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Special Focus Review

Novel developments in the mechanisms of immune tolerance to allergens

, , &
Pages 1485-1491 | Received 10 May 2012, Accepted 28 May 2012, Published online: 01 Oct 2012

References

  • Noon L. Prophylactic inoculation against hayfever. Lancet 1911; http://dx.doi.org/10.1016/S0140-6736(00)78276-6
  • Rebane A, Zimmermann M, Aab A, Baurecht H, Koreck A, Karelson M, et al. Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. J Allergy Clin Immunol 2012; 129:1297 - 306; http://dx.doi.org/10.1016/j.jaci.2012.02.020; PMID: 22445417
  • Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, et al. Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011; 127:701 - 21, e1-70; http://dx.doi.org/10.1016/j.jaci.2010.11.050; PMID: 21377040
  • Akkoc T, de Koning PJ, Rückert B, Barlan I, Akdis M, Akdis CA. Increased activation-induced cell death of high IFN-gamma-producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases. J Allergy Clin Immunol 2008; 121:652 - 8, e1; http://dx.doi.org/10.1016/j.jaci.2007.12.1171; PMID: 18328893
  • Basinski TM, Holzmann D, Eiwegger T, Zimmermann M, Klunker S, Meyer N, et al. Dual nature of T cell-epithelium interaction in chronic rhinosinusitis. J Allergy Clin Immunol 2009; 124:74 - 80, e1-8; http://dx.doi.org/10.1016/j.jaci.2009.04.019; PMID: 19523671
  • Soyka MB, Treis A, Eiwegger T, Menz G, Zhang S, Holzmann D, et al. Regulation and expression of IL-32 in chronic rhinosinusitis. Allergy 2012; 67:790 - 8; http://dx.doi.org/10.1111/j.1398-9995.2012.02820.x; PMID: 22486709
  • Meyer N, Zimmermann M, Bürgler S, Bassin C, Woehrl S, Moritz K, et al. IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol 2010; 125:858 - 65, e10; http://dx.doi.org/10.1016/j.jaci.2010.01.016; PMID: 20227751
  • Meyer N, Christoph J, Makrinioti H, Indermitte P, Rhyner C, Soyka M, et al. Inhibition of angiogenesis by IL-32: possible role in asthma. J Allergy Clin Immunol 2012; 129:964 - 73, e7; http://dx.doi.org/10.1016/j.jaci.2011.12.1002; PMID: 22336080
  • Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF Jr., Tocker JE, et al. IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 2010; 464:1362 - 6; http://dx.doi.org/10.1038/nature08901; PMID: 20200520
  • Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 2010; 464:1367 - 70; http://dx.doi.org/10.1038/nature08900; PMID: 20200518
  • Eiwegger T, Akdis CA. IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma. Eur J Immunol 2011; 41:1535 - 8; http://dx.doi.org/10.1002/eji.201141668; PMID: 21618506
  • McGuirk P, McCann C, Mills KH. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 2002; 195:221 - 31; http://dx.doi.org/10.1084/jem.20011288; PMID: 11805149
  • Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317:256 - 60; http://dx.doi.org/10.1126/science.1145697; PMID: 17569825
  • Urry Z, Xystrakis E, Richards DF, McDonald J, Sattar Z, Cousins DJ, et al. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest 2009; 119:387 - 98; PMID: 19139565
  • Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001; 2:725 - 31; http://dx.doi.org/10.1038/90667; PMID: 11477409
  • de Heer HJ, Hammad H, Soullié T, Hijdra D, Vos N, Willart MA, et al. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med 2004; 200:89 - 98; http://dx.doi.org/10.1084/jem.20040035; PMID: 15238608
  • Ito T, Yang M, Wang YH, Lande R, Gregorio J, Perng OA, et al. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 2007; 204:105 - 15; http://dx.doi.org/10.1084/jem.20061660; PMID: 17200410
  • Palomares O, Rückert B, Jartti T, Kücüksezer UC, Puhakka T, Gomez E, et al. Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance. J Allergy Clin Immunol 2012; 129:510 - 20, 520, e1-9; http://dx.doi.org/10.1016/j.jaci.2011.09.031; PMID: 22051696
  • Allam JP, Würtzen PA, Reinartz M, Winter J, Vrtala S, Chen KW, et al. Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties. J Allergy Clin Immunol 2010; 126:638 - 45, e1; http://dx.doi.org/10.1016/j.jaci.2010.04.039; PMID: 20584546
  • Novak N, Bieber T, Allam JP. Immunological mechanisms of sublingual allergen-specific immunotherapy. Allergy 2011; 66:733 - 9; http://dx.doi.org/10.1111/j.1398-9995.2010.02535.x; PMID: 21251016
  • Allam JP, Bieber T, Novak N. Dendritic cells as potential targets for mucosal immunotherapy. Curr Opin Allergy Clin Immunol 2009; 9:554 - 7; http://dx.doi.org/10.1097/ACI.0b013e32833239a9; PMID: 19745726
  • Rocklin RE, Sheffer AL, Greineder DK, Melmon KL. Generation of antigen-specific suppressor cells during allergy desensitization. N Engl J Med 1980; 302:1213 - 9; http://dx.doi.org/10.1056/NEJM198005293022201; PMID: 6154241
  • McHugh RS, Shevach EM. The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002; 110:693 - 702; http://dx.doi.org/10.1067/mai.2002.129339; PMID: 12417876
  • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133:775 - 87; http://dx.doi.org/10.1016/j.cell.2008.05.009; PMID: 18510923
  • Kearley J, Robinson DS, Lloyd CM. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol 2008; 122:617 - 24, e6; http://dx.doi.org/10.1016/j.jaci.2008.05.048; PMID: 18672278
  • Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004; 363:608 - 15; http://dx.doi.org/10.1016/S0140-6736(04)15592-X; PMID: 14987885
  • Verhagen J, Akdis M, Traidl-Hoffmann C, Schmid-Grendelmeier P, Hijnen D, Knol EF, et al. Absence of T-regulatory cell expression and function in atopic dermatitis skin. J Allergy Clin Immunol 2006; 117:176 - 83; http://dx.doi.org/10.1016/j.jaci.2005.10.040; PMID: 16387603
  • Orihara K, Narita M, Tobe T, Akasawa A, Ohya Y, Matsumoto K, et al. Circulating Foxp3+CD4+ cell numbers in atopic patients and healthy control subjects. J Allergy Clin Immunol 2007; 120:960 - 2; http://dx.doi.org/10.1016/j.jaci.2007.05.036; PMID: 17631953
  • Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow’s milk allergy. J Exp Med 2004; 199:1679 - 88; http://dx.doi.org/10.1084/jem.20032121; PMID: 15197226
  • Akdis M. Healthy immune response to allergens: T regulatory cells and more. Curr Opin Immunol 2006; 18:738 - 44; http://dx.doi.org/10.1016/j.coi.2006.06.003; PMID: 17023149
  • Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005; 116:961 - 8, quiz 969; http://dx.doi.org/10.1016/j.jaci.2005.09.004; PMID: 16275361
  • Zimmermann M, Koreck A, Meyer N, Basinski T, Meiler F, Simone B, et al. TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol 2011; 127:200 - 7, 207, e1-10; http://dx.doi.org/10.1016/j.jaci.2010.11.005; PMID: 21211655
  • Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33:1205 - 14; http://dx.doi.org/10.1002/eji.200322919; PMID: 12731045
  • Radulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev 2010; 12:CD002893; PMID: 21154351
  • Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998; 102:98 - 106; http://dx.doi.org/10.1172/JCI2250; PMID: 9649562
  • Aslam A, Chan H, Warrell DA, Misbah S, Ogg GS. Tracking antigen-specific T-cells during clinical tolerance induction in humans. PLoS One 2010; 5:e11028; http://dx.doi.org/10.1371/journal.pone.0011028; PMID: 20543955
  • Radulovic S, Jacobson MR, Durham SR, Nouri-Aria KT. Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa. J Allergy Clin Immunol 2008; 121:1467 - 72, 1472, e1; http://dx.doi.org/10.1016/j.jaci.2008.03.013; PMID: 18423565
  • Scadding GW, Shamji MH, Jacobson MR, Lee DI, Wilson D, Lima MT, et al. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy 2010; 40:598 - 606; PMID: 20184605
  • Akkoc T, Akdis M, Akdis CA. Update in the mechanisms of allergen-specific immunotheraphy. Allergy Asthma Immunol Res 2011; 3:11 - 20; http://dx.doi.org/10.4168/aair.2011.3.1.11; PMID: 21217920
  • Palomares O, Yaman G, Azkur AK, Akkoc T, Akdis M, Akdis CA. Role of Treg in immune regulation of allergic diseases. Eur J Immunol 2010; 40:1232 - 40; http://dx.doi.org/10.1002/eji.200940045; PMID: 20148422
  • Meiler F, Klunker S, Zimmermann M, Akdis CA, Akdis M. Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors. Allergy 2008; 63:1455 - 63; http://dx.doi.org/10.1111/j.1398-9995.2008.01774.x; PMID: 18925882
  • Bellinghausen I, König B, Böttcher I, Knop J, Saloga J. Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendritic cells and transforming growth factor-beta for their induction. Clin Exp Allergy 2006; 36:1546 - 55; http://dx.doi.org/10.1111/j.1365-2222.2006.02601.x; PMID: 17177678
  • Steinbrink K, Wölfl M, Jonuleit H, Knop J, Enk AH. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159:4772 - 80; PMID: 9366401
  • Gri G, Piconese S, Frossi B, Manfroi V, Merluzzi S, Tripodo C, et al. CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 2008; 29:771 - 81; http://dx.doi.org/10.1016/j.immuni.2008.08.018; PMID: 18993084
  • Burchell JT, Wikstrom ME, Stumbles PA, Sly PD, Turner DJ. Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells. Am J Physiol Lung Cell Mol Physiol 2009; 296:L307 - 19; http://dx.doi.org/10.1152/ajplung.00521.2007; PMID: 19028981
  • Bellinghausen I, Metz G, Enk AH, Christmann S, Knop J, Saloga J. Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects. Eur J Immunol 1997; 27:1131 - 9; http://dx.doi.org/10.1002/eji.1830270513; PMID: 9174602
  • Francis JN, Till SJ, Durham SR. Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol 2003; 111:1255 - 61; http://dx.doi.org/10.1067/mai.2003.1570; PMID: 12789226
  • Taylor A, Akdis M, Joss A, Akkoç T, Wenig R, Colonna M, et al. IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1. J Allergy Clin Immunol 2007; 120:76 - 83; http://dx.doi.org/10.1016/j.jaci.2007.04.004; PMID: 17531298
  • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209 - 20; http://dx.doi.org/10.1084/jem.174.5.1209; PMID: 1940799
  • Royer B, Varadaradjalou S, Saas P, Guillosson JJ, Kantelip JP, Arock M. Inhibition of IgE-induced activation of human mast cells by IL-10. Clin Exp Allergy 2001; 31:694 - 704; http://dx.doi.org/10.1046/j.1365-2222.2001.01069.x; PMID: 11422128
  • Huber S, Schramm C, Lehr HA, Mann A, Schmitt S, Becker C, et al. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J Immunol 2004; 173:6526 - 31; PMID: 15557141
  • Fillatreau S, Gray D, Anderton SM. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 2008; 8:391 - 7; http://dx.doi.org/10.1038/nri2315; PMID: 18437156
  • Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008; 28:639 - 50; http://dx.doi.org/10.1016/j.immuni.2008.03.017; PMID: 18482568
  • Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011; 117:530 - 41; http://dx.doi.org/10.1182/blood-2010-07-294249; PMID: 20962324
  • Hussaarts L, van der Vlugt LE, Yazdanbakhsh M, Smits HH. Regulatory B-cell induction by helminths: implications for allergic disease. J Allergy Clin Immunol 2011; 128:733 - 9; http://dx.doi.org/10.1016/j.jaci.2011.05.012; PMID: 21684587
  • Creticos PS, Van Metre TE, Mardiney MR, Rosenberg GL, Norman PS, Adkinson NF Jr.. Dose response of IgE and IgG antibodies during ragweed immunotherapy. J Allergy Clin Immunol 1984; 73:94 - 104; http://dx.doi.org/10.1016/0091-6749(84)90490-1; PMID: 6607272
  • Lichtenstein LM, Ishizaka K, Norman PS, Sobotka AK, Hill BM. IgE antibody measurements in ragweed hay fever. Relationship to clinical severity and the results of immunotherapy. J Clin Invest 1973; 52:472 - 82; http://dx.doi.org/10.1172/JCI107204; PMID: 4119162
  • Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O. Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 2005; 116:608 - 13; http://dx.doi.org/10.1016/j.jaci.2005.06.004; PMID: 16159631
  • Müller U, Helbling A, Bischof M. Predictive value of venom-specific IgE, IgG and IgG subclass antibodies in patients on immunotherapy with honey bee venom. Allergy 1989; 44:412 - 8; http://dx.doi.org/10.1111/j.1398-9995.1989.tb04172.x; PMID: 2802114
  • Luger EO, Fokuhl V, Wegmann M, Abram M, Tillack K, Achatz G, et al. Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge. J Allergy Clin Immunol 2009; 124:819 - 26, e4; http://dx.doi.org/10.1016/j.jaci.2009.06.047; PMID: 19815119
  • Piconi S, Trabattoni D, Rainone V, Borgonovo L, Passerini S, Rizzardini G, et al. Immunological effects of sublingual immunotherapy: clinical efficacy is associated with modulation of programmed cell death ligand 1, IL-10, and IgG4. J Immunol 2010; 185:7723 - 30; http://dx.doi.org/10.4049/jimmunol.1002465; PMID: 21076061
  • Gleich GJ, Zimmermann EM, Henderson LL, Yunginger JW. Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study. J Allergy Clin Immunol 1982; 70:261 - 71; http://dx.doi.org/10.1016/0091-6749(82)90062-8; PMID: 6811645
  • Djurup R, Malling HJ. High IgG4 antibody level is associated with failure of immunotherapy with inhalant allergens. Clin Allergy 1987; 17:459 - 68; http://dx.doi.org/10.1111/j.1365-2222.1987.tb02040.x; PMID: 3677372
  • Ewan PW, Deighton J, Wilson AB, Lachmann PJ. Venom-specific IgG antibodies in bee and wasp allergy: lack of correlation with protection from stings. Clin Exp Allergy 1993; 23:647 - 60; http://dx.doi.org/10.1111/j.1365-2222.1993.tb01791.x; PMID: 8221268
  • Francis JN, James LK, Paraskevopoulos G, Wong C, Calderon MA, Durham SR, et al. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J Allergy Clin Immunol 2008; 121:1120 - 5, e2; http://dx.doi.org/10.1016/j.jaci.2008.01.072; PMID: 18374405
  • Goldberg A, Confino-Cohen R. Bee venom immunotherapy - how early is it effective?. Allergy 2010; 65:391 - 5; http://dx.doi.org/10.1111/j.1398-9995.2009.02198.x; PMID: 19839973
  • Michils A, Baldassarre S, Ledent C, Mairesse M, Gossart B, Duchateau J. Early effect of ultrarush venom immunotherapy on the IgG antibody response. Allergy 2000; 55:455 - 62; http://dx.doi.org/10.1034/j.1398-9995.2000.00412.x; PMID: 10843426
  • Wachholz PA, Durham SR. Mechanisms of immunotherapy: IgG revisited. Curr Opin Allergy Clin Immunol 2004; 4:313 - 8; http://dx.doi.org/10.1097/01.all.0000136753.35948.c0; PMID: 15238798
  • Daëron M, Malbec O, Latour S, Arock M, Fridman WH. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 1995; 95:577 - 85; http://dx.doi.org/10.1172/JCI117701; PMID: 7860741
  • Till SJ, Francis JN, Nouri-Aria K, Durham SR. Mechanisms of immunotherapy. J Allergy Clin Immunol 2004; 113:1025 - 34, quiz 1035; http://dx.doi.org/10.1016/j.jaci.2004.03.024; PMID: 15208578
  • Ebner C, Siemann U, Bohle B, Willheim M, Wiedermann U, Schenk S, et al. Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 1997; 27:1007 - 15; http://dx.doi.org/10.1111/j.1365-2222.1997.tb01252.x; PMID: 9678832
  • Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Müller UR. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 1995; 154:4187 - 94; PMID: 7706753
  • Klimek L, Dormann D, Jarman ER, Cromwell O, Riechelmann H, Reske-Kunz AB. Short-term preseasonal birch pollen allergoid immunotherapy influences symptoms, specific nasal provocation and cytokine levels in nasal secretions, but not peripheral T-cell responses, in patients with allergic rhinitis. Clin Exp Allergy 1999; 29:1326 - 35; http://dx.doi.org/10.1046/j.1365-2222.1999.00651.x; PMID: 10520053
  • Till S, Walker S, Dickason R, Huston D, O’Brien F, Lamb J, et al. IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis. Clin Exp Immunol 1997; 110:114 - 21; http://dx.doi.org/10.1111/j.1365-2249.1997.494-ce1392.x; PMID: 9353157
  • Wachholz PA, Nouri-Aria KT, Wilson DR, Walker SM, Verhoef A, Till SJ, et al. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology 2002; 105:56 - 62; http://dx.doi.org/10.1046/j.1365-2567.2002.01338.x; PMID: 11849315
  • Varney VA, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993; 92:644 - 51; http://dx.doi.org/10.1172/JCI116633; PMID: 8349803
  • Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, et al. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. J Allergy Clin Immunol 1996; 97:1356 - 65; http://dx.doi.org/10.1016/S0091-6749(96)70205-1; PMID: 8648033
  • Larché M. Update on the current status of peptide immunotherapy. J Allergy Clin Immunol 2007; 119:906 - 9; http://dx.doi.org/10.1016/j.jaci.2007.02.015; PMID: 17418662
  • Schandené L, Alonso-Vega C, Willems F, Gérard C, Delvaux A, Velu T, et al. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. J Immunol 1994; 152:4368 - 74; PMID: 7512591
  • Eberlein-König B, Ullmann S, Thomas P, Przybilla B. Tryptase and histamine release due to a sting challenge in bee venom allergic patients treated successfully or unsuccessfully with hyposensitization. Clin Exp Allergy 1995; 25:704 - 12; http://dx.doi.org/10.1111/j.1365-2222.1995.tb00007.x; PMID: 7584681
  • Jutel M, Müller UR, Fricker M, Rihs S, Pichler WJ, Dahinden C. Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils. Clin Exp Allergy 1996; 26:1112 - 8; http://dx.doi.org/10.1111/j.1365-2222.1996.tb00496.x; PMID: 8911695
  • Makino Y, Noguchi E, Takahashi N, Matsumoto Y, Kubo S, Yamada T, et al. Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 2010; 126:1163 - 9, e5; http://dx.doi.org/10.1016/j.jaci.2010.06.031; PMID: 20810159
  • Pierkes M, Bellinghausen I, Hultsch T, Metz G, Knop J, Saloga J. Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. J Allergy Clin Immunol 1999; 103:326 - 32; http://dx.doi.org/10.1016/S0091-6749(99)70509-9; PMID: 9949326
  • Rak S, Björnson A, Håkanson L, Sörenson S, Venge P. The effect of immunotherapy on eosinophil accumulation and production of eosinophil chemotactic activity in the lung of subjects with asthma during natural pollen exposure. J Allergy Clin Immunol 1991; 88:878 - 88; http://dx.doi.org/10.1016/0091-6749(91)90244-I; PMID: 1744358
  • Håkansson L, Heinrich C, Rak S, Venge P. Priming of eosinophil adhesion in patients with birch pollen allergy during pollen season: effect of immunotherapy. J Allergy Clin Immunol 1997; 99:551 - 62; http://dx.doi.org/10.1016/S0091-6749(97)70084-8; PMID: 9111502
  • Uermösi C, Beerli RR, Bauer M, Manolova V, Dietmeier K, Buser RB, et al. Mechanisms of allergen-specific desensitization. J Allergy Clin Immunol 2010; 126:375 - 83; http://dx.doi.org/10.1016/j.jaci.2010.05.040; PMID: 20624641
  • Bussmann C, Xia J, Allam JP, Maintz L, Bieber T, Novak N. Early markers for protective mechanisms during rush venom immunotherapy. Allergy 2010; 65:1558 - 65; http://dx.doi.org/10.1111/j.1398-9995.2010.02430.x; PMID: 20584008
  • Iliopoulos O, Proud D, Adkinson NF Jr., Creticos PS, Norman PS, Kagey-Sobotka A, et al. Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells. J Allergy Clin Immunol 1991; 87:855 - 66; http://dx.doi.org/10.1016/0091-6749(91)90134-A; PMID: 2013680
  • Rak S, Löwhagen O, Venge P. The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients. J Allergy Clin Immunol 1988; 82:470 - 80; http://dx.doi.org/10.1016/0091-6749(88)90021-8; PMID: 3170995
  • Dehlink E, Gruber S, Eiwegger T, Gruber D, Mueller T, Huber WD, et al. Immunosuppressive therapy does not prevent the occurrence of immunoglobulin E-mediated allergies in children and adolescents with organ transplants. Pediatrics 2006; 118:e764 - 70; http://dx.doi.org/10.1542/peds.2006-0370; PMID: 16950967
  • Eiwegger T, Gruber S, Geiger C, Mayer E, Dehlink E, Bannert C, et al. Impact of systemic immuno-suppression after solid organ transplantation on allergen-specific responses. Allergy 2011; 66:271 - 8; http://dx.doi.org/10.1111/j.1398-9995.2010.02475.x; PMID: 21208218
  • Gruber S, Dehlink E, Eiwegger T, Gut S, Jaksch P, Klepetko W, et al. Immunoglobulin e-mediated allergies in lung-transplanted adults. Transplantation 2007; 84:275 - 9; http://dx.doi.org/10.1097/01.tp.0000268075.82161.9d; PMID: 17667823
  • Crameri R, Flückiger S, Daigle I, Kündig T, Rhyner C. Design, engineering and in vitro evaluation of MHC class-II targeting allergy vaccines. Allergy 2007; 62:197 - 206; http://dx.doi.org/10.1111/j.1398-9995.2006.01292.x; PMID: 17298430
  • Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, et al. Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections. J Allergy Clin Immunol 2012; 129:1290 - 6; http://dx.doi.org/10.1016/j.jaci.2012.02.026; PMID: 22464647
  • Senti G, Crameri R, Kuster D, Johansen P, Martinez-Gomez JM, Graf N, et al. Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections. J Allergy Clin Immunol 2012; 129:1290 - 6; http://dx.doi.org/10.1016/j.jaci.2012.02.026; PMID: 22464647

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