Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

References

• Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008; 473:139 - 46; http://dx.doi.org/10.1016/j.abb.2008.03.018; PMID: 18395508
   PubMed Web of Science ®Google Scholar
• Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998; 95:3597 - 602; http://dx.doi.org/10.1073/pnas.95.7.3597; PMID: 9520411
   PubMed Web of Science ®Google Scholar
• Lum L, Wong BR, Josien R, Becherer JD, Erdjument-Bromage H, Schlondorff J, et al. Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem 1999; 274:13613 - 8; http://dx.doi.org/10.1074/jbc.274.19.13613; PMID: 10224132
   PubMed Web of Science ®Google Scholar
• Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89:309 - 19; http://dx.doi.org/10.1016/S0092-8674(00)80209-3; PMID: 9108485
   PubMed Web of Science ®Google Scholar
• Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397:315 - 23; http://dx.doi.org/10.1038/16852; PMID: 9950424
   PubMed Web of Science ®Google Scholar
• Aoki S, Honma M, Kariya Y, Nakamichi Y, Ninomiya T, Takahashi N, et al. Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis. J Bone Miner Res 2010; 25:1907 - 21; http://dx.doi.org/10.1002/jbmr.89; PMID: 20560139
   PubMed Web of Science ®Google Scholar
• Bone HG, Bolognese MA, Yuen CK, Kendler DL, Wang H, Liu Y, et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J Clin Endocrinol Metab 2008; 93:2149 - 57; http://dx.doi.org/10.1210/jc.2007-2814; PMID: 18381571
   PubMed Web of Science ®Google Scholar
• Genant HK, Engelke K, Hanley DA, Brown JP, Omizo M, Bone HG, et al. Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density. Bone 2010; 47:131 - 9; http://dx.doi.org/10.1016/j.bone.2010.04.594; PMID: 20399288
   PubMed Web of Science ®Google Scholar
• Silvestrini G, Ballanti P, Patacchioli F, Leopizzi M, Gualtieri N, Monnazzi P, et al. Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat. J Mol Histol 2005; 36:59 - 67; http://dx.doi.org/10.1007/s10735-004-3839-1; PMID: 15704000
   PubMed Web of Science ®Google Scholar
• Ikeda T, Utsuyama M, Hirokawa K. Expression profiles of receptor activator of nuclear factor kappaB ligand, receptor activator of nuclear factor kappaB, and osteoprotegerin messenger RNA in aged and ovariectomized rat bones. J Bone Miner Res 2001; 16:1416 - 25; http://dx.doi.org/10.1359/jbmr.2001.16.8.1416; PMID: 11499864
   PubMed Web of Science ®Google Scholar
• Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med 2011; 17:1235 - 41; http://dx.doi.org/10.1038/nm.2448; PMID: 21909103
   PubMed Web of Science ®Google Scholar
• Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 2011; 17:1231 - 4; http://dx.doi.org/10.1038/nm.2452; PMID: 21909105
   PubMed Web of Science ®Google Scholar
• Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem 2002; 277:48868 - 75; http://dx.doi.org/10.1074/jbc.M208494200; PMID: 12364326
   PubMed Web of Science ®Google Scholar
• Kim S, Yamazaki M, Zella LA, Shevde NK, Pike JW. Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Mol Cell Biol 2006; 26:6469 - 86; http://dx.doi.org/10.1128/MCB.00353-06; PMID: 16914732
   PubMed Web of Science ®Google Scholar
• O'Brien CA, Gubrij I, Lin SC, Saylors RL, Manolagas SC. STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone. J Biol Chem 1999; 274:19301 - 8; http://dx.doi.org/10.1074/jbc.274.27.19301; PMID: 10383440
   PubMed Web of Science ®Google Scholar
• Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R, et al. EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Dev Cell 2005; 9:757 - 67; http://dx.doi.org/10.1016/j.devcel.2005.10.009; PMID: 16326388
   PubMed Web of Science ®Google Scholar
• Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005; 8:751 - 64; http://dx.doi.org/10.1016/j.devcel.2005.02.017; PMID: 15866165
   PubMed Web of Science ®Google Scholar
• Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006; 31:89 - 97; http://dx.doi.org/10.1016/j.tibs.2005.12.008; PMID: 16403636
   PubMed Web of Science ®Google Scholar
• Kitazawa R, Kitazawa S. Methylation status of a single CpG locus 3 bases upstream of TATA-box of receptor activator of nuclear factor-kappaB ligand (RANKL) gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis. Mol Endocrinol 2007; 21:148 - 58; http://dx.doi.org/10.1210/me.2006-0205; PMID: 17008384
   PubMed Web of Science ®Google Scholar
• Lu TY, Kao CF, Lin CT, Huang DY, Chiu CY, Huang YS, et al. DNA methylation and histone modification regulate silencing of OPG during tumor progression. J Cell Biochem 2009; 108:315 - 25; http://dx.doi.org/10.1002/jcb.22256; PMID: 19565568
   PubMed Web of Science ®Google Scholar
• Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell 2010; 19:698 - 711; http://dx.doi.org/10.1016/j.devcel.2010.10.005; PMID: 21074720
   PubMed Web of Science ®Google Scholar
• Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358:1148 - 59; http://dx.doi.org/10.1056/NEJMra072067; PMID: 18337604
   PubMed Web of Science ®Google Scholar
• Ulaner GA, Vu TH, Li T, Hu JF, Yao XM, Yang Y, et al. Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. Hum Mol Genet 2003; 12:535 - 49; http://dx.doi.org/10.1093/hmg/ddg034; PMID: 12588801
   PubMed Web of Science ®Google Scholar
• Suzuki J, Ikeda T, Kuroyama H, Seki S, Kasai M, Utsuyama M, et al. Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells. Biochem Biophys Res Commun 2004; 314:1021 - 7; http://dx.doi.org/10.1016/j.bbrc.2003.12.191; PMID: 14751235
   PubMed Web of Science ®Google Scholar
• Carda C, Silvestrini G, Gomez de Ferraris ME, Peydro A, Bonucci E. Osteoprotegerin (OPG) and RANKL expression and distribution in developing human craniomandibular joint. Tissue Cell 2005; 37:247 - 55; http://dx.doi.org/10.1016/j.tice.2005.03.002; PMID: 15899507
   PubMed Web of Science ®Google Scholar
• Patra SK, Patra A, Rizzi F, Ghosh TC, Bettuzzi S. Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development. Cancer Metastasis Rev 2008; 27:315 - 34; http://dx.doi.org/10.1007/s10555-008-9118-y; PMID: 18246412
   PubMed Web of Science ®Google Scholar
• Dequeker J, Aerssens J, Luyten FP. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 2003; 15:426 - 39; PMID: 14703009
   PubMed Web of Science ®Google Scholar
• Neilson M, White A, Malik U, Morrison E, McGill PE, McDonald SW. Changes in bone architecture in the femoral head and neck in osteoarthritis. Clin Anat 2004; 17:378 - 91; http://dx.doi.org/10.1002/ca.10177; PMID: 15176035
   PubMed Web of Science ®Google Scholar
• Jordan GR, Loveridge N, Bell KL, Power J, Dickson GR, Vedi S, et al. Increased femoral neck cancellous bone and connectivity in coxarthrosis (hip osteoarthritis). Bone 2003; 32:86 - 95; http://dx.doi.org/10.1016/S8756-3282(02)00920-1; PMID: 12584040
   PubMed Web of Science ®Google Scholar
• Logar DB, Komadina R, Prezelj J, Ostanek B, Trost Z, Marc J. Expression of bone resorption genes in osteoarthritis and in osteoporosis. J Bone Miner Metab 2007; 25:219 - 25; http://dx.doi.org/10.1007/s00774-007-0753-0; PMID: 17593491
   PubMed Web of Science ®Google Scholar
• D'Amelio P, Roato I, D'Amico L, Veneziano L, Suman E, Sassi F, et al. Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures. Osteoporos Int 2011; 22:2869 - 77; http://dx.doi.org/10.1007/s00198-010-1496-7; PMID: 21116815
   PubMed Web of Science ®Google Scholar
• Fraga MF, Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet 2007; 23:413 - 8; http://dx.doi.org/10.1016/j.tig.2007.05.008; PMID: 17559965
   PubMed Web of Science ®Google Scholar
• Fraga MF. Genetic and epigenetic regulation of aging. Curr Opin Immunol 2009; 21:446 - 53; http://dx.doi.org/10.1016/j.coi.2009.04.003; PMID: 19500963
   PubMed Web of Science ®Google Scholar
• Penolazzi L, Lambertini E, Giordano S, Sollazzo V, Traina G, del Senno L, et al. Methylation analysis of the promoter F of estrogen receptor alpha gene: effects on the level of transcription on human osteoblastic cells. J Steroid Biochem Mol Biol 2004; 91:1 - 9; http://dx.doi.org/10.1016/j.jsbmb.2004.02.005; PMID: 15261302
   PubMed Web of Science ®Google Scholar
• Kang MI, Kim HS, Jung YC, Kim YH, Hong SJ, Kim MK, et al. Transitional CpG methylation between promoters and retroelements of tissue-specific genes during human mesenchymal cell differentiation. J Cell Biochem 2007; 102:224 - 39; http://dx.doi.org/10.1002/jcb.21291; PMID: 17352407
   PubMed Web of Science ®Google Scholar
• Fu Q, Manolagas SC, O'Brien CA. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol 2006; 26:6453 - 68; http://dx.doi.org/10.1128/MCB.00356-06; PMID: 16914731
   PubMed Web of Science ®Google Scholar
• McAllister RM, Gardner MB, Greene AE, Bradt C, Nichols WW, Landing BH. Cultivation in vitro of cells derived from a human osteosarcoma. Cancer 1971; 27:397 - 402; http://dx.doi.org/10.1002/1097-0142(197102)27:2<397::AID-CNCR2820270224>3.0.CO;2-X; PMID: 5100401
   PubMed Web of Science ®Google Scholar
• Heremans H, Billiau A, Cassiman JJ, Mulier JC, de Somer P. In vitro cultivation of human tumor tissues. II. Morphological and virological characterization of three cell lines. Oncology 1978; 35:246 - 52; http://dx.doi.org/10.1159/000225298; PMID: 218153
   PubMed Web of Science ®Google Scholar
• Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 1977; 36:59 - 74; http://dx.doi.org/10.1099/0022-1317-36-1-59; PMID: 886304
   PubMed Web of Science ®Google Scholar
• Jonsson KB, Frost A, Nilsson O, Ljunghall S, Ljunggren O. Three isolation techniques for primary culture of human osteoblast-like cells: a comparison. Acta Orthop Scand 1999; 70:365 - 73; http://dx.doi.org/10.3109/17453679908997826; PMID: 10569267
   PubMed Web of Science ®Google Scholar
• Sasaki M, Anast J, Bassett W, Kawakami T, Sakuragi N, Dahiya R. Bisulfite conversion-specific and methylation-specific PCR: a sensitive technique for accurate evaluation of CpG methylation. Biochem Biophys Res Commun 2003; 309:305 - 9; http://dx.doi.org/10.1016/j.bbrc.2003.08.005; PMID: 12951050
   PubMed Web of Science ®Google Scholar
• Tost J, Gut IG. DNA methylation analysis by pyrosequencing. Nat Protoc 2007; 2:2265 - 75; http://dx.doi.org/10.1038/nprot.2007.314; PMID: 17853883
   PubMed Web of Science ®Google Scholar
• Colella S, Shen L, Baggerly KA, Issa JP, Krahe R. Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques 2003; 35:146 - 50; PMID: 12866414
   PubMed Web of Science ®Google Scholar