RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia

References

• Niemeyer CM, Aricò M, Basso G, Biondi A, Cantù Rajnoldi A, Creutzig U, Haas O, Harbott J, Hasle H, Kerndrup G, et al, European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS). Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood 1997; 89:3534 - 43; PMID: 9160658
   PubMed Web of Science ®Google Scholar
• Locatelli F, Nöllke P, Zecca M, Korthof E, Lanino E, Peters C, Pession A, Kabisch H, Uderzo C, Bonfim CS, et al, European Working Group on Childhood MDS, European Blood and Marrow Transplantation Group. Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood 2005; 105:410 - 9; http://dx.doi.org/10.1182/blood-2004-05-1944; PMID: 15353481
   PubMed Web of Science ®Google Scholar
• Niemeyer CM, Locatelli F. Chronic myeloproliferative disorders. In: Pui CH, ed. Childhood Leukemias. 3rd Edition. New York: Cambridge University Press; 2012:444-502.
   Google Scholar
• Olk-Batz C, Poetsch AR, Nöllke P, Claus R, Zucknick M, Sandrock I, Witte T, Strahm B, Hasle H, Zecca M, et al, European Working Group of Myelodysplastic Syndromes in Childhood (EWOG-MDS). Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome. Blood 2011; 117:4871 - 80; http://dx.doi.org/10.1182/blood-2010-08-298968; PMID: 21406719
   PubMed Web of Science ®Google Scholar
• Flotho C, Valcamonica S, Mach-Pascual S, Schmahl G, Corral L, Ritterbach J, Hasle H, Aricò M, Biondi A, Niemeyer CM. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia 1999; 13:32 - 7; http://dx.doi.org/10.1038/sj.leu.2401240; PMID: 10049057
   PubMed Web of Science ®Google Scholar
• Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, Hählen K, Hasle H, Licht JD, Gelb BD. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34:148 - 50; http://dx.doi.org/10.1038/ng1156; PMID: 12717436
   PubMed Web of Science ®Google Scholar
• Flotho C, Steinemann D, Mullighan CG, Neale G, Mayer K, Kratz CP, Schlegelberger B, Downing JR, Niemeyer CM. Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. Oncogene 2007; 26:5816 - 21; http://dx.doi.org/10.1038/sj.onc.1210361; PMID: 17353900
   PubMed Web of Science ®Google Scholar
• Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, Mullighan CG, Chen L, Bergstraesser E, Bueso-Ramos CE, et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood 2009; 114:1859 - 63; http://dx.doi.org/10.1182/blood-2009-01-198416; PMID: 19571318
   PubMed Web of Science ®Google Scholar
• Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, et al. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet 2010; 42:794 - 800; http://dx.doi.org/10.1038/ng.641; PMID: 20694012
   PubMed Web of Science ®Google Scholar
• Flotho C, Kratz CP, Bergsträsser E, Hasle H, Starý J, Trebo M, van den Heuvel-Eibrink MM, Wójcik D, Zecca M, Locatelli F, et al, European Working Group of Myelodysplastic Syndromes in Childhood. Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations. Blood 2008; 111:966 - 7, author reply 967-8; http://dx.doi.org/10.1182/blood-2007-09-111831; PMID: 18182584
   PubMed Web of Science ®Google Scholar
• Yoshida N, Yagasaki H, Xu Y, Matsuda K, Yoshimi A, Takahashi Y, Hama A, Nishio N, Muramatsu H, Watanabe N, et al. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. Pediatr Res 2009; 65:334 - 40; http://dx.doi.org/10.1203/PDR.0b013e3181961d2a; PMID: 19047918
   PubMed Web of Science ®Google Scholar
• Niemeyer CM, Strahm B, Dworzak M, de Moerloose B, Hasle H, Stary J, et al. JMML revisited: role and outcome of hematopoietic stem cell transplantation in subtypes of juvenile myelomonocytic leukemia. Blood 2012; 120:955
   Web of Science ®Google Scholar
• Luna-Fineman S, Shannon KM, Atwater SK, Davis J, Masterson M, Ortega J, Sanders J, Steinherz P, Weinberg V, Lange BJ. Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients. Blood 1999; 93:459 - 66; PMID: 9885207
   PubMed Web of Science ®Google Scholar
• Lockyer PJ, Kupzig S, Cullen PJ. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Curr Biol 2001; 11:981 - 6; http://dx.doi.org/10.1016/S0960-9822(01)00261-5; PMID: 11448776
   PubMed Web of Science ®Google Scholar
• Zhang J, Guo J, Dzhagalov I, He YW. An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Nat Immunol 2005; 6:911 - 9; http://dx.doi.org/10.1038/ni1232; PMID: 16041389
   PubMed Web of Science ®Google Scholar
• Kupzig S, Deaconescu D, Bouyoucef D, Walker SA, Liu Q, Polte CL, Daumke O, Ishizaki T, Lockyer PJ, Wittinghofer A, et al. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem 2006; 281:9891 - 900; http://dx.doi.org/10.1074/jbc.M512802200; PMID: 16431904
   PubMed Web of Science ®Google Scholar
• Yarwood S, Bouyoucef-Cherchalli D, Cullen PJ, Kupzig S. The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling. Biochem Soc Trans 2006; 34:846 - 50; http://dx.doi.org/10.1042/BST0340846; PMID: 17052212
   PubMed Web of Science ®Google Scholar
• Dai Y, Walker SA, de Vet E, Cook S, Welch HC, Lockyer PJ. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities. J Biol Chem 2011; 286:19905 - 16; http://dx.doi.org/10.1074/jbc.M110.201301; PMID: 21460216
   PubMed Web of Science ®Google Scholar
• Ehrich M, Nelson MR, Stanssens P, Zabeau M, Liloglou T, Xinarianos G, Cantor CR, Field JK, van den Boom D. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci U S A 2005; 102:15785 - 90; http://dx.doi.org/10.1073/pnas.0507816102; PMID: 16243968
   PubMed Web of Science ®Google Scholar
• Sakaguchi H, Okuno Y, Muramatsu H, Yoshida K, Shiraishi Y, Takahashi M, Kon A, Sanada M, Chiba K, Tanaka H, et al. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet 2013; 45:937 - 41; http://dx.doi.org/10.1038/ng.2698; PMID: 23832011
   PubMed Web of Science ®Google Scholar
• Batz C, Sandrock I, Niemeyer CM, Flotho C. Methylation of the PTEN gene CpG island is infrequent in juvenile myelomonocytic leukemia: Comments on “PTEN deficiency is a common defect in juvenile myelomonocytic leukemia” [Leuk. Res. 2009;33:671-677 (Epub 2008 November 17)]. Leuk Res 2009; 33:1578 - 9, author reply 1580; http://dx.doi.org/10.1016/j.leukres.2009.04.040; PMID: 19487024
   PubMed Web of Science ®Google Scholar
• Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A 2004; 101:6062 - 7; http://dx.doi.org/10.1073/pnas.0400782101; PMID: 15075390
   PubMed Web of Science ®Google Scholar
• Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, et al. Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia. Br J Haematol 2005; 128:805 - 12; http://dx.doi.org/10.1111/j.1365-2141.2005.05392.x; PMID: 15755284
   PubMed Web of Science ®Google Scholar