Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia

References

• Saha S, Chant D, Welham J, McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Med 2005; 2:e141; http://dx.doi.org/10.1371/journal.pmed.0020141; PMID: 15916472
   PubMed Web of Science ®Google Scholar
• Brown AS, Bottiglieri T, Schaefer CA, Quesenberry CP Jr., Liu L, Bresnahan M, et al. Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch Gen Psychiatry 2007; 64:31 - 9; http://dx.doi.org/10.1001/archpsyc.64.1.31; PMID: 17199052
   PubMed Web of Science ®Google Scholar
• Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry 2006; 11:143 - 9; http://dx.doi.org/10.1038/sj.mp.4001746; PMID: 16172608
   PubMed Web of Science ®Google Scholar
• Dietrich-Muszalska A, Malinowska J, Olas B, Głowacki R, Bald E, Wachowicz B, et al. The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients. Neurochem Res 2012; 37:1057 - 62; http://dx.doi.org/10.1007/s11064-012-0707-3; PMID: 22270909
   PubMed Web of Science ®Google Scholar
• Liu CC, Ho WY, Leu KL, Tsai HM, Yang TH. Effects of S-adenosylhomocysteine and homocysteine on DNA damage and cell cytotoxicity in murine hepatic and microglia cell lines. J Biochem Mol Toxicol 2009; 23:349 - 56; http://dx.doi.org/10.1002/jbt.20298; PMID: 19827130
   PubMed Web of Science ®Google Scholar
• Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, et al. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 2000; 20:6920 - 6; PMID: 10995836
   PubMed Web of Science ®Google Scholar
• Tyagi N, Moshal KS, Ovechkin AV, Rodriguez W, Steed M, Henderson B, et al. Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia. J Cell Biochem 2005; 96:665 - 71; http://dx.doi.org/10.1002/jcb.20578; PMID: 16149054
   PubMed Web of Science ®Google Scholar
• Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet 2006; 15:3132 - 45; http://dx.doi.org/10.1093/hmg/ddl253; PMID: 16984965
   PubMed Web of Science ®Google Scholar
• Abdolmaleky HM, Yaqubi S, Papageorgis P, Lambert AW, Ozturk S, Sivaraman V, et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res 2011; 129:183 - 90; http://dx.doi.org/10.1016/j.schres.2011.04.007; PMID: 21550210
   PubMed Web of Science ®Google Scholar
• Bromberg A, Levine J, Nemetz B, Belmaker RH, Agam G. No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients. Schizophr Res 2008; 101:50 - 7; http://dx.doi.org/10.1016/j.schres.2008.01.009; PMID: 18276118
   PubMed Web of Science ®Google Scholar
• Carrard A, Salzmann A, Malafosse A, Karege F. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J Affect Disord 2011; 132:450 - 3; http://dx.doi.org/10.1016/j.jad.2011.03.018; PMID: 21453976
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang J, Zhang L, Shen Y, Xu Q. Effects of MAOA promoter methylation on susceptibility to paranoid schizophrenia. Hum Genet 2012; 131:1081 - 7; http://dx.doi.org/10.1007/s00439-011-1131-5; PMID: 22198720
   PubMed Web of Science ®Google Scholar
• Dempster EL, Mill J, Craig IW, Collier DA. The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet 2006; 7:10; http://dx.doi.org/10.1186/1471-2350-7-10; PMID: 16483362
   PubMed Web of Science ®Google Scholar
• Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet 2011; 20:4786 - 96; http://dx.doi.org/10.1093/hmg/ddr416; PMID: 21908516
   PubMed Web of Science ®Google Scholar
• Ghadirivasfi M, Nohesara S, Ahmadkhaniha HR, Eskandari MR, Mostafavi S, Thiagalingam S, et al. Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2011; 156B:536 - 45; http://dx.doi.org/10.1002/ajmg.b.31192; PMID: 21598376
   PubMed Web of Science ®Google Scholar
• Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, et al. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A 2005; 102:9341 - 6; http://dx.doi.org/10.1073/pnas.0503736102; PMID: 15961543
   PubMed Web of Science ®Google Scholar
• Iwamoto K, Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T, et al. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J Neurosci 2005; 25:5376 - 81; http://dx.doi.org/10.1523/JNEUROSCI.0766-05.2005; PMID: 15930386
   PubMed Web of Science ®Google Scholar
• Kinoshita M, Numata S, Tajima A, Shimodera S, Ono S, Imamura A, et al. DNA methylation signatures of peripheral leukocytes in schizophrenia. Neuromolecular Med 2013; 15:95 - 101; http://dx.doi.org/10.1007/s12017-012-8198-6; PMID: 22961555
   PubMed Web of Science ®Google Scholar
• Melas PA, Rogdaki M, Ösby U, Schalling M, Lavebratt C, Ekström TJ. Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset. FASEB J 2012; 26:2712 - 8; http://dx.doi.org/10.1096/fj.11-202069; PMID: 22426120
   PubMed Web of Science ®Google Scholar
• Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008; 82:696 - 711; http://dx.doi.org/10.1016/j.ajhg.2008.01.008; PMID: 18319075
   PubMed Web of Science ®Google Scholar
• Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, et al. Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia. J Hum Genet 2013; 58:91 - 7; http://dx.doi.org/10.1038/jhg.2012.140; PMID: 23235336
   PubMed Web of Science ®Google Scholar
• Nohesara S, Ghadirivasfi M, Mostafavi S, Eskandari MR, Ahmadkhaniha H, Thiagalingam S, et al. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res 2011; 45:1432 - 8; http://dx.doi.org/10.1016/j.jpsychires.2011.06.013; PMID: 21820670
   PubMed Web of Science ®Google Scholar
• Petronis A, Gottesman II, Kan P, Kennedy JL, Basile VS, Paterson AD, et al. Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?. Schizophr Bull 2003; 29:169 - 78; http://dx.doi.org/10.1093/oxfordjournals.schbul.a006988; PMID: 12908672
   PubMed Web of Science ®Google Scholar
• Pun FW, Zhao C, Lo WS, Ng SK, Tsang SY, Nimgaonkar V, et al. Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor β(2) subunit. Mol Psychiatry 2011; 16:557 - 68; http://dx.doi.org/10.1038/mp.2010.47; PMID: 20404824
   PubMed Web of Science ®Google Scholar
• Shimabukuro M, Sasaki T, Imamura A, Tsujita T, Fuke C, Umekage T, et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J Psychiatr Res 2007; 41:1042 - 6; http://dx.doi.org/10.1016/j.jpsychires.2006.08.006; PMID: 17049557
   PubMed Web of Science ®Google Scholar
• Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, et al. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol Psychiatry 2008; 63:530 - 3; http://dx.doi.org/10.1016/j.biopsych.2007.07.003; PMID: 17870056
   PubMed Web of Science ®Google Scholar
• Tolosa A, Sanjuán J, Dagnall AM, Moltó MD, Herrero N, de Frutos R. FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies. BMC Med Genet 2010; 11:114; http://dx.doi.org/10.1186/1471-2350-11-114; PMID: 20649982
   PubMed Web of Science ®Google Scholar
• Bönsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S. Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm 2004; 111:1611 - 6; http://dx.doi.org/10.1007/s00702-004-0232-x; PMID: 15565495
   PubMed Web of Science ®Google Scholar
• Huang YS, Zhi YF, Wang SR. Hypermethylation of estrogen receptor-α gene in atheromatosis patients and its correlation with homocysteine. Pathophysiology 2009; 16:259 - 65; http://dx.doi.org/10.1016/j.pathophys.2009.02.010; PMID: 19285843
   PubMedGoogle Scholar
• Ingrosso D, Cimmino A, Perna AF, Masella L, De Santo NG, De Bonis ML, et al. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet 2003; 361:1693 - 9; http://dx.doi.org/10.1016/S0140-6736(03)13372-7; PMID: 12767735
   PubMed Web of Science ®Google Scholar
• Lv H, Ma X, Che T, Chen Y. Methylation of the promoter A of estrogen receptor alpha gene in hBMSC and osteoblasts and its correlation with homocysteine. Mol Cell Biochem 2011; 355:35 - 45; http://dx.doi.org/10.1007/s11010-011-0836-z; PMID: 21523370
   PubMed Web of Science ®Google Scholar
• Fryer AA, Emes RD, Ismail KM, Haworth KE, Mein C, Carroll WD, et al. Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics 2011; 6:86 - 94; http://dx.doi.org/10.4161/epi.6.1.13392; PMID: 20864804
   PubMed Web of Science ®Google Scholar
• Corradi JP, Ravyn V, Robbins AK, Hagan KW, Peters MF, Bostwick R, et al. Alternative transcripts and evidence of imprinting of GNAL on 18p11.2. Mol Psychiatry 2005; 10:1017 - 25; http://dx.doi.org/10.1038/sj.mp.4001713; PMID: 16044173
   PubMed Web of Science ®Google Scholar
• Gutiérrez B, Rosa A, Papiol S, Arrufat FJ, Catalán R, Salgado P, et al. Identification of two risk haplotypes for schizophrenia and bipolar disorder in the synaptic vesicle monoamine transporter gene (SVMT). Am J Med Genet B Neuropsychiatr Genet 2007; 144B:502 - 7; http://dx.doi.org/10.1002/ajmg.b.30499; PMID: 17427184
   PubMed Web of Science ®Google Scholar
• Schwab SG, Hallmayer J, Lerer B, Albus M, Borrmann M, Hönig S, et al. Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. Am J Hum Genet 1998; 63:1139 - 52; http://dx.doi.org/10.1086/302046; PMID: 9758604
   PubMed Web of Science ®Google Scholar
• Talkowski ME, Kirov G, Bamne M, Georgieva L, Torres G, Mansour H, et al. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Hum Mol Genet 2008; 17:747 - 58; http://dx.doi.org/10.1093/hmg/ddm347; PMID: 18045777
   PubMed Web of Science ®Google Scholar
• Taylor SF, Koeppe RA, Tandon R, Zubieta JK, Frey KA. In vivo measurement of the vesicular monoamine transporter in schizophrenia. Neuropsychopharmacology 2000; 23:667 - 75; http://dx.doi.org/10.1016/S0893-133X(00)00165-2; PMID: 11063922
   PubMed Web of Science ®Google Scholar
• Simons CJ, van Winkel R, GROUP. Intermediate phenotype analysis of patients, unaffected siblings, and healthy controls identifies VMAT2 as a candidate gene for psychotic disorder and neurocognition. Schizophr Bull 2012; http://dx.doi.org/10.1093/schbul/sbs067; PMID: 22532702
   PubMed Web of Science ®Google Scholar
• Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, et al. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet 1995; 57:1384 - 94; PMID: 8533768
   PubMed Web of Science ®Google Scholar
• Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, et al. The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. World J Biol Psychiatry 2013; 14:114 - 20; http://dx.doi.org/10.3109/15622975.2011.604350; PMID: 21936766
   PubMed Web of Science ®Google Scholar
• Huffaker SJ, Chen J, Nicodemus KK, Sambataro F, Yang F, Mattay V, et al. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med 2009; 15:509 - 18; http://dx.doi.org/10.1038/nm.1962; PMID: 19412172
   PubMed Web of Science ®Google Scholar
• Eastwood SL, Harrison PJ. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. Neuropsychopharmacology 2008; 33:933 - 45; http://dx.doi.org/10.1038/sj.npp.1301457; PMID: 17507910
   PubMed Web of Science ®Google Scholar
• Eastwood SL, Harrison PJ. Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. Biol Psychiatry 2010; 67:1010 - 6; http://dx.doi.org/10.1016/j.biopsych.2009.12.004; PMID: 20079890
   PubMed Web of Science ®Google Scholar
• Aoki-Suzuki M, Yamada K, Meerabux J, Iwayama-Shigeno Y, Ohba H, Iwamoto K, et al. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol Psychiatry 2005; 57:382 - 93; http://dx.doi.org/10.1016/j.biopsych.2004.11.022; PMID: 15705354
   PubMed Web of Science ®Google Scholar
• Shimabukuro M, Jinno Y, Fuke C, Okazaki Y. Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats. Behav Brain Funct 2006; 2:37; http://dx.doi.org/10.1186/1744-9081-2-37; PMID: 17132176
   PubMedGoogle Scholar
• Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Davis J, Pinna G, et al. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry 2005; 57:500 - 9; http://dx.doi.org/10.1016/j.biopsych.2004.11.046; PMID: 15737665
   PubMed Web of Science ®Google Scholar
• Krebs MO, Bellon A, Mainguy G, Jay TM, Frieling H. One-carbon metabolism and schizophrenia: current challenges and future directions. Trends Mol Med 2009; 15:562 - 70; http://dx.doi.org/10.1016/j.molmed.2009.10.001; PMID: 19896901
   PubMed Web of Science ®Google Scholar
• Ulrey CL, Liu L, Andrews LG, Tollefsbol TO. The impact of metabolism on DNA methylation. Hum Mol Genet 2005; 14:Spec No 1 R139 - 47; http://dx.doi.org/10.1093/hmg/ddi100; PMID: 15809266
   PubMed Web of Science ®Google Scholar
• Bouaziz N, Ayedi I, Sidhom O, Kallel A, Rafrafi R, Jomaa R, et al. Plasma homocysteine in schizophrenia: determinants and clinical correlations in Tunisian patients free from antipsychotics. Psychiatry Res 2010; 179:24 - 9; http://dx.doi.org/10.1016/j.psychres.2010.04.008; PMID: 20471108
   PubMed Web of Science ®Google Scholar
• Hazra A, Kraft P, Lazarus R, Chen C, Chanock SJ, Jacques P, et al. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet 2009; 18:4677 - 87; http://dx.doi.org/10.1093/hmg/ddp428; PMID: 19744961
   PubMed Web of Science ®Google Scholar
• Paré G, Chasman DI, Parker AN, Zee RR, Mälarstig A, Seedorf U, et al. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women’s Genome Health Study. Circ Cardiovasc Genet 2009; 2:142 - 50; http://dx.doi.org/10.1161/CIRCGENETICS.108.829804; PMID: 20031578
   PubMed Web of Science ®Google Scholar
• Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet 2009; 84:477 - 82; http://dx.doi.org/10.1016/j.ajhg.2009.02.011; PMID: 19303062
   PubMed Web of Science ®Google Scholar
• Almeida OP, McCaul K, Hankey GJ, Norman P, Jamrozik K, Flicker L. Homocysteine and depression in later life. Arch Gen Psychiatry 2008; 65:1286 - 94; http://dx.doi.org/10.1001/archpsyc.65.11.1286; PMID: 18981340
   PubMed Web of Science ®Google Scholar
• Bjelland I, Tell GS, Vollset SE, Refsum H, Ueland PM. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry 2003; 60:618 - 26; http://dx.doi.org/10.1001/archpsyc.60.6.618; PMID: 12796225
   PubMed Web of Science ®Google Scholar
• Wald DS, Kasturiratne A, Simmonds M. Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants. Alzheimers Dement 2011; 7:412 - 7; http://dx.doi.org/10.1016/j.jalz.2010.08.234; PMID: 21784352
   PubMed Web of Science ®Google Scholar
• Bibikova M, Barnes B, Tsan C, Ho V, Klotzle B, Le JM, et al. High density DNA methylation array with single CpG site resolution. Genomics 2011; 98:288 - 95; http://dx.doi.org/10.1016/j.ygeno.2011.07.007; PMID: 21839163
   PubMed Web of Science ®Google Scholar
• Dedeurwaerder S, Defrance M, Calonne E, Denis H, Sotiriou C, Fuks F. Evaluation of the Infinium Methylation 450K technology. Epigenomics 2011; 3:771 - 84; http://dx.doi.org/10.2217/epi.11.105; PMID: 22126295
   PubMed Web of Science ®Google Scholar
• Sandoval J, Heyn H, Moran S, Serra-Musach J, Pujana MA, Bibikova M, et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics 2011; 6:692 - 702; http://dx.doi.org/10.4161/epi.6.6.16196; PMID: 21593595
   PubMed Web of Science ®Google Scholar
• Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2007; 2:e895; http://dx.doi.org/10.1371/journal.pone.0000895; PMID: 17878930
   PubMed Web of Science ®Google Scholar
• Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, et al. Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet 2009; 18:4808 - 17; http://dx.doi.org/10.1093/hmg/ddp445; PMID: 19776032
   PubMed Web of Science ®Google Scholar
• Numata S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, et al. DNA methylation signatures in development and aging of the human prefrontal cortex. Am J Hum Genet 2012; 90:260 - 72; http://dx.doi.org/10.1016/j.ajhg.2011.12.020; PMID: 22305529
   PubMed Web of Science ®Google Scholar