7:862 - 9; http://dx.doi.org/10.1016/0955-0674(95)80071-9; PMID: 8608017
   PubMed Web of Science ®Google Scholar
• Aberdam E, Barak E, Rouleau M, de LaForest S, Berrih-Aknin S, Suter DM, et al. A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells 2008; 26:440 - 4; http://dx.doi.org/10.1634/stemcells.2007-0588; PMID: 18032703
   PubMed Web of Science ®Google Scholar
• Bibel M, Richter J, Schrenk K, Tucker KL, Staiger V, Korte M, et al. Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nat Neurosci 2004; 7:1003 - 9; http://dx.doi.org/10.1038/nn1301; PMID: 15332090
   PubMed Web of Science ®Google Scholar
• Strübing C, Ahnert-Hilger G, Shan J, Wiedenmann B, Hescheler J, Wobus AM. Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech Dev 1995; 53:275 - 87; http://dx.doi.org/10.1016/0925-4773(95)00446-8; PMID: 8562428
   PubMed Web of Science ®Google Scholar
• Rathjen J, Haines BP, Hudson KM, Nesci A, Dunn S, Rathjen PD. Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population. Development 2002; 129:2649 - 61; PMID: 12015293
   PubMed Web of Science ®Google Scholar
• Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 2000; 18:675 - 9; http://dx.doi.org/10.1038/76536; PMID: 10835609
   PubMed Web of Science ®Google Scholar
• O’Shea KS. Neural differentiation of embryonic stem cells. Methods Mol Biol 2002; 198:3 - 14; PMID: 11951633
   PubMedGoogle Scholar
• Metallo CM, Ji L, de Pablo JJ, Palecek SP. Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells. Stem Cells 2008; 26:372 - 80; http://dx.doi.org/10.1634/stemcells.2007-0501; PMID: 17962700
   PubMed Web of Science ®Google Scholar
• Nguyen Ngoc TD, Son YO, Lim SS, Shi X, Kim JG, Heo JS, et al. Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways. Toxicol Appl Pharmacol 2012; 259:329 - 37; http://dx.doi.org/10.1016/j.taap.2012.01.010; PMID: 22285274
   PubMed Web of Science ®Google Scholar
• Chae HD, Broxmeyer HE. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev 2011; 20:1277 - 85; http://dx.doi.org/10.1089/scd.2010.0465; PMID: 21083429
   PubMed Web of Science ®Google Scholar
• Kim MH, Kim MO, Heo JS, Kim JS, Han HJ. Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells. Apoptosis 2008; 13:295 - 304; http://dx.doi.org/10.1007/s10495-007-0160-y; PMID: 18049903
   PubMed Web of Science ®Google Scholar
• Huang FJ, Lan KC, Kang HY, Lin PY, Chan WH, Hsu YC, et al. Retinoic acid influences the embryoid body formation in mouse embryonic stem cells by induction of caspase and p38 MAPK/JNK-mediated apoptosis. Environ Toxicol 2011; Epub ahead of print http://dx.doi.org/10.1002/tox.20709; PMID: 21626648
   PubMed Web of Science ®Google Scholar
• Lee SH, Heo JS, Lee MY, Han HJ. Effect of dihydrotestosterone on hydrogen peroxide-induced apoptosis of mouse embryonic stem cells. J Cell Physiol 2008; 216:269 - 75; http://dx.doi.org/10.1002/jcp.21402; PMID: 18330893
   PubMed Web of Science ®Google Scholar
• Krishnamoorthy M, Heimburg-Molinaro J, Bargo AM, Nash RJ, Nash RJ. Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells. J Biochem 2009; 145:177 - 84; http://dx.doi.org/10.1093/jb/mvn153; PMID: 19010935
   PubMed Web of Science ®Google Scholar
• Hsuuw YD, Kuo TF, Lee KH, Liu YC, Huang YT, Lai CY, et al. Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells. Ann N Y Acad Sci 2009; 1171:501 - 8; http://dx.doi.org/10.1111/j.1749-6632.2009.04691.x; PMID: 19723096
   PubMed Web of Science ®Google Scholar
• Xu P, Davis RJ. c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal. Mol Cell Biol 2010; 30:1329 - 40; http://dx.doi.org/10.1128/MCB.00795-09; PMID: 20065035
   PubMed Web of Science ®Google Scholar
• Aubert J, Dunstan H, Chambers I, Smith A. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol 2002; 20:1240 - 5; http://dx.doi.org/10.1038/nbt763; PMID: 12447396
   PubMed Web of Science ®Google Scholar
• Haegele L, Ingold B, Naumann H, Tabatabai G, Ledermann B, Brandner S. Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression. Mol Cell Neurosci 2003; 24:696 - 708; http://dx.doi.org/10.1016/S1044-7431(03)00232-X; PMID: 14664819
   PubMed Web of Science ®Google Scholar
• Amura CR, Marek L, Winn RA, Heasley LE. Inhibited neurogenesis in JNK1-deficient embryonic stem cells. Mol Cell Biol 2005; 25:10791 - 802; http://dx.doi.org/10.1128/MCB.25.24.10791-10802.2005; PMID: 16314504
   PubMed Web of Science ®Google Scholar
• Onizuka T, Yuasa S, Kusumoto D, Shimoji K, Egashira T, Ohno Y, et al. Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway. J Mol Cell Cardiol 2012; 52:650 - 9; http://dx.doi.org/10.1016/j.yjmcc.2011.11.010; PMID: 22146296
   PubMed Web of Science ®Google Scholar
• Aouadi M, Bost F, Caron L, Laurent K, Le Marchand Brustel Y, Binétruy B. p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem Cells 2006; 24:1399 - 406; http://dx.doi.org/10.1634/stemcells.2005-0398; PMID: 16424397
   PubMed Web of Science ®Google Scholar
• Aouadi M, Laurent K, Prot M, Le Marchand-Brustel Y, Binétruy B, Bost F. Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages. Diabetes 2006; 55:281 - 9; http://dx.doi.org/10.2337/diabetes.55.02.06.db05-0963; PMID: 16443758
   PubMed Web of Science ®Google Scholar
• Graichen R, Xu X, Braam SR, Balakrishnan T, Norfiza S, Sieh S, et al. Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 2008; 76:357 - 70; http://dx.doi.org/10.1111/j.1432-0436.2007.00236.x; PMID: 18021257
   PubMed Web of Science ®Google Scholar
• Barruet E, Hadadeh O, Peiretti F, Renault VM, Hadjal Y, Bernot D, et al. p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells. Stem Cells Dev 2011; 20:1233 - 46; http://dx.doi.org/10.1089/scd.2010.0213; PMID: 20954847
   PubMed Web of Science ®Google Scholar
• Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, et al. p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev 2010; 19:1723 - 34; http://dx.doi.org/10.1089/scd.2010.0066; PMID: 20412016
   PubMed Web of Science ®Google Scholar
• Ding L, Liang XG, Hu Y, Zhu DY, Lou YJ. Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells Dev 2008; 17:751 - 60; http://dx.doi.org/10.1089/scd.2007.0206; PMID: 18484897
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Kang B, Huang F, Guo YL. Mouse embryonic stem cells lacking p38alpha and p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells. Differentiation 2009; 78:143 - 50; http://dx.doi.org/10.1016/j.diff.2009.05.006; PMID: 19539422
   PubMed Web of Science ®Google Scholar
• Huang Z, Yu J, Toselli P, Bhawan J, Sudireddy V, Taylor L, et al. Angiotensin II type 1 and bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells. J Cell Physiol 2007; 211:816 - 25; http://dx.doi.org/10.1002/jcp.20985; PMID: 17299793
   PubMed Web of Science ®Google Scholar
• Li Z, Theus MH, Wei L. Role of ERK 1/2 signaling in neuronal differentiation of cultured embryonic stem cells. Dev Growth Differ 2006; 48:513 - 23; http://dx.doi.org/10.1111/j.1440-169X.2006.00889.x; PMID: 17026715
   PubMed Web of Science ®Google Scholar
• Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, et al. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Proc Natl Acad Sci U S A 2001; 98:4599 - 604; http://dx.doi.org/10.1073/pnas.081021898; PMID: 11274363
   PubMed Web of Science ®Google Scholar
• Hamazaki T, Iiboshi Y, Oka M, Papst PJ, Meacham AM, Zon LI, et al. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett 2001; 497:15 - 9; http://dx.doi.org/10.1016/S0014-5793(01)02423-1; PMID: 11376655
   PubMed Web of Science ®Google Scholar
• Wang J, Chen L, Ko CI, Zhang L, Puga A, Xia Y. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. J Biol Chem 2012; 287:2787 - 97; http://dx.doi.org/10.1074/jbc.M111.281915; PMID: 22130668
   PubMed Web of Science ®Google Scholar
• Kempf H, Lecina M, Ting S, Zweigerdt R, Oh S. Distinct regulation of mitogen-activated protein kinase activities is coupled with enhanced cardiac differentiation of human embryonic stem cells. Stem Cell Res 2011; 7:198 - 209; http://dx.doi.org/10.1016/j.scr.2011.06.001; PMID: 21907163
   PubMed Web of Science ®Google Scholar
• Wan CR, Chung S, Kamm RD. Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system. Ann Biomed Eng 2011; 39:1840 - 7; http://dx.doi.org/10.1007/s10439-011-0275-8; PMID: 21336802
   PubMed Web of Science ®Google Scholar
• Tiwari VK, Stadler MB, Wirbelauer C, Paro R, Schübeler D, Beisel C. A chromatin-modifying function of JNK during stem cell differentiation. Nat Genet 2012; 44:94 - 100; http://dx.doi.org/10.1038/ng.1036; PMID: 22179133
   PubMed Web of Science ®Google Scholar