2,363
Views
33
CrossRef citations to date
0
Altmetric
Research Paper

Identification and characterization of antigens as vaccine candidates against Klebsiella pneumoniae

, , , &
Pages 497-505 | Received 18 Oct 2012, Accepted 27 Oct 2012, Published online: 18 Dec 2012

References

  • Stamm WE, Weinstein RA, Mannheim W. Comparison of endemic and epidemic nosocomial infection. Nosocomial infection. In: Dixon R E, ed. Nosocomial infections. Atlanta, Ga: Yorke Medical Books; 1981:9-13.
  • Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet 2005; 365:1175 - 88; http://dx.doi.org/10.1016/S0140-6736(05)71881-X; PMID: 15794973
  • Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39:309 - 17; http://dx.doi.org/10.1086/421946; PMID: 15306996
  • Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998; 11:589 - 603; PMID: 9767057
  • Wu LT, Hung SW, Chuang YC, Chen HE, Jones RN, Yu WL. Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan. Clin Microbiol Infect 2005; 11:893 - 7; http://dx.doi.org/10.1111/j.1469-0691.2005.01252.x; PMID: 16216104
  • Hawkey P, Finch R. Tigecycline: in-vitro performance as a predictor of clinical efficacy. Clin Microbiol Infect 2007; 13:354 - 62; http://dx.doi.org/10.1111/j.1469-0691.2006.01621.x; PMID: 17359318
  • Ahmad TA, El-Sayed LH, Haroun M, Hussein AA, El Ashry SH. Development of immunization trials against Klebsiella pneumoniae. Vaccine 2012; 30:2411 - 20; http://dx.doi.org/10.1016/j.vaccine.2011.11.027; PMID: 22100884
  • Campbell WN, Hendrix E, Cryz S Jr., Cross AS. Immunogenicity of a 24-valent Klebsiella capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide conjugate vaccine administered to victims of acute trauma. Clin Infect Dis 1996; 23:179 - 81; http://dx.doi.org/10.1093/clinids/23.1.179; PMID: 8816151
  • Chhibber S, Bajaj J. Polysaccharide-iron-regulated cell surface protein conjugate vaccine: its role in protection against Klebsiella pneumoniae-induced lobar pneumonia. Vaccine 1995; 13:179 - 84; http://dx.doi.org/10.1016/0264-410X(95)93133-T; PMID: 7625113
  • Edelman R, Taylor DN, Wasserman SS, McClain JB, Cross AS, Sadoff JC, et al. Phase 1 trial of a 24-valent Klebsiella capsular polysaccharide vaccine and an eight-valent Pseudomonas O-polysaccharide conjugate vaccine administered simultaneously. Vaccine 1994; 12:1288 - 94; http://dx.doi.org/10.1016/S0264-410X(94)80054-4; PMID: 7856293
  • Cryz SJ Jr., Mortimer PM, Mansfield V, Germanier R. Seroepidemiology of Klebsiella bacteremic isolates and implications for vaccine development. J Clin Microbiol 1986; 23:687 - 90; PMID: 3517058
  • Yadav V, Sharma S, Harjai K, Mohan H, Chhibber S. Lipopolysaccharide-mediated protection against Klebsiella pneumoniae-induced lobar pneumonia: intranasal vs. intramuscular route of immunization. Folia Microbiol (Praha) 2005; 50:83 - 6; http://dx.doi.org/10.1007/BF02931298; PMID: 15954538
  • Cryz SJ Jr., Fürer E, Germanier R. Safety and immunogenicity of Klebsiella pneumoniae K1 capsular polysaccharide vaccine in humans. J Infect Dis 1985; 151:665 - 71; http://dx.doi.org/10.1093/infdis/151.4.665; PMID: 3882856
  • Cryz SJ Jr., Mortimer P, Cross AS, Fürer E, Germanier R. Safety and immunogenicity of a polyvalent Klebsiella capsular polysaccharide vaccine in humans. Vaccine 1986; 4:15 - 20; http://dx.doi.org/10.1016/0264-410X(86)90092-7; PMID: 3962447
  • Cryz SJ Jr., Mortimer P, Cross AS, Fürer E, Germanier R. Safety and immunogenicity of a polyvalent Klebsiella capsular polysaccharide vaccine in humans. Vaccine 1986; 4:15 - 20; http://dx.doi.org/10.1016/0264-410X(86)90092-7; PMID: 3962447
  • Kurupati P, Teh BK, Kumarasinghe G, Poh CL. Identification of vaccine candidate antigens of an ESBL producing Klebsiella pneumoniae clinical strain by immunoproteome analysis. Proteomics 2006; 6:836 - 44; http://dx.doi.org/10.1002/pmic.200500214; PMID: 16372264
  • Kurupati P, Ramachandran NP, Poh CL. Protective efficacy of DNA vaccines encoding outer membrane protein A and OmpK36 of Klebsiella pneumoniae in mice. Clin Vaccine Immunol 2011; 18:82 - 8; http://dx.doi.org/10.1128/CVI.00275-10; PMID: 21048001
  • Etz H, Minh DB, Henics T, Dryla A, Winkler B, Triska C, et al. Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus. Proc Natl Acad Sci U S A 2002; 99:6573 - 8; http://dx.doi.org/10.1073/pnas.092569199; PMID: 11997460
  • Giefing C, Meinke AL, Hanner M, Henics T, Bui MD, Gelbmann D, et al. Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies. J Exp Med 2008; 205:117 - 31; http://dx.doi.org/10.1084/jem.20071168; PMID: 18166586
  • Henics T, Winkler B, Pfeifer U, Gill SR, Buschle M, von Gabain A, et al. Small-fragment genomic libraries for the display of putative epitopes from clinically significant pathogens. Biotechniques 2003; 35:196 - 202, 204, 206 passim; PMID: 12866421
  • Meinke A, Henics T, Hanner M, Minh DB, Nagy E. Antigenome technology: a novel approach for the selection of bacterial vaccine candidate antigens. Vaccine 2005; 23:2035 - 41; http://dx.doi.org/10.1016/j.vaccine.2005.01.005; PMID: 15755567
  • www.ecdc.europa.eu/en/publications/Publications/120215_SUR_HAI_2007.pdf
  • Lavender H, Jagnow JJ, Clegg S. Klebsiella pneumoniae type 3 fimbria-mediated immunity to infection in the murine model of respiratory disease. Int J Med Microbiol 2005; 295:153 - 9; http://dx.doi.org/10.1016/j.ijmm.2005.04.001; PMID: 16047414
  • Regué M, Hita B, Piqué N, Izquierdo L, Merino S, Fresno S, et al. A gene, uge, is essential for Klebsiella pneumoniae virulence. Infect Immun 2004; 72:54 - 61; http://dx.doi.org/10.1128/IAI.72.1.54-61.2004; PMID: 14688080
  • Kuenen JD, van Dijke EE, Hol C, Bootsma HJ, Verhoef J, van Dijk H. Protective effects of orally administered, Klebsiella-containing bacterial lysates in mice. FEMS Immunol Med Microbiol 1994; 8:69 - 75; http://dx.doi.org/10.1111/j.1574-695X.1994.tb00427.x; PMID: 8156053
  • Tomás JM, Benedí VJ, Ciurana B, Jofre J. Role of capsule and O antigen in resistance of Klebsiella pneumoniae to serum bactericidal activity. Infect Immun 1986; 54:85 - 9; PMID: 3531020
  • Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, et al, National Healthcare Safety Network Team, Participating National Healthcare Safety Network Facilities. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008; 29:996 - 1011; http://dx.doi.org/10.1086/591861; PMID: 18947320
  • Ullmann U. [Bacterial infection agents in hospitalized patients]. Zentralbl Bakteriol Mikrobiol Hyg B 1986; 183:103 - 13; PMID: 3107262
  • Ortega M, Marco F, Soriano A, Almela M, Martínez JA, López J, et al. Epidemiology and prognostic determinants of bacteraemic biliary tract infection. J Antimicrob Chemother 2012; 67:1508 - 13; http://dx.doi.org/10.1093/jac/dks062; PMID: 22408140
  • Hansen DS, Mestre F, Alberti S, Hernández-Allés S, Alvarez D, Doménech-Sánchez A, et al. Klebsiella pneumoniae lipopolysaccharide O typing: revision of prototype strains and O-group distribution among clinical isolates from different sources and countries. J Clin Microbiol 1999; 37:56 - 62; PMID: 9854064
  • Tomas JM, Camprubi S, Williams P. Surface exposure of the O-antigen in Klebsiella pneumoniae O1:K1 serotype strains. Microb Pathog 1988; 5:141 - 7; http://dx.doi.org/10.1016/0882-4010(88)90016-2; PMID: 3070259
  • Rukavina T, Tícac B, Susa M, Jendrike N, Jonjíc S, Lucin P, et al. Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. Infect Immun 1997; 65:1754 - 60; PMID: 9125558
  • Mandine E, Salles MF, Zalisz R, Guenounou M, Smets P. Murine monoclonal antibodies to Klebsiella pneumoniae protect against lethal endotoxemia and experimental infection with capsulated K. pneumoniae. Infect Immun 1990; 58:2828 - 33; PMID: 1696932
  • Goetsch L, Gonzalez A, Plotnicky-Gilquin H, Haeuw JF, Aubry JP, Beck A, et al. Targeting of nasal mucosa-associated antigen-presenting cells in vivo with an outer membrane protein A derived from Klebsiella pneumoniae. Infect Immun 2001; 69:6434 - 44; http://dx.doi.org/10.1128/IAI.69.10.6434-6444.2001; PMID: 11553588
  • Struve C, Bojer M, Krogfelt KA. Identification of a conserved chromosomal region encoding Klebsiella pneumoniae type 1 and type 3 fimbriae and assessment of the role of fimbriae in pathogenicity. Infect Immun 2009; 77:5016 - 24; http://dx.doi.org/10.1128/IAI.00585-09; PMID: 19703972
  • Struve C, Bojer M, Krogfelt KA. Characterization of Klebsiella pneumoniae type 1 fimbriae by detection of phase variation during colonization and infection and impact on virulence. Infect Immun 2008; 76:4055 - 65; http://dx.doi.org/10.1128/IAI.00494-08; PMID: 18559432
  • Klipstein FA, Engert RF, Houghten RA. Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin. Infect Immun 1983; 42:838 - 41; PMID: 6358035
  • Struve C, Forestier C, Krogfelt KA. Application of a novel multi-screening signature-tagged mutagenesis assay for identification of Klebsiella pneumoniae genes essential in colonization and infection. Microbiology 2003; 149:167 - 76; http://dx.doi.org/10.1099/mic.0.25833-0; PMID: 12576590
  • Lai YC, Peng HL, Chang HY. Identification of genes induced in vivo during Klebsiella pneumoniae CG43 infection. Infect Immun 2001; 69:7140 - 5; http://dx.doi.org/10.1128/IAI.69.11.7140-7145.2001; PMID: 11598090
  • Meinke A, Storm M, Henics T, Gelbmann D, Prustomersky S, Kovács Z, et al. Composition of the ANTIGENome of Helicobacter pylori defined by human serum antibodies. Vaccine 2009; 27:3251 - 9; http://dx.doi.org/10.1016/j.vaccine.2009.01.066; PMID: 19200834
  • Roe EA, Jones RJ, Dyster RE. Passive immunization of mice against Klebsiella aerogenes. Br J Exp Pathol 1986; 67:25 - 32; PMID: 3511939
  • Rukavina T, Ticac B, Vasiljev V. IL-10 in antilipopolysaccharide immunity against systemic Klebsiella infections. Mediators Inflamm 2006; 2006:69431; http://dx.doi.org/10.1155/MI/2006/69431; PMID: 17392590
  • Zisman DA, Strieter RM, Kunkel SL, Tsai WC, Wilkowski JM, Bucknell KA, et al. Ethanol feeding impairs innate immunity and alters the expression of Th1- and Th2-phenotype cytokines in murine Klebsiella pneumonia. Alcohol Clin Exp Res 1998; 22:621 - 7; http://dx.doi.org/10.1111/j.1530-0277.1998.tb04303.x; PMID: 9622442
  • Curtis MM, Way SS. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009; 126:177 - 85; http://dx.doi.org/10.1111/j.1365-2567.2008.03017.x; PMID: 19125888
  • Peck A, Mellins ED. Precarious balance: Th17 cells in host defense. Infect Immun 2010; 78:32 - 8; http://dx.doi.org/10.1128/IAI.00929-09; PMID: 19901061

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.