The role of microbiota in hepatic encephalopathy

References

• Quigley EM, Stanton C, Murphy EF. The gut microbiota and the liver. Pathophysiological and clinical implications. J Hepatol 2013; 58:1020 - 7; http://dx.doi.org/10.1016/j.jhep.2012.11.023; PMID: 23183530
   PubMed Web of Science ®Google Scholar
• Tandon P, Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28:26 - 42; http://dx.doi.org/10.1055/s-2008-1040319; PMID: 18293275
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Gillevet PM, Patel NR, Ahluwalia V, Ridlon JM, Kettenmann B, Schubert CM, Sikaroodi M, Heuman DM, Crossey MM, et al. A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy. Metab Brain Dis 2012; 27:205 - 15; http://dx.doi.org/10.1007/s11011-012-9303-0; PMID: 22527995
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Wade JB, Sanyal AJ. Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathy. Hepatology 2009; 50:2014 - 21; http://dx.doi.org/10.1002/hep.23216; PMID: 19787808
   PubMed Web of Science ®Google Scholar
• Ortiz M, Jacas C, Córdoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005; 42:Suppl S45 - 53; http://dx.doi.org/10.1016/j.jhep.2004.11.028; PMID: 15777572
   PubMed Web of Science ®Google Scholar
• Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002; 35:716 - 21; http://dx.doi.org/10.1053/jhep.2002.31250; PMID: 11870389
   PubMed Web of Science ®Google Scholar
• Shawcross DL, Wright G, Olde Damink SW, Jalan R. Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis 2007; 22:125 - 38; http://dx.doi.org/10.1007/s11011-006-9042-1; PMID: 17260161
   PubMed Web of Science ®Google Scholar
• Bajaj JS. Review article: the modern management of hepatic encephalopathy. Aliment Pharmacol Ther 2010; 31:537 - 47; http://dx.doi.org/10.1111/j.1365-2036.2009.04211.x; PMID: 20002027
   PubMed Web of Science ®Google Scholar
• Romero-Gómez M, Jover M, Del Campo JA, Royo JL, Hoyas E, Galán JJ, Montoliu C, Baccaro E, Guevara M, Córdoba J, et al. Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis: a cohort study. Ann Intern Med 2010; 153:281 - 8; http://dx.doi.org/10.7326/0003-4819-153-5-201009070-00002; PMID: 20820037
   PubMed Web of Science ®Google Scholar
• Riggio O, Varriale M, Testore GP, Di Rosa R, Di Rosa E, Merli M, Romiti A, Candiani C, Capocaccia L. Effect of lactitol and lactulose administration on the fecal flora in cirrhotic patients. J Clin Gastroenterol 1990; 12:433 - 6; http://dx.doi.org/10.1097/00004836-199008000-00016; PMID: 2398251
   PubMed Web of Science ®Google Scholar
• Tarao K, Tamai S, Ito Y, Okawa S, Hayashi M. [Effects of lactitol on fecal bacterial flora in patients with liver cirrhosis and hepatic encephalopathy]. Nihon Shokakibyo Gakkai Zasshi 1995; 92:1037 - 50; PMID: 7643458
   PubMedGoogle Scholar
• Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J, Riordan SM. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004; 39:1441 - 9; http://dx.doi.org/10.1002/hep.20194; PMID: 15122774
   PubMed Web of Science ®Google Scholar
• Kamath PS, Kim WR, Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology 2007; 45:797 - 805; http://dx.doi.org/10.1002/hep.21563; PMID: 17326206
   PubMed Web of Science ®Google Scholar
• Chen Y, Yang F, Lu H, Wang B, Chen Y, Lei D, Wang Y, Zhu B, Li L. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 2011; 54:562 - 72; http://dx.doi.org/10.1002/hep.24423; PMID: 21574172
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Ridlon JM, Hylemon PB, Thacker LR, Heuman DM, Smith S, Sikaroodi M, Gillevet PM. Linkage of gut microbiome with cognition in hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol 2012; 302:G168 - 75; http://dx.doi.org/10.1152/ajpgi.00190.2011; PMID: 21940902
   PubMed Web of Science ®Google Scholar
• Nava GM, Stappenbeck TS. Diversity of the autochthonous colonic microbiota. Gut Microbes 2011; 2:99 - 104; http://dx.doi.org/10.4161/gmic.2.2.15416; PMID: 21694499
   PubMedGoogle Scholar
• Bajaj JS, Hylemon PB, Heuman DM, et al. The Cirrhosis Dysbiosis Ratio defines Changes in the Gut Microbiome Associated with Cirrhosis and its Complications. J Hepatol 2014.; http://dx.doi.org/10.1016/j.jhep.2013.12.019
   Web of Science ®Google Scholar
• Zhang Z, Zhai H, Geng J, Yu R, Ren H, Fan H, Shi P. Large-scale survey of gut microbiota associated with MHE Via 16S rRNA-based pyrosequencing. Am J Gastroenterol 2013; 108:1601 - 11; http://dx.doi.org/10.1038/ajg.2013.221; PMID: 23877352
   PubMed Web of Science ®Google Scholar
• Teltschik Z, Wiest R, Beisner J, Nuding S, Hofmann C, Schoelmerich J, Bevins CL, Stange EF, Wehkamp J. Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense. Hepatology 2012; 55:1154 - 63; http://dx.doi.org/10.1002/hep.24789; PMID: 22095436
   PubMed Web of Science ®Google Scholar
• Kappus MR, Bajaj JS. Covert hepatic encephalopathy: not as minimal as you might think. Clin Gastroenterol Hepatol 2012; 10:1208 - 19; http://dx.doi.org/10.1016/j.cgh.2012.05.026; PMID: 22728384
   PubMed Web of Science ®Google Scholar
• Ahluwalia V, Wade JB, Heuman DM, Hammeke TA, Sanyal AJ, Sterling RK, Stravitz RT, Luketic V, Siddiqui MS, Puri P, et al. Enhancement of functional connectivity, working memory and inhibitory control on multi-modal brain MR imaging with Rifaximin in Cirrhosis: Implications for the gut-liver-brain axis. Metab Brain Dis 2014; http://dx.doi.org/10.1007/s11011-014-9507-6; PMID: 24590688
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Saeian K, Christensen KM, Hafeezullah M, Varma RR, Franco J, Pleuss JA, Krakower G, Hoffmann RG, Binion DG. Probiotic yogurt for the treatment of minimal hepatic encephalopathy. Am J Gastroenterol 2008; 103:1707 - 15; http://dx.doi.org/10.1111/j.1572-0241.2008.01861.x; PMID: 18691193
   PubMed Web of Science ®Google Scholar
• Mittal VV, Sharma BC, Sharma P, Sarin SK. A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy. Eur J Gastroenterol Hepatol 2011; 23:725 - 32; http://dx.doi.org/10.1097/MEG.0b013e32834696f5; PMID: 21646910
   PubMed Web of Science ®Google Scholar
• Jain L, Sharma BC, Srivastava S, Puri SK, Sharma P, Sarin S. Serum endotoxin, inflammatory mediators, and magnetic resonance spectroscopy before and after treatment in patients with minimal hepatic encephalopathy. J Gastroenterol Hepatol 2013; 28:1187 - 93; http://dx.doi.org/10.1111/jgh.12160; PMID: 23425082
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Heuman DM, Sanyal AJ, Hylemon PB, Sterling RK, Stravitz RT, Fuchs M, Ridlon JM, Daita K, Monteith P, et al. Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 2013; 8:e60042; http://dx.doi.org/10.1371/journal.pone.0060042; PMID: 23565181
   PubMed Web of Science ®Google Scholar
• Ahluwalia V, Wade JB, Heuman DM, Hammeke TA, Sanyal AJ, Sterling RK, Stravitz RT, Luketic V, Siddiqui MS, Puri P, et al. Enhancement of functional connectivity, working memory and inhibitory control on multi-modal brain MR imaging with Rifaximin in Cirrhosis: Implications for the gut-liver-brain axis. Metab Brain Dis 2014; http://dx.doi.org/10.1007/s11011-014-9507-6; PMID: 24590688
   PubMed Web of Science ®Google Scholar
• Jiang ZD, Ke S, Dupont HL. Rifaximin-induced alteration of virulence of diarrhoea-producing Escherichia coli and Shigella sonnei. Int J Antimicrob Agents 2010; 35:278 - 81; http://dx.doi.org/10.1016/j.ijantimicag.2009.11.013; PMID: 20045287
   PubMed Web of Science ®Google Scholar
• Vanhoutte T, De Preter V, De Brandt E, Verbeke K, Swings J, Huys G. Molecular monitoring of the fecal microbiota of healthy human subjects during administration of lactulose and Saccharomyces boulardii. Appl Environ Microbiol 2006; 72:5990 - 7; http://dx.doi.org/10.1128/AEM.00233-06; PMID: 16957220
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Hylemon PB, Ridlon JM, Heuman DM, Daita K, White MB, Monteith P, Noble NA, Sikaroodi M, Gillevet PM. Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol 2012; 303:G675 - 85; http://dx.doi.org/10.1152/ajpgi.00152.2012; PMID: 22821944
   PubMed Web of Science ®Google Scholar
• Vlahcevic ZR, Buhac I, Bell CC Jr., Swell L. Abnormal metabolism of secondary bile acids in patients with cirrhosis. Gut 1970; 11:420 - 2; http://dx.doi.org/10.1136/gut.11.5.420; PMID: 5428044
   PubMed Web of Science ®Google Scholar
• Kakiyama G, Pandak WM, Gillevet PM, Hylemon PB, Heuman DM, Daita K, Takei H, Muto A, Nittono H, Ridlon JM, et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol 2013; 58:949 - 55; http://dx.doi.org/10.1016/j.jhep.2013.01.003; PMID: 23333527
   PubMed Web of Science ®Google Scholar
• Ridlon JM, Alves JM, Hylemon PB, Bajaj JS. Cirrhosis, bile acids, and gut microbiota: Unraveling a complex relationship. Gut Microbes 2013; 4:4; http://dx.doi.org/10.4161/gmic.25723; PMID: 23851335
   PubMedGoogle Scholar
• Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 2008; 105:16731 - 6; http://dx.doi.org/10.1073/pnas.0804812105; PMID: 18936492
   PubMed Web of Science ®Google Scholar
• Zoetendal EG, Ben-Amor K, Harmsen HJ, Schut F, Akkermans AD, de Vos WM. Quantification of uncultured Ruminococcus obeum-like bacteria in human fecal samples by fluorescent in situ hybridization and flow cytometry using 16S rRNA-targeted probes. Appl Environ Microbiol 2002; 68:4225 - 32; http://dx.doi.org/10.1128/AEM.68.9.4225-4232.2002; PMID: 12200269
   PubMed Web of Science ®Google Scholar
• Zapater P, Francés R, González-Navajas JM, de la Hoz MA, Moreu R, Pascual S, Monfort D, Montoliu S, Vila C, Escudero A, et al. Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis. Hepatology 2008; 48:1924 - 31; http://dx.doi.org/10.1002/hep.22564; PMID: 19003911
   PubMed Web of Science ®Google Scholar
• Montano-Loza AJ, Meza-Junco J, Prado CM, Lieffers JR, Baracos VE, Bain VG, Sawyer MB. Muscle wasting is associated with mortality in patients with cirrhosis. Clin Gastroenterol Hepatol 2012; 10:166 - 73, e1; http://dx.doi.org/10.1016/j.cgh.2011.08.028; PMID: 21893129
   PubMed Web of Science ®Google Scholar
• Olde Damink SW, Jalan R, Dejong CH. Interorgan ammonia trafficking in liver disease. Metab Brain Dis 2009; 24:169 - 81; http://dx.doi.org/10.1007/s11011-008-9122-5; PMID: 19067143
   PubMed Web of Science ®Google Scholar
• McPhail MJ, Taylor-Robinson SD. The role of magnetic resonance imaging and spectroscopy in hepatic encephalopathy. Metab Brain Dis 2010; 25:65 - 72; http://dx.doi.org/10.1007/s11011-010-9171-4; PMID: 20221679
   PubMed Web of Science ®Google Scholar
• Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, Kwasny M, Lau CK, Keshavarzian A. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 2012; 302:G966 - 78; http://dx.doi.org/10.1152/ajpgi.00380.2011; PMID: 22241860
   PubMed Web of Science ®Google Scholar
• Hartmann P, Chen WC, Schnabl B. The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease. Front Physiol 2012; 3:402; http://dx.doi.org/10.3389/fphys.2012.00402; PMID: 23087650
   PubMedGoogle Scholar
• Bajaj JS, Forton DM. Cognitive improvement after HCV eradication: Extending the benefits. Hepatology 2013; 58:480 - 2; http://dx.doi.org/10.1002/hep.26481; PMID: 23696270
   PubMed Web of Science ®Google Scholar
• Lu H, Wu Z, Xu W, Yang J, Chen Y, Li L. Intestinal microbiota was assessed in cirrhotic patients with hepatitis B virus infection. Intestinal microbiota of HBV cirrhotic patients. Microb Ecol 2011; 61:693 - 703; http://dx.doi.org/10.1007/s00248-010-9801-8; PMID: 21286703
   PubMed Web of Science ®Google Scholar
• Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, Puri P, Sterling RK, Luketic V, Stravitz RT, Siddiqui MS, Fuchs M, et al. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014; 39:1113 - 25; http://dx.doi.org/10.1111/apt.12695; PMID: 24628464
   PubMed Web of Science ®Google Scholar