Advanced search
Publication Cover
Human Vaccines & Immunotherapeutics Volume 8, 2012 - Issue 6
Submit an article Journal homepage
2,383
Views
78
CrossRef citations to date
0
Altmetric
Commentary

Hepatitis E vaccine development

A 14 year odyssey

Ting Wu National Institute of Diagnostics and Vaccine Development in Infectious Diseases; Xiamen University; Xiamen, China; School of Public Health; Xiamen University; Xiamen, China; School of Life Sciences; Xiamen University; Xiamen, China
,
Shao-Wei Li National Institute of Diagnostics and Vaccine Development in Infectious Diseases; Xiamen University; Xiamen, China; School of Public Health; Xiamen University; Xiamen, China; School of Life Sciences; Xiamen University; Xiamen, China
,
Jun Zhang National Institute of Diagnostics and Vaccine Development in Infectious Diseases; Xiamen University; Xiamen, China; School of Public Health; Xiamen University; Xiamen, China; School of Life Sciences; Xiamen University; Xiamen, China
,
Mun-Hon Ng National Institute of Diagnostics and Vaccine Development in Infectious Diseases; Xiamen University; Xiamen, China; School of Public Health; Xiamen University; Xiamen, China
,
Ning-Shao Xia National Institute of Diagnostics and Vaccine Development in Infectious Diseases; Xiamen University; Xiamen, China; School of Public Health; Xiamen University; Xiamen, China; School of Life Sciences; Xiamen University; Xiamen, China
&
Qinjian Zhao National Institute of Diagnostics and Vaccine Development in Infectious Diseases; Xiamen University; Xiamen, China; School of Public Health; Xiamen University; Xiamen, ChinaCorrespondence[email protected]
Pages 823-827 | Published online: 01 Jun 2012

References

  • Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J, et al. Hepatitis E. Lancet 2012; 379 In press
  • Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol 2008; 48:494 - 503; http://dx.doi.org/10.1016/j.jhep.2007.12.008; PMID: 18192058
  • Navaneethan U, Al Mohajer M, Shata MT. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int 2008; 28:1190 - 9; http://dx.doi.org/10.1111/j.1478-3231.2008.01840.x; PMID: 18662274
  • Dalton HR, Hazeldine S, Banks M, Ijaz S, Bendall R. Locally acquired hepatitis E in chronic liver disease. Lancet 2007; 369:1260; http://dx.doi.org/10.1016/S0140-6736(07)60595-9; PMID: 17434400
  • Teshale EH, Howard CM, Grytdal SP, Handzel TR, Barry V, Kamili S, et al. Hepatitis E epidemic, Uganda. Emerg Infect Dis 2010; 16:126 - 9; http://dx.doi.org/10.3201/eid1601.090764; PMID: 20031058
  • Zhuang H, Cao XY, Liu CB, Wang GM. Epidemiology of hepatitis E in China. Gastroenterol Jpn 1991; 26:Suppl 3 135 - 8; PMID: 1909252
  • Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 2010; 376:895 - 902; http://dx.doi.org/10.1016/S0140-6736(10)61030-6; PMID: 20728932
  • Li SW, Zhang J, Li YM, Ou SH, Huang GY, He ZQ, et al. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine 2005; 23:2893 - 901; http://dx.doi.org/10.1016/j.vaccine.2004.11.064; PMID: 15780738
  • Zhang J, Gu Y, Ge SX, Li SW, He ZQ, Huang GY, et al. Analysis of hepatitis E virus neutralization sites using monoclonal antibodies directed against a virus capsid protein. Vaccine 2005; 23:2881 - 92; http://dx.doi.org/10.1016/j.vaccine.2004.11.065; PMID: 15780737
  • Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, et al. Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A 2011; 108:10266 - 71; http://dx.doi.org/10.1073/pnas.1101309108; PMID: 21642534
  • Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, et al. Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction. PLoS Pathog 2009; 5:e1000537; http://dx.doi.org/10.1371/journal.ppat.1000537; PMID: 19662165
  • Zhang JZ, Ng MH, Xia NS, Lau SH, Che XY, Chau TN, et al. Conformational antigenic determinants generated by interactions between a bacterially expressed recombinant peptide of the hepatitis E virus structural protein. J Med Virol 2001; 64:125 - 32; http://dx.doi.org/10.1002/jmv.1027; PMID: 11360244
  • Zhang J, Liu CB, Li RC, Li YM, Zheng YJ, Li YP, et al. Randomized-controlled phase II clinical trial of a bacterially expressed recombinant hepatitis E vaccine. Vaccine 2009; 27:1869 - 74; http://dx.doi.org/10.1016/j.vaccine.2008.12.061; PMID: 19168109
  • Wu T, Zhu FC, Huang SJ, Zhang XF, Wang ZZ, Zhang J, et al. Safety of the hepatitis E vaccine for pregnant women: A preliminary analysis. Hepatology 2011; In press http://dx.doi.org/10.1002/hep.25522; PMID: 22161542
  • Sarin SK, Kumar M. A vaccine for hepatitis e: has it finally arrived?. Gastroenterology 2011; 140:1349 - 52, discussion 1352-3; http://dx.doi.org/10.1053/j.gastro.2011.02.040; PMID: 21354166
  • Shrestha MP, Scott RM, Joshi DM, Mammen MP Jr., Thapa GB, Thapa N, et al. Safety and efficacy of a recombinant hepatitis E vaccine. N Engl J Med 2007; 356:895 - 903; http://dx.doi.org/10.1056/NEJMoa061847; PMID: 17329696

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.