Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling

References

• Hunter T. Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol 2009; 21:140 - 146; http://dx.doi.org/10.1016/j.ceb.2009.01.028
   PubMed Web of Science ®Google Scholar
• Rao N, Dodge I, Band H. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol 2002; 71:753 - 763
   PubMed Web of Science ®Google Scholar
• Thien CB, Langdon WY. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001; 2:294 - 307; http://dx.doi.org/10.1038/35067100
   PubMed Web of Science ®Google Scholar
• Duan L, Reddi AL, Ghosh A, Dimri M, Band H. The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity 2004; 21:7 - 17; http://dx.doi.org/10.1016/j.immuni.2004.06.012
   PubMed Web of Science ®Google Scholar
• Schmidt MHH, Dikic I. The Cbl interactome and its functions. Nat Rev Mol Cell Biol 2005; 6:907 - 918; http://dx.doi.org/10.1038/nrm1762
   PubMed Web of Science ®Google Scholar
• Levkowitz G, Waterman H, Zamir E, Kam Z, Oved S, Langdon WY, et al. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 1998; 12:3663 - 3674
   PubMed Web of Science ®Google Scholar
• Lee PS, Wang Y, Dominguez MG, Yeung YG, Murphy MA, Bowtell DD, et al. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J 1999; 18:3616 - 3628; http://dx.doi.org/10.1093/emboj/18.13.3616
   PubMed Web of Science ®Google Scholar
• Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, et al. Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci USA 2002; 99:3794 - 3799; http://dx.doi.org/10.1073/pnas.062055999
   PubMed Web of Science ®Google Scholar
• Fang D, Liu YC. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2001; 2:870 - 875; http://dx.doi.org/10.1038/ni0901-870
   PubMed Web of Science ®Google Scholar
• Murphy MA, Schnall RG, Venter DJ, Barnett L, Bertoncello I, Thien CB, et al. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol 1998; 18:4872 - 4882
   PubMed Web of Science ®Google Scholar
• Naramura M, Kole HK, Hu RJ, Gu H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci USA 1998; 95:15547 - 15552
   PubMed Web of Science ®Google Scholar
• Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CBF, et al. c-Cbl-deficient mice have reduced adiposity, higher energy expenditure and improved peripheral insulin action. J Clin Invest 2004; 114:1326 - 1333; http://dx.doi.org/10.1172/JCI21480
   PubMed Web of Science ®Google Scholar
• El Chami N, Ikhlef F, Kaszas K, Yakoub S, Tabone E, Siddeek B, et al. Androgen-dependent apoptosis in male germ cells is regulated through the protooncoprotein Cbl. J Cell Biol 2005; 171:651 - 661; http://dx.doi.org/10.1083/jcb.200507076
   PubMed Web of Science ®Google Scholar
• Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 2000; 403:211 - 216; http://dx.doi.org/10.1038/35003228
   PubMed Web of Science ®Google Scholar
• Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 2000; 403:216 - 220; http://dx.doi.org/10.1038/35003235
   PubMed Web of Science ®Google Scholar
• Chiang JY, Jang IK, Hodes R, Gu H. Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest 2007; 117:1029 - 1036; http://dx.doi.org/10.1172/JCI29472
   PubMed Web of Science ®Google Scholar
• Loeser S, Loser K, Bijker MS, Rangachari M, van der Burg SH, Wada T, et al. Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med 2007; 204:879 - 891; http://dx.doi.org/10.1084/jem.20061699
   PubMed Web of Science ®Google Scholar
• Yokoi N, Komeda K, Wang H, Yano H, Kitada K, Saitoh Y, et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet 2002; 31:391 - 394; http://dx.doi.org/10.1038/ng927
   PubMed Web of Science ®Google Scholar
• Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, Park GY, et al. E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med 2007; 13:920 - 926; http://dx.doi.org/10.1038/nm1607
   PubMed Web of Science ®Google Scholar
• Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, Harada N, et al. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 2007; 56:2511 - 2522; http://dx.doi.org/10.2337/db061768
   PubMed Web of Science ®Google Scholar
• Oh SY, Park J, Zheng T, Kim Y, Wu F, Cho SH, et al. Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy 2010; 41:434 - 442; http://dx.doi.org/10.1111/j.1365-2222.2010.03593x
   PubMed Web of Science ®Google Scholar
• Naramura M, Jang I, Kole H, Huang F, Haines D, Gu H. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol 2002; 3:1192 - 1199; http://dx.doi.org/10.1038/ni855
   PubMed Web of Science ®Google Scholar
• Griffiths EK, Sanchez O, Mill P, Krawczyk C, Hojilla CV, Rubin E, et al. Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol 2003; 23:7708 - 7718
   PubMed Web of Science ®Google Scholar
• Fiore F, Estebe B, Gibier P, Orsoni J, Courbard J, Chodosh LA, et al. Abnormal mammary gland development in MMTV-CBLC transgenic mouse. In Vivo 2009; 23:225 - 228
   PubMed Web of Science ®Google Scholar
• Huang F, Kitaura Y, Jang I, Naramura M, Kole HH, Liu L, et al. Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. Immunity 2006; 25:571 - 581; http://dx.doi.org/10.1016/j.immuni.2006.08.021
   PubMed Web of Science ®Google Scholar
• Kitaura Y, Jang IK, Wang Y, Han Y, Inazu T, Cadera EJ, et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 2007; 26:567 - 578; http://dx.doi.org/10.1016/j.immuni.2007.03.015
   PubMed Web of Science ®Google Scholar
• Naramura M, Nandwani N, Gu H, Band V, Band H. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci USA 2010; 107:16274 - 16279; http://dx.doi.org/10.1073/pnas.1007575107
   PubMed Web of Science ®Google Scholar
• Rathinam C, Thien CBF, Langdon WY, Gu H, Flavell RA. The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells. Genes Dev 2008; 22:992 - 997; http://dx.doi.org/10.1101/gad.1651408
   PubMed Web of Science ®Google Scholar
• Thien CBF, Scaife RM, Papadimitriou JM, Murphy MA, Bowtell DDL, Langdon WY. A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med 2003; 197:503 - 513
   PubMed Web of Science ®Google Scholar
• Thien CBF, Blystad FD, Zhan Y, Lew AM, Voigt V, Andoniou CE, et al. Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion. EMBO J 2005; 24:3807 - 3819; http://dx.doi.org/10.1038/sj.emboj.7600841
   PubMed Web of Science ®Google Scholar
• Thien CBF, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, et al. c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol-3-kinase/Akt pathway. J Biol Chem 2010; 285:10969 - 10981; http://dx.doi.org/10.1074/jbc.M109.094920
   PubMed Web of Science ®Google Scholar
• Oksvold MP, Dagger SA, Thien CBF, Langdon WY. The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells. Mol Immunol 2008; 45:925 - 936; http://dx.doi.org/10.1016/j.molimm.2007.08.002
   PubMed Web of Science ®Google Scholar
• Yoon CH, Lee J, Jongeward GD, Sternberg PW. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science 1995; 269:1102 - 1105
   PubMed Web of Science ®Google Scholar
• Rao N, Lupher ML, Ota S, Reedquist KA, Druker BJ, Band H. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. J Immunol 2000; 164:4616 - 4626
   PubMed Web of Science ®Google Scholar
• Rathinam C, Thien CBF, Flavell RA, Langdon WY. Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. Cancer Cell 2010; 18:341 - 352; http://dx.doi.org/10.1016/j.ccr.2010.09.008
   PubMed Web of Science ®Google Scholar
• Ogawa S, Shih L, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, et al. Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms. Clin Cancer Res 2010; 16:3825 - 3831; http://dx.doi.org/10.1158/1078-0432.CCR-09-2341
   PubMed Web of Science ®Google Scholar