841
Views
12
CrossRef citations to date
0
Altmetric
Research Paper

Helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis C virus pathogenesis

, , , , , , & show all
Pages 577-590 | Received 28 May 2013, Accepted 04 Aug 2013, Published online: 07 Aug 2013

References

  • Suerbaum S, Josenhans C. Helicobacter pylori evolution and phenotypic diversification in a changing host. Nat Rev Microbiol 2007; 5:441 - 52; http://dx.doi.org/10.1038/nrmicro1658; PMID: 17505524
  • El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012; 142:1264 - 73, e1; http://dx.doi.org/10.1053/j.gastro.2011.12.061; PMID: 22537432
  • Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum 1994; 61:1 - 241; PMID: 7715068
  • Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest 2007; 117:60 - 9; http://dx.doi.org/10.1172/JCI30111; PMID: 17200707
  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127:2893 - 917; http://dx.doi.org/10.1002/ijc.25516; PMID: 21351269
  • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132:2557 - 76; http://dx.doi.org/10.1053/j.gastro.2007.04.061; PMID: 17570226
  • Antúnez I, Aponte N, Fernández-Carbia A, Rodríguez-Perez F, Toro DH. Steatosis as a predictive factor for treatment response in patients with chronic hepatitis C. P R Health Sci J 2004; 23:Suppl 57 - 60; PMID: 16929588
  • Ohata K, Hamasaki K, Toriyama K, Matsumoto K, Saeki A, Yanagi K, Abiru S, Nakagawa Y, Shigeno M, Miyazoe S, et al. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 2003; 97:3036 - 43; http://dx.doi.org/10.1002/cncr.11427; PMID: 12784339
  • Ponzetto A, Pellicano R, Leone N, Cutufia MA, Turrini F, Grigioni WF, D’Errico A, Mortimer P, Rizzetto M, Silengo L. Helicobacter infection and cirrhosis in hepatitis C virus carriage: is it an innocent bystander or a troublemaker?. Med Hypotheses 2000; 54:275 - 7; http://dx.doi.org/10.1054/mehy.1999.0987; PMID: 10790764
  • Dore MP, Realdi G, Mura D, Graham DY, Sepulveda AR. Helicobacter infection in patients with HCV-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Dig Dis Sci 2002; 47:1638 - 43; http://dx.doi.org/10.1023/A:1015848009444; PMID: 12141829
  • Pellicano R, Mazzaferro V, Grigioni WF, Cutufia MA, Fagoonee S, Silengo L, Rizzetto M, Ponzetto A. Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma. World J Gastroenterol 2004; 10:598 - 601; PMID: 14966925
  • Rocha M, Avenaud P, Ménard A, Le Bail B, Balabaud C, Bioulac-Sage P, de Magalhães Queiroz DM, Mégraud F. Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. Gut 2005; 54:396 - 401; http://dx.doi.org/10.1136/gut.2004.042168; PMID: 15710989
  • Castéra L, Pedeboscq A, Rocha M, Le Bail B, Asencio C, de Lédinghen V, Bernard PH, Laurent C, Lafon ME, Capdepont M, et al. Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: a prospective study. World J Gastroenterol 2006; 12:7278 - 84; PMID: 17143941
  • Cindoruk M, Cirak MY, Unal S, Karakan T, Erkan G, Engin D, Dumlu S, Turet S. Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases. Eur J Gastroenterol Hepatol 2008; 20:33 - 6; http://dx.doi.org/10.1097/MEG.0b013e3282efa4f2; PMID: 18090988
  • Fox JG, Dewhirst FE, Shen Z, Feng Y, Taylor NS, Paster BJ, Ericson RL, Lau CN, Correa P, Araya JC, et al. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology 1998; 114:755 - 63; http://dx.doi.org/10.1016/S0016-5085(98)70589-X; PMID: 9516396
  • Pellicano R, Ménard A, Rizzetto M, Mégraud F. Helicobacter species and liver diseases: association or causation?. Lancet Infect Dis 2008; 8:254 - 60; http://dx.doi.org/10.1016/S1473-3099(08)70066-5; PMID: 18353266
  • de Magalhães Queiroz DM, Santos A. Isolation of a Helicobacter strain from the human liver. Gastroenterology 2001; 121:1023 - 4; PMID: 11665691
  • Ito K, Yamaoka Y, Yoffe B, Graham DY. Disturbance of apoptosis and DNA synthesis by Helicobacter pylori infection of hepatocytes. Dig Dis Sci 2008; 53:2532 - 40; http://dx.doi.org/10.1007/s10620-007-0163-0; PMID: 18253829
  • Le Roux-Goglin E, Varon C, Spuul P, Asencio C, Mégraud F, Génot E. Helicobacter infection induces podosome assembly in primary hepatocytes in vitro. Eur J Cell Biol 2012; 91:161 - 70; http://dx.doi.org/10.1016/j.ejcb.2011.11.003; PMID: 22306377
  • Okoli AS, Raftery MJ, Mendz GL. Comparison of Helicobacter bilis-Associated Protein Expression in Huh7 Cells Harbouring HCV Replicon and in Replicon-Cured Cells. Int J Hepatol 2012; 2012:501671; http://dx.doi.org/10.1155/2012/501671; PMID: 22900193
  • Fox JG, Li X, Yan L, Cahill RJ, Hurley R, Lewis R, Murphy JC. Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: a model of helicobacter-induced carcinogenesis. Infect Immun 1996; 64:1548 - 58; PMID: 8613359
  • Fox JG, Feng Y, Theve EJ, Raczynski AR, Fiala JL, Doernte AL, Williams M, McFaline JL, Essigmann JM, Schauer DB, et al. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 2010; 59:88 - 97; http://dx.doi.org/10.1136/gut.2009.183749; PMID: 19850960
  • Raimondi S, Bruno S, Mondelli MU, Maisonneuve P. Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis. J Hepatol 2009; 50:1142 - 54; http://dx.doi.org/10.1016/j.jhep.2009.01.019; PMID: 19395111
  • Lemon SM, Lerat H, Weinman SA, Honda M. A transgenic mouse model of steatosis and hepatocellular carcinoma associated with chronic hepatitis C virus infection in humans. Trans Am Clin Climatol Assoc 2000; 111:146 - 56, discussion 156-7; PMID: 10881339
  • Lerat H, Honda M, Beard MR, Loesch K, Sun J, Yang Y, Okuda M, Gosert R, Xiao SY, Weinman SA, et al. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 2002; 122:352 - 65; http://dx.doi.org/10.1053/gast.2002.31001; PMID: 11832450
  • Disson O, Haouzi D, Desagher S, Loesch K, Hahne M, Kremer EJ, Jacquet C, Lemon SM, Hibner U, Lerat H. Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2004; 126:859 - 72; http://dx.doi.org/10.1053/j.gastro.2003.12.005; PMID: 14988840
  • Furutani T, Hino K, Okuda M, Gondo T, Nishina S, Kitase A, Korenaga M, Xiao SY, Weinman SA, Lemon SM, et al. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2006; 130:2087 - 98; http://dx.doi.org/10.1053/j.gastro.2006.02.060; PMID: 16762631
  • Lerat H, Kammoun HL, Hainault I, Mérour E, Higgs MR, Callens C, Lemon SM, Foufelle F, Pawlotsky JM. Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice. J Biol Chem 2009; 284:33466 - 74; http://dx.doi.org/10.1074/jbc.M109.019810; PMID: 19808675
  • Hailey JR, Haseman JK, Bucher JR, Radovsky AE, Malarkey DE, Miller RT, Nyska A, Maronpot RR. Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies. Toxicol Pathol 1998; 26:602 - 11; PMID: 9789946
  • Queiroz DM, Rocha AM, Rocha GA, Cinque SM, Oliveira AG, Godoy A, Tanno H. Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus. Dig Dis Sci 2006; 51:370 - 3; http://dx.doi.org/10.1007/s10620-006-3150-y; PMID: 16534683
  • El-Masry S, El-Shahat M, Badra G, Aboel-Nour MF, Lotfy M. Helicobacter pylori and Hepatitis C Virus Coinfection in Egyptian Patients. J Glob Infect Dis 2010; 2:4 - 9; http://dx.doi.org/10.4103/0974-777X.59244; PMID: 20300411
  • Esmat G, El-Bendary M, Zakarya S, Ela MA, Zalata K. Role of Helicobacter pylori in patients with HCV-related chronic hepatitis and cirrhosis with or without hepatocellular carcinoma: possible association with disease progression. J Viral Hepat 2012; 19:473 - 9; http://dx.doi.org/10.1111/j.1365-2893.2011.01567.x; PMID: 22676359
  • Silva LD, Rocha AM, Rocha GA, de Moura SB, Rocha MM, Dani R, de Melo FF, Guerra JB, de Castro LP, Mendes GS, et al. The presence of Helicobacter pylori in the liver depends on the Th1, Th17 and Treg cytokine profile of the patient. Mem Inst Oswaldo Cruz 2011; 106:748 - 54; PMID: 22012231
  • Boonyanugomol W, Chomvarin C, Sripa B, Bhudhisawasdi V, Khuntikeo N, Hahnvajanawong C, Chamsuwan A. Helicobacter pylori in Thai patients with cholangiocarcinoma and its association with biliary inflammation and proliferation. HPB (Oxford) 2012; 14:177 - 84; http://dx.doi.org/10.1111/j.1477-2574.2011.00423.x; PMID: 22321036
  • Crabtree JE, Ferrero RL, Kusters JG. The mouse colonizing Helicobacter pylori strain SS1 may lack a functional cag pathogenicity island. Helicobacter 2002; 7:139 - 40, author reply 140-1; http://dx.doi.org/10.1046/j.1083-4389.2002.00071.x; PMID: 11966874
  • Nilsson HO, Taneera J, Castedal M, Glatz E, Olsson R, Wadström T. Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis. J Clin Microbiol 2000; 38:1072 - 6; PMID: 10698999
  • Matsukura N, Yokomuro S, Yamada S, Tajiri T, Sundo T, Hadama T, Kamiya S, Naito Z, Fox JG. Association between Helicobacter bilis in bile and biliary tract malignancies: H. bilis in bile from Japanese and Thai patients with benign and malignant diseases in the biliary tract. Jpn J Cancer Res 2002; 93:842 - 7; http://dx.doi.org/10.1111/j.1349-7006.2002.tb01327.x; PMID: 12149151
  • Tiwari SK, Khan AA, Ibrahim M, Habeeb MA, Habibullah CM. Helicobacter pylori and other Helicobacter species DNA in human bile samples from patients with various hepato-biliary diseases. World J Gastroenterol 2006; 12:2181 - 6; PMID: 16610018
  • Hamada T, Yokota K, Ayada K, Hirai K, Kamada T, Haruma K, Chayama K, Oguma K. Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease. Helicobacter 2009; 14:545 - 51; http://dx.doi.org/10.1111/j.1523-5378.2009.00729.x; PMID: 19889072
  • Krüttgen A, Horz HP, Weber-Heynemann J, Vucur M, Trautwein C, Haase G, Luedde T, Roderburg C. Study on the association of Helicobacter species with viral hepatitis-induced hepatocellular carcinoma. Gut Microbes 2012; 3:228 - 33; http://dx.doi.org/10.4161/gmic.19922; PMID: 22572832
  • Innes JR, Ulland BM, Valerio MG, Petrucelli L, Fishbein L, Hart ER, Pallotta AJ, Bates RR, Falk HL, Gart JJ, et al. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J Natl Cancer Inst 1969; 42:1101 - 14; PMID: 5793189
  • McGivern DR, Lemon SM. Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene 2011; 30:1969 - 83; http://dx.doi.org/10.1038/onc.2010.594; PMID: 21258404
  • Naas T, Ghorbani M, Alvarez-Maya I, Lapner M, Kothary R, De Repentigny Y, Gomes S, Babiuk L, Giulivi A, Soare C, et al. Characterization of liver histopathology in a transgenic mouse model expressing genotype 1a hepatitis C virus core and envelope proteins 1 and 2. J Gen Virol 2005; 86:2185 - 96; http://dx.doi.org/10.1099/vir.0.80969-0; PMID: 16033966
  • Klopstock N, Katzenellenbogen M, Pappo O, Sklair-Levy M, Olam D, Mizrahi L, Potikha T, Galun E, Goldenberg D. HCV tumor promoting effect is dependent on host genetic background. PLoS One 2009; 4:e5025; http://dx.doi.org/10.1371/journal.pone.0005025; PMID: 19340302
  • Durante-Mangoni E, Zampino R, Marrone A, Tripodi MF, Rinaldi L, Restivo L, Cioffi M, Ruggiero G, Adinolfi LE. Hepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor-alpha in chronic hepatitis C patients. Aliment Pharmacol Ther 2006; 24:1349 - 57; http://dx.doi.org/10.1111/j.1365-2036.2006.03114.x; PMID: 17059516
  • Schnyder-Candrian S, Czarniecki J, Lerondel S, Corpataux J, Ryffel B, Schnyder B. Hepatic steatosis in the absence of tumor necrosis factor in mice. Cytokine 2005; 32:287 - 95; http://dx.doi.org/10.1016/j.cyto.2005.11.004; PMID: 16406654
  • Court M, Robinson PA, Dixon MF, Jeremy AH, Crabtree JE. The effect of gender on Helicobacter felis-mediated gastritis, epithelial cell proliferation, and apoptosis in the mouse model. J Pathol 2003; 201:303 - 11; http://dx.doi.org/10.1002/path.1422; PMID: 14517848
  • Sheh A, Lee CW, Masumura K, Rickman BH, Nohmi T, Wogan GN, Fox JG, Schauer DB. Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection. Proc Natl Acad Sci U S A 2010; 107:15217 - 22; http://dx.doi.org/10.1073/pnas.1009017107; PMID: 20699385
  • Every AL, Ng GZ, Skene CD, Harbour SN, Walduck AK, McGuckin MA, Sutton P. Localized suppression of inflammation at sites of Helicobacter pylori colonization. Infect Immun 2011; 79:4186 - 92; http://dx.doi.org/10.1128/IAI.05602-11; PMID: 21807907
  • Orłowski M, Stalke P, Michalska Z, Sikorska K, Witczak-Malinowska K, Eilert-Zygadłowska J, Stolarczyk J. Assessment of correlation between histopathologic changes of gastric mucosa according to Whitehead’s classification and extent of liver damage according to Knodell’s scale in patients with chronic hepatopathy. Med Sci Monit 2003; 9:Suppl 3 60 - 3; PMID: 15156615
  • Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK, Wang TC. Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 2007; 171:1520 - 8; http://dx.doi.org/10.2353/ajpath.2007.070249; PMID: 17982128
  • Crabtree JE, Court M, Aboshkiwa MA, Jeremy AH, Dixon MF, Robinson PA. Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils. J Pathol 2004; 202:197 - 207; http://dx.doi.org/10.1002/path.1498; PMID: 14743502
  • Yamamoto T, Kita M, Ohno T, Iwakura Y, Sekikawa K, Imanishi J. Role of tumor necrosis factor-alpha and interferon-gamma in Helicobacter pylori infection. Microbiol Immunol 2004; 48:647 - 54; PMID: 15383700
  • Ki MR, Goo MJ, Park JK, Hong IH, Ji AR, Han SY, You SY, Lee EM, Kim AY, Park SJ, et al. Helicobacter pylori accelerates hepatic fibrosis by sensitizing transforming growth factor-β1-induced inflammatory signaling. Lab Invest 2010; 90:1507 - 16; http://dx.doi.org/10.1038/labinvest.2010.109; PMID: 20531291
  • Cheshire JL, Baldwin AS Jr.. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Mol Cell Biol 1997; 17:6746 - 54; PMID: 9343439
  • Chuang SC, La Vecchia C, Boffetta P. Liver cancer: descriptive epidemiology and risk factors other than HBV and HCV infection. Cancer Lett 2009; 286:9 - 14; http://dx.doi.org/10.1016/j.canlet.2008.10.040; PMID: 19091458
  • Sumida Y, Kanemasa K, Yamaoka Y, Imamura S, Katoh N, Nakashima T, Tachibana S, Mitsuyoshi H, Itoh Y, Okanoue T. Influence of Helicobacter pylori infection on iron accumulation in hepatitis C. Liver Int 2006; 26:827 - 33; http://dx.doi.org/10.1111/j.1478-3231.2006.01305.x; PMID: 16911465
  • Muhsen K, Cohen D. Helicobacter pylori infection and iron stores: a systematic review and meta-analysis. Helicobacter 2008; 13:323 - 40; http://dx.doi.org/10.1111/j.1523-5378.2008.00617.x; PMID: 19250507
  • Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, et al. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest 2013; 123:479 - 92; http://dx.doi.org/10.1172/JCI64373; PMID: 23257361
  • Thomson MJ, Pritchard DM, Boxall SA, Abuderman AA, Williams JM, Varro A, Crabtree JE. Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse. PLoS One 2012; 7:e50194; http://dx.doi.org/10.1371/journal.pone.0050194; PMID: 23185574
  • Shirai M, Arichi T, Nakazawa T, Berzofsky JA. Persistent infection by Helicobacter pylori down-modulates virus-specific CD8+ cytotoxic T cell response and prolongs viral infection. J Infect Dis 1998; 177:72 - 80; http://dx.doi.org/10.1086/513827; PMID: 9419172
  • Luther J, Owyang SY, Takeuchi T, Cole TS, Zhang M, Liu M, Erb-Downward J, Rubenstein JH, Chen CC, Pierzchala AV, et al. Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis. Gut 2011; 60:1479 - 86; http://dx.doi.org/10.1136/gut.2010.220087; PMID: 21471567
  • Owyang SY, Luther J, Owyang CC, Zhang M, Kao JY. Helicobacter pylori DNA’s anti-inflammatory effect on experimental colitis. Gut Microbes 2012; 3:168 - 71; http://dx.doi.org/10.4161/gmic.19181; PMID: 22356863
  • Blindenbacher A, Duong FH, Hunziker L, Stutvoet ST, Wang X, Terracciano L, Moradpour D, Blum HE, Alonzi T, Tripodi M, et al. Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice. Gastroenterology 2003; 124:1465 - 75; http://dx.doi.org/10.1016/S0016-5085(03)00290-7; PMID: 12730885
  • Duong FH, Filipowicz M, Tripodi M, La Monica N, Heim MH. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 2004; 126:263 - 77; http://dx.doi.org/10.1053/j.gastro.2003.10.076; PMID: 14699505
  • Desai MM, Gong B, Chan T, Davey RA, Soong L, Kolokoltsov AA, Sun J. Differential, type I interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver. Gastroenterology 2011; 141:674 - 85, e1-6; http://dx.doi.org/10.1053/j.gastro.2011.04.060; PMID: 21683701
  • Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W. NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest 2010; 120:1645 - 62; http://dx.doi.org/10.1172/JCI39481; PMID: 20389019
  • Mercer DF, Schiller DE, Elliott JF, Douglas DN, Hao C, Rinfret A, Addison WR, Fischer KP, Churchill TA, Lakey JR, et al. Hepatitis C virus replication in mice with chimeric human livers. Nat Med 2001; 7:927 - 33; http://dx.doi.org/10.1038/90968; PMID: 11479625
  • García A, Ihrig MM, Fry RC, Feng Y, Xu S, Boutin SR, Rogers AB, Muthupalani S, Samson LD, Fox JG. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks. Infect Immun 2008; 76:1866 - 76; http://dx.doi.org/10.1128/IAI.01044-07; PMID: 18285497
  • Le Roux-Goglin E, Dubus P, Asencio C, Jutand MA, Rosenbaum J, Mégraud F. Hepatic lesions observed in hepatitis C virus transgenic mice infected by Helicobacter hepaticus.. Helicobacter 2013; 18:33 - 40; http://dx.doi.org/10.1111/j.1523-5378.2012.00995.x; PMID: 23067369
  • Lofgren JL, Esmail M, Mobley M, McCabe A, Taylor NS, Shen Z, Erdman S, Hewes C, Whary MT, Fox JG. Prevalence of murine Helicobacter spp. Infection is reduced by restocking research colonies with Helicobacter-free mice. J Am Assoc Lab Anim Sci 2012; 51:436 - 42; PMID: 23043808
  • Rogers AB, Taylor NS, Whary MT, Stefanich ED, Wang TC, Fox JG. Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res 2005; 65:10709 - 15; http://dx.doi.org/10.1158/0008-5472.CAN-05-1846; PMID: 16322215
  • Erdman SE, Poutahidis T, Tomczak M, Rogers AB, Cormier K, Plank B, Horwitz BH, Fox JG. CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol 2003; 162:691 - 702; http://dx.doi.org/10.1016/S0002-9440(10)63863-1; PMID: 12547727
  • Rogers AB, Theve EJ, Feng Y, Fry RC, Taghizadeh K, Clapp KM, Boussahmain C, Cormier KS, Fox JG. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res 2007; 67:11536 - 46; http://dx.doi.org/10.1158/0008-5472.CAN-07-1479; PMID: 18089782
  • Gilat T, Leikin-Frenkel A, Goldiner I, Juhel C, Lafont H, Gobbi D, Konikoff FM. Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC). Hepatology 2003; 38:436 - 42; http://dx.doi.org/10.1053/jhep.2003.50348; PMID: 12883488
  • García A, Zeng Y, Muthupalani S, Ge Z, Potter A, Mobley MW, Boussahmain C, Feng Y, Wishnok JS, Fox JG. Helicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response. Cancer Res 2011; 71:2529 - 40; http://dx.doi.org/10.1158/0008-5472.CAN-10-1975; PMID: 21335546
  • Trebesius K, Panthel K, Strobel S, Vogt K, Faller G, Kirchner T, Kist M, Heesemann J, Haas R. Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation. Gut 2000; 46:608 - 14; http://dx.doi.org/10.1136/gut.46.5.608; PMID: 10764702
  • Maurer KJ, Rogers AB, Ge Z, Wiese AJ, Carey MC, Fox JG. Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study. Am J Physiol Gastrointest Liver Physiol 2006; 290:G175 - 82; http://dx.doi.org/10.1152/ajpgi.00272.2005; PMID: 16109843
  • Martin RM, Brady JL, Lew AM. The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice. J Immunol Methods 1998; 212:187 - 92; http://dx.doi.org/10.1016/S0022-1759(98)00015-5; PMID: 9672206
  • Whary MT, Morgan TJ, Dangler CA, Gaudes KJ, Taylor NS, Fox JG. Chronic active hepatitis induced by Helicobacter hepaticus in the A/JCr mouse is associated with a Th1 cell-mediated immune response. Infect Immun 1998; 66:3142 - 8; PMID: 9632578
  • Takahashi M, Dinse GE, Foley JF, Hardisty JF, Maronpot RR. Comparative prevalence, multiplicity, and progression of spontaneous and vinyl carbamate-induced liver lesions in five strains of male mice. Toxicol Pathol 2002; 30:599 - 605; http://dx.doi.org/10.1080/01926230290105776; PMID: 12371669
  • Sakr SA, Badrah GA, Sheir RA. Histological and histochemical alterations in liver of chronic hepatitis C patients with Helicobacter pylori infection. Biomed Pharmacother 2013; 67:367 - 74; http://dx.doi.org/10.1016/j.biopha.2013.03.004; PMID: 23659901

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.