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Review

Estrogens and aging skin

Pages 264-270 | Received 07 Aug 2012, Accepted 04 Feb 2013, Published online: 01 Apr 2013

References

  • Allen E, Doisy EA. An ovarian hormone preliminary report on its localisation, extraction and partial purification, and action in test animals. JAMA 1923; 81:819 - 21; http://dx.doi.org/10.1001/jama.1923.02650100027012
  • Wend K, Wend P, Krum SA. Tissue-specifc effects of loss of estrogen during menopause and aging. Front Endocrinol (Lausanne) 2012; 3:1 - 14; PMID: 22649402
  • Simpson ER. Genetic mutations resulting in estrogen insufficiency in the male. Mol Cell Endocrinol 1998; 145:55 - 9; http://dx.doi.org/10.1016/S0303-7207(98)00169-5; PMID: 9922099
  • Labrie F. Adrenal androgens and intracrinology. Semin Reprod Med 2004; 22:299 - 309; http://dx.doi.org/10.1055/s-2004-861547; PMID: 15635498
  • Thornton MJ. The biological actions of estrogens on skin. Exp Dermatol 2002; 11:487 - 502; http://dx.doi.org/10.1034/j.1600-0625.2002.110601.x; PMID: 12473056
  • Thornton MJ. Oestrogen functions in skin and skin appendages. Expert Opin Ther Targets 2005; 9:617 - 29; http://dx.doi.org/10.1517/14728222.9.3.617; PMID: 15948678
  • Gustafsson JA. Estrogen receptor beta--a new dimension in estrogen mechanism of action. J Endocrinol 1999; 163:379 - 83; http://dx.doi.org/10.1677/joe.0.1630379; PMID: 10588810
  • Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 2001; 29:2905 - 19; http://dx.doi.org/10.1093/nar/29.14.2905; PMID: 11452016
  • Webb P, Nguyen P, Kushner PJ. Differential SERM effects on corepressor binding dictate ERalpha activity in vivo. J Biol Chem 2003; 278:6912 - 20; http://dx.doi.org/10.1074/jbc.M208501200; PMID: 12482846
  • Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997; 277:1508 - 10; http://dx.doi.org/10.1126/science.277.5331.1508; PMID: 9278514
  • Smith CL, O’Malley BW. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev 2004; 25:45 - 71; http://dx.doi.org/10.1210/er.2003-0023; PMID: 14769827
  • Thornton MJ, Nelson LD, Taylor AH, Birch MP, Laing I, Messenger AG. The modulation of aromatase and estrogen receptor alpha in cultured human dermal papilla cells by dexamethasone: a novel mechanism for selective action of estrogen via estrogen receptor beta?. J Invest Dermatol 2006; 126:2010 - 8; http://dx.doi.org/10.1038/sj.jid.5700344; PMID: 16691199
  • Stevenson S, Thornton J. Effect of estrogens on skin aging and the potential role of SERMs. Clin Interv Aging 2007; 2:283 - 97; PMID: 18044179
  • Levin ER. Minireview: Extranuclear steroid receptors: roles in modulation of cell functions. Mol Endocrinol 2011; 25:377 - 84; http://dx.doi.org/10.1210/me.2010-0284; PMID: 20861220
  • Levin ER. G protein-coupled receptor 30: estrogen receptor or collaborator?. Endocrinology 2009; 150:1563 - 5; http://dx.doi.org/10.1210/en.2008-1759; PMID: 19307418
  • Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem 2007; 282:22278 - 88; http://dx.doi.org/10.1074/jbc.M611877200; PMID: 17535799
  • Santen RJ, Fan P, Zhang Z, Bao Y, Song RX, Yue W. Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells. Steroids 2009; 74:586 - 94; http://dx.doi.org/10.1016/j.steroids.2008.11.020; PMID: 19138696
  • Song RX, Fan P, Yue W, Chen Y, Santen RJ. Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer. Endocr Relat Cancer 2006; 13:Suppl 1 S3 - 13; http://dx.doi.org/10.1677/erc.1.01322; PMID: 17259556
  • Lebesgue D, Chevaleyre V, Zukin RS, Etgen AM. Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 2009; 74:555 - 61; http://dx.doi.org/10.1016/j.steroids.2009.01.003; PMID: 19428444
  • Makrantonaki E, Vogel K, Fimmel S, Oeff M, Seltmann H, Zouboulis CC. Interplay of IGF-I and 17beta-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro. Exp Gerontol 2008; 43:939 - 46; http://dx.doi.org/10.1016/j.exger.2008.07.005; PMID: 18755261
  • Emmerson E, Campbell L, Davies FC, Ross NL, Ashcroft GS, Krust A, et al. Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERα cross talk. J Invest Dermatol 2012; 132:2838 - 48; http://dx.doi.org/10.1038/jid.2012.228; PMID: 22810305
  • Inoue T, Miki Y, Abe K, Hatori M, Hosaka M, Kariya Y, et al. The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis. Mol Cell Endocrinol 2011; 344:35 - 40; http://dx.doi.org/10.1016/j.mce.2011.06.015; PMID: 21740958
  • Punnonen R. Effect of castration and peroral estrogen therapy on the skin. Acta Obstet Gynecol Scand Suppl 1972; 21:3 - 44; PMID: 4511789
  • Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, et al. A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol 1994; 170:642 - 9; PMID: 8116726
  • Son ED, Lee JY, Lee S, Kim MS, Lee BG, Chang IS, et al. Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo. J Invest Dermatol 2005; 124:1149 - 61; http://dx.doi.org/10.1111/j.0022-202X.2005.23736.x; PMID: 15955089
  • Brincat M, Versi E, Moniz CF, Magos A, de Trafford J, Studd JW. Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet Gynecol 1987; 70:123 - 7; PMID: 3601260
  • Brincat M, Moniz CJ, Studd JW, Darby A, Magos A, Emburey G, et al. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynaecol 1985; 92:256 - 9; http://dx.doi.org/10.1111/j.1471-0528.1985.tb01091.x; PMID: 3978054
  • Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP, et al. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas 1999; 33:239 - 47; http://dx.doi.org/10.1016/S0378-5122(99)00077-8; PMID: 10656502
  • Sauerbronn AV, Fonseca AM, Bagnoli VR, Saldiva PH, Pinotti JA. The effects of systemic hormonal replacement therapy on the skin of postmenopausal women. Int J Gynaecol Obstet 2000; 68:35 - 41; http://dx.doi.org/10.1016/S0020-7292(99)00166-6; PMID: 10687834
  • Savvas M, Bishop J, Laurent G, Watson N, Studd J. Type III collagen content in the skin of postmenopausal women receiving oestradiol and testosterone implants. Br J Obstet Gynaecol 1993; 100:154 - 6; http://dx.doi.org/10.1111/j.1471-0528.1993.tb15212.x; PMID: 8476808
  • Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. Int J Dermatol 1996; 35:669 - 74; http://dx.doi.org/10.1111/j.1365-4362.1996.tb03701.x; PMID: 8876303
  • Varila E, Rantala I, Oikarinen A, Risteli J, Reunala T, Oksanen H, et al. The effect of topical oestradiol on skin collagen of postmenopausal women. Br J Obstet Gynaecol 1995; 102:985 - 9; http://dx.doi.org/10.1111/j.1471-0528.1995.tb10906.x; PMID: 8652490
  • Shah MG, Maibach HI. Estrogen and skin. An overview. Am J Clin Dermatol 2001; 2:143 - 50; http://dx.doi.org/10.2165/00128071-200102030-00003; PMID: 11705091
  • Henry F, Piérard-Franchimont C, Cauwenbergh G, Piérard GE. Age-related changes in facial skin contours and rheology. J Am Geriatr Soc 1997; 45:220 - 2; PMID: 9033524
  • Wolff EF, Narayan D, Taylor HS. Long-term effects of hormone therapy on skin rigidity and wrinkles. Fertil Steril 2005; 84:285 - 8; http://dx.doi.org/10.1016/j.fertnstert.2004.12.062; PMID: 16084862
  • Emmerson E, Hardman MJ. The role of estrogen deficiency in skin ageing and wound healing. Biogerontology 2012; 13:3 - 20; http://dx.doi.org/10.1007/s10522-011-9322-y; PMID: 21369728
  • Margolis DJ, Knauss J, Bilker W. Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers. Lancet 2002; 359:675 - 7; http://dx.doi.org/10.1016/S0140-6736(02)07806-6; PMID: 11879867
  • Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MWJ. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol 1999; 155:1137 - 46; http://dx.doi.org/10.1016/S0002-9440(10)65217-0; PMID: 10514397
  • Ashcroft GS, Lei KJ, Jin WW, Longenecker G, Kulkarni AB, Greenwell-Wild T, et al. Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 2000; 6:1147 - 53; http://dx.doi.org/10.1038/80489; PMID: 11017147
  • Ashcroft GS, Horan MA, Herrick SE, Tarnuzzer RW, Schultz GS, Ferguson MWJ. Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans. Cell Tissue Res 1997; 290:581 - 91; http://dx.doi.org/10.1007/s004410050963; PMID: 9369533
  • Ashcroft GS, Mills SJ, Lei KJ, Gibbons L, Jeong MJ, Taniguchi M, et al. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest 2003; 111:1309 - 18; PMID: 12727922
  • Ashcroft GS, Dodsworth J, van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med 1997; 3:1209 - 15; http://dx.doi.org/10.1038/nm1197-1209; PMID: 9359694
  • Stevenson S, Taylor AH, Meskiri A, Sharpe DT, Thornton MJ. Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: effects of estrogen on vascular endothelial growth factor secretion. Wound Repair Regen 2008; 16:243 - 53; http://dx.doi.org/10.1111/j.1524-475X.2008.00365.x; PMID: 18318810
  • Stevenson S, Nelson LD, Sharpe DT, Thornton MJ. 17beta-estradiol regulates the secretion of TGF-β by cultured human dermal fibroblasts. J Biomater Sci Polym Ed 2008; 19:1097 - 109; http://dx.doi.org/10.1163/156856208784909354; PMID: 18644234
  • Stevenson S, Sharpe DT, Thornton MJ. Effects of oestrogen agonists on human dermal fibroblasts in an in vitro wounding assay. Exp Dermatol 2009; 18:988 - 90; http://dx.doi.org/10.1111/j.1600-0625.2009.00864.x; PMID: 19469894
  • Ohnemus U, Uenalan M, Inzunza J, Gustafsson JA, Paus R. The hair follicle as an estrogen target and source. Endocr Rev 2006; 27:677 - 706; http://dx.doi.org/10.1210/er.2006-0020; PMID: 16877675
  • Lynfield YL. Effect of pregnancy on the human hair cycle. J Invest Dermatol 1960; 35:323 - 7; PMID: 13764567
  • Yip L, Zaloumis S, Irwin D, Severi G, Hopper J, Giles G, et al. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Br J Dermatol 2012; 166:1131 - 4; http://dx.doi.org/10.1111/j.1365-2133.2011.10702.x; PMID: 22014031
  • Yip L, Zaloumis S, Irwin D, Severi G, Hopper J, Giles G, et al. Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss. Br J Dermatol 2012; 161:289 - 94; http://dx.doi.org/10.1111/j.1365-2133.2009.09186.x; PMID: 22014031
  • Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O’Driscoll J, et al. Estrogen receptor beta (ERβ) is the predominant estrogen receptor in human scalp. Exp Dermatol 2003; 12:181 - 90; http://dx.doi.org/10.1034/j.1600-0625.2003.120209.x; PMID: 12702147
  • Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O’Driscoll J, et al. The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit. J Investig Dermatol Symp Proc 2003; 8:100 - 3; http://dx.doi.org/10.1046/j.1523-1747.2003.12181.x; PMID: 12895004
  • Beas F, Vargas L, Spada RP, Merchak N. Pseudoprecocious puberty in infants caused by a dermal ointment containing estrogens. J Pediatr 1969; 75:127 - 30; http://dx.doi.org/10.1016/S0022-3476(69)80113-7; PMID: 5790395
  • Schallreuter KU, Kothari S, Chavan B, Spencer JD. Regulation of melanogenesis--controversies and new concepts. Exp Dermatol 2008; 17:395 - 404; http://dx.doi.org/10.1111/j.1600-0625.2007.00675.x; PMID: 18177348
  • Schwahn DJ, Timchenko NA, Shibahara S, Medrano EE. Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. Pigment Cell Res 2005; 18:203 - 13; http://dx.doi.org/10.1111/j.1600-0749.2005.00229.x; PMID: 15892717
  • Preston DS, Stern RS. Nonmelanoma cancers of the skin. N Engl J Med 1992; 327:1649 - 62; http://dx.doi.org/10.1056/NEJM199212033272307; PMID: 1435901
  • Karagas MR, The Skin Cancer Prevention Study Group. Occurrence of cutaneous basal cell and squamous cell malignancies among those with a prior history of skin cancer. J Invest Dermatol 1994; 102:10S - 3S; http://dx.doi.org/10.1111/1523-1747.ep12386072; PMID: 8006426
  • Weinstock MA. Epidemiologic investigation of nonmelanoma skin cancer mortality: the Rhode Island Follow-Back Study. J Invest Dermatol 1994; 102:6S - 9S; http://dx.doi.org/10.1111/1523-1747.ep12385735; PMID: 8006441
  • Iddamalgoda A, Le QT, Ito K, Tanaka K, Kojima H, Kido H. Mast cell tryptase and photoaging: possible involvement in the degradation of extra cellular matrix and basement membrane proteins. Arch Dermatol Res 2008; 300:Suppl 1 S69 - 76; http://dx.doi.org/10.1007/s00403-007-0806-1; PMID: 17968569
  • Masaki H. Role of antioxidants in the skin: anti-aging effects. J Dermatol Sci 2010; 58:85 - 90; http://dx.doi.org/10.1016/j.jdermsci.2010.03.003; PMID: 20399614
  • Richardson TE, Yang SH, Wen Y, Simpkins JW. Estrogen protection in Friedreich’s ataxia skin fibroblasts. Endocrinology 2011; 152:2742 - 9; http://dx.doi.org/10.1210/en.2011-0184; PMID: 21540287
  • Simpkins JW, Dykens JA. Mitochondrial mechanisms of estrogen neuroprotection. Brain Res Rev 2008; 57:421 - 30; http://dx.doi.org/10.1016/j.brainresrev.2007.04.007; PMID: 17512984
  • Prokai L, Prokai-Tatrai K, Perjesi P, Zharikova AD, Perez EJ, Liu R, et al. Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection. Proc Natl Acad Sci U S A 2003; 100:11741 - 6; http://dx.doi.org/10.1073/pnas.2032621100; PMID: 14504383
  • Richardson TE, Yu AE, Wen Y, Yang SH, Simpkins JW. Estrogen prevents oxidative damage to the mitochondria in Friedreich’s ataxia skin fibroblasts. PLoS One 2012; 7:e34600; http://dx.doi.org/10.1371/journal.pone.0034600; PMID: 22509330
  • Chang KCN, Wang Y, Oh IG, Jenkins S, Freedman LP, Thompson CC, et al. Estrogen receptor β is a novel therapeutic target for photoaging. Mol Pharmacol 2010; 77:744 - 50; http://dx.doi.org/10.1124/mol.109.062877; PMID: 20110405
  • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al, Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002; 288:321 - 33; http://dx.doi.org/10.1001/jama.288.3.321; PMID: 12117397
  • Jordan VC. Selective estrogen receptor modulation: a personal perspective. Cancer Res 2001; 61:5683 - 7; PMID: 11479197
  • Surazynski A, Jarzabek K, Haczynski J, Laudanski P, Palka J, Wolczynski S. Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts. Int J Mol Med 2003; 12:803 - 9; PMID: 14533013
  • Sumino H, Ichikawa S, Kasama S, Takahashi T, Kumakura H, Takayama Y, et al. Effects of raloxifene and hormone replacement therapy on forearm skin elasticity in postmenopausal women. Maturitas 2009; 62:53 - 7; http://dx.doi.org/10.1016/j.maturitas.2008.10.005; PMID: 19042101
  • Tham DM, Gardner CD, Haskell WL. Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 1998; 83:2223 - 35; http://dx.doi.org/10.1210/jc.83.7.2223; PMID: 9661587
  • Xu L, Lu A, Zhao X, Chen X, Cummings SR. Very low rates of hip fracture in Beijing, People’s Republic of China the Beijing Osteoporosis Project. Am J Epidemiol 1996; 144:901 - 7; http://dx.doi.org/10.1093/oxfordjournals.aje.a009024; PMID: 8890668
  • Hwang CS, Kwak HS, Lim HJ, Lee SH, Kang YS, Choe TB, et al. Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J Steroid Biochem Mol Biol 2006; 101:246 - 53; http://dx.doi.org/10.1016/j.jsbmb.2006.06.020; PMID: 16965913
  • Muthyala RS, Ju YH, Sheng S, Williams LD, Doerge DR, Katzenellenbogen BS, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004; 12:1559 - 67; http://dx.doi.org/10.1016/j.bmc.2003.11.035; PMID: 15018930
  • Jackson RL, Greiwe JS, Schwen RJ. Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome. Exp Dermatol 2011; 20:879 - 82; http://dx.doi.org/10.1111/j.1600-0625.2011.01362.x; PMID: 21913999
  • Wang YN, Wu W, Chen HC, Fang H. Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation. J Dermatol Sci 2010; 58:19 - 27; http://dx.doi.org/10.1016/j.jdermsci.2010.02.002; PMID: 20211546
  • Robb EL, Stuart JA. Resveratrol interacts with estrogen receptor-β to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase. Free Radic Biol Med 2011; 50:821 - 31; http://dx.doi.org/10.1016/j.freeradbiomed.2010.12.038; PMID: 21215799