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Research Paper

Generation of antigen-specific immunity following systemic immunization with DNA vaccine encoding CCL25 chemokine immunoadjuvant

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Pages 1607-1619 | Received 14 Sep 2012, Accepted 16 Oct 2012, Published online: 01 Nov 2012

References

  • Schoenly KA, Weiner DB. Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform “spotty business”. J Virol 2008; 82:3166 - 80; PMID: 17989174
  • Kodihalli S, Kobasa DL, Webster RG. Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines. Vaccine 2000; 18:2592 - 9; http://dx.doi.org/10.1016/S0264-410X(99)00485-5; PMID: 10775793
  • Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, et al. Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. J Immunol 2005; 175:112 - 23; PMID: 15972637
  • Chattergoon MA, Saulino V, Shames JP, Stein J, Montaner LJ, Weiner DB. Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice. Vaccine 2004; 22:1744 - 50; http://dx.doi.org/10.1016/j.vaccine.2004.01.036; PMID: 15068858
  • Chattergoon MA, Kim JJ, Yang JS, Robinson TM, Lee DJ, Dentchev T, et al. Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis. Nat Biotechnol 2000; 18:974 - 9; http://dx.doi.org/10.1038/79470; PMID: 10973219
  • Toka FN, Pack CD, Rouse BT. Molecular adjuvants for mucosal immunity. Immunol Rev 2004; 199:100 - 12; http://dx.doi.org/10.1111/j.0105-2896.2004.0147.x; PMID: 15233729
  • Neeson P, Boyer J, Kumar S, Lewis MG, Mattias L, Veazey R, et al. A DNA prime-oral Listeria boost vaccine in rhesus macaques induces a SIV-specific CD8 T cell mucosal response characterized by high levels of alpha4beta7 integrin and an effector memory phenotype. Virology 2006; 354:299 - 315; http://dx.doi.org/10.1016/j.virol.2006.06.036; PMID: 16904153
  • Lee S, Gierynska M, Eo SK, Kuklin N, Rouse BT. Influence of DNA encoding cytokines on systemic and mucosal immunity following genetic vaccination against herpes simplex virus. Microbes Infect 2003; 5:571 - 8; http://dx.doi.org/10.1016/S1286-4579(03)00108-4; PMID: 12787733
  • Kaneko H, Bednarek I, Wierzbicki A, Kiszka I, Dmochowski M, Wasik TJ, et al. Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein. Virology 2000; 267:8 - 16; http://dx.doi.org/10.1006/viro.1999.0093; PMID: 10648178
  • Kusakabe K, Xin KQ, Katoh H, Sumino K, Hagiwara E, Kawamoto S, et al. The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine. J Immunol 2000; 164:3102 - 11; PMID: 10706700
  • Biragyn A, Belyakov IM, Chow YH, Dimitrov DS, Berzofsky JA, Kwak LW. DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. Blood 2002; 100:1153 - 9; http://dx.doi.org/10.1182/blood-2002-01-0086; PMID: 12149191
  • Bagarazzi ML, Boyer JD, Javadian MA, Chattergoon MA, Shah AR, Cohen AD, et al. Systemic and mucosal immunity is elicited after both intramuscular and intravaginal delivery of human immunodeficiency virus type 1 DNA plasmid vaccines to pregnant chimpanzees. J Infect Dis 1999; 180:1351 - 5; http://dx.doi.org/10.1086/314978; PMID: 10479171
  • Wang B, Dang K, Agadjanyan MG, Srikantan V, Li F, Ugen KE, et al. Mucosal immunization with a DNA vaccine induces immune responses against HIV-1 at a mucosal site. Vaccine 1997; 15:821 - 5; http://dx.doi.org/10.1016/S0264-410X(96)00259-9; PMID: 9234524
  • Kutzler MA, Kraynyak KA, Nagle SJ, Parkinson RM, Zharikova D, Chattergoon M, et al. Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo. Gene Ther 2010; 17:72 - 82; http://dx.doi.org/10.1038/gt.2009.112; PMID: 19847203
  • Kraynyak KA, Kutzler MA, Cisper NJ, Khan AS, Draghia-Akli R, Sardesal NY, et al. Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques. Vaccine 2010; 28:1942 - 51; http://dx.doi.org/10.1016/j.vaccine.2009.10.095; PMID: 20188250
  • McKenzie BS, Corbett AJ, Johnson S, Brady JL, Pleasance J, Kramer DR, et al. Bypassing luminal barriers, delivery to a gut addressin by parenteral targeting elicits local IgA responses. Int Immunol 2004; 16:1613 - 22; http://dx.doi.org/10.1093/intimm/dxh163; PMID: 15466913
  • Bourges D, Zhan Y, Brady JL, Braley H, Caminschi I, Prato S, et al. Targeting the gut vascular endothelium induces gut effector CD8 T cell responses via cross-presentation by dendritic cells. J Immunol 2007; 179:5678 - 85; PMID: 17947639
  • Rainone V, Dubois G, Temchura V, Überla K, Clivio A, Nebuloni M, et al. CCL28 induces mucosal homing of HIV-1-specific IgA-secreting plasma cells in mice immunized with HIV-1 virus-like particles. PLoS One 2011; 6:e26979; http://dx.doi.org/10.1371/journal.pone.0026979; PMID: 22066023
  • Boyer JD, Kim J, Ugen K, Cohen AD, Ahn L, Schumann K, et al. HIV-1 DNA vaccines and chemokines. Vaccine 1999; 17:Suppl 2 S53 - 64; http://dx.doi.org/10.1016/S0264-410X(99)00235-2; PMID: 10506409
  • Sin J, Kim JJ, Pachuk C, Satishchandran C, Weiner DB. DNA vaccines encoding interleukin-8 and RANTES enhance antigen-specific Th1-type CD4(+) T-cell-mediated protective immunity against herpes simplex virus type 2 in vivo. J Virol 2000; 74:11173 - 80; http://dx.doi.org/10.1128/JVI.74.23.11173-11180.2000; PMID: 11070014
  • Kim JJ, Yang JS, Dentchev T, Dang K, Weiner DB. Chemokine gene adjuvants can modulate immune responses induced by DNA vaccines. J Interferon Cytokine Res 2000; 20:487 - 98; http://dx.doi.org/10.1089/10799900050023906; PMID: 10841077
  • McKay PF, Barouch DH, Santra S, Sumida SM, Jackson SS, Gorgone DA, et al. Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses. Eur J Immunol 2004; 34:1011 - 20; http://dx.doi.org/10.1002/eji.200324840; PMID: 15048711
  • Kutzler MA, Weiner DB. Developing DNA vaccines that call to dendritic cells. J Clin Invest 2004; 114:1241 - 4; PMID: 15520855
  • Feng N, Jaimes MC, Lazarus NH, Monak D, Zhang C, Butcher EC, et al. Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. J Immunol 2006; 176:5749 - 59; PMID: 16670280
  • Hieshima K, Kawasaki Y, Hanamoto H, Nakayama T, Nagakubo D, Kanamaru A, et al. CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. J Immunol 2004; 173:3668 - 75; PMID: 15356112
  • Nakayama T, Hieshima K, Izawa D, Tatsumi Y, Kanamaru A, Yoshie O. Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J Immunol 2003; 170:1136 - 40; PMID: 12538668
  • Lazarus NH, Kunkel EJ, Johnston B, Wilson E, Youngman KR, Butcher EC. A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol 2003; 170:3799 - 805; PMID: 12646646
  • Wurbel MA, Malissen M, Guy-Grand D, Malissen B, Campbell JJ. Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol 2007; 178:7598 - 606; PMID: 17548595
  • Marsal J, Svensson M, Ericsson A, Iranpour AH, Carramolino L, Márquez G, et al. Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8alpha alpha+CD3+ intraepithelial lymphocyte compartment. Eur J Immunol 2002; 32:3488 - 97; http://dx.doi.org/10.1002/1521-4141(200212)32:12<3488::AID-IMMU3488>3.0.CO;2-E; PMID: 12442331
  • Svensson M, Johansson-Lindbom B, Wurbel MA, Malissen B, Márquez G, Agace W. Selective generation of gut-tropic T cells in gut-associated lymphoid tissues: requirement for GALT dendritic cells and adjuvant. Ann N Y Acad Sci 2004; 1029:405 - 7; http://dx.doi.org/10.1196/annals.1309.025; PMID: 15681793
  • Stenstad H, Ericsson A, Johansson-Lindbom B, Svensson M, Marsal J, Mack M, et al. Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine. Blood 2006; 107:3447 - 54; http://dx.doi.org/10.1182/blood-2005-07-2860; PMID: 16391017
  • Sundström P, Lundin SB, Nilsson LA, Quiding-Järbrink M. Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC). Eur J Immunol 2008; 38:3327 - 38; http://dx.doi.org/10.1002/eji.200838506; PMID: 19003934
  • Wendland M, Czeloth N, Mach N, Malissen B, Kremmer E, Pabst O, et al. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci U S A 2007; 104:6347 - 52; http://dx.doi.org/10.1073/pnas.0609180104; PMID: 17404233
  • Morteau O, Gerard C, Lu B, Ghiran S, Rits M, Fujiwara Y, et al. An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation. J Immunol 2008; 181:6309 - 15; PMID: 18941222
  • Mata M, Travers PJ, Liu Q, Frankel FR, Paterson Y. The MHC class I-restricted immune response to HIV-gag in BALB/c mice selects a single epitope that does not have a predictable MHC-binding motif and binds to Kd through interactions between a glutamine at P3 and pocket D. J Immunol 1998; 161:2985 - 93; PMID: 9743362
  • Toka FN, Rouse BT. Mucosal application of plasmid-encoded IL-15 sustains a highly protective anti-Herpes simplex virus immunity. J Leukoc Biol 2005; 78:178 - 86; http://dx.doi.org/10.1189/jlb.1004621; PMID: 15817700
  • Sin JI, Kim JJ, Arnold RL, Shroff KE, McCallus D, Pachuk C, et al. IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge. J Immunol 1999; 162:2912 - 21; PMID: 10072541
  • Okada E, Sasaki S, Ishii N, Aoki I, Yasuda T, Nishioka K, et al. Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J Immunol 1997; 159:3638 - 47; PMID: 9317164
  • Eo SK, Lee S, Kumaraguru U, Rouse BT. Immunopotentiation of DNA vaccine against herpes simplex virus via co-delivery of plasmid DNA expressing CCR7 ligands. Vaccine 2001; 19:4685 - 93; http://dx.doi.org/10.1016/S0264-410X(01)00241-9; PMID: 11535317
  • McDermott MR, Bienenstock J. Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues. J Immunol 1979; 122:1892 - 8; PMID: 448111
  • Masopust D, Vezys V, Wherry EJ, Barber DL, Ahmed R. Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. J Immunol 2006; 176:2079 - 83; PMID: 16455963
  • Belyakov IM, Hammond SA, Ahlers JD, Glenn GM, Berzofsky JA. Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells. J Clin Invest 2004; 113:998 - 1007; PMID: 15057306
  • Berry LJ, Hickey DK, Skelding KA, Bao S, Rendina AM, Hansbro PM, et al. Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect Immun 2004; 72:1019 - 28; http://dx.doi.org/10.1128/IAI.72.2.1019-1028.2004; PMID: 14742549
  • Glenn GM, Scharton-Kersten T, Vassell R, Mallett CP, Hale TL, Alving CR. Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge. J Immunol 1998; 161:3211 - 4; PMID: 9759833
  • Godefroy S, Goestch L, Plotnicky-Gilquin H, Nguyen TN, Schmitt D, Staquet MJ, et al. Immunization onto shaved skin with a bacterial enterotoxin adjuvant protects mice against respiratory syncytial virus (RSV). Vaccine 2003; 21:1665 - 71; http://dx.doi.org/10.1016/S0264-410X(02)00733-8; PMID: 12639488
  • Guebre-Xabier M, Hammond SA, Epperson DE, Yu J, Ellingsworth L, Glenn GM. Immunostimulant patch containing heat-labile enterotoxin from Escherichia coli enhances immune responses to injected influenza virus vaccine through activation of skin dendritic cells. J Virol 2003; 77:5218 - 25; http://dx.doi.org/10.1128/JVI.77.9.5218-5225.2003; PMID: 12692224
  • Güereña-Burgueño F, Hall ER, Taylor DN, Cassels FJ, Scott DA, Wolf MK, et al. Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously. Infect Immun 2002; 70:1874 - 80; http://dx.doi.org/10.1128/IAI.70.4.1874-1880.2002; PMID: 11895950
  • Scharton-Kersten T, Yu J, Vassell R, O’Hagan D, Alving CR, Glenn GM. Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants. Infect Immun 2000; 68:5306 - 13; http://dx.doi.org/10.1128/IAI.68.9.5306-5313.2000; PMID: 10948159
  • Yu J, Cassels F, Scharton-Kersten T, Hammond SA, Hartman A, Angov E, et al. Transcutaneous immunization using colonization factor and heat-labile enterotoxin induces correlates of protective immunity for enterotoxigenic Escherichia coli. Infect Immun 2002; 70:1056 - 68; http://dx.doi.org/10.1128/IAI.70.3.1056-1068.2002; PMID: 11854183
  • Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, et al. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest 2003; 111:1001 - 10; PMID: 12671049
  • Chattergoon MA, Robinson TM, Boyer JD, Weiner DB. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen-presenting cells. J Immunol 1998; 160:5707 - 18; PMID: 9637479
  • Robinson HL, Boyle CA, Feltquate DM, Morin MJ, Santoro JC, Webster RG. DNA immunization for influenza virus: studies using hemagglutinin- and nucleoprotein-expressing DNAs. J Infect Dis 1997; 176:Suppl 1 S50 - 5; http://dx.doi.org/10.1086/514176; PMID: 9240695
  • Kim JJ, Nottingham LK, Sin JI, Tsai A, Morrison L, Oh J, et al. CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. J Clin Invest 1998; 102:1112 - 24; http://dx.doi.org/10.1172/JCI3986; PMID: 9739045
  • Ogawa T, Tarkowski A, McGhee ML, Moldoveanu Z, Mestecky J, Hirsch HZ, et al. Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue. J Immunol 1989; 142:1150 - 8; PMID: 2644350
  • Mestecky J, Jackson S, Moldoveanu Z, Nesbit LR, Kulhavy R, Prince SJ, et al. Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals. AIDS Res Hum Retroviruses 2004; 20:972 - 88; http://dx.doi.org/10.1089/aid.2004.20.972; PMID: 15585085
  • Slifka MK, Ahmed R. Limiting dilution analysis of virus-specific memory B cells by an ELISPOT assay. J Immunol Methods 1996; 199:37 - 46; http://dx.doi.org/10.1016/S0022-1759(96)00146-9; PMID: 8960096
  • Brown KA, Kriss JA, Moser CA, Wenner WJ, Offit PA. Circulating rotavirus-specific antibody-secreting cells (ASCs) predict the presence of rotavirus-specific ASCs in the human small intestinal lamina propria. J Infect Dis 2000; 182:1039 - 43; http://dx.doi.org/10.1086/315808; PMID: 10979897
  • Crotty S, Aubert RD, Glidewell J, Ahmed R. Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. J Immunol Methods 2004; 286:111 - 22; http://dx.doi.org/10.1016/j.jim.2003.12.015; PMID: 15087226
  • Qadri F, Ryan ET, Faruque AS, Ahmed F, Khan AI, Islam MM, et al. Antigen-specific immunoglobulin A antibodies secreted from circulating B cells are an effective marker for recent local immune responses in patients with cholera: comparison to antibody-secreting cell responses and other immunological markers. Infect Immun 2003; 71:4808 - 14; http://dx.doi.org/10.1128/IAI.71.8.4808-4814.2003; PMID: 12874365
  • Mozdzanowska K, Feng J, Eid M, Zharikova D, Gerhard W. Enhancement of neutralizing activity of influenza virus-specific antibodies by serum components. Virology 2006; 352:418 - 26; http://dx.doi.org/10.1016/j.virol.2006.05.008; PMID: 16777168

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