Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma

References

• Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69 - 90; http://dx.doi.org/10.3322/caac.20107; PMID: 21296855
   PubMed Web of Science ®Google Scholar
• Guo M, Ren J, House MG, Qi Y, Brock MV, Herman JG. Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. Clin Cancer Res 2006; 12:4515 - 22; http://dx.doi.org/10.1158/1078-0432.CCR-05-2858; PMID: 16899597
   PubMed Web of Science ®Google Scholar
• Zhang XM, Guo MZ. The value of epigenetic markers in esophageal cancer. Front Med China 2010; 4:378 - 84; http://dx.doi.org/10.1007/s11684-010-0230-3; PMID: 21107750
   PubMedGoogle Scholar
• Baylin SB, Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat Rev Cancer 2006; 6:107 - 16; http://dx.doi.org/10.1038/nrc1799; PMID: 16491070
   PubMed Web of Science ®Google Scholar
• Jia Y, Yang Y, Liu S, Herman JG, Lu F, Guo M. SOX17 antagonizes WNT/β-catenin signaling pathway in hepatocellular carcinoma. Epigenetics 2010; 5:743 - 9; http://dx.doi.org/10.4161/epi.5.8.13104; PMID: 20716954
   PubMed Web of Science ®Google Scholar
• Guo M, Liu S, Lu F. Gefitinib-sensitizing mutations in esophageal carcinoma. N Engl J Med 2006; 354:2193 - 4; http://dx.doi.org/10.1056/NEJMc052698; PMID: 16707764
   PubMed Web of Science ®Google Scholar
• Guo M, House MG, Suzuki H, Ye Y, Brock MV, Lu F, et al. Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer 2007; 121:1219 - 26; http://dx.doi.org/10.1002/ijc.22828; PMID: 17534889
   PubMed Web of Science ®Google Scholar
• Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, et al. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer 2006; 119:2078 - 83; http://dx.doi.org/10.1002/ijc.22092; PMID: 16823849
   PubMed Web of Science ®Google Scholar
• Liu W, Li X, Chu ES, Go MY, Xu L, Zhao G, et al. Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway. Hepatology 2011; 53:843 - 53; http://dx.doi.org/10.1002/hep.24124; PMID: 21319196
   PubMed Web of Science ®Google Scholar
• Wong CM, Wong CC, Lee JM, Fan DN, Au SL, Ng IO. Sequential alterations of miRNA expression in hepatocellular carcinoma development and venous metastasis. Hepatology 2011; 55:1453 - 61; http://dx.doi.org/10.1002/hep.25512
   Web of Science ®Google Scholar
• Wang Y, Lee CG. Role of miR-224 in hepatocellular carcinoma: a tool for possible therapeutic intervention?. Epigenomics 2011; 3:235 - 43; http://dx.doi.org/10.2217/epi.11.5; PMID: 22122284
   PubMed Web of Science ®Google Scholar
• Jiang X, Tan J, Li J, Kivimäe S, Yang X, Zhuang L, et al. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell 2008; 13:529 - 41; http://dx.doi.org/10.1016/j.ccr.2008.04.019; PMID: 18538736
   PubMed Web of Science ®Google Scholar
• Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008; 8:387 - 98; http://dx.doi.org/10.1038/nrc2389; PMID: 18432252
   PubMed Web of Science ®Google Scholar
• Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, Yu E, et al. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 2008; 48:780 - 91; http://dx.doi.org/10.1016/j.jhep.2007.12.020; PMID: 18313787
   PubMed Web of Science ®Google Scholar
• Bengochea A, de Souza MM, Lefrançois L, Le Roux E, Galy O, Chemin I, et al. Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br J Cancer 2008; 99:143 - 50; http://dx.doi.org/10.1038/sj.bjc.6604422; PMID: 18577996
   PubMed Web of Science ®Google Scholar
• Lee HC, Kim M, Wands JR. Wnt/Frizzled signaling in hepatocellular carcinoma. Front Biosci 2006; 11:1901 - 15; http://dx.doi.org/10.2741/1933; PMID: 16368566
   PubMed Web of Science ®Google Scholar
• Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, et al. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell 2002; 2:449 - 61; http://dx.doi.org/10.1016/S1534-5807(02)00140-5; PMID: 11970895
   PubMed Web of Science ®Google Scholar
• Katoh M, Katoh M. Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. Int J Oncol 2003; 22:907 - 13; PMID: 12632086
   PubMed Web of Science ®Google Scholar
• Fisher DA, Kivimäe S, Hoshino J, Suriben R, Martin PM, Baxter N, et al. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. Dev Dyn 2006; 235:2620 - 30; http://dx.doi.org/10.1002/dvdy.20917; PMID: 16881060
   PubMed Web of Science ®Google Scholar
• Yau TO, Chan CY, Chan KL, Lee MF, Wong CM, Fan ST, et al. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene 2005; 24:1607 - 14; http://dx.doi.org/10.1038/sj.onc.1208340; PMID: 15580286
   PubMed Web of Science ®Google Scholar
• Xun WW, Brennan P, Tjonneland A, Vogel U, Overvad K, Kaaks R, et al. Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC). Mutagenesis 2011; 26:657 - 66; http://dx.doi.org/10.1093/mutage/ger030; PMID: 21750227
   PubMed Web of Science ®Google Scholar
• Li BC, Chan WY, Li CY, Chow C, Ng EK, Chung SC. Allelic loss of chromosome 6q in gastric carcinoma. Diagn Mol Pathol 2003; 12:193 - 200; http://dx.doi.org/10.1097/00019606-200312000-00003; PMID: 14639105
   PubMed Web of Science ®Google Scholar
• Carvalho B, van der Veen A, Gärtner F, Carneiro F, Seruca R, Buys CH, et al. Allelic gains and losses in distinct regions of chromosome 6 in gastric carcinoma. Cancer Genet Cytogenet 2001; 131:54 - 9; http://dx.doi.org/10.1016/S0165-4608(01)00514-3; PMID: 11734319
   PubMed Web of Science ®Google Scholar
• Qu XY, Hauptschein RS, Rzhetsky A, Scotto L, Chien MC, Ye X, et al. Analysis of a 69-kb contiguous genomic sequence at a putative tumor suppressor gene locus on human chromosome 6q27. DNA Seq 1998; 9:189 - 204; PMID: 10520750
   PubMed Web of Science ®Google Scholar
• Rodriguez C, Causse A, Ursule E, Theillet C. At least five regions of imbalance on 6q in breast tumors, combining losses and gains. Genes Chromosomes Cancer 2000; 27:76 - 84; http://dx.doi.org/10.1002/(SICI)1098-2264(200001)27:1<76::AID-GCC10>3.0.CO;2-E; PMID: 10564589
   PubMed Web of Science ®Google Scholar
• Minaguchi T, Matsushima M, Saito S, Kanamori Y, Shirahama S, Okamoto S, et al. Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer. DNA Res 1999; 6:131 - 6; http://dx.doi.org/10.1093/dnares/6.2.131; PMID: 10382971
   PubMedGoogle Scholar
• Liu Y, Emilion G, Mungall AJ, Dunham I, Beck S, Le Meuth-Metzinger VG, et al. Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer. Oncogene 2002; 21:387 - 99; http://dx.doi.org/10.1038/sj.onc.1205067; PMID: 11821951
   PubMed Web of Science ®Google Scholar
• Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 2003; 12:1251 - 60; http://dx.doi.org/10.1016/S1097-2765(03)00427-1; PMID: 14636582
   PubMed Web of Science ®Google Scholar
• Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 2006; 5:997 - 1014; http://dx.doi.org/10.1038/nrd2154; PMID: 17139285
   PubMed Web of Science ®Google Scholar
• Yue W, Sun Q, Dacic S, Landreneau RJ, Siegfried JM, Yu J, et al. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis 2008; 29:84 - 92; http://dx.doi.org/10.1093/carcin/bgm267; PMID: 18048388
   PubMed Web of Science ®Google Scholar
• Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, et al. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem 2008; 283:35679 - 88; http://dx.doi.org/10.1074/jbc.M804088200; PMID: 18936100
   PubMed Web of Science ®Google Scholar
• Waxman JS, Hocking AM, Stoick CL, Moon RT. Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development 2004; 131:5909 - 21; http://dx.doi.org/10.1242/dev.01520; PMID: 15539487
   PubMed Web of Science ®Google Scholar
• Gillhouse M, Wagner Nyholm M, Hikasa H, Sokol SY, Grinblat Y. Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish. Dev Dyn 2004; 230:403 - 9; http://dx.doi.org/10.1002/dvdy.20060; PMID: 15188426
   PubMed Web of Science ®Google Scholar
• Waxman JS. Regulation of the early expression patterns of the zebrafish Dishevelled-interacting proteins Dapper1 and Dapper2. Dev Dyn 2005; 233:194 - 200; http://dx.doi.org/10.1002/dvdy.20301; PMID: 15765513
   PubMed Web of Science ®Google Scholar
• Teran E, Branscomb AD, Seeling JM. Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon. PLoS One 2009; 4:e5522; http://dx.doi.org/10.1371/journal.pone.0005522; PMID: 19440376
   PubMed Web of Science ®Google Scholar
• Kivimäe S, Yang XY, Cheyette BN. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem 2011; 12:33; http://dx.doi.org/10.1186/1471-2091-12-33; PMID: 21718540
   PubMed Web of Science ®Google Scholar
• Su Y, Zhang L, Gao X, Meng F, Wen J, Zhou H, et al. The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J 2007; 21:682 - 90; http://dx.doi.org/10.1096/fj.06-6246com; PMID: 17197390
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, et al. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science 2004; 306:114 - 7; http://dx.doi.org/10.1126/science.1100569; PMID: 15459392
   PubMed Web of Science ®Google Scholar
• Jia Y, Yang Y, Brock MV, Zhan Q, Herman JG, Guo M. Epigenetic Regulation of DACT2, A Key Component of the Wnt Signaling Pathway in Human Lung Cancer. [Epub ahead of print] J Pathol 2012; http://dx.doi.org/10.1002/path.4073; PMID: 22806826
   PubMed Web of Science ®Google Scholar
• Herman JG, Graff JR, Myöhänen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996; 93:9821 - 6; http://dx.doi.org/10.1073/pnas.93.18.9821; PMID: 8790415
   PubMed Web of Science ®Google Scholar
• Zhang W, Glöckner SC, Guo M, Machida EO, Wang DH, Easwaran H, et al. Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer. Cancer Res 2008; 68:2764 - 72; http://dx.doi.org/10.1158/0008-5472.CAN-07-6349; PMID: 18413743
   PubMed Web of Science ®Google Scholar
• Finn RS, Press MF, Dering J, Arbushites M, Koehler M, Oliva C, et al. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer. J Clin Oncol 2009; 27:3908 - 15; http://dx.doi.org/10.1200/JCO.2008.18.1925; PMID: 19620495
   PubMed Web of Science ®Google Scholar
• Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997; 16:3797 - 804; http://dx.doi.org/10.1093/emboj/16.13.3797; PMID: 9233789
   PubMed Web of Science ®Google Scholar