Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells

References

• Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 2008; 134:306 - 23; http://dx.doi.org/10.1053/j.gastro.2007.11.009; PMID: 18166359
   PubMed Web of Science ®Google Scholar
• Atherton JC, Blaser MJ. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest 2009; 119:2475 - 87; http://dx.doi.org/10.1172/JCI38605; PMID: 19729845
   PubMed Web of Science ®Google Scholar
• Polk DB, Peek RM Jr.. Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer 2010; 10:403 - 14; http://dx.doi.org/10.1038/nrc2857; PMID: 20495574
   PubMed Web of Science ®Google Scholar
• Salama NR, Hartung ML, Müller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori.. Nat Rev Microbiol 2013; 11:385 - 99; http://dx.doi.org/10.1038/nrmicro3016; PMID: 23652324
   PubMed Web of Science ®Google Scholar
• Covacci A, Rappuoli R. Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med 2000; 191:587 - 92; http://dx.doi.org/10.1084/jem.191.4.587; PMID: 10684850
   PubMed Web of Science ®Google Scholar
• Backert S, Meyer TF. Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 2006; 9:207 - 17; http://dx.doi.org/10.1016/j.mib.2006.02.008; PMID: 16529981
   PubMed Web of Science ®Google Scholar
• Backert S, Tegtmeyer N, Selbach M. The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis. Helicobacter 2010; 15:163 - 76; http://dx.doi.org/10.1111/j.1523-5378.2010.00759.x; PMID: 20557357
   PubMed Web of Science ®Google Scholar
• Boquet P, Ricci V. Intoxication strategy of Helicobacter pylori VacA toxin. Trends Microbiol 2012; 20:165 - 74; http://dx.doi.org/10.1016/j.tim.2012.01.008; PMID: 22364673
   PubMed Web of Science ®Google Scholar
• Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, Athman R, Mémet S, Huerre MR, Coyle AJ, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004; 5:1166 - 74; http://dx.doi.org/10.1038/ni1131; PMID: 15489856
   PubMed Web of Science ®Google Scholar
• Wessler S, Backert S. Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.. Trends Microbiol 2008; 16:397 - 405; http://dx.doi.org/10.1016/j.tim.2008.05.005; PMID: 18619844
   PubMed Web of Science ®Google Scholar
• Olofsson A, Vallström A, Petzold K, Tegtmeyer N, Schleucher J, Carlsson S, Haas R, Backert S, Wai SN, Gröbner G, et al. Biochemical and functional characterization of Helicobacter pylori vesicles. Mol Microbiol 2010; 77:1539 - 55; http://dx.doi.org/10.1111/j.1365-2958.2010.07307.x; PMID: 20659286
   PubMed Web of Science ®Google Scholar
• Hoy B, Löwer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Schröder P, Sewald N, Backert S, Schneider G, et al. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep 2010; 11:798 - 804; http://dx.doi.org/10.1038/embor.2010.114; PMID: 20814423
   PubMed Web of Science ®Google Scholar
• Rubin EJ, Trent MS. Colonize, evade, flourish: How glyco-conjugates promote virulence of Helicobacter pylori. [Epub ahead of print]. Gut Microbes 2013; 4:4; PMID:23859890; http://dx.doi.org/10.4161/gmic.25721
   Google Scholar
• Backert S, Clyne M, Tegtmeyer N. Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori.. Cell Commun Signal 2011; 9:28; http://dx.doi.org/10.1186/1478-811X-9-28; PMID: 22044679
   PubMed Web of Science ®Google Scholar
• Aspholm M, Kalia A, Ruhl S, Schedin S, Arnqvist A, Lindén S, Sjöström R, Gerhard M, Semino-Mora C, Dubois A, et al. Helicobacter pylori adhesion to carbohydrates. Methods Enzymol 2006; 417:293 - 339; http://dx.doi.org/10.1016/S0076-6879(06)17020-2; PMID: 17132512
   PubMed Web of Science ®Google Scholar
• Jiménez-Soto LF, Clausen S, Sprenger A, Ertl C, Haas R. Dynamics of the Cag-type IV secretion system of Helicobacter pylori as studied by bacterial co-infections. Cell Microbiol 2013; 15:1924 - 37; http://dx.doi.org/10.1111/cmi.12166; PMID: 23844976
   PubMed Web of Science ®Google Scholar
• Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, et al. Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor. Cell Microbiol 2013; 15:1896 - 912; http://dx.doi.org/10.1111/cmi.12158; PMID: 23782461
   PubMed Web of Science ®Google Scholar
• Cover TL, Blanke SR. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol 2005; 3:320 - 32; http://dx.doi.org/10.1038/nrmicro1095; PMID: 15759043
   PubMed Web of Science ®Google Scholar
• Backert S, Tegtmeyer N. the versatility of the Helicobacter pylori vacuolating cytotoxin vacA in signal transduction and molecular crosstalk. Toxins (Basel) 2010; 2:69 - 92; http://dx.doi.org/10.3390/toxins2010069; PMID: 22069547
   PubMed Web of Science ®Google Scholar
• Odenbreit S, Till M, Hofreuter D, Faller G, Haas R. Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue. Mol Microbiol 1999; 31:1537 - 48; http://dx.doi.org/10.1046/j.1365-2958.1999.01300.x; PMID: 10200971
   PubMed Web of Science ®Google Scholar
• Rokbi B, Seguin D, Guy B, Mazarin V, Vidor E, Mion F, Cadoz M, Quentin-Millet MJ. Assessment of Helicobacter pylori gene expression within mouse and human gastric mucosae by real-time reverse transcriptase PCR. Infect Immun 2001; 69:4759 - 66; http://dx.doi.org/10.1128/IAI.69.8.4759-4766.2001; PMID: 11447148
   PubMed Web of Science ®Google Scholar
• Odenbreit S, Swoboda K, Barwig I, Ruhl S, Borén T, Koletzko S, Haas R. Outer membrane protein expression profile in Helicobacter pylori clinical isolates. Infect Immun 2009; 77:3782 - 90; http://dx.doi.org/10.1128/IAI.00364-09; PMID: 19546190
   PubMed Web of Science ®Google Scholar
• de Jonge R, Durrani Z, Rijpkema SG, Kuipers EJ, van Vliet AH, Kusters JG. Role of the Helicobacter pylori outer-membrane proteins AlpA and AlpB in colonization of the guinea pig stomach. J Med Microbiol 2004; 53:375 - 9; http://dx.doi.org/10.1099/jmm.0.45551-0; PMID: 15096545
   PubMed Web of Science ®Google Scholar
• Lu H, Wu JY, Beswick EJ, Ohno T, Odenbreit S, Haas R, Reyes VE, Kita M, Graham DY, Yamaoka Y. Functional and intracellular signaling differences associated with the Helicobacter pylori AlpAB adhesin from Western and East Asian strains. J Biol Chem 2007; 282:6242 - 54; http://dx.doi.org/10.1074/jbc.M611178200; PMID: 17202133
   PubMed Web of Science ®Google Scholar
• Senkovich OA, Yin J, Ekshyyan V, Conant C, Traylor J, Adegboyega P, McGee DJ, Rhoads RE, Slepenkov S, Testerman TL. Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils. Infect Immun 2011; 79:3106 - 16; http://dx.doi.org/10.1128/IAI.01275-10; PMID: 21576328
   PubMed Web of Science ®Google Scholar
• Telford JL, Ghiara P, Dell’Orco M, Comanducci M, Burroni D, Bugnoli M, Tecce MF, Censini S, Covacci A, Xiang Z, et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994; 179:1653 - 8; http://dx.doi.org/10.1084/jem.179.5.1653; PMID: 8163943
   PubMed Web of Science ®Google Scholar
• Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB. Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain. Proc Natl Acad Sci U S A 2007; 104:16293 - 8; http://dx.doi.org/10.1073/pnas.0707447104; PMID: 17911250
   PubMed Web of Science ®Google Scholar
• Yahiro K, Niidome T, Kimura M, Hatakeyama T, Aoyagi H, Kurazono H, Imagawa Ki, Wada A, Moss J, Hirayama T. Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase β. J Biol Chem 1999; 274:36693 - 9; http://dx.doi.org/10.1074/jbc.274.51.36693; PMID: 10593974
   PubMed Web of Science ®Google Scholar
• Fujikawa A, Shirasaka D, Yamamoto S, Ota H, Yahiro K, Fukada M, Shintani T, Wada A, Aoyama N, Hirayama T, et al. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.. Nat Genet 2003; 33:375 - 81; http://dx.doi.org/10.1038/ng1112; PMID: 12598897
   PubMed Web of Science ®Google Scholar
• Yahiro K, Wada A, Nakayama M, Kimura T, Ogushi K, Niidome T, Aoyagi H, Yoshino K, Yonezawa K, Moss J, et al. Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. J Biol Chem 2003; 278:19183 - 9; http://dx.doi.org/10.1074/jbc.M300117200; PMID: 12626515
   PubMed Web of Science ®Google Scholar
• Hennig EE, Godlewski MM, Butruk E, Ostrowski J. Helicobacter pylori VacA cytotoxin interacts with fibronectin and alters HeLa cell adhesion and cytoskeletal organization in vitro.. FEMS Immunol Med Microbiol 2005; 44:143 - 50; http://dx.doi.org/10.1016/j.femsim.2004.10.020; PMID: 15866208
   PubMed Web of Science ®Google Scholar
• Padilla PI, Wada A, Yahiro K, Kimura M, Niidome T, Aoyagi H, Kumatori A, Anami M, Hayashi T, Fujisawa J, et al. Morphologic differentiation of HL-60 cells is associated with appearance of RPTPbeta and induction of Helicobacter pylori VacA sensitivity. J Biol Chem 2000; 275:15200 - 6; http://dx.doi.org/10.1074/jbc.275.20.15200; PMID: 10809755
   PubMed Web of Science ®Google Scholar
• Nakayama M, Hisatsune J, Yamasaki E, Nishi Y, Wada A, Kurazono H, Sap J, Yahiro K, Moss J, Hirayama T. Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase β, is required for intoxication in AZ-521 Cells. Infect Immun 2006; 74:6571 - 80; http://dx.doi.org/10.1128/IAI.00356-06; PMID: 17030583
   PubMed Web of Science ®Google Scholar
• de Bernard M, Moschioni M, Napolitani G, Rappuoli R, Montecucco C. The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. EMBO J 2000; 19:48 - 56; http://dx.doi.org/10.1093/emboj/19.1.48; PMID: 10619843
   PubMed Web of Science ®Google Scholar
• Hennig EE, Butruk E, Ostrowski J. RACK1 protein interacts with Helicobacter pylori VacA cytotoxin: the yeast two-hybrid approach. Biochem Biophys Res Commun 2001; 289:103 - 10; http://dx.doi.org/10.1006/bbrc.2001.5950; PMID: 11708784
   PubMed Web of Science ®Google Scholar
• Satin B, Norais N, Telford J, Rappuoli R, Murgia M, Montecucco C, Papini E. Effect of helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation. J Biol Chem 1997; 272:25022 - 8; http://dx.doi.org/10.1074/jbc.272.40.25022; PMID: 9312109
   PubMed Web of Science ®Google Scholar
• Nakayama M, Kimura M, Wada A, Yahiro K, Ogushi K, Niidome T, Fujikawa A, Shirasaka D, Aoyama N, Kurazono H, et al. Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells. J Biol Chem 2004; 279:7024 - 8; http://dx.doi.org/10.1074/jbc.M308898200; PMID: 14630932
   PubMed Web of Science ®Google Scholar
• Boncristiano M, Paccani SR, Barone S, Ulivieri C, Patrussi L, Ilver D, Amedei A, D’Elios MM, Telford JL, Baldari CT. The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med 2003; 198:1887 - 97; http://dx.doi.org/10.1084/jem.20030621; PMID: 14676300
   PubMed Web of Science ®Google Scholar
• Beswick EJ, Bland DA, Suarez G, Barrera CA, Fan X, Reyes VE. Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production. Infect Immun 2005; 73:2736 - 43; http://dx.doi.org/10.1128/IAI.73.5.2736-2743.2005; PMID: 15845476
   PubMed Web of Science ®Google Scholar
• Beswick EJ, Pinchuk IV, Minch K, Suarez G, Sierra JC, Yamaoka Y, Reyes VE. The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production. Infect Immun 2006; 74:1148 - 55; http://dx.doi.org/10.1128/IAI.74.2.1148-1155.2006; PMID: 16428763
   PubMed Web of Science ®Google Scholar
• Sharma SA, Tummuru MK, Miller GG, Blaser MJ. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro.. Infect Immun 1995; 63:1681 - 7; PMID: 7729872
   PubMed Web of Science ®Google Scholar
• Basmarke-Wehelie R, Sjölinder H, Jurkowski W, Elofsson A, Arnqvist A, Engstrand L, Hagner M, Wallin E, Guan N, Kuranasekera H, et al. The complement regulator CD46 is bactericidal to Helicobacter pylori and blocks urease activity. Gastroenterology 2011; 141:918 - 28; http://dx.doi.org/10.1053/j.gastro.2011.05.009; PMID: 21699774
   PubMed Web of Science ®Google Scholar
• Backert S, Naumann M. What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori.. Trends Microbiol 2010; 18:479 - 86; http://dx.doi.org/10.1016/j.tim.2010.08.003; PMID: 20863705
   PubMed Web of Science ®Google Scholar
• Fischer W, Püls J, Buhrdorf R, Gebert B, Odenbreit S, Haas R. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol Microbiol 2001; 42:1337 - 48; http://dx.doi.org/10.1046/j.1365-2958.2001.02714.x; PMID: 11886563
   PubMed Web of Science ®Google Scholar
• Backert S, Selbach M. Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol 2008; 10:1573 - 81; http://dx.doi.org/10.1111/j.1462-5822.2008.01156.x; PMID: 18410539
   PubMed Web of Science ®Google Scholar
• Allison CC, Kufer TA, Kremmer E, Kaparakis M, Ferrero RL. Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. J Immunol 2009; 183:8099 - 109; http://dx.doi.org/10.4049/jimmunol.0900664; PMID: 20007577
   PubMed Web of Science ®Google Scholar
• Hutton ML, Kaparakis-Liaskos M, Turner L, Cardona A, Kwok T, Ferrero RL. Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells. Infect Immun 2010; 78:4523 - 31; http://dx.doi.org/10.1128/IAI.00439-10; PMID: 20713621
   PubMed Web of Science ®Google Scholar
• Boughan PK, Argent RH, Body-Malapel M, Park JH, Ewings KE, Bowie AG, Ong SJ, Cook SJ, Sorensen OE, Manzo BA, et al. Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. J Biol Chem 2006; 281:11637 - 48; http://dx.doi.org/10.1074/jbc.M510275200; PMID: 16513653
   PubMed Web of Science ®Google Scholar
• Girardin SE, Boneca IG, Carneiro LA, Antignac A, Jéhanno M, Viala J, Tedin K, Taha MK, Labigne A, Zähringer U, et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 2003; 300:1584 - 7; http://dx.doi.org/10.1126/science.1084677; PMID: 12791997
   PubMed Web of Science ®Google Scholar
• Hirata Y, Ohmae T, Shibata W, Maeda S, Ogura K, Yoshida H, Kawabe T, Omata M. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. J Immunol 2006; 176:3796 - 803; PMID: 16517750
   PubMed Web of Science ®Google Scholar
• Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W. NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest 2010; 120:1645 - 62; http://dx.doi.org/10.1172/JCI39481; PMID: 20389019
   PubMed Web of Science ®Google Scholar
• Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, König W, et al. Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 2007; 449:862 - 6; http://dx.doi.org/10.1038/nature06187; PMID: 17943123
   PubMed Web of Science ®Google Scholar
• Barczyk M, Carracedo S, Gullberg D. Integrins. Cell Tissue Res 2010; 339:269 - 80; http://dx.doi.org/10.1007/s00441-009-0834-6; PMID: 19693543
   PubMed Web of Science ®Google Scholar
• Backert S, Fronzes R, Waksman G. VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?. Trends Microbiol 2008; 16:409 - 13; http://dx.doi.org/10.1016/j.tim.2008.07.001; PMID: 18706815
   PubMed Web of Science ®Google Scholar
• Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH. A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL. Structure 2013; 21:1931 - 41; http://dx.doi.org/10.1016/j.str.2013.08.018; PMID: 24076404
   PubMed Web of Science ®Google Scholar
  PMID:24076404; http://dx.doi.org/10.1016/j.str.2013.08.018.
   Google Scholar
• Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S. A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem 2010; 285:23515 - 26; http://dx.doi.org/10.1074/jbc.M109.096214; PMID: 20507990
   PubMed Web of Science ®Google Scholar
• Conradi J, Tegtmeyer N, Woźna M, Wissbrock M, Michalek C, Gagell C, Cover TL, Frank R, Sewald N, Backert S. An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA. Front Cell Infect Microbiol 2012; 2:70; http://dx.doi.org/10.3389/fcimb.2012.00070; PMID: 22919661
   PubMed Web of Science ®Google Scholar
• Gorrell RJ, Guan J, Xin Y, Tafreshi MA, Hutton ML, McGuckin MA, Ferrero RL, Kwok T. A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system. Cell Microbiol 2012; 15:554 - 70; http://dx.doi.org/10.1111/cmi.12055; PMID: 23107019
   PubMed Web of Science ®Google Scholar
• Jiménez-Soto LF, Kutter S, Sewald X, Ertl C, Weiss E, Kapp U, Rohde M, Pirch T, Jung K, Retta SF, et al. Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog 2009; 5:e1000684; http://dx.doi.org/10.1371/journal.ppat.1000684; PMID: 19997503
   PubMed Web of Science ®Google Scholar
• Kaplan-Türköz B, Jiménez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L. Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin. Proc Natl Acad Sci U S A 2012; 109:14640 - 5; http://dx.doi.org/10.1073/pnas.1206098109; PMID: 22908298
   PubMed Web of Science ®Google Scholar
• Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL. Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog 2011; 7:e1002237; http://dx.doi.org/10.1371/journal.ppat.1002237; PMID: 21909278
   PubMedGoogle Scholar
• Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM Jr., Cover TL, et al. Functional plasticity in the type IV secretion system of Helicobacter pylori.. PLoS Pathog 2013; 9:e1003189; http://dx.doi.org/10.1371/journal.ppat.1003189; PMID: 23468628
   PubMed Web of Science ®Google Scholar
• Tegtmeyer N, Wessler S, Backert S. Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J 2011; 278:1190 - 202; http://dx.doi.org/10.1111/j.1742-4658.2011.08035.x; PMID: 21352489
   PubMed Web of Science ®Google Scholar
• Smolka AJ, Backert S. How Helicobacter pylori infection controls gastric acid secretion. J Gastroenterol 2012; 47:609 - 18; http://dx.doi.org/10.1007/s00535-012-0592-1; PMID: 22565637
   PubMed Web of Science ®Google Scholar
• Saha A, Hammond CE, Trojanowska M, Smolka AJ. Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. Am J Physiol Gastrointest Liver Physiol 2008; a 294:G795 - 807; http://dx.doi.org/10.1152/ajpgi.00431.2007; PMID: 18202112
   PubMed Web of Science ®Google Scholar
• Saha A, Hammond CE, Gooz M, Smolka AJ. The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription. Am J Physiol Gastrointest Liver Physiol 2008; b 295:G977 - 86; http://dx.doi.org/10.1152/ajpgi.90338.2008; PMID: 18772363
   PubMedGoogle Scholar
• Saha A, Hammond CE, Beeson C, Peek RM Jr., Smolka AJ. Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa. Gut 2010; a 59:874 - 81; http://dx.doi.org/10.1136/gut.2009.194795; PMID: 20581234
   PubMed Web of Science ®Google Scholar
• Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ. Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology 2010; b 139:239 - 48; http://dx.doi.org/10.1053/j.gastro.2010.03.036; PMID: 20303353
   PubMed Web of Science ®Google Scholar
• Fischer OM, Hart S, Gschwind A, Ullrich A. EGFR signal transactivation in cancer cells. Biochem Soc Trans 2003; 31:1203 - 8; http://dx.doi.org/10.1042/BST0311203; PMID: 14641026
   PubMed Web of Science ®Google Scholar
• Coyle WJ, Sedlack RE, Nemec R, Peterson R, Duntemann T, Murphy M, Lawson JM. Eradication of Helicobacter pylori normalizes elevated mucosal levels of epidermal growth factor and its receptor. Am J Gastroenterol 1999; 94:2885 - 9; http://dx.doi.org/10.1111/j.1572-0241.1999.01432.x; PMID: 10520838
   PubMed Web of Science ®Google Scholar
• Wong BC, Wang WP, So WH, Shin VY, Wong WM, Fung FM, Liu ES, Hiu WM, Lam SK, Cho CH. Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Aliment Pharmacol Ther 2001; 15:1459 - 65; http://dx.doi.org/10.1046/j.1365-2036.2001.01051.x; PMID: 11552919
   PubMed Web of Science ®Google Scholar
• Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM Jr., Shaw LM, Kelly CP. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem 2001; 276:48127 - 34; http://dx.doi.org/10.1074/jbc.M107630200; PMID: 11604402
   PubMed Web of Science ®Google Scholar
• Wallasch C, Crabtree JE, Bevec D, Robinson PA, Wagner H, Ullrich A. Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem Biophys Res Commun 2002; 295:695 - 701; http://dx.doi.org/10.1016/S0006-291X(02)00740-4; PMID: 12099696
   PubMed Web of Science ®Google Scholar
• Bauer B, Pang E, Holland C, Kessler M, Bartfeld S, Meyer TF. The Helicobacter pylori virulence effector CagA abrogates human β-defensin 3 expression via inactivation of EGFR signaling. Cell Host Microbe 2012; 11:576 - 86; http://dx.doi.org/10.1016/j.chom.2012.04.013; PMID: 22704618
   PubMed Web of Science ®Google Scholar
• Keates S, Keates AC, Nath S, Peek RM Jr., Kelly CP. Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut 2005; 54:1363 - 9; http://dx.doi.org/10.1136/gut.2005.066977; PMID: 15863471
   PubMed Web of Science ®Google Scholar
• Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM Jr., Cover TL, Washington MK, Wilson KT, et al. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology 2009; 136:1297-307, e1-3; http://dx.doi.org/10.1053/j.gastro.2008.12.059; PMID:19250983
   Google Scholar
• Tabel G, Hoa NT, Tarnawski A, Chen J, Domek M, Ma TY. Helicobacter pylori infection inhibits healing of the wounded duodenal epithelium in vitro.. J Lab Clin Med 2003; 142:421 - 30; http://dx.doi.org/10.1016/j.lab.2003.06.001; PMID: 14713894
   PubMed Web of Science ®Google Scholar
• Tegtmeyer N, Zabler D, Schmidt D, Hartig R, Brandt S, Backert S. Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol 2009; 11:488 - 505; http://dx.doi.org/10.1111/j.1462-5822.2008.01269.x; PMID: 19046339
   PubMed Web of Science ®Google Scholar
• Churin Y, Al-Ghoul L, Kepp O, Meyer TF, Birchmeier W, Naumann M. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 2003; 161:249 - 55; http://dx.doi.org/10.1083/jcb.200208039; PMID: 12719469
   PubMed Web of Science ®Google Scholar
• Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, et al. Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. J Biol Chem 2006; 281:34888 - 96; http://dx.doi.org/10.1074/jbc.M607067200; PMID: 16990273
   PubMed Web of Science ®Google Scholar
• Oliveira MJ, Costa AM, Costa AC, Ferreira RM, Sampaio P, Machado JC, Seruca R, Mareel M, Figueiredo C. CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype. J Infect Dis 2009; 200:745 - 55; http://dx.doi.org/10.1086/604727; PMID: 19604117
   PubMed Web of Science ®Google Scholar
• Suzuki M, Mimuro H, Kiga K, Fukumatsu M, Ishijima N, Morikawa H, Nagai S, Koyasu S, Gilman RH, Kersulyte D, et al. Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. Cell Host Microbe 2009; 5:23 - 34; http://dx.doi.org/10.1016/j.chom.2008.11.010; PMID: 19154985
   PubMed Web of Science ®Google Scholar
• Snider JL, Cardelli JA. Helicobacter pylori induces cancer cell motility independent of the c-Met receptor. J Carcinog 2009; 8:7; http://dx.doi.org/10.4103/1477-3163.50892; PMID: 19439912
   PubMedGoogle Scholar
• Brandt S, Kwok T, Hartig R, König W, Backert S. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci U S A 2005; 102:9300 - 5; http://dx.doi.org/10.1073/pnas.0409873102; PMID: 15972330
   PubMed Web of Science ®Google Scholar
• Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M. Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells. J Biol Chem 2006; 281:32344 - 52; http://dx.doi.org/10.1074/jbc.M606172200; PMID: 16954210
   PubMed Web of Science ®Google Scholar
• Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, et al. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 2007; 447:330 - 3; http://dx.doi.org/10.1038/nature05765; PMID: 17507984
   PubMed Web of Science ®Google Scholar
• Wang TC, Goldenring JR. Inflammation intersection: gp130 balances gut irritation and stomach cancer. Nat Med 2002; 8:1080 - 2; http://dx.doi.org/10.1038/nm1002-1080; PMID: 12357240
   PubMed Web of Science ®Google Scholar
• Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002; 8:1089 - 97; http://dx.doi.org/10.1038/nm763; PMID: 12219085
   PubMed Web of Science ®Google Scholar
• Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S. c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest 2012; 122:1553 - 66; http://dx.doi.org/10.1172/JCI61143; PMID: 22378042
   PubMed Web of Science ®Google Scholar
• Lee IO, Kim JH, Choi YJ, Pillinger MH, Kim SY, Blaser MJ, Lee YC. Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. J Biol Chem 2010; 285:16042 - 50; http://dx.doi.org/10.1074/jbc.M110.111054; PMID: 20348091
   PubMed Web of Science ®Google Scholar
• Wiedemann T, Hofbaur S, Tegtmeyer N, Huber S, Sewald N, Wessler S, Backert S, Rieder G. Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut 2012; l 61:986 - 96; http://dx.doi.org/10.1136/gutjnl-2011-300525; PMID: 22287591
   PubMed Web of Science ®Google Scholar
• Conradi J, Huber S, Gaus K, Mertink F, Royo Gracia S, Strijowski U, Backert S, Sewald N. Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins αVβ3 and α5β1. Amino Acids 2012; b 43:219 - 32; http://dx.doi.org/10.1007/s00726-011-1066-0; PMID: 21915696
   PubMed Web of Science ®Google Scholar
• Cavallaro U, Dejana E. Adhesion molecule signalling: not always a sticky business. Nat Rev Mol Cell Biol 2011; 12:189 - 97; http://dx.doi.org/10.1038/nrm3068; PMID: 21346732
   PubMed Web of Science ®Google Scholar
• Frees D, Brøndsted L, Ingmer H. Bacterial proteases and virulence. Subcell Biochem 2013; 66:161 - 92; http://dx.doi.org/10.1007/978-94-007-5940-4_7; PMID: 23479441
   PubMedGoogle Scholar
• Bumann D, Aksu S, Wendland M, Janek K, Zimny-Arndt U, Sabarth N, Meyer TF, Jungblut PR. Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pylori.. Infect Immun 2002; 70:3396 - 403; http://dx.doi.org/10.1128/IAI.70.7.3396-3403.2002; PMID: 12065478
   PubMed Web of Science ®Google Scholar
• Salama NR, Shepherd B, Falkow S. Global transposon mutagenesis and essential gene analysis of Helicobacter pylori.. J Bacteriol 2004; 186:7926 - 35; http://dx.doi.org/10.1128/JB.186.23.7926-7935.2004; PMID: 15547264
   PubMed Web of Science ®Google Scholar
• Hoy B, Geppert T, Boehm M, Reisen F, Plattner P, Gadermaier G, Sewald N, Ferreira F, Briza P, Schneider G, et al. Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin. J Biol Chem 2012; 287:10115 - 20; http://dx.doi.org/10.1074/jbc.C111.333419; PMID: 22337879
   PubMed Web of Science ®Google Scholar
• Boehm M, Hoy B, Rohde M, Tegtmeyer N, Bæk KT, Oyarzabal OA, Brøndsted L, Wessler S, Backert S. Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin. Gut Pathog 2012; 4:3; http://dx.doi.org/10.1186/1757-4749-4-3; PMID: 22534208
   PubMed Web of Science ®Google Scholar
• Schirrmeister W, Gnad T, Wex T, Higashiyama S, Wolke C, Naumann M, Lendeckel U. Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection. Exp Cell Res 2009; 315:3500 - 8; http://dx.doi.org/10.1016/j.yexcr.2009.07.029; PMID: 19665015
   PubMed Web of Science ®Google Scholar
• Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, Fiocca R, Ricci V, Solcia E. Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori.. Gastroenterology 2007; 132:1009 - 23; http://dx.doi.org/10.1053/j.gastro.2007.01.049; PMID: 17383424
   PubMed Web of Science ®Google Scholar
• Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM Jr., Azuma T, et al. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene 2007; 26:4617 - 26; http://dx.doi.org/10.1038/sj.onc.1210251; PMID: 17237808
   PubMed Web of Science ®Google Scholar
• Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, et al. Activation of beta-catenin by carcinogenic Helicobacter pylori.. Proc Natl Acad Sci U S A 2005; 102:10646 - 51; http://dx.doi.org/10.1073/pnas.0504927102; PMID: 16027366
   PubMed Web of Science ®Google Scholar
• Molinari M, Salio M, Galli C, Norais N, Rappuoli R, Lanzavecchia A, Montecucco C. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med 1998; a 187:135 - 40; http://dx.doi.org/10.1084/jem.187.1.135; PMID: 9419220
   PubMed Web of Science ®Google Scholar
• Sewald X, Gebert-Vogl B, Prassl S, Barwig I, Weiss E, Fabbri M, Osicka R, Schiemann M, Busch DH, Semmrich M, et al. Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. Cell Host Microbe 2008; 3:20 - 9; http://dx.doi.org/10.1016/j.chom.2007.11.003; PMID: 18191791
   PubMed Web of Science ®Google Scholar
• Sewald X, Jiménez-Soto L, Haas R. PKC-dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. Cell Microbiol 2011; 13:482 - 96; http://dx.doi.org/10.1111/j.1462-5822.2010.01551.x; PMID: 21083636
   PubMed Web of Science ®Google Scholar
• Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 2003; 301:1099 - 102; http://dx.doi.org/10.1126/science.1086871; PMID: 12934009
   PubMed Web of Science ®Google Scholar
• Sundrud MS, Torres VJ, Unutmaz D, Cover TL. Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci U S A 2004; 101:7727 - 32; http://dx.doi.org/10.1073/pnas.0401528101; PMID: 15128946
   PubMed Web of Science ®Google Scholar
• Yokoyama K, Higashi H, Ishikawa S, Fujii Y, Kondo S, Kato H, Azuma T, Wada A, Hirayama T, Aburatani H, et al. Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc Natl Acad Sci U S A 2005; 102:9661 - 6; http://dx.doi.org/10.1073/pnas.0502529102; PMID: 15980153
   PubMed Web of Science ®Google Scholar
• Kim JM, Kim JS, Yoo DY, Ko SH, Kim N, Kim H, Kim YJ. Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1. Clin Exp Immunol 2011; 166:34 - 45; http://dx.doi.org/10.1111/j.1365-2249.2011.04447.x; PMID: 21910723
   PubMed Web of Science ®Google Scholar
• Zheng PY, Jones NL. Helicobacter pylori strains expressing the vacuolating cytotoxin interrupt phagosome maturation in macrophages by recruiting and retaining TACO (coronin 1) protein. Cell Microbiol 2003; 5:25 - 40; http://dx.doi.org/10.1046/j.1462-5822.2003.00250.x; PMID: 12542468
   PubMed Web of Science ®Google Scholar
• Ramarao N, Gray-Owen SD, Backert S, Meyer TF. Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components. Mol Microbiol 2000; 37:1389 - 404; http://dx.doi.org/10.1046/j.1365-2958.2000.02089.x; PMID: 10998171
   PubMed Web of Science ®Google Scholar
• Rittig MG, Shaw B, Letley DP, Thomas RJ, Argent RH, Atherton JC. Helicobacter pylori-induced homotypic phagosome fusion in human monocytes is independent of the bacterial vacA and cag status. Cell Microbiol 2003; 5:887 - 99; http://dx.doi.org/10.1046/j.1462-5822.2003.00328.x; PMID: 14641174
   PubMed Web of Science ®Google Scholar
• Yuan J, Li P, Tao J, Shi X, Hu B, Chen H, Guo X. H. pylori escape host immunoreaction through inhibiting ILK expression by VacA. Cell Mol Immunol 2009; 6:191 - 7; http://dx.doi.org/10.1038/cmi.2009.26; PMID: 19567202
   PubMed Web of Science ®Google Scholar
• Herranz B, Marquez S, Guijarro B, Aracil E, Aicart-Ramos C, Rodriguez-Crespo I, Serrano I, Rodríguez-Puyol M, Zaragoza C, Saura M. Integrin-linked kinase regulates vasomotor function by preventing endothelial nitric oxide synthase uncoupling: role in atherosclerosis. Circ Res 2012; 110:439 - 49; http://dx.doi.org/10.1161/CIRCRESAHA.111.253948; PMID: 22194624
   PubMed Web of Science ®Google Scholar
• de Bernard M, Cappon A, Pancotto L, Ruggiero P, Rivera J, Del Giudice G, Montecucco C. The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations. Cell Microbiol 2005; 7:191 - 8; http://dx.doi.org/10.1111/j.1462-5822.2004.00446.x; PMID: 15659063
   PubMed Web of Science ®Google Scholar
• Supajatura V, Ushio H, Wada A, Yahiro K, Okumura K, Ogawa H, Hirayama T, Ra C. Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines. J Immunol 2002; 168:2603 - 7; PMID: 11884423
   PubMed Web of Science ®Google Scholar
• Faure-André G, Vargas P, Yuseff MI, Heuzé M, Diaz J, Lankar D, Steri V, Manry J, Hugues S, Vascotto F, et al. Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain. Science 2008; 322:1705 - 10; http://dx.doi.org/10.1126/science.1159894; PMID: 19074353
   PubMed Web of Science ®Google Scholar
• Mitchell PJ, Afzali B, Fazekasova H, Chen D, Ali N, Powell N, Lord GM, Lechler RI, Lombardi G. Helicobacter pylori induces in-vivo expansion of human regulatory T cells through stimulating interleukin-1β production by dendritic cells. Clin Exp Immunol 2012; 170:300 - 9; http://dx.doi.org/10.1111/j.1365-2249.2012.04659.x; PMID: 23121671
   PubMed Web of Science ®Google Scholar
• Enarsson K, Brisslert M, Backert S, Quiding-Järbrink M. Helicobacter pylori induces transendothelial migration of activated memory T cells. Infect Immun 2005; 73:761 - 9; http://dx.doi.org/10.1128/IAI.73.2.761-769.2005; PMID: 15664914
   PubMed Web of Science ®Google Scholar
• Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, Zaitoun AM, Atherton JC. Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut 2008; 57:1375 - 85; http://dx.doi.org/10.1136/gut.2007.137539; PMID: 18467372
   PubMed Web of Science ®Google Scholar
• Fan X, Gunasena H, Cheng Z, Espejo R, Crowe SE, Ernst PB, Reyes VE. Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis. J Immunol 2000; 165:1918 - 24; PMID: 10925273
   PubMed Web of Science ®Google Scholar
• Li Y, Jiang Y, Xi Y, Zhang L, Luo J, He D, Zeng S, Ning Y. Identification and characterization of H-2d restricted CD4+ T cell epitopes on Lpp20 of Helicobacter pylori.. BMC Immunol 2012; 13:68; http://dx.doi.org/10.1186/1471-2172-13-68; PMID: 23234363
   PubMed Web of Science ®Google Scholar
• Chen L, Li B, Yang WC, He JL, Li NY, Hu J, He YF, Yu S, Zhao Z, Luo P, et al. A dominant CD4(+) T-cell response to Helicobacter pylori reduces risk for gastric disease in humans. Gastroenterology 2013; 144:591 - 600; http://dx.doi.org/10.1053/j.gastro.2012.12.002; PMID: 23232294
   PubMed Web of Science ®Google Scholar
• Yang WC, Chen L, Li HB, Li B, Hu J, Zhang JY, Yang SM, Zou QM, Guo H, Wu C. Identification of two novel immunodominant UreB CD4(+) T cell epitopes in Helicobacter pylori infected subjects. Vaccine 2013; 31:1204 - 9; http://dx.doi.org/10.1016/j.vaccine.2012.12.058; PMID: 23306364
   PubMed Web of Science ®Google Scholar
• Avadhanula V, Rodriguez CA, Ulett GC, Bakaletz LO, Adderson EE. Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression. Infect Immun 2006; 74:830 - 8; http://dx.doi.org/10.1128/IAI.74.2.830-838.2006; PMID: 16428725
   PubMed Web of Science ®Google Scholar
• Hayes SH, Seigel GM. Immunoreactivity of ICAM-1 in human tumors, metastases and normal tissues. Int J Clin Exp Pathol 2009; 2:553 - 60; PMID: 19636402
   PubMed Web of Science ®Google Scholar
• Moese S, Selbach M, Meyer TF, Backert S. cag+ Helicobacter pylori induces homotypic aggregation of macrophage-like cells by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface. Infect Immun 2002; 70:4687 - 91; http://dx.doi.org/10.1128/IAI.70.8.4687-4691.2002; PMID: 12117984
   PubMed Web of Science ®Google Scholar
• Hogg N, Patzak I, Willenbrock F. The insider’s guide to leukocyte integrin signalling and function. Nat Rev Immunol 2011; 11:416 - 26; http://dx.doi.org/10.1038/nri2986; PMID: 21597477
   PubMed Web of Science ®Google Scholar
• Ishihara S, Rumi MA, Kadowaki Y, Ortega-Cava CF, Yuki T, Yoshino N, Miyaoka Y, Kazumori H, Ishimura N, Amano Y, et al. Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol 2004; 173:1406 - 16; PMID: 15240737
   PubMed Web of Science ®Google Scholar
• Maeda S, Akanuma M, Mitsuno Y, Hirata Y, Ogura K, Yoshida H, Shiratori Y, Omata M. Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells. J Biol Chem 2001; 276:44856 - 64; http://dx.doi.org/10.1074/jbc.M105381200; PMID: 11546774
   PubMed Web of Science ®Google Scholar
• Yokota S, Ohnishi T, Muroi M, Tanamoto K, Fujii N, Amano K. Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex. FEMS Immunol Med Microbiol 2007; 51:140 - 8; http://dx.doi.org/10.1111/j.1574-695X.2007.00288.x; PMID: 17645528
   PubMed Web of Science ®Google Scholar
• Kumar Pachathundikandi S, Brandt S, Madassery J, Backert S. Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. PLoS One 2011; 6:e19614; http://dx.doi.org/10.1371/journal.pone.0019614; PMID: 21573018
   PubMedGoogle Scholar
• Zhao Y, Yokota K, Ayada K, Yamamoto Y, Okada T, Shen L, Oguma K. Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes. J Med Microbiol 2007; 56:154 - 64; http://dx.doi.org/10.1099/jmm.0.46882-0; PMID: 17244794
   PubMed Web of Science ®Google Scholar
• Gobert AP, Bambou JC, Werts C, Balloy V, Chignard M, Moran AP, Ferrero RL. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism. J Biol Chem 2004; 279:245 - 50; http://dx.doi.org/10.1074/jbc.M307858200; PMID: 14573621
   PubMed Web of Science ®Google Scholar
• Rad R, Brenner L, Krug A, Voland P, Mages J, Lang R, et al. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 2007; 133:150-163.e3.
   Google Scholar
• Koch M, Mollenkopf HJ, Klemm U, Meyer TF. Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis. Proc Natl Acad Sci U S A 2012; 109:E1153 - 62; http://dx.doi.org/10.1073/pnas.1116125109; PMID: 22509021
   PubMed Web of Science ®Google Scholar
• Smith MF Jr., Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem 2003; 278:32552 - 60; http://dx.doi.org/10.1074/jbc.M305536200; PMID: 12807870
   PubMed Web of Science ®Google Scholar
• Smith SM, Moran AP, Duggan SP, Ahmed SE, Mohamed AS, Windle HJ, O’Neill LA, Kelleher DP. Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide. J Immunol 2011; 186:2462 - 71; http://dx.doi.org/10.4049/jimmunol.1000864; PMID: 21220698
   PubMed Web of Science ®Google Scholar
• Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG, Wang TC, Kurt-Jones EA. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun 2004; 72:6446 - 54; http://dx.doi.org/10.1128/IAI.72.11.6446-6454.2004; PMID: 15501775
   PubMed Web of Science ®Google Scholar
• Lepper PM, Triantafilou M, Schumann C, Schneider EM, Triantafilou K. Lipopolysaccharides from Helicobacter pylori can act as antagonists for Toll-like receptor 4. Cell Microbiol 2005; 7:519 - 28; http://dx.doi.org/10.1111/j.1462-5822.2005.00482.x; PMID: 15760452
   PubMed Web of Science ®Google Scholar
• Uno K, Kato K, Atsumi T, Suzuki T, Yoshitake J, Morita H, Ohara S, Kotake Y, Shimosegawa T, Yoshimura T. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol 2007; 293:G1004 - 12; http://dx.doi.org/10.1152/ajpgi.00096.2007; PMID: 17855767
   PubMed Web of Science ®Google Scholar
• Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A. Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci U S A 2005; 102:9247 - 52; http://dx.doi.org/10.1073/pnas.0502040102; PMID: 15956202
   PubMed Web of Science ®Google Scholar
• Owyang SY, Luther J, Owyang CC, Zhang M, Kao JY. Helicobacter pylori DNA’s anti-inflammatory effect on experimental colitis. Gut Microbes 2012; 3:168 - 71; http://dx.doi.org/10.4161/gmic.19181; PMID: 22356863
   PubMed Web of Science ®Google Scholar
• Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005; 26:447 - 54; http://dx.doi.org/10.1016/j.it.2005.06.004; PMID: 15967716
   PubMed Web of Science ®Google Scholar
• Broz P, Monack DM. Newly described pattern recognition receptors team up against intracellular pathogens. Nat Rev Immunol 2013; 13:551 - 65; http://dx.doi.org/10.1038/nri3479; PMID: 23846113
   PubMed Web of Science ®Google Scholar
• Tomita T, Jackson AM, Hida N, Hayat M, Dixon MF, Shimoyama T, Axon AT, Robinson PA, Crabtree JE. Expression of Interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection. J Infect Dis 2001; 183:620 - 7; http://dx.doi.org/10.1086/318541; PMID: 11170988
   PubMed Web of Science ®Google Scholar
• Yamauchi K, Choi IJ, Lu H, Ogiwara H, Graham DY, Yamaoka Y. Regulation of IL-18 in Helicobacter pylori infection. J Immunol 2008; 180:1207 - 16; PMID: 18178861
   PubMed Web of Science ®Google Scholar
• Hitzler I, Sayi A, Kohler E, Engler DB, Koch KN, Hardt WD, Müller A. Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1β and IL-18. J Immunol 2012; 188:3594 - 602; http://dx.doi.org/10.4049/jimmunol.1103212; PMID: 22403439
   PubMed Web of Science ®Google Scholar
• Oertli M, Sundquist M, Hitzler I, Engler DB, Arnold IC, Reuter S, Maxeiner J, Hansson M, Taube C, Quiding-Järbrink M, et al. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Invest 2012; 122:1082 - 96; http://dx.doi.org/10.1172/JCI61029; PMID: 22307326
   PubMed Web of Science ®Google Scholar
• Kim DJ, Park JH, Franchi L, Backert S, Núñez G. The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. Eur J Immunol 2013; 43:2650 - 8; http://dx.doi.org/10.1002/eji.201243281; PMID: 23818043
   PubMed Web of Science ®Google Scholar