1,570
Views
43
CrossRef citations to date
0
Altmetric
Report

Zileuton, a new efficient and safe systemic anti-acne drug

Pages 188-192 | Published online: 01 Jun 2009

References

  • Zouboulis CC. Is acne vulgaris a genuine inflammatory disease?. Dermatology 2001; 203:277 - 279
  • Zouboulis CC, Eady A, Philpott M, Goldsmith LA, Orfanos CE, Cunliffe WC, Rosenfield R. What is the pathogenesis of acne?. Exp Dermatol 2005; 14:143 - 152
  • Zouboulis CC, Baron JM, Böhm M, Kippenberger S, Kurzen H, Reichrath J, Thielitz A. Frontiers in sebaceous gland biology and pathology. Exp Dermatol 2008; 17:542 - 551
  • Zouboulis CC, Schagen S, Alestas T. The sebocyte culture-a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne. Arch Dermatol Res 2008; 300:397 - 413
  • Hindson C, Lawlor F, Wacks H. Benoxaprofen for nodular acne. Lancet 1982; 1415
  • Wong RC, Kang S, Heezen JL, Voorhees JJ, Ellis CN. Oral ibuprofen and tetracycline for the treatment of acne vulgaris. J Am Acad Dermatol 1984; 11:1076 - 1081
  • Karvonen SL, Vaalasti A, Kautiainen H, Reunala T. Systemic corticosteroid and isotretinoin treatment in cystic acne. Acta Derm Venereol 1993; 73:452 - 455
  • Seukeran DC, Cunliffe WJ. The treatment of acne fulminans: a review of 25 cases. Br J Dermatol 1999; 141:307 - 309
  • Bass D, Zouboulis CC. Behandlung der Acne fulminans mit Isotretinoin und Prednisolon. Z Hautkr 2001; 76:473
  • Alestas T, Ganceviciene R, Fimmel S, Müller-Decker K, Zouboulis CC. Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. J Mol Med 2006; 84:75 - 87
  • Yokomizo T, Izumi T, Shimizu T. Leukotriene B4: Metabolism and signal transduction. Arch Biochem Biophys 2001; 355:231 - 241
  • Haeggstrom JZ. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic LTB4 biosynthesis. J Biol Chem 2004; 279:50639 - 50642
  • Wróbel A, Seltmann H, Fimmel S, Müller-Decker K, Tsukada M, Bogdanoff B, et al. Differentiation and apoptosis in human immortalized sebocytes. J Invest Dermatol 2003; 120:175 - 181
  • Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARalphaleukotriene B4 pathway to inflammation control. Nature 1996; 384:39 - 43
  • Delerive P, Fruchart J-C, Staels B. Eurosterone Meeting—Peroxisome proliferatoractivated receptors in inflammation control. J Endocrinol 2001; 169:453 - 459
  • Devchand PR, Hihi AK, Perroud M, Schleuning WD, Spiegelman BM, Wahli W. Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4). J Biol Chem 1999; 274:23341 - 23348
  • Chinetti G, Fruchart J-C, Staels B. Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 2000; 49:497 - 505
  • Rosenfield RL, Deplewski D, Kentsis A, Ciletti N. Mechanisms of androgen induction of sebocyte differentiation. Dermatology 1998; 196:43 - 46
  • Lin Q, Ruuska SE, Shaw NS, Dong D, Noy N. Ligand selectivity of the peroxisome proliferator-activated receptor alpha. Biochemistry 1999; 38:185 - 190
  • Zouboulis CC. Leukotrien-Antagonisten bei atopischen Erkrankungen und Akne. Akt Dermatol 2003; 29:419 - 425
  • Carter GW, Young PR, Albert DH, Bouska J, Dyer R, Bell RL, et al. 5-lipoxygenase inhibitory activity of zileuton. J Pharm Exp Ther 1990; 256:929 - 937
  • Zouboulis CC, Seltmann H, Alestas T. Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis. Exp Dermatol in press
  • Zouboulis CC, Nestoris S, Adler YD, Picardo M, Camera E, Orth M, et al. A new concept for acne therapy: a pilot study with zileuton, an oral 5-lipoxygenase inhibitor. Arch Dermatol 2003; 139:668 - 670
  • Zouboulis CC, Saborowski A, Boschnakow A. Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production. Dermatology 2005; 210:36 - 38
  • Zouboulis CC, Seltmann H, Neitzel H, Orfanos CE. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol 1999; 113:1011 - 1020
  • Allen BS, Smith JG. Various parameters for grading acne. Arch Dermatol 1982; 118:23 - 25
  • Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003; 121:20 - 27
  • Critical Therapeutics announces results from phase II study of Zileuton in acne patients 2005; (http://findarticles.com/p/articles/mi_m0EIN/is_2005_July_14/ai_n14787787)
  • Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294:1871 - 1875