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Research Paper

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

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Pages 1413-1420 | Published online: 01 Nov 2012

References

  • Hitchler MJ, Domann FE. Metabolic defects provide a spark for the epigenetic switch in cancer. Free Radic Biol Med 2009; 47:115 - 27; http://dx.doi.org/10.1016/j.freeradbiomed.2009.04.010; PMID: 19362589
  • Teperino R, Schoonjans K, Auwerx J. Histone methyl transferases and demethylases; can they link metabolism and transcription?. Cell Metab 2010; 12:321 - 7; http://dx.doi.org/10.1016/j.cmet.2010.09.004; PMID: 20889125
  • Burgio G, Onorati MC, Corona DF. Chromatin remodeling regulation by small molecules and metabolites. Biochim Biophys Acta 2010; 1799:671 - 80; http://dx.doi.org/10.1016/j.bbagrm.2010.05.007; PMID: 20493981
  • Rajendran P, Williams DE, Ho E, Dashwood RH. Metabolism as a key to histone deacetylase inhibition. Crit Rev Biochem Mol Biol 2011; 46:181 - 99; http://dx.doi.org/10.3109/10409238.2011.557713; PMID: 21599534
  • Thangaraju M, Gopal E, Martin PM, Ananth S, Smith SB, Prasad PD, et al. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer Res 2006; 66:11560 - 4; http://dx.doi.org/10.1158/0008-5472.CAN-06-1950; PMID: 17178845
  • Ferreira LMR, Hebrant A, Dumont JE. Metabolic reprogramming of the tumor. Oncogene 2012; 31:3999 - 4011; http://dx.doi.org/10.1038/onc.2011.576; PMID: 22231450
  • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683 - 92; http://dx.doi.org/10.1016/j.cell.2007.01.029; PMID: 17320506
  • Sandoval J, Esteller M. Cancer epigenomics: beyond genomics. Curr Opin Genet Dev 2012; 22:50 - 5; http://dx.doi.org/10.1016/j.gde.2012.02.008; PMID: 22402447
  • Simpson NE, Tryndyak VP, Beland FA, Pogribny IP. An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression. Breast Cancer Res Treat 2012; 133:959 - 68; http://dx.doi.org/10.1007/s10549-011-1871-x; PMID: 22101407
  • DeBerardinis RJ, Cheng T. Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010; 29:313 - 24; http://dx.doi.org/10.1038/onc.2009.358; PMID: 19881548
  • Erickson JW, Cerione RA. Glutaminase: a hot spot for regulation of cancer cell metabolism?. Oncotarget 2010; 1:734 - 40; PMID: 21234284
  • Daye D, Wellen KE. Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin Cell Dev Biol 2012; 23:362 - 9; http://dx.doi.org/10.1016/j.semcdb.2012.02.002; PMID: 22349059
  • Wang J-B, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010; 18:207 - 19; http://dx.doi.org/10.1016/j.ccr.2010.08.009; PMID: 20832749
  • Asiago VM, Alvarado LZ, Shanaiah N, Gowda GA, Owusu-Sarfo K, Ballas RA, et al. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res 2010; 70:8309 - 18; http://dx.doi.org/10.1158/0008-5472.CAN-10-1319; PMID: 20959483
  • Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009; 324:1076 - 80; http://dx.doi.org/10.1126/science.1164097; PMID: 19461003
  • Katt WP, Ramachandran S, Erickson JW, Cerione RA. Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation. Mol Cancer Ther 2012; 11:1269 - 78; http://dx.doi.org/10.1158/1535-7163.MCT-11-0942; PMID: 22496480
  • Steward MM, Lee J-S, O’Donovan A, Wyatt M, Bernstein BE, Shilatifard A. Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol 2006; 13:852 - 4; http://dx.doi.org/10.1038/nsmb1131; PMID: 16892064
  • Tate CM, Lee JH, Skalnik DG. CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin. FEBS J 2010; 277:210 - 23; http://dx.doi.org/10.1111/j.1742-4658.2009.07475.x; PMID: 19951360
  • Robin P, Fritsch L, Philipot O, Svinarchuk F, Ait-Si-Ali S. Post-translational modifications of histones H3 and H4 associated with the histone methyltransferases Suv39h1 and G9a. Genome Biol 2007; 8:R270; http://dx.doi.org/10.1186/gb-2007-8-12-r270; PMID: 18096052
  • Vaquero A, Sternglanz R, Reinberg D. NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 2007; 26:5505 - 20; http://dx.doi.org/10.1038/sj.onc.1210617; PMID: 17694090
  • Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 2010; 70:8981 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-10-1666; PMID: 21045145
  • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 2010; 330:1340 - 4; http://dx.doi.org/10.1126/science.1193494; PMID: 21127244
  • Cuello M, Ettenberg SA, Clark AS, Keane MM, Posner RH, Nau MM, et al. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res 2001; 61:4892 - 900; PMID: 11406568
  • Zhang M, Guo R, Zhai Y, Yang D. LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members. Cancer Lett 2003; 195:201 - 10; http://dx.doi.org/10.1016/S0304-3835(03)00148-4; PMID: 12767529
  • Carbone GM, Napoli S, Valentini A, Cavalli F, Watson DK, Catapano CV. Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells. Nucleic Acids Res 2004; 32:4358 - 67; http://dx.doi.org/10.1093/nar/gkh744; PMID: 15314206
  • Dubská L, Andera L, Sheard MA. HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis. FEBS Lett 2005; 579:4149 - 58; http://dx.doi.org/10.1016/j.febslet.2005.06.047; PMID: 16023111
  • Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Res 2006; 66:3963 - 6; http://dx.doi.org/10.1158/0008-5472.CAN-06-0743; PMID: 16618711
  • Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, et al. Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett 2009; 277:133 - 40; http://dx.doi.org/10.1016/j.canlet.2008.11.029; PMID: 19135778
  • Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL. Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 2011; 11:558 - 72; http://dx.doi.org/10.1038/nrc3090; PMID: 21734724
  • Lin Y, Cui H, Xu H, Yue L, Xu H, Jiang L, et al. Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway. Oncol Rep 2012; 27:1976 - 80; PMID: 22426554
  • Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T’Ang A, Fung YK, et al. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J 1995; 14:461 - 72; PMID: 7859736
  • Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444:61 - 6; http://dx.doi.org/10.1038/nature05194; PMID: 17080083
  • Tryndyak VP, Beland FA, Pogribny IP. E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer 2010; 126:2575 - 83; PMID: 19839049
  • Zhang Y, Pu X, Shi M, Chen L, Qian L, Song Y, et al. c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy. Oncol Rep 2007; 18:1207 - 12; PMID: 17914574
  • Engelmann D, Pützer BM. The dark side of E2F1: in transit beyond apoptosis. Cancer Res 2012; 72:571 - 5; http://dx.doi.org/10.1158/0008-5472.CAN-11-2575; PMID: 22298593
  • Kwon MJ, Kim SS, Choi YL, Jung HS, Balch C, Kim SH, et al. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis 2010; 31:974 - 83; http://dx.doi.org/10.1093/carcin/bgp336; PMID: 20053926
  • Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012; 13:343 - 57; http://dx.doi.org/10.1038/nrg3173; PMID: 22473383
  • Kouzarides T. Chromatin modifications and their function. Cell 2007; 128:693 - 705; http://dx.doi.org/10.1016/j.cell.2007.02.005; PMID: 17320507
  • Sims RJ 3rd, Reinberg D. Histone H3 Lys 4 methylation: caught in a bind?. Genes Dev 2006; 20:2779 - 86; http://dx.doi.org/10.1101/gad.1468206; PMID: 17043307
  • Kooistra SM, Helin K. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 2012; 13:297 - 311; PMID: 22473470
  • Lüscher-Firzlaff J, Gawlista I, Vervoorts J, Kapelle K, Braunschweig T, Walsemann G, et al. The human trithorax protein hASH2 functions as an oncoprotein. Cancer Res 2008; 68:749 - 58; http://dx.doi.org/10.1158/0008-5472.CAN-07-3158; PMID: 18245475
  • Kassis ES, Zhao M, Hong JA, Chen GA, Nguyen DM, Schrump DS. Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells. J Thorac Cardiovasc Surg 2006; 131:298 - 306; http://dx.doi.org/10.1016/j.jtcvs.2005.05.022; PMID: 16434257
  • Lee J-H, You J, Dobrota E, Skalnik DG. Identification and characterization of a novel human PP1 phosphatase complex. J Biol Chem 2010; 285:24466 - 76; http://dx.doi.org/10.1074/jbc.M110.109801; PMID: 20516061
  • Menssen A, Hydbring P, Kapelle K, Vervoorts J, Diebold J, Lüscher B, et al. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A 2012; 109:E187 - 96; http://dx.doi.org/10.1073/pnas.1105304109; PMID: 22190494
  • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3:1101 - 8; http://dx.doi.org/10.1038/nprot.2008.73; PMID: 18546601

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