Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice

References

• Sung H, Schleiss MR. Update on the current status of cytomegalovirus vaccines. Expert Rev Vaccines 2010; 9:1303 - 14; http://dx.doi.org/10.1586/erv.10.125; PMID: 21087108
   PubMed Web of Science ®Google Scholar
• Atkinson C, Emery VC. Cytomegalovirus quantification: where to next in optimising patient management?. J Clin Virol 2011; 51:223 - 8; http://dx.doi.org/10.1016/j.jcv.2011.04.007; PMID: 21620764
   PubMed Web of Science ®Google Scholar
• Li S, Zhu J, Zhang W, Chen Y, Zhang K, Popescu LM, et al. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation 2011; 124:175 - 84; http://dx.doi.org/10.1161/CIRCULATIONAHA.110.012237; PMID: 21690488
   PubMed Web of Science ®Google Scholar
• Sandalova E, Laccabue D, Boni C, Tan AT, Fink K, Ooi EE, et al. Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans. PLoS Pathog 2010; 6:e1001051; http://dx.doi.org/10.1371/journal.ppat.1001051; PMID: 20808900
   PubMedGoogle Scholar
• Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 2005; 202:673 - 85; http://dx.doi.org/10.1084/jem.20050882; PMID: 16147978
   PubMed Web of Science ®Google Scholar
• Sinclair J, Sissons P. Latency and reactivation of human cytomegalovirus. J Gen Virol 2006; 87:1763 - 79; http://dx.doi.org/10.1099/vir.0.81891-0; PMID: 16760381
   PubMed Web of Science ®Google Scholar
• Revello MG, Gerna G. Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin Microbiol Rev 2002; 15:680 - 715; http://dx.doi.org/10.1128/CMR.15.4.680-715.2002; PMID: 12364375
   PubMed Web of Science ®Google Scholar
• McMichael G, Maclennan A, Gibson C, Alvino E, Goldwater P, Haan E, et al. Cytomegalovirus and Epstein-Barr virus may be associated with some cases of cerebral palsy. J Matern Fetal Neonatal Med 2012:Early Online: 1-4.
   Google Scholar
• Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J, Darabi A, et al. Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest 2011; 121:4043 - 55; http://dx.doi.org/10.1172/JCI57147; PMID: 21946257
   PubMed Web of Science ®Google Scholar
• Komanduri KV, Donahoe SM, Moretto WJ, Schmidt DK, Gillespie G, Ogg GS, et al. Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects. Virology 2001; 279:459 - 70; http://dx.doi.org/10.1006/viro.2000.0697; PMID: 11162802
   PubMed Web of Science ®Google Scholar
• Riddell SR. Pathogenesis of cytomegalovirus pneumonia in immunocompromised hosts. Semin Respir Infect 1995; 10:199 - 208; PMID: 8668847
   PubMedGoogle Scholar
• Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med 1998; 338:1741 - 51; http://dx.doi.org/10.1056/NEJM199806113382407; PMID: 9624195
   PubMed Web of Science ®Google Scholar
• Wloch MK, Smith LR, Boutsaboualoy S, Reyes L, Han C, Kehler J, et al. Safety and immunogenicity of a bivalent cytomegalovirus DNA vaccine in healthy adult subjects. J Infect Dis 2008; 197:1634 - 42; http://dx.doi.org/10.1086/588385; PMID: 18444883
   PubMed Web of Science ®Google Scholar
• Kharfan-Dabaja MA, Boeckh M, Wilck MB, Langston AA, Chu AH, Wloch MK, et al. A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Infect Dis 2012; 12:290 - 9; http://dx.doi.org/10.1016/S1473-3099(11)70344-9; PMID: 22237175
   PubMed Web of Science ®Google Scholar
• Boeckh M, Ljungman P. How we treat cytomegalovirus in hematopoietic cell transplant recipients. Blood 2009; 113:5711 - 9; http://dx.doi.org/10.1182/blood-2008-10-143560; PMID: 19299333
   PubMed Web of Science ®Google Scholar
• Drew WL. Is combination antiviral therapy for CMV superior to monotherapy?. J Clin Virol 2006; 35:485 - 8; http://dx.doi.org/10.1016/j.jcv.2005.09.021; PMID: 16387546
   PubMed Web of Science ®Google Scholar
• Limaye AP, Corey L, Koelle DM, Davis CL, Boeckh M. Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants. Lancet 2000; 356:645 - 9; http://dx.doi.org/10.1016/S0140-6736(00)02607-6; PMID: 10968438
   PubMed Web of Science ®Google Scholar
• Söderberg-Nauclér C. HCMV microinfections in inflammatory diseases and cancer. J Clin Virol 2008; 41:218 - 23; http://dx.doi.org/10.1016/j.jcv.2007.11.009; PMID: 18164235
   PubMed Web of Science ®Google Scholar
• Harkins L, Volk AL, Samanta M, Mikolaenko I, Britt WJ, Bland KI, et al. Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 2002; 360:1557 - 63; http://dx.doi.org/10.1016/S0140-6736(02)11524-8; PMID: 12443594
   PubMed Web of Science ®Google Scholar
• Zhou YF, Leon MB, Waclawiw MA, Popma JJ, Yu ZX, Finkel T, et al. Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy. N Engl J Med 1996; 335:624 - 30; http://dx.doi.org/10.1056/NEJM199608293350903; PMID: 8687516
   PubMed Web of Science ®Google Scholar
• Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al, American Heart Association Advocacy Coordinating Committee, Stroke Council, Council on Cardiovascular Radiology and Intervention, Council on Clinical Cardiology, Council on Epidemiology and Prevention, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Cardiovascular Nursing, Council on the Kidney in Cardiovascular Disease, Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 2011; 123:933 - 44; http://dx.doi.org/10.1161/CIR.0b013e31820a55f5; PMID: 21262990
   PubMed Web of Science ®Google Scholar
• Schmidt GM, Horak DA, Niland JC, Duncan SR, Forman SJ, Zaia JA. A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants; The City of Hope-Stanford-Syntex CMV Study Group. N Engl J Med 1991; 324:1005 - 11; http://dx.doi.org/10.1056/NEJM199104113241501; PMID: 1848679
   PubMed Web of Science ®Google Scholar
• Nieto FJ, Adam E, Sorlie P, Farzadegan H, Melnick JL, Comstock GW, et al. Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis. Circulation 1996; 94:922 - 7; http://dx.doi.org/10.1161/01.CIR.94.5.922; PMID: 8790026
   PubMed Web of Science ®Google Scholar
• Speir E, Modali R, Huang ES, Leon MB, Shawl F, Finkel T, et al. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 1994; 265:391 - 4; http://dx.doi.org/10.1126/science.8023160; PMID: 8023160
   PubMed Web of Science ®Google Scholar
• Streblow DN, Soderberg-Naucler C, Vieira J, Smith P, Wakabayashi E, Ruchti F, et al. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Cell 1999; 99:511 - 20; http://dx.doi.org/10.1016/S0092-8674(00)81539-1; PMID: 10589679
   PubMed Web of Science ®Google Scholar
• Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, King PH, et al. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 2002; 62:3347 - 50; PMID: 12067971
   PubMed Web of Science ®Google Scholar
• Huang G, Yan Q, Wang Z, Chen X, Zhang X, Guo Y, et al. Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin’s disease. Int J Oncol 2002; 21:31 - 6; PMID: 12063546
   PubMed Web of Science ®Google Scholar
• Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS. High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 2003; 170:998 - 1002; http://dx.doi.org/10.1097/01.ju.0000080263.46164.97; PMID: 12913758
   PubMed Web of Science ®Google Scholar
• Cobbs CS, Soroceanu L, Denham S, Zhang W, Britt WJ, Pieper R, et al. Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasiveness. J Neurooncol 2007; 85:271 - 80; http://dx.doi.org/10.1007/s11060-007-9423-2; PMID: 17589804
   PubMed Web of Science ®Google Scholar
• Rahbar A, Boström L, Lagerstedt U, Magnusson I, Söderberg-Naucler C, Sundqvist VA. Evidence of active cytomegalovirus infection and increased production of IL-6 in tissue specimens obtained from patients with inflammatory bowel diseases. Inflamm Bowel Dis 2003; 9:154 - 61; http://dx.doi.org/10.1097/00054725-200305000-00002; PMID: 12792220
   PubMed Web of Science ®Google Scholar
• Institute of Medicine (U.S.). Committee to Study Priorities for Vaccine Development., Stratton KR, Durch J, Lawrence RS. Vaccines for the 21st century: a tool for decisionmaking. Washington, D.C.: National Academy Press, 2000.
   Google Scholar
• Reske A, Pollara G, Krummenacher C, Chain BM, Katz DR. Understanding HSV-1 entry glycoproteins. Rev Med Virol 2007; 17:205 - 15; http://dx.doi.org/10.1002/rmv.531; PMID: 17295428
   PubMed Web of Science ®Google Scholar
• Adler SP, Starr SE, Plotkin SA, Hempfling SH, Buis J, Manning ML, et al. Immunity induced by primary human cytomegalovirus infection protects against secondary infection among women of childbearing age. J Infect Dis 1995; 171:26 - 32; http://dx.doi.org/10.1093/infdis/171.1.26; PMID: 7798679
   PubMed Web of Science ®Google Scholar
• Pass RF, Zhang C, Evans A, Simpson T, Andrews W, Huang ML, et al. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med 2009; 360:1191 - 9; http://dx.doi.org/10.1056/NEJMoa0804749; PMID: 19297572
   PubMed Web of Science ®Google Scholar
• Schleiss MR. Comparison of vaccine strategies against congenital CMV infection in the guinea pig model. J Clin Virol 2008; 41:224 - 30; http://dx.doi.org/10.1016/j.jcv.2007.10.008; PMID: 18060834
   PubMed Web of Science ®Google Scholar
• Schleiss MR, Lacayo JC, Belkaid Y, McGregor A, Stroup G, Rayner J, et al. Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis 2007; 195:789 - 98; http://dx.doi.org/10.1086/511982; PMID: 17299708
   PubMed Web of Science ®Google Scholar
• Wynn KK, Khanna R. Models of CMV infection. Drug Discov Today Dis Models 2006; 3:91 - 6; http://dx.doi.org/10.1016/j.ddmod.2006.03.011
   Google Scholar
• Frey SE, Harrison C, Pass RF, Yang E, Boken D, Sekulovich RE, et al. Effects of antigen dose and immunization regimens on antibody responses to a cytomegalovirus glycoprotein B subunit vaccine. J Infect Dis 1999; 180:1700 - 3; http://dx.doi.org/10.1086/315060; PMID: 10515836
   PubMed Web of Science ®Google Scholar
• Mitchell DK, Holmes SJ, Burke RL, Duliege AM, Adler SP. Immunogenicity of a recombinant human cytomegalovirus gB vaccine in seronegative toddlers. Pediatr Infect Dis J 2002; 21:133 - 8; http://dx.doi.org/10.1097/00006454-200202000-00009; PMID: 11840080
   PubMed Web of Science ®Google Scholar
• Pass RF, Duliegè AM, Boppana S, Sekulovich R, Percell S, Britt W, et al. A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant. J Infect Dis 1999; 180:970 - 5; http://dx.doi.org/10.1086/315022; PMID: 10479120
   PubMed Web of Science ®Google Scholar
• Costa C, Astegiano S, Terlizzi ME, Sidoti F, Curtoni A, Solidoro P, et al. Evaluation and significance of cytomegalovirus-specific cellular immune response in lung transplant recipients. Transplant Proc 2011; 43:1159 - 61; http://dx.doi.org/10.1016/j.transproceed.2011.03.024; PMID: 21620077
   PubMed Web of Science ®Google Scholar
• Gamadia LE, Remmerswaal EB, Weel JF, Bemelman F, van Lier RA, Ten Berge IJ. Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood 2003; 101:2686 - 92; http://dx.doi.org/10.1182/blood-2002-08-2502; PMID: 12411292
   PubMed Web of Science ®Google Scholar
• Eid AJ, Razonable RR. New developments in the management of cytomegalovirus infection after solid organ transplantation. Drugs 2010; 70:965 - 81; http://dx.doi.org/10.2165/10898540-000000000-00000; PMID: 20481654
   PubMed Web of Science ®Google Scholar
• Razonable RR. Immune-based therapies for cytomegalovirus infection. Immunotherapy 2010; 2:117 - 30; http://dx.doi.org/10.2217/imt.09.82; PMID: 20635892
   PubMed Web of Science ®Google Scholar
• Komanduri KV, Viswanathan MN, Wieder ED, Schmidt DK, Bredt BM, Jacobson MA, et al. Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and highly active antiretroviral therapy in individuals infected with HIV-1. Nat Med 1998; 4:953 - 6; http://dx.doi.org/10.1038/nm0898-953; PMID: 9701250
   PubMed Web of Science ®Google Scholar
• Wang D, Li F, Freed DC, Finnefrock AC, Tang A, Grimes SN, et al. Quantitative analysis of neutralizing antibody response to human cytomegalovirus in natural infection. Vaccine 2011; 29:9075 - 80; http://dx.doi.org/10.1016/j.vaccine.2011.09.056; PMID: 21945962
   PubMed Web of Science ®Google Scholar
• Nigro G, Adler SP, La Torre R, Best AM, Congenital Cytomegalovirus Collaborating Group. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 2005; 353:1350 - 62; http://dx.doi.org/10.1056/NEJMoa043337; PMID: 16192480
   PubMed Web of Science ®Google Scholar
• Britt WJ, Boppana S. Human cytomegalovirus virion proteins. Hum Immunol 2004; 65:395 - 402; http://dx.doi.org/10.1016/j.humimm.2004.02.008; PMID: 15172437
   PubMed Web of Science ®Google Scholar
• Cunningham C, Gatherer D, Hilfrich B, Baluchova K, Dargan DJ, Thomson M, et al. Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens. J Gen Virol 2010; 91:605 - 15; http://dx.doi.org/10.1099/vir.0.015891-0; PMID: 19906940
   PubMed Web of Science ®Google Scholar
• Rasmussen L, Geissler A, Cowan C, Chase A, Winters M. The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates. J Virol 2002; 76:10841 - 8; http://dx.doi.org/10.1128/JVI.76.21.10841-10848.2002; PMID: 12368327
   PubMed Web of Science ®Google Scholar
• Pignatelli S, Dal Monte P, Rossini G, Landini MP. Genetic polymorphisms among human cytomegalovirus (HCMV) wild-type strains. Rev Med Virol 2004; 14:383 - 410; http://dx.doi.org/10.1002/rmv.438; PMID: 15386592
   PubMed Web of Science ®Google Scholar
• Campadelli-Fiume G, Amasio M, Avitabile E, Cerretani A, Forghieri C, Gianni T, et al. The multipartite system that mediates entry of herpes simplex virus into the cell. Rev Med Virol 2007; 17:313 - 26; http://dx.doi.org/10.1002/rmv.546; PMID: 17573668
   PubMed Web of Science ®Google Scholar
• Britt WJ, Vugler LG. Processing of the gp55-116 envelope glycoprotein complex (gB) of human cytomegalovirus. J Virol 1989; 63:403 - 10; PMID: 2535741
   PubMed Web of Science ®Google Scholar
• Navarro D, Lennette E, Tugizov S, Pereira L. Humoral immune response to functional regions of human cytomegalovirus glycoprotein B. J Med Virol 1997; 52:451 - 9; http://dx.doi.org/10.1002/(SICI)1096-9071(199708)52:4<451::AID-JMV18>3.0.CO;2-J; PMID: 9260696
   PubMed Web of Science ®Google Scholar
• Tugizov S, Wang Y, Qadri I, Navarro D, Maidji E, Pereira L. Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation. Virology 1995; 209:580 - 91; http://dx.doi.org/10.1006/viro.1995.1290; PMID: 7778290
   PubMed Web of Science ®Google Scholar
• Cui X, Meza BP, Adler SP, McVoy MA. Cytomegalovirus vaccines fail to induce epithelial entry neutralizing antibodies comparable to natural infection. Vaccine 2008; 26:5760 - 6; http://dx.doi.org/10.1016/j.vaccine.2008.07.092; PMID: 18718497
   PubMed Web of Science ®Google Scholar
• Shimamura M, Mach M, Britt WJ. Human cytomegalovirus infection elicits a glycoprotein M (gM)/gN-specific virus-neutralizing antibody response. J Virol 2006; 80:4591 - 600; http://dx.doi.org/10.1128/JVI.80.9.4591-4600.2006; PMID: 16611919
   PubMed Web of Science ®Google Scholar
• Genini E, Percivalle E, Sarasini A, Revello MG, Baldanti F, Gerna G. Serum antibody response to the gH/gL/pUL128-131 five-protein complex of human cytomegalovirus (HCMV) in primary and reactivated HCMV infections. J Clin Virol 2011; 52:113 - 8; http://dx.doi.org/10.1016/j.jcv.2011.06.018; PMID: 21820353
   PubMed Web of Science ®Google Scholar
• Fouts AE, Chan P, Stephan JP, Vandlen R, Feierbach B. Antibodies against the gH/gL/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (anti-CMV) neutralizing antibody response in CMV hyperimmune globulin. J Virol 2012; 86:7444 - 7; http://dx.doi.org/10.1128/JVI.00467-12; PMID: 22532696
   PubMed Web of Science ®Google Scholar
• Hobom U, Brune W, Messerle M, Hahn G, Koszinowski UH. Fast screening procedures for random transposon libraries of cloned herpesvirus genomes: mutational analysis of human cytomegalovirus envelope glycoprotein genes. J Virol 2000; 74:7720 - 9; http://dx.doi.org/10.1128/JVI.74.17.7720-7729.2000; PMID: 10933677
   PubMed Web of Science ®Google Scholar
• Cha TA, Tom E, Kemble GW, Duke GM, Mocarski ES, Spaete RR. Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J Virol 1996; 70:78 - 83; PMID: 8523595
   PubMed Web of Science ®Google Scholar
• Murphy E, Yu D, Grimwood J, Schmutz J, Dickson M, Jarvis MA, et al. Coding potential of laboratory and clinical strains of human cytomegalovirus. Proc Natl Acad Sci USA 2003; 100:14976 - 81; http://dx.doi.org/10.1073/pnas.2136652100; PMID: 14657367
   PubMed Web of Science ®Google Scholar
• Laddy DJ, Yan J, Kutzler M, Kobasa D, Kobinger GP, Khan AS, et al. Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens. PLoS ONE 2008; 3:e2517; http://dx.doi.org/10.1371/journal.pone.0002517; PMID: 18575608
   PubMed Web of Science ®Google Scholar
• Yan J, Yoon H, Kumar S, Ramanathan MP, Corbitt N, Kutzler M, et al. Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine. Mol Ther 2007; 15:411 - 21; http://dx.doi.org/10.1038/sj.mt.6300036; PMID: 17235321
   PubMed Web of Science ®Google Scholar
• Chou SW, Dennison KM. Analysis of interstrain variation in cytomegalovirus glycoprotein B sequences encoding neutralization-related epitopes. J Infect Dis 1991; 163:1229 - 34; http://dx.doi.org/10.1093/infdis/163.6.1229; PMID: 1709960
   PubMed Web of Science ®Google Scholar
• Haberland M, Meyer-König U, Hufert FT. Variation within the glycoprotein B gene of human cytomegalovirus is due to homologous recombination. J Gen Virol 1999; 80:1495 - 500; PMID: 10374968
   PubMed Web of Science ®Google Scholar
• Rasmussen L, Hong C, Zipeto D, Morris S, Sherman D, Chou S, et al. Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients. J Infect Dis 1997; 175:179 - 84; http://dx.doi.org/10.1093/infdis/175.1.179; PMID: 8985216
   PubMed Web of Science ®Google Scholar
• Shepp DH, Match ME, Lipson SM, Pergolizzi RG. A fifth human cytomegalovirus glycoprotein B genotype. Res Virol 1998; 149:109 - 14; http://dx.doi.org/10.1016/S0923-2516(98)80086-1; PMID: 9602505
   PubMedGoogle Scholar
• Wu X, Wang Y, Xu Y, Wu D, Sun A, Zhu Z, et al. Cytomegalovirus glycoprotein B genotype in hematopoietic stem cell transplant patients from China. Biol Blood Marrow Transplant 2010; 16:647 - 52; http://dx.doi.org/10.1016/j.bbmt.2009.12.001; PMID: 20025986
   PubMed Web of Science ®Google Scholar
• Bergallo M, Costa C, Gambarino S, Tornicelli A, Astegiano S, Terlizzi ME, et al. Human cytomegalovirus glycoprotein B genotyping from bronchoalveolar lavage specimens. Can J Microbiol 2011; 57:273 - 7; http://dx.doi.org/10.1139/w11-014; PMID: 21491978
   PubMed Web of Science ®Google Scholar
• Görzer I, Kerschner H, Jaksch P, Bauer C, Seebacher G, Klepetko W, et al. Virus load dynamics of individual CMV-genotypes in lung transplant recipients with mixed-genotype infections. J Med Virol 2008; 80:1405 - 14; http://dx.doi.org/10.1002/jmv.21225; PMID: 18551598
   PubMed Web of Science ®Google Scholar
• Kashiwagi Y, Kawashima H, Matsuura K, Sasamoto M, Takekuma K, Hoshika A, et al. Clinical characteristics and gB genotype of cytomegalovirus infection in Japan. In Vivo 2002; 16:447 - 50; PMID: 12494888
   PubMed Web of Science ®Google Scholar
• Jung GS, Kim YY, Kim JI, Ji GY, Jeon JS, Yoon HW, et al. Full genome sequencing and analysis of human cytomegalovirus strain JHC isolated from a Korean patient. Virus Res 2011; 156:113 - 20; http://dx.doi.org/10.1016/j.virusres.2011.01.005; PMID: 21255625
   PubMed Web of Science ®Google Scholar
• Simpson JA, Chow JC, Baker J, Avdalovic N, Yuan S, Au D, et al. Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sites. J Virol 1993; 67:489 - 96; PMID: 7677958
   PubMed Web of Science ®Google Scholar
• Pignatelli S, Dal Monte P, Rossini G, Lazzarotto T, Gatto MR, Landini MP. Intrauterine cytomegalovirus infection and glycoprotein N (gN) genotypes. J Clin Virol 2003; 28:38 - 43; http://dx.doi.org/10.1016/S1386-6532(02)00236-6; PMID: 12927749
   PubMed Web of Science ®Google Scholar
• Huber MT, Compton T. Characterization of a novel third member of the human cytomegalovirus glycoprotein H-glycoprotein L complex. J Virol 1997; 71:5391 - 8; PMID: 9188610
   PubMed Web of Science ®Google Scholar
• Li L, Nelson JA, Britt WJ. Glycoprotein H-related complexes of human cytomegalovirus: identification of a third protein in the gCIII complex. J Virol 1997; 71:3090 - 7; PMID: 9060671
   PubMed Web of Science ®Google Scholar
• Ryckman BJ, Rainish BL, Chase MC, Borton JA, Nelson JA, Jarvis MA, et al. Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells. J Virol 2008; 82:60 - 70; http://dx.doi.org/10.1128/JVI.01910-07; PMID: 17942555
   PubMed Web of Science ®Google Scholar
• Wang D, Shenk T. Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. Proc Natl Acad Sci USA 2005; 102:18153 - 8; http://dx.doi.org/10.1073/pnas.0509201102; PMID: 16319222
   PubMed Web of Science ®Google Scholar
• Macagno A, Bernasconi NL, Vanzetta F, Dander E, Sarasini A, Revello MG, et al. Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex. J Virol 2010; 84:1005 - 13; http://dx.doi.org/10.1128/JVI.01809-09; PMID: 19889756
   PubMed Web of Science ®Google Scholar
• Hahn G, Revello MG, Patrone M, Percivalle E, Campanini G, Sarasini A, et al. Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes. J Virol 2004; 78:10023 - 33; http://dx.doi.org/10.1128/JVI.78.18.10023-10033.2004; PMID: 15331735
   PubMed Web of Science ®Google Scholar
• McLaughlin-Taylor E, Pande H, Forman SJ, Tanamachi B, Li CR, Zaia JA, et al. Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes. J Med Virol 1994; 43:103 - 10; http://dx.doi.org/10.1002/jmv.1890430119; PMID: 8083644
   PubMed Web of Science ®Google Scholar
• Wills MR, Carmichael AJ, Mynard K, Jin X, Weekes MP, Plachter B, et al. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 1996; 70:7569 - 79; PMID: 8892876
   PubMed Web of Science ®Google Scholar
• Ruckwardt TJ, Luongo C, Malloy AM, Liu J, Chen M, Collins PL, et al. Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope. J Immunol 2010; 185:4673 - 80; http://dx.doi.org/10.4049/jimmunol.1001606; PMID: 20833834
   PubMed Web of Science ®Google Scholar
• van der Most RG, Concepcion RJ, Oseroff C, Alexander J, Southwood S, Sidney J, et al. Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice. J Virol 1997; 71:5110 - 4; PMID: 9188577
   PubMed Web of Science ®Google Scholar
• Ebert S, Lemmermann NA, Thomas D, Renzaho A, Reddehase MJ, Holtappels R. Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells. Med Microbiol Immunol 2012; http://dx.doi.org/10.1007/s00430-012-0268-8; PMID: 22976556
   PubMed Web of Science ®Google Scholar
• Kutzler MA, Weiner DB. DNA vaccines: ready for prime time?. Nat Rev Genet 2008; 9:776 - 88; http://dx.doi.org/10.1038/nrg2432; PMID: 18781156
   PubMed Web of Science ®Google Scholar
• Kublin J. Welcome to the HVTNews. HVTNEWS: HIV Vaccine Trials Network, 2011:1.
   Google Scholar
• Yan H, Koyano S, Inami Y, Yamamoto Y, Suzutani T, Mizuguchi M, et al. Genetic variations in the gB, UL144 and UL149 genes of human cytomegalovirus strains collected from congenitally and postnatally infected Japanese children. Arch Virol 2008; 153:667 - 74; http://dx.doi.org/10.1007/s00705-008-0044-7; PMID: 18273679
   PubMed Web of Science ®Google Scholar
• Kee ST, Gehl J. W. LE. Clinical Aspects of Electroporation. Springer, New York, NY, 2011.
   Google Scholar
• Selinsky C, Luke C, Wloch M, Geall A, Hermanson G, Kaslow D, et al. A DNA-based vaccine for the prevention of human cytomegalovirus-associated diseases. Hum Vaccin 2005; 1:16 - 23; PMID: 17038834
   PubMed Web of Science ®Google Scholar
• Khan AS, Pope MA, Draghia-Akli R. Highly efficient constant-current electroporation increases in vivo plasmid expression. DNA Cell Biol 2005; 24:810 - 8; http://dx.doi.org/10.1089/dna.2005.24.810; PMID: 16332178
   PubMed Web of Science ®Google Scholar
• Shedlock DJ, Talbott KT, Cress C, Ferraro B, Tuyishme S, Mallilankaraman K, et al. A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge. Vaccine 2011; 29:6755 - 62; http://dx.doi.org/10.1016/j.vaccine.2010.12.064; PMID: 21238574
   PubMed Web of Science ®Google Scholar
• Kuzushima K, Hayashi N, Kimura H, Tsurumi T. Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay. Blood 2001; 98:1872 - 81; http://dx.doi.org/10.1182/blood.V98.6.1872; PMID: 11535524
   PubMed Web of Science ®Google Scholar
• Liu YN, Curtsinger J, Donahue PR, Klaus A, Optiz G, Cooper J, et al. Molecular analysis of the immune response to human cytomegalovirus glycoprotein B. I. Mapping of HLA-restricted helper T cell epitopes on gp93. J Gen Virol 1993; 74:2207 - 14; http://dx.doi.org/10.1099/0022-1317-74-10-2207; PMID: 7691989
   PubMed Web of Science ®Google Scholar
• Nastke MD, Herrgen L, Walter S, Wernet D, Rammensee HG, Stevanović S. Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire. Cell Mol Life Sci 2005; 62:77 - 86; http://dx.doi.org/10.1007/s00018-004-4363-x; PMID: 15619009
   PubMed Web of Science ®Google Scholar
• Lim JB, Provenzano M, Kwon OH, Bettinotti M, Caruccio L, Nagorsen D, et al. Identification of HLA-A33-restricted CMV pp65 epitopes as common targets for CD8(+) CMV-specific cytotoxic T lymphocytes. Exp Hematol 2006; 34:296 - 307; http://dx.doi.org/10.1016/j.exphem.2005.12.006; PMID: 16543064
   PubMed Web of Science ®Google Scholar
• Beninga J, Kalbacher H, Mach M. Analysis of T helper cell response to glycoprotein H (gpUL75) of human cytomegalovirus: evidence for strain-specific T cell determinants. J Infect Dis 1996; 173:1051 - 61; http://dx.doi.org/10.1093/infdis/173.5.1051; PMID: 8627054
   PubMed Web of Science ®Google Scholar
• Elkington R, Walker S, Crough T, Menzies M, Tellam J, Bharadwaj M, et al. Ex vivo profiling of CD8+-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. J Virol 2003; 77:5226 - 40; http://dx.doi.org/10.1128/JVI.77.9.5226-5240.2003; PMID: 12692225
   PubMed Web of Science ®Google Scholar